LOCUS       NM_005828               6324 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 7 (DCAF7), transcript
            variant 1, mRNA.
ACCESSION   NM_005828
VERSION     NM_005828.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6324)
  AUTHORS   Xu,J., Ye,Z., Zhuo,Q., Gao,H., Qin,Y., Lou,X., Zhang,W., Wang,F.,
            Wang,Y., Jing,D., Fan,G., Zhang,Y., Chen,X., Chen,J., Xu,X., Yu,X.
            and Ji,S.
  TITLE     MEN1 Degradation Induced by Neddylation and the CUL4B-DCAF7 Axis
            Promotes Pancreatic Neuroendocrine Tumor Progression
  JOURNAL   Cancer Res 83 (13), 2226-2247 (2023)
   PUBMED   36939378
  REMARK    GeneRIF: MEN1 Degradation Induced by Neddylation and the
            CUL4B-DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor
            Progression.
REFERENCE   2  (bases 1 to 6324)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6324)
  AUTHORS   Alerasool,N., Leng,H., Lin,Z.Y., Gingras,A.C. and Taipale,M.
  TITLE     Identification and functional characterization of transcriptional
            activators in human cells
  JOURNAL   Mol Cell 82 (3), 677-695 (2022)
   PUBMED   35016035
REFERENCE   4  (bases 1 to 6324)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 6324)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 6324)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   7  (bases 1 to 6324)
  AUTHORS   Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J Biol Chem 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   8  (bases 1 to 6324)
  AUTHORS   Bouwmeester,T., Bauch,A., Ruffner,H., Angrand,P.O., Bergamini,G.,
            Croughton,K., Cruciat,C., Eberhard,D., Gagneur,J., Ghidelli,S.,
            Hopf,C., Huhse,B., Mangano,R., Michon,A.M., Schirle,M., Schlegl,J.,
            Schwab,M., Stein,M.A., Bauer,A., Casari,G., Drewes,G., Gavin,A.C.,
            Jackson,D.B., Joberty,G., Neubauer,G., Rick,J., Kuster,B. and
            Superti-Furga,G.
  TITLE     A physical and functional map of the human TNF-alpha/NF-kappa B
            signal transduction pathway
  JOURNAL   Nat Cell Biol 6 (2), 97-105 (2004)
   PUBMED   14743216
  REMARK    Erratum:[Nat Cell Biol. 2004 May;6(5):465]
REFERENCE   9  (bases 1 to 6324)
  AUTHORS   Skurat,A.V. and Dietrich,A.D.
  TITLE     Phosphorylation of Ser640 in muscle glycogen synthase by DYRK
            family protein kinases
  JOURNAL   J Biol Chem 279 (4), 2490-2498 (2004)
   PUBMED   14593110
REFERENCE   10 (bases 1 to 6324)
  AUTHORS   de Vetten,N., Quattrocchio,F., Mol,J. and Koes,R.
  TITLE     The an11 locus controlling flower pigmentation in petunia encodes a
            novel WD-repeat protein conserved in yeast, plants, and animals
  JOURNAL   Genes Dev 11 (11), 1422-1434 (1997)
   PUBMED   9192870
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY023965.1, U94747.1,
            AC046185.14 and BF507629.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005828.4.
            
            Summary: This gene encodes a protein with multiple WD40 repeats
            which facilitate protein-protein interactions and thereby enable
            the assembly of multiprotein complexes. This protein has been shown
            to function as a scaffold protein for protein complexes involved in
            kinase signaling. This highly conserved gene is present in
            eukaryotic plants, fungi, and animals. The ortholog of this gene
            was first identified in plants as a key regulator of anthocyanin
            biosynthesis and flower pigmentation. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.572775.1,
                                           SRR1803613.247797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614556.5/ ENSP00000483236.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               HY023965.1         44-172
