LOCUS       NM_001353450            3485 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 8 like 2 (DCAF8L2),
            transcript variant 3, mRNA.
ACCESSION   NM_001353450
VERSION     NM_001353450.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3485)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 3485)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat Genet 36 (1), 40-45 (2004)
   PUBMED   14702039
REFERENCE   3  (bases 1 to 3485)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   4  (bases 1 to 3485)
  AUTHORS   Venter,J.C., Adams,M.D., Myers,E.W., Li,P.W., Mural,R.J.,
            Sutton,G.G., Smith,H.O., Yandell,M., Evans,C.A., Holt,R.A.,
            Gocayne,J.D., Amanatides,P., Ballew,R.M., Huson,D.H., Wortman,J.R.,
            Zhang,Q., Kodira,C.D., Zheng,X.H., Chen,L., Skupski,M.,
            Subramanian,G., Thomas,P.D., Zhang,J., Gabor Miklos,G.L.,
            Nelson,C., Broder,S., Clark,A.G., Nadeau,J., McKusick,V.A.,
            Zinder,N., Levine,A.J., Roberts,R.J., Simon,M., Slayman,C.,
            Hunkapiller,M., Bolanos,R., Delcher,A., Dew,I., Fasulo,D.,
            Flanigan,M., Florea,L., Halpern,A., Hannenhalli,S., Kravitz,S.,
            Levy,S., Mobarry,C., Reinert,K., Remington,K., Abu-Threideh,J.,
            Beasley,E., Biddick,K., Bonazzi,V., Brandon,R., Cargill,M.,
            Chandramouliswaran,I., Charlab,R., Chaturvedi,K., Deng,Z., Di
            Francesco,V., Dunn,P., Eilbeck,K., Evangelista,C., Gabrielian,A.E.,
            Gan,W., Ge,W., Gong,F., Gu,Z., Guan,P., Heiman,T.J., Higgins,M.E.,
            Ji,R.R., Ke,Z., Ketchum,K.A., Lai,Z., Lei,Y., Li,Z., Li,J.,
            Liang,Y., Lin,X., Lu,F., Merkulov,G.V., Milshina,N., Moore,H.M.,
            Naik,A.K., Narayan,V.A., Neelam,B., Nusskern,D., Rusch,D.B.,
            Salzberg,S., Shao,W., Shue,B., Sun,J., Wang,Z., Wang,A., Wang,X.,
            Wang,J., Wei,M., Wides,R., Xiao,C., Yan,C., Yao,A., Ye,J., Zhan,M.,
            Zhang,W., Zhang,H., Zhao,Q., Zheng,L., Zhong,F., Zhong,W., Zhu,S.,
            Zhao,S., Gilbert,D., Baumhueter,S., Spier,G., Carter,C.,
            Cravchik,A., Woodage,T., Ali,F., An,H., Awe,A., Baldwin,D.,
            Baden,H., Barnstead,M., Barrow,I., Beeson,K., Busam,D., Carver,A.,
            Center,A., Cheng,M.L., Curry,L., Danaher,S., Davenport,L.,
            Desilets,R., Dietz,S., Dodson,K., Doup,L., Ferriera,S., Garg,N.,
            Gluecksmann,A., Hart,B., Haynes,J., Haynes,C., Heiner,C.,
            Hladun,S., Hostin,D., Houck,J., Howland,T., Ibegwam,C., Johnson,J.,
            Kalush,F., Kline,L., Koduru,S., Love,A., Mann,F., May,D.,
            McCawley,S., McIntosh,T., McMullen,I., Moy,M., Moy,L., Murphy,B.,
            Nelson,K., Pfannkoch,C., Pratts,E., Puri,V., Qureshi,H.,
            Reardon,M., Rodriguez,R., Rogers,Y.H., Romblad,D., Ruhfel,B.,
            Scott,R., Sitter,C., Smallwood,M., Stewart,E., Strong,R., Suh,E.,
            Thomas,R., Tint,N.N., Tse,S., Vech,C., Wang,G., Wetter,J.,
            Williams,S., Williams,M., Windsor,S., Winn-Deen,E., Wolfe,K.,
            Zaveri,J., Zaveri,K., Abril,J.F., Guigo,R., Campbell,M.J.,
