LOCUS       NM_152418               3269 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 4 like 2 (DCAF4L2),
            mRNA.
ACCESSION   NM_152418
VERSION     NM_152418.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3269)
  AUTHORS   Zhang,X., Xu,S., Hu,C., Fang,K., Zhou,J., Guo,Z., Zhu,G. and Li,L.
  TITLE     LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma progression by
            regulating MAGEA3 and DCAF4L2 expression
  JOURNAL   Biochem Biophys Res Commun 533 (4), 1039-1047 (2020)
   PUBMED   33012505
  REMARK    GeneRIF: LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma
            progression by regulating MAGEA3 and DCAF4L2 expression.
REFERENCE   2  (bases 1 to 3269)
  AUTHORS   Beaty,T.H., Taub,M.A., Scott,A.F., Murray,J.C., Marazita,M.L.,
            Schwender,H., Parker,M.M., Hetmanski,J.B., Balakrishnan,P.,
            Mansilla,M.A., Mangold,E., Ludwig,K.U., Noethen,M.M., Rubini,M.,
            Elcioglu,N. and Ruczinski,I.
  TITLE     Confirming genes influencing risk to cleft lip with/without cleft
            palate in a case-parent trio study
  JOURNAL   Hum Genet 132 (7), 771-781 (2013)
   PUBMED   23512105
  REMARK    GeneRIF: In addition, eight genes classified as 'second tier' hits
            in the original study (PAX7, THADA, COL8A1/FILIP1L, DCAF4L2,
            GADD45G, NTN1, RBFOX3 and FOXE1) showed evidence of linkage and
            association in this replication sample.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK093094.1, AL833507.1, AC005066.1 and BC035011.2.
            
            On Nov 22, 2018 this sequence version replaced NM_152418.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AL833507.1, BC035011.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319675.5/ ENSP00000316496.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1490              AK093094.1         54-1543
            1491-1513           AL833507.1         1492-1514
            1514-1514           AC005066.1         109768-109768
            1515-1678           AL833507.1         1515-1678
            1679-3269           BC035011.2         1660-3250
FEATURES             Location/Qualifiers
     source          1..3269
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..3269
                     /gene="DCAF4L2"
                     /gene_synonym="WDR21C"
                     /note="DDB1 and CUL4 associated factor 4 like 2"
                     /db_xref="GeneID:138009"
                     /db_xref="HGNC:HGNC:26657"
                     /db_xref="MIM:620421"
     exon            1..3269
                     /gene="DCAF4L2"
                     /gene_synonym="WDR21C"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1232
                     /gene="DCAF4L2"
                     /gene_synonym="WDR21C"
                     /note="WD repeat domain 21C; WD repeat-containing protein
                     21C"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 4-like protein
                     2"
                     /protein_id="NP_689631.1"
                     /db_xref="CCDS:CCDS6245.1"
                     /db_xref="GeneID:138009"
                     /db_xref="HGNC:HGNC:26657"
                     /db_xref="MIM:620421"
                     /translation="MESKRPRLLEEADKQKKTVRVGLNAPSMLRKNQLGFLRFANYCR
                     IARELRVSCMQRKKVQIHSWDPSSLASDRFNRILANTNTDQLFTVNQVEAGGSKYGII
                     TMRGLTTPELRVYPHKTLYVPNRKVNSMCWASLNHLDSHLLLCFVGLADTPSCAVLLP
                     ASLFIGSFPGMRRPGMLCSFQIPDAWSCAWSLSIHAYHSFSTGLSQQVLLTNVVTGHQ
                     QSFGTSSDVLAQQFAIMTPLLFNGCRSGEIFGIDLRCGNQGSGWKAICLSHDSAVTSL
                     QILQDGQFLVSSDMTGTIKLWDLRATKCVTQYEGHVNNSAYLPVHVNEEEGVVAAVGQ
                     DCYTRIWSLRHGHLLTTIPSPYPASENDIPSVAFSSRLGGFRGAPGLLMAVREDLYCF
                     SYG"
     regulatory      3249..3254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF4L2"
                     /gene_synonym="WDR21C"
                     /note="hexamer: AATAAA"
     polyA_site      3269
                     /gene="DCAF4L2"
                     /gene_synonym="WDR21C"
                     /note="major polyA site"
