LOCUS       NM_001288655            2171 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dephospho-CoA kinase domain containing (DCAKD),
            transcript variant 4, mRNA.
ACCESSION   NM_001288655 XM_005257685
VERSION     NM_001288655.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2171)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2171)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2171)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
REFERENCE   4  (bases 1 to 2171)
  AUTHORS   Daugherty,M., Polanuyer,B., Farrell,M., Scholle,M., Lykidis,A., de
            Crecy-Lagard,V. and Osterman,A.
  TITLE     Complete reconstitution of the human coenzyme A biosynthetic
            pathway via comparative genomics
  JOURNAL   J Biol Chem 277 (24), 21431-21439 (2002)
   PUBMED   11923312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116493.10 and AC015936.14.
            
            On Nov 23, 2018 this sequence version replaced NM_001288655.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 3. Variants 1-5 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.354465.1,
                                           SRR1803617.218145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267766, SAMN03465408
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651974.1/ ENSP00000498268.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               AC116493.10        49612-49883
            273-498             AC116493.10        66245-66470
            499-702             AC116493.10        66854-67057
            703-790             AC116493.10        71065-71152
            791-2171            AC015936.14        197665-199045       c
FEATURES             Location/Qualifiers
     source          1..2171
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2171
                     /gene="DCAKD"
                     /note="dephospho-CoA kinase domain containing"
                     /db_xref="GeneID:79877"
                     /db_xref="HGNC:HGNC:26238"
     exon            1..272
                     /gene="DCAKD"
                     /inference="alignment:Splign:2.1.0"
     exon            273..498
                     /gene="DCAKD"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..1082
                     /gene="DCAKD"
                     /codon_start=1
                     /product="dephospho-CoA kinase domain-containing protein"
                     /protein_id="NP_001275584.1"
                     /db_xref="CCDS:CCDS11493.1"
                     /db_xref="GeneID:79877"
                     /db_xref="HGNC:HGNC:26238"
                     /translation="MFLVGLTGGIASGKSSVIQVFQQLGCAVIDVDVMARHVVQPGYP
                     AHRRIVEVFGTEVLLENGDINRKVLGDLIFNQPDRRQLLNAITHPEIRKEMMKETFKY
                     FLRGYRYVILDIPLLFETKKLLKYMKHTVVVYCDRDTQLARLMRRNSLNRKDAEARIN
                     AQLPLTDKARMARHVLDNSGEWSVTKRQVILLHTELERSLEYLPLRFGVLTGLAAIAS
                     LLYLLTHYLLPYA"
     exon            499..702
                     /gene="DCAKD"
                     /inference="alignment:Splign:2.1.0"
     exon            703..790
                     /gene="DCAKD"
                     /inference="alignment:Splign:2.1.0"
     exon            791..2171
                     /gene="DCAKD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2137..2142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAKD"
                     /note="hexamer: AATAAA"
     polyA_site      2171
                     /gene="DCAKD"
                     /note="major polyA site"
ORIGIN      
        1 gcctcgcccg ctgagccggc ctgtaagcgc tgcggagatt gggctagagg cggaggcctg
       61 ggccacggcg gaggcgctgg gtacgtagcg cgccacgcgg gccggtgaga gccagccggg
      121 cgccggggag ggggcgggcc ctggccgcgg ctgctacgcg gggctgccac cgccccgggc
      181 gacccaattt cgcggcctag tggggcgtac gggcctcttt tgaaagcctg agttacgatg
      241 tattgagcgc gtcgtatgcg gccagcacta aggtccttct ggcactcctc tggtggaccg
      301 cccccatcgg ccacacttgc cctgctctcc agtgattctg tagctcctgg ctccgtagtc
      361 tcgcggacag ctctctttcc tggaagatgt ttctggtggg cctgacaggg ggcattgcct
      421 caggcaagag ctcagtgatc caggtgttcc agcagctggg ctgtgcggtg attgacgtgg
      481 acgtgatggc ccggcacgtc gtgcagccag gataccctgc ccaccggcgc atcgtagagg
      541 tcttcggcac tgaggtcttg ctggagaacg gcgacataaa tcgcaaggtc ctgggggacc
      601 tgatctttaa ccagcctgac cggcggcagc tgctcaacgc catcacccac cccgagattc
      661 gcaaggagat gatgaaggag acgttcaagt acttcctccg gggataccgc tacgtgattc
      721 tggatatccc cctgctgttt gagaccaaga agttgctcaa gtacatgaag cacaccgtgg
      781 tagtatactg cgaccgggac acacagctgg cacggctgat gcggcggaac agcctgaacc
      841 gcaaggacgc agaggcccgc atcaatgccc agctgcccct gacagacaag gcccgcatgg
      901 cccgccatgt cctagacaac tcgggcgagt ggagtgtcac caaacgccag gtcatcctct
      961 tgcacactga gctggagcgc tccctggagt acctgccgct gaggtttggg gtcctcacag
     1021 ggctcgctgc cattgccagc ctcctctacc tgctcaccca ctaccttctg ccttacgcct
     1081 agtggggcac tcaaggcagg gagccccagg cctccatcta tctccttgga ggctgaagcc
     1141 aggtaacaca tcctgtttcc tctcagcccc ctccccacac acacacacac acacacacac
     1201 acacacacac acacacacac acacacacgg actctccgaa tcagggctgg gcctctgtgc
     1261 caggccatcc cgtctttgga gtgtatccta tttgagatca agaaatagcc tgctgtcctt
     1321 cccaccttcc ctgagcagca cctacagaac agcaaccgtg atggtgtgtg aaagcaacag
     1381 tcagagactg ctatacattt ctgtgggtgg gggtagggaa tactggctct gtggccctcc
     1441 tcagagctgg gaggccaagg gttcactggg cttgaatcct ctctaagcac ctaccccatt
     1501 gtggcctaaa cctcctcagt ggaccacggg aaatcatgtt ggaccaaggg tttccatgtt
     1561 caaacagtca acaaggccct cccctaggtt gagatatttt ttatactgaa ggcccaggcc
     1621 ccccagtatg gcttgctgcc agcaagcagc aaggattctc tcgtgggtaa cgctgtagcc
     1681 aggcaggacc agcctcttct gggagacccc tctccccacg tagggtttgt gtagtgctcc
     1741 cacatcctgc ttattgcctg ccacccctgc ttctcgcctg gacctcttgg tattccgtgt
     1801 acaccatcct tgctgtttct tgcctctgtg ccttcaacct gctgctcctg gcctgggata
     1861 ccttttattt tcttttattt cttcttcctt tttttttttt tttttttttt taacctacaa
     1921 ctagctctca gttcaggcac tgtctaaagc cccaggctgg gttaggtggt ctaggatacc
     1981 aactccccct caacatttta ccttaatcca acagtacagt aattagccga aacttgcctg
     2041 gtttttccta ctagactgta agccctctag ggacagggac agtgtcttat tcatctctgt
     2101 gttcttagtg cagagcctgg cccgctgttg gtgtttaata aagtgtgttg atctgaaatg
     2161 ccccagacca a
//
