LOCUS       NM_001017930            3458 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 8 like 1 (DCAF8L1),
            mRNA.
ACCESSION   NM_001017930 XM_066690
VERSION     NM_001017930.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3458)
  AUTHORS   Kerns,S.L., Ostrer,H., Stock,R., Li,W., Moore,J., Pearlman,A.,
            Campbell,C., Shao,Y., Stone,N., Kusnetz,L. and Rosenstein,B.S.
  TITLE     Genome-wide association study to identify single nucleotide
            polymorphisms (SNPs) associated with the development of erectile
            dysfunction in African-American men after radiotherapy for prostate
            cancer
  JOURNAL   Int J Radiat Oncol Biol Phys 78 (5), 1292-1300 (2010)
   PUBMED   20932654
REFERENCE   2  (bases 1 to 3458)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
  REMARK    GeneRIF: Functionally characterizes other DDB1- and CUL4-associated
            factors, including the DCAF8 factor which most closely resembles
            the product of this gene.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK128123.1 and AC004553.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001017930.1.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD),
            which may facilitate the formation of heterotrimeric or
            multi-protein complexes. Members of this family are involved in a
            variety of cellular processes, including cell cycle progression,
            signal transduction, apoptosis, and gene regulation. This gene
            appears to represent an intronless retrocopy of a related
            multi-exon gene located on chromosome 1. However, the CDS of this
            intronless gene remains intact, it is conserved in other primate
            species, it is known to be transcribed, and it is therefore thought
            to encode a functional protein. [provided by RefSeq, May 2010].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK128123.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000441525.4/ ENSP00000405222.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3457              AK128123.1         1-3457
            3458-3458           AC004553.1         43184-43184         c
FEATURES             Location/Qualifiers
     source          1..3458
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.3"
     gene            1..3458
                     /gene="DCAF8L1"
                     /gene_synonym="WDR42B"
                     /note="DDB1 and CUL4 associated factor 8 like 1"
                     /db_xref="GeneID:139425"
                     /db_xref="HGNC:HGNC:31810"
     exon            1..3458
                     /gene="DCAF8L1"
                     /gene_synonym="WDR42B"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1918
                     /gene="DCAF8L1"
                     /gene_synonym="WDR42B"
                     /note="WD repeat domain 42B; WD repeat-containing protein
                     42B"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 8-like protein
                     1"
                     /protein_id="NP_001017930.1"
                     /db_xref="CCDS:CCDS35222.1"
                     /db_xref="GeneID:139425"
                     /db_xref="HGNC:HGNC:31810"
                     /translation="MSHQEGSTGGLPDLVTESLFSSPEEQSGVAAVTAASSDIEMAAT
                     EPSTGDGGDTRDGGFLNDASTENQNTDSESSSEDVELESMGEGLFGYPLVGEETEREE
                     EEEEMEEEGEEEEQPRMCPRCGGTNHDQCLLDEDQALEEWISSETSALPRSRWQVLTA
                     LRQRQLGSSARFVYEACGARTFVQRFRLQYLLGSHAGSVSTIHFNQRGTRLASSGDDL
                     RVIVWDWVRQKPVLNFESGHDINVIQAKFFPNCGDSTLAMCGHDGQVRVAELINASYC
                     ENTKRVAKHRGPAHELALEPDSPYKFLTSGEDAVVFTIDLRQDRPASKVVVTRENDKK
                     VGLYTISMNPANIYQFAVGGHDQFVRIYDQRRIDKKENNGVLKKFTPHHLVYCDFPTN
                     ITCVVYSHDGTELLASYNDEDIYLFNSSLSDGAQYVKRYKGHRNNDTIKCVNFYGPRS
                     EFVVSGSDCGHVFFWEKSSSQIIQFMEGDRGDIVNCLEPHPYLPVLATSGLDQHVRIW
                     TPTAKTATELTGLKDVIKKNKQERDEDNLNYTDSFDNRMLRFFVRHLLQRAHQPGWRD
                     HGAEFPDEEELDESSSTSDTSEEEGQDRVQCIPS"
     regulatory      3434..3439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF8L1"
                     /gene_synonym="WDR42B"
                     /note="hexamer: AATAAA"
     polyA_site      3458
                     /gene="DCAF8L1"
                     /gene_synonym="WDR42B"
                     /note="major polyA site"
