LOCUS       NM_138353               2261 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 15 (DCAF15),
            transcript variant 1, mRNA.
ACCESSION   NM_138353 XM_373433
VERSION     NM_138353.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2261)
  AUTHORS   Grothusen,G.P., Chang,R., Cao,Z., Zhou,N., Mittal,M., Datta,A.,
            Wulfridge,P., Beer,T., Wang,B., Zheng,N., Tang,H.Y., Sarma,K.,
            Greenberg,R.A., Shi,J. and Busino,L.
  TITLE     DCAF15 control of cohesin dynamics sustains acute myeloid leukemia
  JOURNAL   Nat Commun 15 (1), 5604 (2024)
   PUBMED   38961054
  REMARK    GeneRIF: DCAF15 control of cohesin dynamics sustains acute myeloid
            leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2261)
  AUTHORS   Dong,X., Han,Y., Zhang,E., Wang,Y., Zhang,P., Wang,C., Zhong,L. and
            Li,Q.
  TITLE     Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition
            by targeting ZEB1 for proteasomal degradation in hepatocellular
            carcinoma
  JOURNAL   Aging (Albany NY) 13 (7), 10603-10618 (2021)
   PUBMED   33833131
  REMARK    GeneRIF: Tumor suppressor DCAF15 inhibits epithelial-mesenchymal
            transition by targeting ZEB1 for proteasomal degradation in
            hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 2261)
  AUTHORS   Nguyen,K.M. and Busino,L.
  TITLE     Targeting the E3 ubiquitin ligases DCAF15 and cereblon for cancer
            therapy
  JOURNAL   Semin Cancer Biol 67 (Pt 2), 53-60 (2020)
   PUBMED   32200025
  REMARK    GeneRIF: Targeting the E3 ubiquitin ligases DCAF15 and cereblon for
            cancer therapy.
            Review article
REFERENCE   4  (bases 1 to 2261)
  AUTHORS   Li,L., Mi,D., Pei,H., Duan,Q., Wang,X., Zhou,W., Jin,J., Li,D.,
            Liu,M. and Chen,Y.
  TITLE     In vivo target protein degradation induced by PROTACs based on E3
            ligase DCAF15
  JOURNAL   Signal Transduct Target Ther 5 (1), 129 (2020)
   PUBMED   32713946
  REMARK    GeneRIF: In vivo target protein degradation induced by PROTACs
            based on E3 ligase DCAF15.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2261)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2261)
  AUTHORS   Faust,T.B., Yoon,H., Nowak,R.P., Donovan,K.A., Li,Z., Cai,Q.,
            Eleuteri,N.A., Zhang,T., Gray,N.S. and Fischer,E.S.
  TITLE     Structural complementarity facilitates E7820-mediated degradation
            of RBM39 by DCAF15
  JOURNAL   Nat Chem Biol 16 (1), 7-14 (2020)
   PUBMED   31686031
  REMARK    GeneRIF: aryl-sulfonamides neo-functionalize a shallow,
            non-conserved pocket on DCAF15 to selectively bind and degrade
            RBM39 and the closely related splicing factor RBM23 without the
            requirement for a high-affinity ligand
REFERENCE   7  (bases 1 to 2261)
  AUTHORS   Pech,M.F., Fong,L.E., Villalta,J.E., Chan,L.J., Kharbanda,S.,
            O'Brien,J.J., McAllister,F.E., Firestone,A.J., Jan,C.H. and
            Settleman,J.
  TITLE     Systematic identification of cancer cell vulnerabilities to natural
            killer cell-mediated immune surveillance
  JOURNAL   Elife 8, e47362 (2019)
   PUBMED   31452512
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2261)
  AUTHORS   Uehara,T., Minoshima,Y., Sagane,K., Sugi,N.H., Mitsuhashi,K.O.,
            Yamamoto,N., Kamiyama,H., Takahashi,K., Kotake,Y., Uesugi,M.,
            Yokoi,A., Inoue,A., Yoshida,T., Mabuchi,M., Tanaka,A. and Owa,T.