            130-1429            U94747.1           1-1300
            1430-5898           AC046185.14        135783-140251       c
            5899-6324           BF507629.1         29-454              c
FEATURES             Location/Qualifiers
     source          1..6324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..6324
                     /gene="DCAF7"
                     /gene_synonym="AN11; HAN11; SWAN-1; WDR68"
                     /note="DDB1 and CUL4 associated factor 7"
                     /db_xref="GeneID:10238"
                     /db_xref="HGNC:HGNC:30915"
                     /db_xref="MIM:605973"
     exon            1..339
                     /gene="DCAF7"
                     /gene_synonym="AN11; HAN11; SWAN-1; WDR68"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1230
                     /gene="DCAF7"
                     /gene_synonym="AN11; HAN11; SWAN-1; WDR68"
                     /note="human anthocyanin; seven-WD-repeat protein of the
                     AN11 family-1; WD repeat-containing protein 68; WD
                     repeat-containing protein An11 homolog"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 7"
                     /protein_id="NP_005819.3"
                     /db_xref="CCDS:CCDS74127.1"
                     /db_xref="GeneID:10238"
                     /db_xref="HGNC:HGNC:30915"
                     /db_xref="MIM:605973"
                     /translation="MSLHGKRKEIYKYEAPWTVYAMNWSVRPDKRFRLALGSFVEEYN
                     NKVQLVGLDEESSEFICRNTFDHPYPTTKLMWIPDTKGVYPDLLATSGDYLRVWRVGE
                     TETRLECLLNNNKNSDFCAPLTSFDWNEVDPYLLGTSSIDTTCTIWGLETGQVLGRVN
                     LVSGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYED
                     PQHHPLLRLCWNKQDPNYLATMAMDGMEVVILDVRVPCTPVARLNNHRACVNGIAWAP
                     HSSCHICTAADDHQALIWDIQQMPRAIEDPILAYTAEGEINNVQWASTQPDWIAICYN
                     NCLEILRV"
     exon            340..498
                     /gene="DCAF7"
                     /gene_synonym="AN11; HAN11; SWAN-1; WDR68"
                     /inference="alignment:Splign:2.1.0"
     exon            499..610
                     /gene="DCAF7"
                     /gene_synonym="AN11; HAN11; SWAN-1; WDR68"
                     /inference="alignment:Splign:2.1.0"
     exon            611..729
                     /gene="DCAF7"
                     /gene_synonym="AN11; HAN11; SWAN-1; WDR68"
                     /inference="alignment:Splign:2.1.0"
     exon            730..939
                     /gene="DCAF7"
                     /gene_synonym="AN11; HAN11; SWAN-1; WDR68"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1057
                     /gene="DCAF7"
                     /gene_synonym="AN11; HAN11; SWAN-1; WDR68"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..6324
                     /gene="DCAF7"
                     /gene_synonym="AN11; HAN11; SWAN-1; WDR68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6306..6311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF7"
                     /gene_synonym="AN11; HAN11; SWAN-1; WDR68"
                     /note="hexamer: AATAAA"
     polyA_site      6324
                     /gene="DCAF7"
                     /gene_synonym="AN11; HAN11; SWAN-1; WDR68"
                     /note="major polyA site"
ORIGIN      
        1 gtcgtccgtt cccaagctgg tttgaaacta ggggtcgggc tcggccgtcg tcgttgtttg
       61 tcgccgcatc cccgcttccg ggttaggccg ttcctgcccg ccccctcctc tcctcccttc
      121 ggacccatag atctcaggct cggctccccg cccgccgcag cccactgttg acccggcccg
      181 tactgcggcc ccgtggccac catgtccctg cacggcaaac ggaaggagat ctacaagtat
      241 gaagcgccct ggacagtcta cgcgatgaac tggagtgtgc ggcccgataa gcgctttcgc
      301 ttggcgctgg gcagcttcgt ggaggagtac aacaacaagg ttcagcttgt tggtttagat
