LOCUS       NM_001349774            3218 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 6 (DCAF6), transcript
            variant 6, mRNA.
ACCESSION   NM_001349774 XM_017001780
VERSION     NM_001349774.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3218)
  AUTHORS   Ji,Y., Li,J., Liu,S., Zhu,J., Yao,J., Li,K.R. and Yan,B.
  TITLE     Identification of circular RNA-Dcaf6 as a therapeutic target for
            optic nerve crush-induced RGC degeneration
  JOURNAL   Genomics 116 (1), 110776 (2024)
   PUBMED   38163571
  REMARK    GeneRIF: Identification of circular RNA-Dcaf6 as a therapeutic
            target for optic nerve crush-induced RGC degeneration.
REFERENCE   2  (bases 1 to 3218)
  AUTHORS   Tseng,C., Han,Y., Lv,Z., Song,Q., Wang,K., Shen,H. and Chen,Z.
  TITLE     The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic
            signalling and promote intervertebral disc degeneration
  JOURNAL   J Mol Med (Berl) 101 (1-2), 171-181 (2023)
   PUBMED   36688959
  REMARK    GeneRIF: The CRL4[DCAF6] E3 ligase ubiquitinates CtBP1/2 to induce
            apoptotic signalling and promote intervertebral disc degeneration.
REFERENCE   3  (bases 1 to 3218)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3218)
  AUTHORS   Tsai,L.K., Chen,I.H., Chao,C.C., Hsueh,H.W., Chen,H.H., Huang,Y.H.,
            Weng,R.W., Lai,T.Y., Tsai,Y.C., Tsao,Y.P. and Chen,S.L.
  TITLE     Autoantibody of NRIP, a novel AChR-interacting protein, plays a
            detrimental role in myasthenia gravis
  JOURNAL   J Cachexia Sarcopenia Muscle 12 (3), 665-676 (2021)
   PUBMED   33773096
  REMARK    GeneRIF: Autoantibody of NRIP, a novel AChR-interacting protein,
            plays a detrimental role in myasthenia gravis.
REFERENCE   5  (bases 1 to 3218)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3218)
  AUTHORS   Han,C.P., Lee,M.Y., Tzeng,S.L., Yao,C.C., Wang,P.H., Cheng,Y.W.,
            Chen,S.L., Wu,T.S., Tyan,Y.S. and Kok,L.F.
  TITLE     Nuclear Receptor Interaction Protein (NRIP) expression assay using
            human tissue microarray and immunohistochemistry technology
            confirming nuclear localization
  JOURNAL   J Exp Clin Cancer Res 27 (1), 25 (2008)
   PUBMED   18673574
  REMARK    GeneRIF: A survey results showed that ten cancer cases were
            revealed to express the NRIP in six malignancies, but not all of
            these specific tumor types consistently showed positive NRIP
            expression.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3218)
  AUTHORS   Chen,P.H., Tsao,Y.P., Wang,C.C. and Chen,S.L.
  TITLE     Nuclear receptor interaction protein, a coactivator of androgen
            receptors (AR), is regulated by AR and Sp1 to feed forward and
            activate its own gene expression through AR protein stability
  JOURNAL   Nucleic Acids Res 36 (1), 51-66 (2008)
   PUBMED   17984071
  REMARK    GeneRIF: NRIP plays a feed-forward role enhancing androgen receptor
            (AR)-driven NRIP promoter activity via NRIP forming a complex with
            AR to protect AR protein from proteasome degradation.
REFERENCE   8  (bases 1 to 3218)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
REFERENCE   9  (bases 1 to 3218)
  AUTHORS   Tsai,T.C., Lee,Y.L., Hsiao,W.C., Tsao,Y.P. and Chen,S.L.
  TITLE     NRIP, a novel nuclear receptor interaction protein, enhances the
            transcriptional activity of nuclear receptors
  JOURNAL   J Biol Chem 280 (20), 20000-20009 (2005)
   PUBMED   15784617
  REMARK    GeneRIF: NRIP interacts with either androgen or glucocorticoid
            receptors
REFERENCE   10 (bases 1 to 3218)
  AUTHORS   Tureci,O., Sahin,U., Koslowski,M., Buss,B., Bell,C., Ballweber,P.,
            Zwick,C., Eberle,T., Zuber,M., Villena-Heinsen,C., Seitz,G. and
            Pfreundschuh,M.
  TITLE     A novel tumour associated leucine zipper protein targeting to sites
            of gene transcription and splicing
  JOURNAL   Oncogene 21 (24), 3879-3888 (2002)
   PUBMED   12032826
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z97876.1, AL031287.3,
            AL033531.10 and AL033532.36.
