LOCUS       NM_001198956            3486 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 6 (DCAF6), transcript
            variant 3, mRNA.
ACCESSION   NM_001198956
VERSION     NM_001198956.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3486)
  AUTHORS   Ji,Y., Li,J., Liu,S., Zhu,J., Yao,J., Li,K.R. and Yan,B.
  TITLE     Identification of circular RNA-Dcaf6 as a therapeutic target for
            optic nerve crush-induced RGC degeneration
  JOURNAL   Genomics 116 (1), 110776 (2024)
   PUBMED   38163571
  REMARK    GeneRIF: Identification of circular RNA-Dcaf6 as a therapeutic
            target for optic nerve crush-induced RGC degeneration.
REFERENCE   2  (bases 1 to 3486)
  AUTHORS   Tseng,C., Han,Y., Lv,Z., Song,Q., Wang,K., Shen,H. and Chen,Z.
  TITLE     The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic
            signalling and promote intervertebral disc degeneration
  JOURNAL   J Mol Med (Berl) 101 (1-2), 171-181 (2023)
   PUBMED   36688959
  REMARK    GeneRIF: The CRL4[DCAF6] E3 ligase ubiquitinates CtBP1/2 to induce
            apoptotic signalling and promote intervertebral disc degeneration.
REFERENCE   3  (bases 1 to 3486)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3486)
  AUTHORS   Tsai,L.K., Chen,I.H., Chao,C.C., Hsueh,H.W., Chen,H.H., Huang,Y.H.,
            Weng,R.W., Lai,T.Y., Tsai,Y.C., Tsao,Y.P. and Chen,S.L.
  TITLE     Autoantibody of NRIP, a novel AChR-interacting protein, plays a
            detrimental role in myasthenia gravis
  JOURNAL   J Cachexia Sarcopenia Muscle 12 (3), 665-676 (2021)
   PUBMED   33773096
  REMARK    GeneRIF: Autoantibody of NRIP, a novel AChR-interacting protein,
            plays a detrimental role in myasthenia gravis.
REFERENCE   5  (bases 1 to 3486)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3486)
  AUTHORS   Han,C.P., Lee,M.Y., Tzeng,S.L., Yao,C.C., Wang,P.H., Cheng,Y.W.,
            Chen,S.L., Wu,T.S., Tyan,Y.S. and Kok,L.F.
  TITLE     Nuclear Receptor Interaction Protein (NRIP) expression assay using
            human tissue microarray and immunohistochemistry technology
            confirming nuclear localization
  JOURNAL   J Exp Clin Cancer Res 27 (1), 25 (2008)
   PUBMED   18673574
  REMARK    GeneRIF: A survey results showed that ten cancer cases were
            revealed to express the NRIP in six malignancies, but not all of
            these specific tumor types consistently showed positive NRIP
            expression.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3486)
  AUTHORS   Chen,P.H., Tsao,Y.P., Wang,C.C. and Chen,S.L.
  TITLE     Nuclear receptor interaction protein, a coactivator of androgen
            receptors (AR), is regulated by AR and Sp1 to feed forward and
            activate its own gene expression through AR protein stability
  JOURNAL   Nucleic Acids Res 36 (1), 51-66 (2008)
   PUBMED   17984071
  REMARK    GeneRIF: NRIP plays a feed-forward role enhancing androgen receptor
            (AR)-driven NRIP promoter activity via NRIP forming a complex with
            AR to protect AR protein from proteasome degradation.
REFERENCE   8  (bases 1 to 3486)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
REFERENCE   9  (bases 1 to 3486)
  AUTHORS   Tsai,T.C., Lee,Y.L., Hsiao,W.C., Tsao,Y.P. and Chen,S.L.
  TITLE     NRIP, a novel nuclear receptor interaction protein, enhances the
            transcriptional activity of nuclear receptors
  JOURNAL   J Biol Chem 280 (20), 20000-20009 (2005)
   PUBMED   15784617
  REMARK    GeneRIF: NRIP interacts with either androgen or glucocorticoid
            receptors
REFERENCE   10 (bases 1 to 3486)
  AUTHORS   Tureci,O., Sahin,U., Koslowski,M., Buss,B., Bell,C., Ballweber,P.,
            Zwick,C., Eberle,T., Zuber,M., Villena-Heinsen,C., Seitz,G. and
            Pfreundschuh,M.
  TITLE     A novel tumour associated leucine zipper protein targeting to sites
            of gene transcription and splicing
  JOURNAL   Oncogene 21 (24), 3879-3888 (2002)
   PUBMED   12032826
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA128283.1, AF116725.1 and
            CA310484.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001198956.1.
