LOCUS       NM_015604               2474 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 4 (DCAF4), transcript
            variant 1, mRNA.
ACCESSION   NM_015604
VERSION     NM_015604.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2474)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2474)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2474)
  AUTHORS   Liu,H., Lu,W., He,H., Wu,J., Zhang,C., Gong,H. and Yang,C.
  TITLE     Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4
            E3 ligase activity and promotes ubiquitination of ST7 in
            colitis-associated cancer
  JOURNAL   J Pathol 248 (4), 464-475 (2019)
   PUBMED   30945288
REFERENCE   4  (bases 1 to 2474)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2474)
  AUTHORS   Liu,H., Liu,Z., Wang,Y., Stinchcombe,T.E., Owzar,K., Han,Y.,
            Hung,R.J., Brhane,Y., McLaughlin,J., Brennan,P., Bickeboller,H.,
            Rosenberger,A., Houlston,R.S., Caporaso,N., Landi,M.T., Bruske,I.,
            Risch,A., Wu,X., Ye,Y., Christiani,D.C., Amos,C.I. and Wei,Q.
  CONSRTM   Transdisciplinary Research in Cancer of the Lung (TRICL) Research
            Team
  TITLE     Functional variants in DCAF4 associated with lung cancer risk in
            European populations
  JOURNAL   Carcinogenesis 38 (5), 541-551 (2017)
   PUBMED   28383684
  REMARK    GeneRIF: our results suggest that rs12587742 is associated with an
            increased lung cancer risk, possibly by up-regulating mRNA
            expression and decreasing methylation status of DCAF4.
REFERENCE   6  (bases 1 to 2474)
  AUTHORS   Mangino,M., Christiansen,L., Stone,R., Hunt,S.C., Horvath,K.,
            Eisenberg,D.T., Kimura,M., Petersen,I., Kark,J.D., Herbig,U.,
            Reiner,A.P., Benetos,A., Codd,V., Nyholt,D.R., Sinnreich,R.,
            Christensen,K., Nassar,H., Hwang,S.J., Levy,D., Bataille,V.,
            Fitzpatrick,A.L., Chen,W., Berenson,G.S., Samani,N.J., Martin,N.G.,
            Tishkoff,S., Schork,N.J., Kyvik,K.O., Dalgard,C., Spector,T.D. and
            Aviv,A.
  TITLE     DCAF4, a novel gene associated with leucocyte telomere length
  JOURNAL   J Med Genet 52 (3), 157-162 (2015)
   PUBMED   25624462
  REMARK    GeneRIF: Genome-wide association (GWA) meta-analysis and de novo
            genotyping of 20 022 individuals revealed a novel association
            (p=6.4x10(-10)) between LTL and rs2535913, which lies within DCAF4
REFERENCE   7  (bases 1 to 2474)
  AUTHORS   Cho,S.H., Park,B.L., Shin,S.W., Heo,J.S., Park,J.S., Park,S.W.,
            Jang,A.S., Chung,I.Y., Shin,H.D. and Park,C.S.
  TITLE     Association between WDR21A polymorphisms and airway responsiveness
            to inhaled corticosteroids in asthmatic patients
  JOURNAL   Pharmacogenet Genomics 22 (5), 327-335 (2012)
   PUBMED   22366774
  REMARK    GeneRIF: The minor allele of WDR21A may induce a good response to
            inhaled corticosteroids possibly through competition with the
            Gbeta(1) proteins for binding to GRs
REFERENCE   8  (bases 1 to 2474)
  AUTHORS   Li,T., Robert,E.I., van Breugel,P.C., Strubin,M. and Zheng,N.
  TITLE     A promiscuous alpha-helical motif anchors viral hijackers and
            substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery
  JOURNAL   Nat Struct Mol Biol 17 (1), 105-111 (2010)
   PUBMED   19966799
REFERENCE   9  (bases 1 to 2474)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC314513.1, AK315499.1,
            BC018979.2, AK027745.1 and AL442663.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_015604.3.