  TITLE     Selective degradation of splicing factor CAPERalpha by anticancer
            sulfonamides
  JOURNAL   Nat Chem Biol 13 (6), 675-680 (2017)
   PUBMED   28437394
REFERENCE   9  (bases 1 to 2261)
  AUTHORS   Han,T., Goralski,M., Gaskill,N., Capota,E., Kim,J., Ting,T.C.,
            Xie,Y., Williams,N.S. and Nijhawan,D.
  TITLE     Anticancer sulfonamides target splicing by inducing RBM39
            degradation via recruitment to DCAF15
  JOURNAL   Science 356 (6336) (2017)
   PUBMED   28302793
  REMARK    GeneRIF: DCAF15 expression may be a useful biomarker to guide
            clinical trials of splicing inhibitor sulfonamides(SPLAMs).
            Erratum:[Science. 2017 May 26;356(6340):eaan7977. doi:
            10.1126/science.aan7977.. PMID: 28546157]
REFERENCE   10 (bases 1 to 2261)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020916.8.
            
            On Feb 24, 2021 this sequence version replaced NM_138353.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080575.1, AK093072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254337.11/ ENSP00000254337.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC020916.8         165648-165783
            137-234             AC020916.8         167479-167576
            235-370             AC020916.8         167665-167800
            371-477             AC020916.8         169051-169157
            478-617             AC020916.8         169262-169401
            618-788             AC020916.8         169491-169661
            789-1223            AC020916.8         172184-172618
            1224-1315           AC020916.8         172721-172812
            1316-1444           AC020916.8         172906-173034
            1445-1530           AC020916.8         173123-173208
            1531-1635           AC020916.8         173426-173530
            1636-1751           AC020916.8         173604-173719
            1752-2261           AC020916.8         174079-174588
FEATURES             Location/Qualifiers
     source          1..2261
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..2261
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /note="DDB1 and CUL4 associated factor 15"
                     /db_xref="GeneID:90379"
                     /db_xref="HGNC:HGNC:25095"
                     /db_xref="MIM:620109"
     exon            1..136
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..1807
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 15 isoform 1"
                     /protein_id="NP_612362.2"
                     /db_xref="CCDS:CCDS32926.1"
                     /db_xref="GeneID:90379"
                     /db_xref="HGNC:HGNC:25095"
                     /db_xref="MIM:620109"
                     /translation="MAPSSKSERNSGAGSGGGGPGGAGGKRAAGRRREHVLKQLERVK
                     ISGQLSPRLFRKLPPRVCVSLKNIVDEDFLYAGHIFLGFSKCGRYVLSYTSSSGDDDF
                     SFYIYHLYWWEFNVHSKLKLVRQVRLFQDEEIYSDLYLTVCEWPSDASKVIVFGFNTR
                     SANGMLMNMMMMSDENHRDIYVSTVAVPPPGRCAACQDASRAHPGDPNAQCLRHGFML
                     HTKYQVVYPFPTFQPAFQLKKDQVVLLNTSYSLVACAVSVHSAGDRSFCQILYDHSTC
                     PLAPASPPEPQSPELPPALPSFCPEAAPARSSGSPEPSPAIAKAKEFVADIFRRAKEA
                     KGGVPEEARPALCPGPSGSRCRAHSEPLALCGETAPRDSPPASEAPASEPGYVNYTKL
                     YYVLESGEGTEPEDELEDDKISLPFVVTDLRGRNLRPMRERTAVQGQYLTVEQLTLDF
                     EYVINEVIRHDATWGHQFCSFSDYDIVILEVCPETNQVLINIGLLLLAFPSPTEEGQL
                     RPKTYHTSLKVAWDLNTGIFETVSVGDLTEVKGQTSGSVWSSYRKSCVDMVMKWLVPE
                     SSGRYVNRMTNEALHKGCSLKVLADSERYTWIVL"
     exon            137..234
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            235..370
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            371..477