ORIGIN      
        1 gggacagaac ttcccctcag gagggagaac atccgccgaa cgaaatggag agcaaaagac
       61 cgcgactgct cgaggaagca gacaagcaga aaaagacagt cagagtggga ctcaatgcac
      121 cttccatgct acgaaagaac cagctaggtt tcctcagatt cgccaactat tgccgtatag
      181 ctcgcgagct gcgtgtaagc tgcatgcaga ggaaaaaggt ccagattcat agctgggatc
      241 cctcctcttt ggcaagcgac cgatttaacc gcatactggc gaataccaac actgaccagc
      301 tcttcacagt gaaccaagtc gaagctggag gctccaagta cggcatcatc accatgcgag
      361 gcctgacgac ccctgagctc cgggtatacc cgcacaaaac cctctacgtc cctaatcgga
      421 aggtgaattc tatgtgctgg gcctcactga atcacttgga ttcccacctt ctgctgtgct
      481 tcgtgggact tgcagatact ccaagctgtg ccgtgctgct cccagcgtcg ctgttcatag
      541 gtagcttccc aggaatgcgt cggcctggca tgctttgcag tttccagatc cctgatgcct
      601 ggtcctgtgc ctggtccctg agcatccacg cgtatcactc tttcagtaca ggcttgtctc
      661 agcaggtcct gttgaccaac gtggtgacgg gacaccagca gtcatttggg actagcagtg
      721 atgtcttggc ccagcagttt gcaatcatga ctcctttgct gtttaatggc tgtcgctctg
      781 gggagatctt tggcattgat ctgcgctgtg gaaatcaagg cagcgggtgg aaggccattt
      841 gcctgtccca tgattcagca gtgacttctc tgcaaatcct ccaagatggc caattcctgg
      901 tgtcatcaga catgactgga actatcaagc tgtgggactt gagggccact aaatgtgtaa
      961 cacagtacga aggtcatgtg aataactccg cctacctacc cgtgcatgtg aacgaagaag
     1021 aaggagtcgt ggcggccgtg ggccaggact gctacacgag aatctggagc ctccgtcatg
     1081 gccacctgct cacaaccata ccctccccat accccgcctc ggagaacgac attcccagtg
     1141 tggccttctc ttctcgcctc gggggcttcc gaggagcacc agggctgctc atggctgtcc
     1201 gggaggacct ttattgtttc tcctacggtt aattcttcag gatgcagccc ggaggaacgt
     1261 ggatttgact taaagaagta aagagcatcg tattaccgtt tctatgagcg cattttaaga
     1321 gatgttcggt gtttgtagat cccatccatc cggctgctag gggtaaggtg ctgttttatg
     1381 tgaagatagt tctgtaaagt tgtttcagtt aaactgggct gagagagctt gaaagtcctt
     1441 ttcataaaag ataactattt ccttttcttg ttgaatacct tagaatagtt atccccccct
     1501 tttttttttt ttttaacaaa aaaacacttt tctaaggact gaagattggc aaaaactaaa
     1561 ataaattaaa actgcttaca ccagaagcct tttagagaag catgagactg tttgactagt
     1621 cctacctggg ttccggaaat acatgcatca tctgtacttg aagaggccag tgggagagga
     1681 gaggaggggg aggtcattta tctgagtctc tccagaagtt tttaaggcta cattttggaa
     1741 tcattaaact tggccttctc aaactcaata gcagatctct gagattctcc ttttattatt
     1801 ttccataggc aatgggagga aaggtggatc tttttaaata atagaagttt taaacagtcc
     1861 ttaacgtgct tttgttgagg catcttccag aatgtaaggt acagcagctc cggtttctat
     1921 tattgtgact tgaatgtcag gattcaaggg ctcagtgtca aagataattg gctttgactt
     1981 tttgtaatct aggagcagca gtttgtgaga tgtttattca aagtgttagc ctgtttttct
     2041 accaacaata agctagaaaa gacaaaaaaa acaaaaaaca aaaaaacgtg taataaagtt
     2101 agtggctact tcttaatagc caaagcctgg aaatgatctc actttacaat atgctaaaat
     2161 tgataaataa tttgtgctgt agtcatacaa ttggataaag cataatataa aataaggcac
     2221 aattgctata tgaaactgtg gattaatctc aacatgttga ttgtaaatgt aggtagaaat
     2281 gagtacaaac tgattcagtt ctaaagttcc aaagcactaa aaacttatct atggtgatta
     2341 cagtttgaat agtaggtatc tctgtggaag gaagaaagga tattgtttgt ttttttccct
     2401 tttattttta ggatattgtt tggaaagtaa cacggggaaa ctttagaaat gctgttttct
     2461 ttttcttgat ccttgataca tacatatttt gtatgtctat acacttcaca ctttatataa
     2521 tacctcaaaa ataaaaatat gaaaacagta cactgttgta ggttggtcag gaaagggaat
     2581 gattgtggct tggacctgac tatgagaagt agaaataatc agaaaaatca gaaatgattg
     2641 cattggaaga tcattcgaag gtagtattag taagatttgc tgatgagagt aatctagaaa
     2701 gtgaaagaca gcataaagat tgcagctttt ttgttaactt taggactggt ggatggttgg
     2761 tgtcatttac taaaatgggg aggatttgag gtgaaaaaat tttaggtgaa gagaataatg
     2821 ctgagtttta ggcaactatt aaaatgtcca ttctgtagat tagaggtgat gtcaggacat
     2881 aaatgaggtt aatgtaatat tacatattga tagaggaata ggtcaataga gaagatacaa
     2941 aagagtggtt aggtgcatag atttttgaaa tcagttaaat tagtttttga tacttgatgt
     3001 gtgacagggg aaactgtgta agctgtactt gttatttctt tgtaaaatgt cttagataat
     3061 aaaactaaat cataaagtag atattggttt aaaggatgta tacattgtcc cttttacatt
     3121 gtaagcattc aataagaact agctgcggat gtaatttttt ttaaaaaagt ccaaaagcag
     3181 ctatgggcag ttgacaaaag aaaatgtaat gactacgtaa cttgcgaatc tgtttaccct
     3241 cacttgcaaa taaaataagt gcaaataaa
//