            
            Summary: The protein encoded by this gene is a ligand-dependent
            coactivator of nuclear receptors, including nuclear receptor
            subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR),
            and androgen receptor (AR). The encoded protein and DNA damage
            binding protein 2 (DDB2) may act as tumor promoters and tumor
            suppressors, respectively, by regulating the level of androgen
            receptor in prostate tissues. In addition, this protein can act
            with glucocorticoid receptor to promote human papillomavirus gene
            expression. [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (3) is the longest transcript and
            encodes the longest isoform (c).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF116725.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367840.4/ ENSP00000356814.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               DA128283.1         125-259
            136-3302            AF116725.1         1-3167
            3303-3486           CA310484.1         24-207              c
FEATURES             Location/Qualifiers
     source          1..3486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..3486
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /note="DDB1 and CUL4 associated factor 6"
                     /db_xref="GeneID:55827"
                     /db_xref="HGNC:HGNC:30002"
                     /db_xref="MIM:610494"
     exon            1..326
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..3085
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /note="isoform c is encoded by transcript variant 3; IQ
                     motif and WD repeats 1; androgen receptor
                     complex-associated protein; nuclear receptor interaction
                     protein; IQ motif and WD repeat-containing protein 1"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 6 isoform c"
                     /protein_id="NP_001185885.1"
                     /db_xref="CCDS:CCDS55657.1"
                     /db_xref="GeneID:55827"
                     /db_xref="HGNC:HGNC:30002"
                     /db_xref="MIM:610494"
                     /translation="MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLE
                     ATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKF
                     LPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSC
                     GEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRI
                     YDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDY
                     IYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGE
                     QSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDL
                     EVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEA
                     SGHHTHHQSEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQSSHEG
                     SSQDPHASDSPSSVVNKQLGSMSLDEQQDNNNEKLSPKPGTGEPVLSLHYSTEGTTTS
                     TIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDV
                     TKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKA
                     KEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVL
                     IPGARYRAGPGDRFNIRGTTIGDRIMRRSAVARIQEFFRRRKERKEMEELDTLNIRRP
                     LVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVN
                     CLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVP
                     ASFMLRMLASLNHIRADRLEGDRSEGSGQENENEDEE"
     exon            327..388
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            389..481
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            482..667
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            668..781
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            782..917
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1132
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1226
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1346
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1607
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1778
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1838
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1956
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2072
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2159
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2487
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2529
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2668
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2825
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2914
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3020
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3486
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3417..3422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /note="hexamer: AATAAA"