            Sjolander,K.V., Karlak,B., Kejariwal,A., Mi,H., Lazareva,B.,
            Hatton,T., Narechania,A., Diemer,K., Muruganujan,A., Guo,N.,
            Sato,S., Bafna,V., Istrail,S., Lippert,R., Schwartz,R., Walenz,B.,
            Yooseph,S., Allen,D., Basu,A., Baxendale,J., Blick,L., Caminha,M.,
            Carnes-Stine,J., Caulk,P., Chiang,Y.H., Coyne,M., Dahlke,C.,
            Deslattes Mays,A., Dombroski,M., Donnelly,M., Ely,D., Esparham,S.,
            Fosler,C., Gire,H., Glanowski,S., Glasser,K., Glodek,A.,
            Gorokhov,M., Graham,K., Gropman,B., Harris,M., Heil,J.,
            Henderson,S., Hoover,J., Jennings,D., Jordan,C., Jordan,J.,
            Kasha,J., Kagan,L., Kraft,C., Levitsky,A., Lewis,M., Liu,X.,
            Lopez,J., Ma,D., Majoros,W., McDaniel,J., Murphy,S., Newman,M.,
            Nguyen,T., Nguyen,N., Nodell,M., Pan,S., Peck,J., Peterson,M.,
            Rowe,W., Sanders,R., Scott,J., Simpson,M., Smith,T., Sprague,A.,
            Stockwell,T., Turner,R., Venter,E., Wang,M., Wen,M., Wu,D., Wu,M.,
            Xia,A., Zandieh,A. and Zhu,X.
  TITLE     The sequence of the human genome
  JOURNAL   Science 291 (5507), 1304-1351 (2001)
   PUBMED   11181995
  REMARK    Erratum:[Science 2001 Jun 5;292(5523):1838]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006210.4, AC079902.15 and AC107613.15.
            
            On Jun 2, 2019 this sequence version replaced NM_001353450.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB090208.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451261.7/ ENSP00000462745.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC006210.4         173597-173693
            98-219              AC079902.15        59769-59890         c
            220-296             AC079902.15        13857-13933         c
            297-380             AC107613.15        106083-106166       c
            381-3485            AC107613.15        72312-75416         c
FEATURES             Location/Qualifiers
     source          1..3485
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.3"
     gene            1..3485
                     /gene="DCAF8L2"
                     /gene_synonym="WDR42C"
                     /note="DDB1 and CUL4 associated factor 8 like 2"
                     /db_xref="GeneID:347442"
                     /db_xref="HGNC:HGNC:31811"
     exon            1..97
                     /gene="DCAF8L2"
                     /gene_synonym="WDR42C"
                     /inference="alignment:Splign:2.1.0"
     exon            98..219
                     /gene="DCAF8L2"
                     /gene_synonym="WDR42C"
                     /inference="alignment:Splign:2.1.0"
     exon            220..296
                     /gene="DCAF8L2"
                     /gene_synonym="WDR42C"
                     /inference="alignment:Splign:2.1.0"
     exon            297..380
                     /gene="DCAF8L2"
                     /gene_synonym="WDR42C"
                     /inference="alignment:Splign:2.1.0"
     exon            381..3485
                     /gene="DCAF8L2"