            
            On Aug 13, 2020 this sequence version replaced NM_001349774.1.
            
            Summary: The protein encoded by this gene is a ligand-dependent
            coactivator of nuclear receptors, including nuclear receptor
            subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR),
            and androgen receptor (AR). The encoded protein and DNA damage
            binding protein 2 (DDB2) may act as tumor promoters and tumor
            suppressors, respectively, by regulating the level of androgen
            receptor in prostate tissues. In addition, this protein can act
            with glucocorticoid receptor to promote human papillomavirus gene
            expression. [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (6), as well as variants 7-9,
            encodes isoform f.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.123259.1,
                                           SRR1803613.161713.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               Z97876.1           90201-90471
            272-333             AL031287.3         3604-3665
            334-426             AL031287.3         18433-18525
            427-612             AL031287.3         26634-26819
            613-726             AL031287.3         39299-39412
            727-862             AL031287.3         43008-43143
            863-1077            AL031287.3         45030-45244
            1078-1171           AL031287.3         54286-54379
            1172-1291           AL031287.3         55674-55793
            1292-1552           AL031287.3         56337-56597
            1553-1612           AL033531.10        163-222
            1613-1730           AL033531.10        15546-15663
            1731-1846           AL033531.10        20200-20315
            1847-1933           AL033531.10        21760-21846
            1934-2261           AL033531.10        22075-22402
            2262-2400           AL033531.10        40796-40934
            2401-2557           AL033531.10        42765-42921
            2558-2646           AL033531.10        43552-43640
            2647-2752           AL033531.10        45533-45638
            2753-3218           AL033532.36        4208-4673
FEATURES             Location/Qualifiers
     source          1..3218
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..3218
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /note="DDB1 and CUL4 associated factor 6"
                     /db_xref="GeneID:55827"
                     /db_xref="HGNC:HGNC:30002"
                     /db_xref="MIM:610494"
     exon            1..271
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            272..333
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            334..426
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            427..612
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            613..726
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     CDS             616..2817
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /note="isoform f is encoded by transcript variant 6; IQ
                     motif and WD repeats 1; androgen receptor
                     complex-associated protein; nuclear receptor interaction
                     protein; IQ motif and WD repeat-containing protein 1"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 6 isoform f"
                     /protein_id="NP_001336703.1"
                     /db_xref="GeneID:55827"
                     /db_xref="HGNC:HGNC:30002"
                     /db_xref="MIM:610494"
                     /translation="MTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCR
                     RAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHL
                     NNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPV
                     KRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRG
                     RGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHS
                     TSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSDSPSSVVNKQLGSMSLDEQQDN
                     NNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQE
                     ESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPL
                     DSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEA
                     TGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRRSAVARIQEFFRRRKER
                     KEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTA
                     EHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRN
                     ELMLEETRNTITVPASFMLRMLASLNHIRADRLEGDRSEGSGQENENEDEE"
     exon            727..862
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1077
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1171
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1291
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1552
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1612
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1730