     polyA_site      3437
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
     regulatory      3464..3469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /note="hexamer: AAGAAA"
     polyA_site      3486
                     /gene="DCAF6"
                     /gene_synonym="1200006M05Rik; ARCAP; IQWD1; MSTP055; NRIP;
                     PC326"
                     /note="major polyA site"
ORIGIN      
        1 ggatgttctg gttagtctaa gaaggagagt atgaggcgag ctccggcccg ggtgcggccg
       61 ggcttcaggg gcccaggcgc cgctgctgcc accgccatct aacgctgcgc cctggaggcc
      121 cggcgcgcgg atggtgccgg tgcggctcgg gtgttgaaac gggtgtcccc tccccctcct
      181 cccctccccc acgcggtggt ctcccctccc acccggctca ggcagagcca tgtctcgggg
      241 tggctcctac ccacacctgt tgtgggacgt gaggaaaagg tccctcgggc tggaggaccc
      301 gtcccggctg cggagtcgct acctgggaag aagagaattt atccaaagat taaaacttga
      361 agcaaccctt aatgtgcatg atggttgtgt taatacaatc tgttggaatg acactggaga
      421 atatatttta tctggctcag atgacaccaa attagtaatt agtaatcctt acagcagaaa
      481 ggttttgaca acaattcgtt cagggcaccg agcaaacata tttagtgcaa agttcttacc
      541 ttgtacaaat gataaacaga ttgtatcctg ctctggagat ggagtaatat tttataccaa
      601 cgttgagcaa gatgcagaaa ccaacagaca atgccaattt acgtgtcatt atggaactac
      661 ttatgagatt atgactgtac ccaatgaccc ttacactttt ctctcttgtg gtgaagatgg
      721 aactgttagg tggtttgata cacgcatcaa aactagctgc acaaaagaag attgtaaaga
      781 tgatatttta attaactgtc gacgtgctgc cacgtctgtt gctatttgcc caccaatacc
      841 atattacctt gctgttggtt gttctgacag ctcagtacga atatatgatc ggcgaatgct
      901 gggcacaaga gctacaggga attatgcagg tcgagggact actggaatgg ttgcccgttt
      961 tattccttcc catcttaata ataagtcctg cagagtgaca tctctgtgtt acagtgaaga
     1021 tggtcaagag attctcgtta gttactcttc agattacata tatctttttg acccgaaaga
     1081 tgatacagca cgagaactta aaactccttc tgcggaagag agaagagaag agttgcgaca
     1141 accaccagtt aagcgtttga gacttcgtgg tgattggtca gatactggac ccagagcaag
     1201 gccggagagt gaacgagaac gagatggaga gcagagtccc aatgtgtcat tgatgcagag
     1261 aatgtctgat atgttatcaa gatggtttga agaagcaagt gaggttgcac aaagcaatag
     1321 aggacgagga agatctcgac ccagaggtgg aacaagtcaa tcagatattt caactcttcc
     1381 tacggtccca tcaagtcctg atttggaagt gagtgaaact gcaatggaag tagatactcc
     1441 agctgaacaa tttcttcagc cttctacatc ctctacaatg tcagctcagg ctcattcgac
     1501 atcatctccc acagaaagcc ctcattctac tcctttgcta tcttctccag acagtgaaca
     1561 aaggcagtct gttgaggcat ctggacacca cacacatcat cagtctgaat ttttaagggg
     1621 ccctgagata gctttgcttc gtaagcgcct gcaacaactg aggcttaaga aggctgagca
     1681 gcagaggcag caagagctag ctgcacatac ccagcaacag ccttccactt ctgatcagtc
     1741 ttctcatgag ggctcttcac aggaccctca tgcttcagat tctccttctt ctgtggttaa
     1801 caaacagctc ggatccatgt cacttgacga gcaacaggat aacaataatg aaaagctgag
     1861 ccccaaacca gggacaggtg aaccagtttt aagtttgcac tacagcacag aaggaacaac
     1921 tacaagcaca ataaaactga actttacaga tgaatggagc agtatagcat caagttctag
     1981 aggaattggg agccattgca aatctgaggg tcaggaggaa tctttcgtcc cacagagctc
     2041 agtgcaacca ccagaaggag acagtgaaac aaaagctcct gaagaatcat cagaggatgt
     2101 gacaaaatat caggaaggag tatctgcaga aaacccagtt gagaaccata tcaatataac
     2161 acaatcagat aagttcacag ccaagccatt ggattccaac tcaggagaaa gaaatgacct
     2221 caatcttgat cgctcttgtg gggttccaga agaatctgct tcatctgaaa aagccaagga
     2281 accagaaact tcagatcaga ctagcactga gagtgctacc aatgaaaata acaccaatcc
     2341 tgagcctcag ttccaaacag aagccactgg gccttcagct catgaagaaa catccaccag
     2401 ggactctgct cttcaggaca cagatgacag tgatgatgac ccagtcctga tcccaggtgc
     2461 aaggtatcga gcaggacctg gtgatagatt taatatcaga ggaacaacaa taggtgatag
     2521 aataatgaga cgctctgctg ttgcccgtat tcaggagttc ttcagacgga gaaaagaaag
     2581 gaaagaaatg gaagaattgg atactttgaa cattagaagg ccgctagtaa aaatggttta
     2641 taaaggccat cgcaactcca ggacaatgat aaaagaagcc aatttctggg gtgctaactt
     2701 tgtaatgagt ggttctgact gtggccacat tttcatctgg gatcggcaca ctgctgagca
     2761 tttgatgctt ctggaagctg ataatcatgt ggtaaactgc ctgcagccac atccgtttga
     2821 cccaatttta gcctcatctg gcatagatta tgacataaag atctggtcac cattagaaga
     2881 gtcaaggatt tttaaccgaa aacttgctga tgaagttata actcgaaacg aactcatgct
     2941 ggaagaaact agaaacacca ttacagttcc agcctctttc atgttgagga tgttggcttc
     3001 acttaatcat atccgagctg accggttgga gggtgacaga tcagaaggct ctggtcaaga
     3061 gaatgaaaat gaggatgagg aataataaac tctttttggc aagcacttaa atgttctgaa
     3121 atttgtataa gacatttatt atattttttt ctttacagag ctttagtgca attttaaggt
     3181 tatggttttt ggagtttttc cctttttttg ggataaccta acattggttt ggaatgattg
     3241 tgtgcatgaa tttgggagat tgtataaaac aaaactagca gaatgttttt aaaacttttt
     3301 gccgtgtatg aggagtgcta gaaaatgcaa agtgcaatat tttccctaac cttcaaatgt
     3361 gggagcttgg atcaatgttg aagaataatt ttcatcatag tgaaaatgtt ggttcaaata
     3421 aatttctaca cttgccattt gcatgtttgt tgctttctaa ttaaagaaac tggttgtttt
     3481 aagata
//