                     /gene_synonym="WDR42C"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..2334
                     /gene="DCAF8L2"
                     /gene_synonym="WDR42C"
                     /note="WD repeat domain 42C; WD repeat-containing protein
                     42C"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 8-like protein
                     2"
                     /protein_id="NP_001340379.1"
                     /db_xref="CCDS:CCDS59162.1"
                     /db_xref="GeneID:347442"
                     /db_xref="HGNC:HGNC:31811"
                     /translation="MSHQEGSTDGLPDLGTESLFSSPEEQSGAVAATEASSDIDIATS
                     ELSVTVTGDGSDSRDGGFPNDASTENRSSDQESASEDIELESLEDFEHFLMSGESLFH
                     YPLVGEEETEREEEDEEIQEEGGEEEEEEEEEEEEEEEEEEEEEEQPRAGPQGSGGNH
                     EQYSLEEDQALEEWVSSETSALPRPRWQVVTALHQRQLGSRPRFVYEACGARAFVQRF
                     RLQYRLADHVGCVNTVHFNQRGTRLASSGDDLKVIVWDWVRQRPVLNFESGHTNNVFQ
                     AKFLPNCGDSTLAMCARDGQVRVAELINASYFNNTKCVAQHRGPAHKLALEPDSPYKF
                     LTSGEDAVVFTIDLRQDRPASKVVVTRENDKKVGLYTITVNPANTYQFAVGGQDQFVR
                     IYDQRKIDKKENNGVLKKFTPHHLVNCDFPTNITCVVYSHDGTELLASYNDDDIYLFN
                     SSHSDGAQYSKRFKGHRNNTTVKGVNFYGPRSEFVVSGSDCGHIFFWEKSSCQIIQFL
                     KGSREGTINCLEPHPYLPVLACSGLDHDVKIWTPTAKAATELTGLKKVIKKNKWERDE
                     DSLHHGSLFDQYMLWFLLRHVTQRGRHQDWRSGEAEFPDEESDESSSTSETSEEEVQD
                     RVQCMPS"
     regulatory      3461..3466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF8L2"
                     /gene_synonym="WDR42C"
                     /note="hexamer: AATAAA"
     polyA_site      3485
                     /gene="DCAF8L2"
                     /gene_synonym="WDR42C"
                     /note="major polyA site"
ORIGIN      
        1 gtggagtcgc aaaagctgaa catcctcccc acaaggttat ttagaagacg tcttgcactg
       61 ttcaaatgca gaggaaggcg aatgactcga gtctatggtt ttggtatact gagcctgggg
      121 ctactggtgt cagcctggtg gtagtgcagc tcatctgatg cctggggctg caggatccta
      181 gttggttcct gtgacagacc ttgggaagct caatctcaga tgtgttttct taattgaaga
      241 aaatcatatc acatgtgaac tttctgacca tactgtggag cggtgctaat aaggaggaag
      301 ctgcactgtt gcagaggtcc attaactctt tcaggacggt gtggaatcag tggggaaatc
      361 tctaattgct actgacacag agcttttagg ggcctggcct ttgcagttcc agatctacta
      421 cagcaaacat cgttcaagat gtcccaccaa gaaggcagca cagacggctt accagactta
      481 gggactgaaa gcctgttcag cagcccagag gagcagtctg gagccgtggc ggcgacagag
      541 gcctcctcag acattgacat agcgacctca gagctgagtg tgacagtgac cggagatggc
      601 agtgatagca gggatggtgg attccccaac gatgccagca cagaaaatcg aagctcagac
      661 caagaaagcg caagtgaaga catcgaactt gagagcttgg aggactttga gcatttcctc
      721 atgagtggtg aaagtttatt ccattaccct ttagtgggag aggaggagac agaaagggag
      781 gaggaagacg aagagataca agaggaggga ggggaggagg aggaagagga ggaggaggag
      841 gaggaggagg aggaggagga ggaggaggag gaagaagaac agcctcgggc gggtccacaa
      901 ggcagtggcg gcaaccatga gcagtattcg ttagaggagg atcaggcgct ggaggagtgg
      961 gtttcctcag agacatctgc cctgccccga cctcgctggc aggtcgttac tgctcttcac