            
            Summary: This gene encodes a WD repeat-containing protein that
            interacts with the Cul4-Ddb1 E3 ligase macromolecular complex.
            Multiple alternatively spliced transcript variants have been found
            for this gene. [provided by RefSeq, Jul 2009].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.244659.1,
                                           SRR1803617.130185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358377.7/ ENSP00000351147.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                DC314513.1         133-214
            83-1021             AK315499.1         215-1153
            1022-1087           BC018979.2         966-1031
            1088-1576           AK315499.1         1220-1708
            1577-2415           AK027745.1         1536-2374
            2416-2420           BC018979.2         2360-2364
            2421-2474           AL442663.3         145697-145750       c
FEATURES             Location/Qualifiers
     source          1..2474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..2474
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /note="DDB1 and CUL4 associated factor 4"
                     /db_xref="GeneID:26094"
                     /db_xref="HGNC:HGNC:20229"
                     /db_xref="MIM:616372"
     exon            1..80
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /inference="alignment:Splign:2.1.0"
     exon            81..180
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1576
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat domain 21A; WD repeat-containing protein 21A"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 4 isoform 1"
                     /protein_id="NP_056419.2"
                     /db_xref="CCDS:CCDS9809.1"
                     /db_xref="GeneID:26094"
                     /db_xref="HGNC:HGNC:20229"
                     /db_xref="MIM:616372"
                     /translation="MNKSRWQSRRRHGRRSHQQNPWFRLRDSEDRSDSRAAQPAHDSG
                     HGDDESPSTSSGTAGTSSVPELPGFYFDPEKKRYFRLLPGHNNCNPLTKESIRQKEME
                     SKRLRLLQEEDRRKKIARMGFNASSMLRKSQLGFLNVTNYCHLAHELRLSCMERKKVQ
                     IRSMDPSALASDRFNLILADTNSDRLFTVNDVKVGGSKYGIINLQSLKTPTLKVFMHE
                     NLYFTNRKVNSVCWASLNHLDSHILLCLMGLAETPGCATLLPASLFVNSHPGIDRPGM
                     LCSFRIPGAWSCAWSLNIQANNCFSTGLSRRVLLTNVVTGHRQSFGTNSDVLAQQFAL
                     MAPLLFNGCRSGEIFAIDLRCGNQGKGWKATRLFHDSAVTSVRILQDEQYLMASDMAG
                     KIKLWDLRTTKCVRQYEGHVNEYAYLPLHVHEEEGILVAVGQDCYTRIWSLHDARLLR
                     TIPSPYPASKADIPSVAFSSRLGGSRGAPGLLMAVGQDLYCYSYS"
     exon            181..281
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /inference="alignment:Splign:2.1.0"
     exon            282..439
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /inference="alignment:Splign:2.1.0"
     exon            440..519
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /inference="alignment:Splign:2.1.0"
     exon            520..622
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /inference="alignment:Splign:2.1.0"
     exon            623..766
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /inference="alignment:Splign:2.1.0"
     exon            767..816
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /inference="alignment:Splign:2.1.0"
     exon            817..896
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /inference="alignment:Splign:2.1.0"
     exon            897..995
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1093
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1267