ORIGIN      
        1 gcttacctac tgccttctcc gaccgtccgt cctcggggca ggcgtgctct cttccctgag
       61 cttttagggg ttggcttttc cagttccaga tcagctacag caaacatcgt tcgagatgtc
      121 ccaccaagag ggcagcacag gtggcttacc agacttagtg actgaaagcc tgttcagcag
      181 cccagaggag cagtctggag tagcagcggt gacggcggcc tcctcagaca ttgaaatggc
      241 agccacagag ccatcgaccg gagatggtgg tgataccagg gatggtggtt tcctgaacga
      301 tgccagcaca gaaaatcaaa acacagactc agaaagttca agtgaagacg tcgaacttga
      361 aagcatgggt gaaggtttat ttggttaccc gttagtggga gaggagacag aaagggagga
      421 ggaagaagaa gagatggagg aggaagggga ggaggaagaa cagcctcgga tgtgtccacg
      481 atgcggtggc accaaccatg atcagtgttt gttagacgag gatcaggcgt tggaggagtg
      541 gatttcctca gagacatctg ccctgccccg atctcgctgg caagtcctta ctgctcttcg
      601 ccagcggcag ctgggttcaa gtgcccgctt tgtatatgag gcctgtgggg caagaacctt
      661 tgtgcagcgt ttccgcctgc agtatcttct tggaagccat gccggttctg tcagtaccat
      721 acactttaac cagcgtggca cccgactggc cagtagcggt gatgacttaa gggtgatagt
      781 gtgggactgg gtgcggcaga agccagtact gaactttgag agtggtcacg atattaatgt
      841 catccaggct aagttctttc ctaactgtgg tgattccact ctggccatgt gtggccatga
      901 tggacaggta cgggtagcag aactaattaa tgcatcatat tgcgagaata ctaagcgtgt
      961 ggccaagcac aggggacctg cccacgagtt ggctctggag ccagactctc cttataagtt
     1021 cctcacttca ggtgaagatg ccgttgtgtt caccattgac ctcaggcaag accggccagc
     1081 ttcaaaagtt gtggtaacaa gagaaaatga taagaaagtc ggactgtata caatctctat
     1141 gaatcctgcc aatatttacc aatttgcagt gggtggacat gatcagtttg taaggattta
     1201 tgaccagagg agaattgata agaaagaaaa caatggagta ctcaagaaat tcactcctca
     1261 tcatctggtt tattgtgatt tcccaacaaa catcacctgc gttgtgtaca gccacgatgg
     1321 cacagagctc ctggccagct acaatgatga agatatttac ctcttcaact cctctctcag
     1381 tgatggtgct caatatgtta agagatataa ggggcacaga aataatgaca caatcaaatg
     1441 tgttaatttc tatggccccc ggagtgagtt tgtcgtgagc ggtagtgatt gtgggcacgt
     1501 cttcttctgg gagaaatcat cctcccagat catccagttc atggaggggg acagaggaga
     1561 tatagtaaac tgtcttgaac cccaccctta cctacctgtg ttggcgacca gtggcctaga
     1621 tcagcatgtc aggatctgga cacccacagc taaaactgcc actgagctta ctgggttaaa
     1681 agatgtgatt aagaagaaca agcaggagcg agatgaagac aacttgaact atacggactc
     1741 gtttgacaac cgcatgcttc ggttcttcgt gcgtcacctg ttacagagag ctcatcaacc
     1801 cggctggaga gatcatggag ctgagttccc agatgaagaa gagttggatg agtcttccag
     1861 cacctcagat acatccgagg aggagggcca agatcgagtg cagtgcatac catcctgaag
     1921 gcctcatatc cagtccagct agatgccacc taagtacact ggactttaaa attcagtttg
     1981 actaatttag aattgtcaat tgattaacag atttgctttt tgtcttctgt ttttgttacc
     2041 ccttatatga gtgcatacac aacttattta tgcctctttt cctttgttcc cttataattg
     2101 acctctaaaa ttgcataatt ttgttgaaaa aattaatggc cttattagat gtatctactc
     2161 atttcagaca ttctgaaagc tattactttt tagttttttc attttttacc aatttatttt
     2221 gaagataaag ttcttcagtt gagttgaaaa tttcataaac gtgtttattc tttagaggta
     2281 aaataaggca aaccatagtt ctttgaatac tgacacacac atacacacag tctcagaaaa
     2341 ggaaaagaga agtagtgtgt agattaattc ctaacacttg gccacacaca cacacagctt
     2401 caaaagttgt agtaacaaga gagaagaata agaaagtggg actgtataca atctctatga
     2461 atcctgccaa tatttaccaa ttcgcagtgg gtggacatga tcggttttta aggatttatg
     2521 accagaggag aattgatgag aaagaaaaca atggagtact caagaaattc actcttcatc
     2581 atctggttaa ttgtgatttt ccaacaaaca tcacctgcat tgtgtacagc cacgatggca
     2641 cagagctcct ggccagctat gcacacacac atacacacag agccttagaa aaggaaaaca
     2701 agaagtagtg tgtagatgaa ttcctaacca gataattcat ctcctcagag caaataactt
     2761 gggattatcc acattttctg aatcaatatg ttaataatat tgattaattt gagcacactg
     2821 aagctggtaa gaactaaatt aaatttaatc acatgacatt gtttactcta tgcattaaat
     2881 gttcttgaag ttttatggtt gggaactccc acaggattac attccaggaa gtcctcctgg
     2941 cgcaagcatc tcctataaga taccagatag gaatataaaa atctctcata tttgaaaaca
     3001 tttattttaa ttaactttta agaataagtt gcaataaaaa ttgtttatac ttacacataa
     3061 ccatttgata cagttggtag aaaaatccta tttaacatcc atgcattgct taaaatttag
     3121 ctgttttatg agtttgtttt gaaaattgtt gcaataaaaa ttgtttatac ttacaagtga
     3181 tgtagttggt agaaaaatcc tatttgacat ccatgcattg cttaaaattt agctgtttta
     3241 tgagtttgtt ttaaaaattg ttgcagtaaa aattgtttat acttacaagt gatgtagttg
     3301 gtagaaaaat cctatttgac atccatggat tgcttaaagt tctctcagct gtcctcgagt
     3361 ttaaattgtt ttaaaaattg tcttaagctt tacttaatat aaatttaagt tactagatgt
     3421 taaattactg ttcaataaaa atattcattt ttatttta
//