     1021 cagcggcagc tgggttcacg tccccgcttt gtatatgagg cctgtggggc aagagccttt
     1081 gtgcagcgtt tccgcctgca atatcgtctt gcagaccatg tcggctgtgt caatactgta
     1141 cactttaacc agcgtggcac ccggctggcc agtagcggtg atgacctaaa ggtgatagtg
     1201 tgggactggg tgcggcagag gccagtactg aactttgaaa gtggtcacac aaataatgtc
     1261 ttccaggcca agttccttcc taactgtggt gattccactc tggccatgtg tgcccgtgat
     1321 gggcaggtac gggtagcaga gttaattaat gcatcatatt tcaacaatac taagtgtgtg
     1381 gcccagcaca ggggacctgc ccacaagttg gctctggagc ctgactctcc ttataagttc
     1441 ctcacttcag gtgaagatgc tgttgtcttc accattgacc tcagacaaga ccggccagct
     1501 tcaaaagttg tggtaacaag agaaaatgat aagaaagtgg gactgtatac aattactgtg
     1561 aatcccgcca atacctacca atttgcagtg ggtggacaag atcagtttgt aaggatttat
     1621 gaccagagga aaattgataa gaaagaaaac aatggcgtgc tcaagaaatt cactcctcat
     1681 catctggtta attgtgattt cccaacaaac atcacctgcg ttgtgtacag ccacgatggc
     1741 acagagctgc tagccagcta caatgatgac gatatttacc tcttcaactc ctctcacagt
     1801 gatggtgctc aatacagtaa gagatttaag ggacacagaa ataataccac agtcaaaggt
     1861 gttaatttct atggccccag gagtgagttt gtagtgagcg gtagtgattg cgggcacatc
     1921 ttcttctggg agaaatcatc ctgccaaatc atccagttcc taaaggggag cagagaaggt
     1981 acaataaact gtcttgaacc ccacccttac ctacctgtgt tggcgtgcag tggcctagat
     2041 catgatgtca agatctggac acccacagct aaagctgcca ctgagcttac tgggttaaag
     2101 aaggtgatta agaagaacaa gtgggaacga gatgaagaca gcttgcacca tggcagcctg
     2161 tttgaccagt acatgctttg gttcctcctg cgtcacgtga cgcagagagg tcgtcaccag
     2221 gactggagaa gtggtgaagc tgaatttcca gatgaagaat cggatgagtc ttccagcact
     2281 tcagagacat ctgaggagga ggtccaagac cgagtgcagt gcatgccatc ctgaaggcct
     2341 catatccagt ccagctacat gccacctaag tacactggac tttaaaattc agtttgacta
     2401 atttagaatt gtcaatagat taatagattt gctttttgtc ttctattttc cataatatat
     2461 gctgaaaacc gtctcttcca ttccttcctc tctactttcc tttctttctt ccacacattc
     2521 tttctctcat tcctttcctc ttggtttctt tacgcctctt ttgttacccc ttattcttac
     2581 atgagtgcat acacaactta tttatgcctc ttttcctttg ttcccttata gttgacctct
     2641 aaattttctg aattttgctg aaagaattaa tacccttatt agatgcatct actcaaatct
     2701 gacagtctga aaacggttac ctttttactt tttttcatct ttaacaattt tttctgaaga
     2761 tcgagttcct cagttgacct gaaaatttca gaaatgtgtt tcttctttag aaaataagac
     2821 aaactacagt tttgttctgt cgatactgac acttggccgc acacacacag tctcagaaaa
     2881 ggaaaagaga agtagtgtgt agattaattc ttaacacttg gccatacgca gacacagtct
     2941 cagaaaagga aaagaggaga ggtactatgt agattaattc ctaaccagat aattcatctc
     3001 cttagaataa ataacgtggg attgcctaca ttttctgaat ccatatatta ataattttga
     3061 aaaatttgag tacactgtag ctggtaagaa ctaaattaaa tttgatcaca tgacattgtt
     3121 tactctgtgc attaagtttt cttgaagttt taaggttggg aactcccaca gggttacctt
     3181 ccaggaagtc ctcctgggac aagcatgtcc tataaatgcc agcttactga tataaaaatc
     3241 tctcatattt gaaaacgcat tctaattaac ttttaagaac aagttgcaat aaagattgtt
     3301 tatacttaca cataaccatt tggtgtaatt ggtagaaaaa tcctatttga catcctcaca
     3361 ttgcttaaaa ttctctctgc tgtttaaatt gctttaaaaa ttgttttatg cctcatttaa
     3421 tataaattaa ataagggtac tggatgtcca attactgctc aataaaaata tttgttttta
     3481 tttta
//
