LOCUS       NM_130848               3135 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens dendritic cell associated nuclear protein 1 (DCANP1),
            mRNA.
ACCESSION   NM_130848
VERSION     NM_130848.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3135)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3135)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3135)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3135)
  AUTHORS   Chen,D., Li,Y.P., Yu,Y.X., Zhou,T., Liu,C., Fei,E.K., Gao,F.,
            Mu,C.C., Ren,H.G. and Wang,G.H.
  TITLE     Dendritic cell nuclear protein-1 regulates melatonin biosynthesis
            by binding to BMAL1 and inhibiting the transcription of
            N-acetyltransferase in C6 cells
  JOURNAL   Acta Pharmacol Sin 39 (4), 597-606 (2018)
   PUBMED   29219947
  REMARK    GeneRIF: Our study reveals a connection between the major
            depression candidate protein DCNP1, circadian system and melatonin
            biosynthesis, which may contribute to the pathogenesis of
            depression.
REFERENCE   5  (bases 1 to 3135)
  AUTHORS   Li,H., Wang,Y.J., Hua,L., Yang,Y.T., Zhang,M., Zhang,D., Wang,C.
            and Xu,Z.Q.
  TITLE     Lack of association between dendritic cell nuclear protein-1 gene
            and major depressive disorder in the Han Chinese population
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 45, 7-10 (2013)
   PUBMED   23619526
  REMARK    GeneRIF: In the Han Chinese population, common DCNP1 polymorphisms
            are unlikely to be important in the genetic susceptibility to MDD.
REFERENCE   6  (bases 1 to 3135)
  AUTHORS   Bosker,F.J., Hartman,C.A., Nolte,I.M., Prins,B.P., Terpstra,P.,
            Posthuma,D., van Veen,T., Willemsen,G., DeRijk,R.H., de Geus,E.J.,
            Hoogendijk,W.J., Sullivan,P.F., Penninx,B.W., Boomsma,D.I.,
            Snieder,H. and Nolen,W.A.
  TITLE     Poor replication of candidate genes for major depressive disorder
            using genome-wide association data
  JOURNAL   Mol Psychiatry 16 (5), 516-532 (2011)
   PUBMED   20351714
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3135)
  AUTHORS   Zhou,T., Wang,S., Ren,H., Qi,X.R., Luchetti,S., Kamphuis,W.,
            Zhou,J.N., Wang,G. and Swaab,D.F.
  TITLE     Dendritic cell nuclear protein-1, a novel depression-related
            protein, upregulates corticotropin-releasing hormone expression
  JOURNAL   Brain 133 (10), 3069-3079 (2010)
   PUBMED   20693543
  REMARK    GeneRIF: We propose that full-length dendritic cell nucleus
            protein-1 may play a role in the pathogenesis of depressive
            disorders by enhancing corticotropin-releasing hormone expression
            in the hypothalamic paraventricular nucleus.
REFERENCE   8  (bases 1 to 3135)
  AUTHORS   Kim,Y., Park,C.S., Shin,H.D., Choi,J.W., Cheong,H.S., Park,B.L.,
            Choi,Y.H., Jang,A.S., Park,S.W., Lee,Y.M., Lee,E.J., Park,S.G.,
            Lee,J.Y., Lee,J.K., Han,B.G., Oh,B. and Kimm,K.
  TITLE     A promoter nucleotide variant of the dendritic cell-specific DCNP1
            associates with serum IgE levels specific for dust mite allergens
            among the Korean asthmatics
  JOURNAL   Genes Immun 8 (5), 369-378 (2007)
   PUBMED   17460725
  REMARK    GeneRIF: the genetic polymorphism of DCNP1 may influence production
            of specific IgE by altering DC (Dendritic Cells)functions in the
            mite allergen presenting and/or processing.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3135)
  AUTHORS   Willis-Owen,S.A., Shifman,S., Copley,R.R. and Flint,J.
  TITLE     DCNP1: a novel candidate gene for major depression
  JOURNAL   Mol Psychiatry 11 (2), 121-122 (2006)
   PUBMED   16189510
  REMARK    GeneRIF: Marker rs12520799, in dendritic cell nuclear protein 1 on
            chromosome 5, yielded a significant association with lifetime major
            depression.
REFERENCE   10 (bases 1 to 3135)
  AUTHORS   Masuda,M., Senju,S., Fujii Si,S., Terasaki,Y., Takeya,M., Hashimoto
            Si,S., Matsushima,K., Yumoto,E. and Nishimura,Y.