      361 gaggagagtt cagagtttat ttgcagaaac acctttgacc acccataccc caccacaaag
      421 ctcatgtgga tccctgacac aaaaggcgtc tatccagacc tactggcaac aagcggtgac
      481 tatctccgtg tgtggagggt tggtgaaaca gagaccaggc tggagtgttt gctaaacaat
      541 aataagaact ctgatttctg tgctcccctg acctcctttg actggaatga ggtggatcct
      601 tatcttttag gtacctcaag cattgatacg acatgcacca tctgggggct ggagacaggg
      661 caggtgttag ggcgagtgaa tctcgtgtct ggccacgtga agacccagct gatcgcccat
      721 gacaaagagg tctatgatat tgcatttagc cgggccgggg gtggcaggga catgtttgcc
      781 tctgtgggtg ctgatggctc ggtgcggatg tttgacctcc gccatctaga acacagcacc
      841 atcatttacg aagacccaca gcatcaccca ctgcttcgcc tctgctggaa caagcaggac
      901 cctaactacc tggccaccat ggccatggat ggaatggagg tggtgattct agatgtccgg
      961 gttccctgca cacctgtcgc caggttaaac aaccatcgag catgtgtcaa tggcattgct
     1021 tgggccccac attcatcctg ccacatctgc actgcagcgg atgaccacca ggctctcatc
     1081 tgggacatcc agcaaatgcc ccgagccatt gaggacccta tcctggccta cacagctgaa
     1141 ggagagatca acaatgtgca gtgggcatca actcagcccg actggatcgc catctgctac
     1201 aacaactgcc tggagatact cagagtgtag tgttggtggc gctgtgccca cgaggcaggg
     1261 gcttttgtat ttcctgcctc tgccccaccc ccaaagtaag aagaaacatg tttccagtgg
     1321 ccagtatgtc tttcattgct ttgcacccac tgttaccaga agctgctcta ggagttcctg
     1381 gccagtcacc ccatcgccct ctgtggcaga ctcagtgctg tgtggcgcct cctcagccca
     1441 gggctgagtt ttaagatttt ctctcctttc ctcttctcct ttggttcctc aattaaaaaa
     1501 tgtgtgtata tttgtttgtc aggcgttgtg ttgaggagca gttcacgcac tggctgtgtc
     1561 tattcctctg cccaggtgtc tctgtttgct gcccaaggca gcagttcatg tctcgtccat
     1621 gtccatgttc gtgttagcac ttacgtggga acaaatacca atttgtcttt tctcctagta
     1681 tcagtgtgtt taacaaattt taactttgta tatttgttat ctatcaggct aattttttta
     1741 tgaaaagaat tttactctcc tgcttcattt ctttgtctta tagtcctccc tctttgcacc
     1801 ttcttctctt ccctcagtgc ctggagctgg tactgggccc ctggccccat gagcagtttg
     1861 ccttcttgag tcactgcctg tgtagtacat acctgaccgg gagtccaaac caccttggtg
     1921 ctctgaagtc cactgactca tcacaccttt cttagcctgg ctcctctcaa gggcattctg
     1981 ggcttgtaaa cagacatagg aagcctctgt ttaccctgaa gcaccactgt ccagcccatt
     2041 ggttcccact ggcagcatgg tagagctgag agaaacaggc tctcagggta cctgacttga
     2101 ggggaatcgt ttcatgaagc tgaacttcaa gcatatttcc agtacattct ttcagagtct
     2161 gtttttccat ccaaatataa gccccaggcc attccactta gtgtcttttc aatgataggc
     2221 aagaatgata tctgagttga acttcggtgc ttctgttgtt tgagtttact gtgcctggtg
     2281 gtatattggg cattctttgg attgagtgtt ctgaggtgag agagtcttcc cgaggcatcc
     2341 tgtctgtgct tccaaccctg aacaagacct tacatgagag atggactgat ggactgcggc
     2401 aatcctgggc tgtcaagtgg atagatagtt aaaaagcatt atactgtggg taatgaaaag
     2461 ggaggaaaaa aaaagaagga aaaggaatta tagaccccca gggtcagcca gttaagagct
     2521 ctacccacac ctgtcaaccc ctctctcccc cagtttaggt tctgagcagt attggacttg
     2581 tagcctgcag ttgtcttttg acttgcaggc cgcaggtgtc tttctgttat gtgaatgagt
     2641 tccatggagg ggcatatgtg tgattccacc gttagatgag cccttggggc aggcagtttg
     2701 ggatgtgctc ttgggggaaa gttggctgtt tccttgcgct ctgctcctac ccgaaggttt
     2761 ttaagtccct ctgaattgct catctgagat tagtagagta gcaggcctga aggatgatgg
     2821 ttttgtcctc tttggttctc acctgcttga gaagtaaaac agtaactttg ttcttctggg
     2881 cccttaagct tttttggtta agtcttcctt ttcagaagta gatgtcatta tatgccaaaa
     2941 gtctagctct ttgctttacc atacagggac ctgtcccaaa gaaaaaggct ctttttttag
     3001 ccagcatatt tccccttcta cccttttact ttgttgttct gattttagga ctctggctgg
     3061 ccatgtgctt gtggttgcct ctcctgcatt tgccactgga tttgcactgc atcgtttgga
     3121 gatacaaagc gagcagttct tggtcagaac cctcctctgc ttttcattgt gtttgataat
     3181 ggttactggg tccttctctc aagggtagca aggccaagct gatggctgct tgtttaggag
     3241 gccatcagtt ccttcctgtg gagaagggtc tgaaatggaa gtcagtggta gaaggggctg
     3301 gtctgctggg cagggcttac atccactgag ttctaagatt cctttcctga tctgcaccta