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1382
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..2474
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2399..2404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /note="hexamer: AATAAA"
     polyA_site      2417
                     /gene="DCAF4"
                     /gene_synonym="WDR21; WDR21A"
                     /note="major polyA site"
ORIGIN      
        1 ctttccgggt ccttgcacgc ttcgctccaa ctcctgcaga gctgagccgg aggggaatcc
       61 ggaagggaca cgctgaacag gaacagaaat gaataaaagt cgctggcaga gtagaagacg
      121 acatgggaga agaagccacc agcagaaccc ttggttcaga ctccgtgatt ctgaagacag
      181 gtctgactcc cgggcagcac agcccgctca cgattccggc cacggtgatg acgagtctcc
      241 gtcaacctcg tctggcacag ctgggacctc ctctgtgcca gagctacctg ggttttactt
      301 tgaccctgaa aagaaacgct acttccgctt gctccctgga cataacaact gcaaccccct
      361 gacgaaagag agcatccggc agaaggagat ggagagcaag agactgcggc tgctccagga
      421 agaagacaga cggaaaaaga ttgccaggat gggatttaat gcatcttcca tgctacgaaa
      481 aagccagctg ggttttctca acgtcaccaa ttactgccat ttagcccacg agctgcgtct
      541 cagctgcatg gagaggaaaa aggtccagat tcgaagcatg gatccctccg ccttggcaag
      601 cgaccgattt aacctcatac tggcagatac caacagtgac cggctcttca cagtgaacga
      661 tgttaaagtt ggaggctcca agtatggtat catcaacctg caaagtctga agacccctac
      721 gctcaaggtg ttcatgcacg aaaacctcta cttcaccaac cggaaggtga attcggtgtg
      781 ctgggcctcg ctgaatcact tggattccca cattctgcta tgcctcatgg gactcgcaga
      841 gactccaggc tgtgccaccc tgctcccagc atcactgttc gtcaatagtc acccaggaat
      901 agaccggcct ggcatgctct gcagtttccg gatccctggt gcctggtcct gtgcctggtc
      961 cctgaatatc caagcaaata actgcttcag tacaggcttg tctcggcggg tcctgttgac
     1021 caacgtggtg acgggacacc ggcagtcctt tgggaccaac agtgatgtct tggcccagca
     1081 gtttgctctc atggctcctc tgctgtttaa tggctgccgc tctggggaaa tctttgccat
     1141 tgatctgcgt tgtggaaatc aaggcaaggg atggaaggcc acccgcctgt ttcatgattc
     1201 agcagtgacc tctgtgcgga tcctccaaga tgagcaatac ctgatggctt cagacatggc
     1261 tggaaagatc aagctgtggg acctgaggac cacgaagtgc gtaaggcagt acgaaggcca
     1321 cgtgaatgag tacgcctacc tgcccctgca tgtgcacgag gaagaaggaa tcctggtggc
     1381 agtgggccag gactgctaca cgagaatctg gagcctccac gatgcccgcc tactgagaac
     1441 cataccctcc ccgtaccctg cctccaaggc cgacattccc agtgtggcct tctcgtcgcg
     1501 gctggggggc tcccggggcg cgccggggct gctcatggct gtcgggcagg acctttactg
     1561 ttactcctac agctaattct gcagggcaca gcccagagcc atgtggattt gacttacggg
     1621 agtaaagcgt aactttttac tgcatctaat gagggtgttt taagtgacac tcagtgtaca
     1681 cagatcccat cctctggctg ctaggagaga agtgctgaat gttccgtgtg gagatgctca
     1741 ggaaagttat ttgagttaaa ttgctggctg agagagcttg gaagtccttt tcataaaagg
     1801 tacctctttc cttttcttat tgaattctta gaacttagtt aaccctccct gccttttctt
     1861 aacaaaaagg acttttctaa ggactgaaga ttggcaaaaa cgaaaagctt cttcctccaa
     1921 gagcccattg aagaagccca gtgatgagac ggtgagatgg tttgagtcct cggtgcctgg
     1981 gtagcaggaa gaaagacctg catcctgcat ctgtacttgg ggaagccagc ggagaggacg
     2041 gggaggttac ttctctaagt ttctgcagaa atattgaagg ctggagtttg gaatccttaa
     2101 acttggcctt ctcaaactca gcagcagatc tccgggattc tgctgttatt atccaaaggc
     2161 gttggaagga aagatggatc ttcttacatg ctagaagttt taaacggtcc ttaacatgcc
     2221 tttgttcaag caccttccag aatgtaaggt tcagcagctc tggtttctat tacggtgact
     2281 tgaatgtcag attcaagggc ccggcgtcaa aggaaattgg ttttgacttt ttgtaatcta
     2341 ggagcgacag ttcgtgagat gtttattcag tgttaaagag cctgtttttc taccaaacaa
     2401 taaaaccaag agaagaatca tggtgtgaca tgcacttctg tgaatgactt aggagatcat
     2461 gagcttgggc tgct
//