  TITLE     Identification and immunocytochemical analysis of DCNP1, a
            dendritic cell-associated nuclear protein
  JOURNAL   Biochem Biophys Res Commun 290 (3), 1022-1029 (2002)
   PUBMED   11798177
  REMARK    GeneRIF: molecular cloning and immunocytochemical analysis
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022092.8.
            
            On Apr 1, 2019 this sequence version replaced NM_130848.2.
            
            Summary: This intronless gene is specifically expressed in
            dendritic cells (DCs), which are potent antigen-presenting cells
            involved in activating naive T cells to initiate antigen-specific
            immune response. The encoded protein is localized mainly in the
            perinucleus. One of the alleles (A/T) of this gene, that causes
            premature translation termination at aa 117, has been associated
            with an increased prevalence of major depression in humans.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB074498.1, BC069610.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000503143.3/ ENSP00000421871.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3135              AC022092.8         60092-63226         c
FEATURES             Location/Qualifiers
     source          1..3135
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..3135
                     /gene="DCANP1"
                     /gene_synonym="C5orf20; DCNP1"
                     /note="dendritic cell associated nuclear protein 1"
                     /db_xref="GeneID:140947"
                     /db_xref="HGNC:HGNC:24459"
                     /db_xref="MIM:609710"
     exon            1..3135
                     /gene="DCANP1"
                     /gene_synonym="C5orf20; DCNP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..975
                     /gene="DCANP1"
                     /gene_synonym="C5orf20; DCNP1"
                     /note="dendritic cell-associated nuclear protein"
                     /codon_start=1
                     /product="dendritic cell nuclear protein 1"
                     /protein_id="NP_570900.1"
                     /db_xref="CCDS:CCDS4186.1"
                     /db_xref="GeneID:140947"
                     /db_xref="HGNC:HGNC:24459"
                     /db_xref="MIM:609710"
                     /translation="MHYGAATHIQNSRSHGLETVPGHQRLERGAGGETPEFPGCHSPA
                     PPENFGNELLPLSAPLQGLSEGLYPPGRNKTLPAGVLREGAVQFLHRGLCNSNLSSEA
                     SARPSGTQDELHSSRRKTGQTRREGARKHLVCSFRLYPFTVHTVSPGNSHLALYQVFK
                     AVKLCPSETSFFLSRKSLKSSDPWHPPSLSPNSWNRQAGFRAWSSHLISLSLTCSDSQ
                     SRRVSSSQQPPLHSLSSHRRAAHVPE"
     regulatory      3103..3108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCANP1"
                     /gene_synonym="C5orf20; DCNP1"
                     /note="hexamer: ATTAAA"
     polyA_site      3123
                     /gene="DCANP1"
                     /gene_synonym="C5orf20; DCNP1"
                     /note="major polyA site"
ORIGIN      
        1 cagaacccaa gggcttacct gtgctctgtg attccccaac tagggattta gttgtagcca
       61 cggacctggt aggcaacagg gaggggattt taatctgctc cttgcatcag aaggtccaat
      121 aggcagggtt agtataatgg gagatgccct ggtagggctg gcaaggagaa gaagccacat
      181 gtattttggt ctgatgaaaa gcagcagtga tctgtcactg accaaaatgg tcccccaact
      241 atgcattacg gagcagcaac ccacatacag aactcgagaa gccacggcct ggagactgta
      301 cctggacacc aaagactgga gagaggagct ggtggggaaa ccccagagtt cccagggtgc