     3361 cgcctggtct gtatggtgga atttgtcagc tggaactcag aaacaacaac ttgaaaaaaa
     3421 aataataatt agaacatatt tgcataagat agctatttac tctggaaacc aacaactttt
     3481 gagatttccc ttgccctgtg gacgcccagc tcctgtcatc cttccttagg tcctgcagta
     3541 cagtcttccc ctgaatgcca ccggggaccc agggggactc caccccccta agcaagcaca
     3601 cacatactca cagttgatga gttgctggtc tttgagtccc agctctctta ccctcccttt
     3661 actccaccag cccgacgacc catgactgag gaggggattt ctacagtctc aggatttaga
     3721 aagtctgtaa gccatccatg ctccagaaag caccgatctg ttgtagttgc aaaaacaact
     3781 ctgtaatttg ttgaggttct caaactgaca gccagcgaga ctgggtggga ggccctggat
     3841 ctgttctccc tgactgcggg aggagcagcc actaggactt tagcaggaag cccacatgga
     3901 ggctccgcca ggctgtggcc cagctggtga tggccctttt gctcctggca gcctgaggca
     3961 cagctgcctg tattgtcctc atctgttctg actgaaggat ggaggtgctg aataaattag
     4021 gcctcaggcc tctaccacca gagagctgga gaatgggtcc acgtcattca aggacctgaa
     4081 ttttttatgc tcaggagcat tggaatcctc ttcttccagg gaggaattag cctgcaaggt
     4141 taggacttga agagggaagg tatttaataa ctgggcgagg atgggtgtgg tggctcacac
     4201 ctgtaatccc agcattttgg gaggctgagg tggccagatc ccaaggtcag aagatcgaga
     4261 ccatcctggc taacatggtg aaaccccatc tctactaaaa atacaaaaaa aaattagccg
     4321 ggggtggtgg cgggtacctg tagtcctagc tacttgggag gctgaggcag gagaatggcg
     4381 tgaacctggg aggtggagct tgcagtgagc caagatcgtg ccactgcact ccagcctggg
     4441 cgacagagca agactccgtc tcaaaaaata aaaaaaaaaa aaaaataggt gaaaattcct
     4501 tataaatcca ggattggctc tgagagaact ggctaagatt caggaagaaa caaaaaattc
     4561 agaatcctac aaggttttga tgacaattag ggccaaaatt ttaggaggag atgtaggatg
     4621 caggagaaaa ttaaagtgtt ttctttatat cagaggagga aatagtagag gtcagtgaag
     4681 gtctggggta gggaaacatt cagactgtcc attgcatggc tgtggagtga gactgccctt
     4741 agcctgggtc agccttcctg ggccataaat tgggcatccg tgatgctagg taactgtggg
     4801 aacaaaatga cagcttagag cagccatggg tgatgtttgg tggtaaaaaa cctacaggcg
     4861 tttggggtcc catgattgtt ccagaccatg actcttcctg gttgtgggtt tgttacagag
     4921 caggagaagc agaggttatg acagttatgc agactttccc cctccttttt ctcttttctc
     4981 ttccccttgc ttttccactg tttcttcctg ctgccacctg ggccttgaat tcctgggctg
     5041 tgaagacatg tagcagctgc agggtttacc acacgtggga gggcagccca gtactgtccc
     5101 tctgccttcc ccactttgag aatatggcag cccctttcat tcctggcttg gggtagggga
     5161 gaccattgaa gtagaagcct caaagcagac ttttcccttt actgtgtgta ctccaggacg
     5221 aagaaggaag atcatgcttg atacttagat tggttttccc agggaagagg gcggagcaga
     5281 gcaaagtcac tgtgaaccct gggccaggcc ctggctgggc cagctcctga gagcgtctcg
     5341 tgttgcagac ccttgcccac ttcacccacc tgcaccttct ccccctctca cagtgtcact
     5401 gctgctaatg gtcaaagtca aatgtgtggc cacatgggat gggccaggtc ctctcaggct
     5461 actttctgga tgtcattttt aaaatatgga aacatgcagg tgccttccca aagaggcttg
     5521 gactggtata tccaacgaga aacaaataag ctaaagaaag tttaaactca agaagaaaga
     5581 tgttgacagt ctatgtaaca gctggaaagt ttataggcac ccacctttgg gacaacccag
     5641 tgattatgaa catgtgatat ctactattta aaagaaatgt tctcaccttg ggttgattgt
     5701 ggtataccat gtgttatgaa aattgttgag ctgaagcttt gaatcgattt agttgagtct
     5761 gactcacttg ctttggttcc tgtgtatttt actacccctc ttgtcagtga ccttccttcc
     5821 ccaccccacc cagagtgaat ttgtagcatg attgtataaa cctctatgta gaaaatggag
     5881 atttcttgct ctgaaatgtt aagctctaac tgatccattt ctgtgtcctt tagcctagta
     5941 tgtctgaact tccattcttg ttatatattt aaactttccc tctatattat aggttttgtg
     6001 gcatccacgg tcaggtgtag aggaagctgc cccttgcaga actgtactgt aatatttttc
     6061 ttttataaat attttcacag gactgattgt acacagggct tgtaataaaa ttttaacact
     6121 gtgctgtgaa acaactatgg ggaatctcca ttgaaggcta cttcatgggc acctgaaagt
     6181 ggagtgttat agctatgact ttctatttct tgtttcctaa gtaaattaaa cctaattttc
     6241 accctttcat tctgtttcag cctcctgtat aagaagtacc gtattttctg cccatcatac
     6301 tttgtaataa aacttgaaca tgta
//