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1846
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1933
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2261
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2400
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..2557
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2646
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2752
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..3218
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3149..3154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /note="hexamer: AATAAA"
     polyA_site      3169
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
     regulatory      3196..3201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /note="hexamer: AAGAAA"
     polyA_site      3218
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /note="major polyA site"
ORIGIN      
        1 ttctccccat gccctcgagg ccatgttgga gaagggaaag tgaagctgcg ctggttctac
       61 tgccctttca ctttgattaa gcaggcccgt agttaaaatg ggtttttggg ccttcagtgc
      121 ctaaagatga tgccgcacaa ttctcttgct tcttttcact ggagactcgt gagcgagaga
      181 ctacagaatt gagtagcttc tctctctact cgtcttttat ccctagcgac ttaaggatct
      241 ggttagagtg gcccgaatgc attcttccag ggaagaagag aatttatcca aagattaaaa
      301 cttgaagcaa cccttaatgt gcatgatggt tgtgttaata caatctgttg gaatgacact
      361 ggagaatata ttttatctgg ctcagatgac accaaattag taattagtaa tccttacagc
      421 agaaaggttt tgacaacaat tcgttcaggg caccgagcaa acatatttag tgcaaagttc
      481 ttaccttgta caaatgataa acagattgta tcctgctctg gagatggagt aatattttat
      541 accaacgttg agcaagatgc agaaaccaac agacaatgcc aatttacgtg tcattatgga
      601 actacttatg agattatgac tgtacccaat gacccttaca cttttctctc ttgtggtgaa
      661 gatggaactg ttaggtggtt tgatacacgc atcaaaacta gctgcacaaa agaagattgt
      721 aaagatgata ttttaattaa ctgtcgacgt gctgccacgt ctgttgctat ttgcccacca
      781 ataccatatt accttgctgt tggttgttct gacagctcag tacgaatata tgatcggcga
      841 atgctgggca caagagctac agggaattat gcaggtcgag ggactactgg aatggttgcc
      901 cgttttattc cttcccatct taataataag tcctgcagag tgacatctct gtgttacagt
      961 gaagatggtc aagagattct cgttagttac tcttcagatt acatatatct ttttgacccg
     1021 aaagatgata cagcacgaga acttaaaact ccttctgcgg aagagagaag agaagagttg
     1081 cgacaaccac cagttaagcg tttgagactt cgtggtgatt ggtcagatac tggacccaga
     1141 gcaaggccgg agagtgaacg agaacgagat ggagagcaga gtcccaatgt gtcattgatg
     1201 cagagaatgt ctgatatgtt atcaagatgg tttgaagaag caagtgaggt tgcacaaagc
     1261 aatagaggac gaggaagatc tcgacccaga ggtggaacaa gtcaatcaga tatttcaact
     1321 cttcctacgg tcccatcaag tcctgatttg gaagtgagtg aaactgcaat ggaagtagat
     1381 actccagctg aacaatttct tcagccttct acatcctcta caatgtcagc tcaggctcat
     1441 tcgacatcat ctcccacaga aagccctcat tctactcctt tgctatcttc tccagacagt
     1501 gaacaaaggc agtctgttga ggcatctgga caccacacac atcatcagtc tgattctcct
     1561 tcttctgtgg ttaacaaaca gctcggatcc atgtcacttg acgagcaaca ggataacaat
     1621 aatgaaaagc tgagccccaa accagggaca ggtgaaccag ttttaagttt gcactacagc
     1681 acagaaggaa caactacaag cacaataaaa ctgaacttta cagatgaatg gagcagtata
     1741 gcatcaagtt ctagaggaat tgggagccat tgcaaatctg agggtcagga ggaatctttc
     1801 gtcccacaga gctcagtgca accaccagaa ggagacagtg aaacaaaagc tcctgaagaa
     1861 tcatcagagg atgtgacaaa atatcaggaa ggagtatctg cagaaaaccc agttgagaac
     1921 catatcaata taacacaatc agataagttc acagccaagc cattggattc caactcagga
     1981 gaaagaaatg acctcaatct tgatcgctct tgtggggttc cagaagaatc tgcttcatct
     2041 gaaaaagcca aggaaccaga aacttcagat cagactagca ctgagagtgc taccaatgaa
     2101 aataacacca atcctgagcc tcagttccaa acagaagcca ctgggccttc agctcatgaa
     2161 gaaacatcca ccagggactc tgctcttcag gacacagatg acagtgatga tgacccagtc
     2221 ctgatcccag gtgcaaggta tcgagcagga cctggtgata gacgctctgc tgttgcccgt
     2281 attcaggagt tcttcagacg gagaaaagaa aggaaagaaa tggaagaatt ggatactttg
     2341 aacattagaa ggccgctagt aaaaatggtt tataaaggcc atcgcaactc caggacaatg
     2401 ataaaagaag ccaatttctg gggtgctaac tttgtaatga gtggttctga ctgtggccac
     2461 attttcatct gggatcggca cactgctgag catttgatgc ttctggaagc tgataatcat
     2521 gtggtaaact gcctgcagcc acatccgttt gacccaattt tagcctcatc tggcatagat
     2581 tatgacataa agatctggtc accattagaa gagtcaagga tttttaaccg aaaacttgct
     2641 gatgaagtta taactcgaaa cgaactcatg ctggaagaaa ctagaaacac cattacagtt
     2701 ccagcctctt tcatgttgag gatgttggct tcacttaatc atatccgagc tgaccggttg
     2761 gagggtgaca gatcagaagg ctctggtcaa gagaatgaaa atgaggatga ggaataataa
     2821 actctttttg gcaagcactt aaatgttctg aaatttgtat aagacattta ttatattttt
     2881 ttctttacag agctttagtg caattttaag gttatggttt ttggagtttt tccctttttt
     2941 tgggataacc taacattggt ttggaatgat tgtgtgcatg aatttgggag attgtataaa
     3001 acaaaactag cagaatgttt ttaaaacttt ttgccgtgta tgaggagtgc tagaaaatgc
     3061 aaagtgcaat attttcccta accttcaaat gtgggagctt ggatcaatgt tgaagaataa
     3121 ttttcatcat agtgaaaatg ttggttcaaa taaatttcta cacttgccat ttgcatgttt
     3181 gttgctttct aattaaagaa actggttgtt ttaagata
//