      361 cactccccag ctccaccaga gaactttggg aatgagctgc tgcccctgag tgcccctctc
      421 cagggcctca gtgagggtct ctaccctcca gggaggaaca aaaccttgcc agctggggtc
      481 ctgcgagagg gggcagttca attcctccac aggggactct gcaactccaa tctttcgagt
      541 gaagcatctg cgaggccctc agggacccag gatgaactgc atagcagcag aaggaagaca
      601 ggccagacca ggcgggaggg agcccggaaa catctggttt gtagtttcag actctacccg
      661 ttcacagttc acacagtctc accgggaaac tcacaccttg ccctgtacca agtttttaag
      721 gcagttaagc tctgcccatc cgagacttca tttttcttga gtagaaaatc actgaaatca
      781 tcagatccat ggcacccacc ttcactttct cctaacagct ggaaccgtca ggctggcttc
      841 agggcctggt cttcgcactt gatatcacta tccctcacct gctcagacag ccagagcagg
      901 cgggtgagtt cctcccaaca acctccactg cattctctca gctcccaccg cagggcagcc
      961 cacgtgcctg agtgaacatg tgtgcgtgtg cacacacgca agtatgcaca gacatacact
     1021 aaacacgaac atacagtgca catgaacgct gctcccagct agggccctct ggtcagactg
     1081 ctgcctgggt tagaattctt gtccccaccc ccacttacta tagttctgtg atcctggaca
     1141 agtaactgaa tctctccgtg ccacagtttc ttcttgtaga aaacgggaaa gttcacagta
     1201 cttacctcct tagagtcatt gtgaaggtca gtttgaggca tcacaaattt aaggcaccca
     1261 gacataaggg tcaacagggt tagctatcac tgtccagttt ggtgggagga actgaatgca
     1321 tgtaggcaca tggacccagt ctacactcag gcacaaaagg agctacatta gttacattca
     1381 ggcatacccc agagcactac aattctctga gacattgtct ggaaatctag aaatcatctc
     1441 cttgcccttt aaggtatttt aaccctcgca ttcctctgct tttccaagaa tgtgaatctt
     1501 gccaagctgt ccgtgagaga cacgggctcc cctcgaggga gacttgcaaa tgctccataa
     1561 acagccacag tgtggggctc tgccatgagg aagtcacagc agacacgcta gacagcatag
     1621 tcctggatgc aacctggagg aagggaggcc catggtggag cactcactcc gtgcctgtct
     1681 gcccggtgag acctcaagtt ccttgcagac aaaggccatg ggttgttggc tcttgtgttc
     1741 ccggtggcct ttccagagct gaacagagga cagatgcaca gacggggggg ctctggtggt
     1801 caaggcagca gtccccttgg atactaaagt ctgagccagg cccctcaggc ccggcatggg
     1861 cagtgcgagg cccatagtgg tgggaagcca gttggccagc tggggtgaga aggccgcgaa
     1921 gccatgggca gacaggaagt ggaggtgaat gtctctgcct cctgtaggcc tcagcaggga
     1981 cagcacagac cctctggctg gggcagcgca gaccctctag ctggggcaga acaaggctgg
     2041 tgcttccttc tagtccttga gactttgtag ctctaactca agcagaaccc tggggttttg
     2101 ggattctgtg tggtgactgc tgaggaaggt ttatggattt gacagggtgc atgtcacaga
     2161 gagacagttc tcagtcagca cttcctgtcc cctgcagagg ctcatagggg acagcccctg
     2221 ccaaggagac cctggagggg ctctgaggat agcaatcaga ggttgggctg gctggactga
     2281 gcccaggcct gttgcccacc aagtctccat aggttctagt ctgacccctc tctccacccc
     2341 tgggctatgc aggccagccc gtgcagacca cccccgacgc gtccacttgc aacacccgcc
     2401 tcactgtgcc aacactccat ccacacagga aaggactgag aacgtgatgc ttaacccaaa
     2461 ggagtgagtt tcataggatg ggtggcttta acagtttcac agcaggacac tgagggaata
     2521 tttccctatc ccttcaaatg gacggtcact acagaaacgt gtagagcaag actttgtcaa
     2581 ggggctgttt ccaggtctcc cggtgtctaa atagcagagc tggaatggga actgagaacc
     2641 gattctttcc acaaccgccc actgagcagc aaggctgcag ccagcaaaga ggtgcggagg
     2701 caagcaagct ccatgtggtg gggacagcgc attgcgacct ccaccacccc tgcagtgggc
     2761 tgccagctga gccacctgtc ttccactgta tctactgtac gaacttctcc agctctgctc
     2821 tgttttctct tcctcagcat ccaccccgtg acacgtagtg gtggctgatg tcgccacagt
     2881 accatgaggt taacaggtcc tccctccagc ttccctcatg gtggcagcct aacctgcatt
     2941 gcagccgttc accggacacc gcaccagacc ctcaaaaccc atccaagact gtgggaggag
     3001 taaacaaccc agcccagtta agaggagatg ccgaatttaa tgaaccctat ttgaattgca
     3061 gggctgtgat tcctcttacc tttaacgtga actcacaggc ggattaaagt gaaataaaac
     3121 ctaccatttg agtta
//