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            478..617
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            618..788
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            789..1223
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1315
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1444
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1530
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1635
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1751
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..2261
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2235..2240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /note="hexamer: AATAAA"
     polyA_site      2261
                     /gene="DCAF15"
                     /gene_synonym="C19orf72"
                     /note="major polyA site"
ORIGIN      
        1 gaaaatggcg cccagctcga aatcggagcg gaacagcggg gctgggagcg gcggcggcgg
       61 ccccggggga gccggaggga agcgggcagc agggcggcgg cgggagcacg tcctcaagca
      121 gctggagcgg gtcaagatca gcggacagct ctcccctcgc ctcttccgga agctgcctcc
      181 ccgggtgtgc gtgtccctca agaacattgt ggatgaggac ttcctctatg caggacatat
      241 cttcctgggc ttttccaaat gcggccgcta cgtcctctcc tacaccagca gcagtgggga
      301 tgacgacttc tccttctaca tctaccatct gtactggtgg gagttcaacg ttcacagcaa
      361 gctcaagctg gtccggcagg ttcggctatt ccaggacgag gagatctaca gcgacctgta
      421 cctgaccgta tgcgagtggc ccagcgacgc ctccaaggtc atcgtcttcg gcttcaacac
      481 ccgctcggcc aacgggatgc tcatgaacat gatgatgatg agtgacgaga accaccgtga
      541 catctacgtc agcaccgtgg ccgtgccacc gccaggccgc tgtgctgctt gccaggatgc
      601 cagccgagcc cacccaggag acccgaatgc acagtgccta cggcatggct tcatgctgca
      661 caccaagtac caggtggtct accccttccc caccttccag cccgccttcc agctcaagaa
      721 ggaccaggtg gtgctgctca acaccagcta ctccctggtg gcctgcgccg tctccgtcca
      781 ctcggcaggt gacaggagtt tctgccaaat cctgtatgac cacagcacct gccccctggc
      841 gcctgccagc ccccctgagc cccagagccc agagctgccc cctgccctcc ccagcttctg
      901 ccctgaggcg gccccagccc gttcttctgg gtctcctgag ccctcgcccg ccattgccaa
      961 agccaaggag tttgtggctg acatcttccg ccgggccaaa gaggccaagg gcggggtccc
     1021 tgaggaagcc cggcctgccc tgtgcccagg accctctggc agccgctgcc gtgcgcactc
     1081 tgagccccta gccctgtgtg gagagacggc accccgggac agcccccctg cctcggaggc
     1141 acctgcctcc gagcctggct atgtcaacta caccaagctg tactatgtgc tggagtccgg
     1201 agaggggacg gagccggagg atgagttgga ggacgacaag atctccctgc ccttcgtggt
     1261 gactgatctt cgtggccgca acctgcggcc catgcgggag cggactgctg tccagggcca
     1321 gtacctgaca gtggagcagc tcacactaga cttcgaatat gttatcaatg aggtcatccg
     1381 ccacgacgct acctggggcc atcagttctg ttctttcagc gactatgaca tcgtcattct
     1441 ggaggtctgc ccagaaacca accaggtcct catcaacatt ggcctgctgc tcctggcctt
     1501 cccgtccccc actgaggagg gccagctccg accaaagacc tatcacacca gcctcaaggt
     1561 ggcatgggac ctcaacacag ggatcttcga gacagtcagt gtaggcgacc tgactgaggt
     1621 caaagggcag accagcggca gtgtctggag ctcctaccgc aagagctgcg tggacatggt
     1681 catgaagtgg ctggtgccgg agagcagcgg ccgctacgtc aacaggatga ccaatgaggc
     1741 gctgcacaaa gggtgctccc tgaaggttct ggcggacagc gagcgatata cgtggatcgt
     1801 gctgtgaggg ccaggccgcc ccggacactg actccaacta cctccgtggc ctgggaccgg
     1861 cccccttcct ggggtggcct cttcctggcc ggctggccca ccgactgatg accggcacta
     1921 gtgttagcct gcggaacggg gctgggcagg gcagcctctg ttggcctgag ggtctggacg
     1981 ctttttattt atgcctattt aagttgggaa ggggcagaga gagggcgccc cctgccccac
     2041 cagcctgagt gccccgcctt caccccgagc tgggcatggg cctggcccct cgtgcatttg
     2101 cccttttctc ggctacagct gtggacgttg ccctcgggga ggtcgaatgg accccattcc
     2161 ccctgccctg cccgccccca gcctccccac ccaggccggc aacctggcca tccccattcc
     2221 gttcttcttc atgtaataaa tgttttaatt tctgaacctc a
//
