LOCUS       NM_015420               1970 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 13 (DCAF13),
            transcript variant 1, mRNA.
ACCESSION   NM_015420 NM_014156
VERSION     NM_015420.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1970)
  AUTHORS   Tang,Z.Y., Wang,X.M., Xu,C.W., Sun,Q.Q., Hua,Y.X., Zhou,Q.Y.,
            Hu,H.Y., Liu,S.B., Guo,Y.J., Ao,L., Che,X., Zhang,X.C., Heger,M.,
            Zheng,X., Liu,A.J., Wang,Q., Zhan,Z.J., Cheng,S.Q. and Pan,W.W.
  TITLE     DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 421 (2024)
   PUBMED   39367995
  REMARK    GeneRIF: DCAF13 promotes ovarian cancer progression by activating
            FRAS1-mediated FAK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1970)
  AUTHORS   Ren,P., Tong,X., Li,J., Jiang,H., Liu,S., Li,X., Lai,M., Yang,W.,
            Rong,Y., Zhang,Y., Jin,J., Ma,Y., Pan,W., Fan,H.Y., Zhang,S. and
            Zhang,Y.L.
  TITLE     CRL4DCAF13 E3 ubiquitin ligase targets MeCP2 for degradation to
            prevent DNA hypermethylation and ensure normal transcription in
            growing oocytes
  JOURNAL   Cell Mol Life Sci 81 (1), 165 (2024)
   PUBMED   38578457
  REMARK    GeneRIF: CRL4[DCAF13] E3 ubiquitin ligase targets MeCP2 for
            degradation to prevent DNA hypermethylation and ensure normal
            transcription in growing oocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1970)
  AUTHORS   Manzoor,H., Zahid,H., Emerling,C.A., Kumar,K.R., Hussain,H.M.J.,
            Seo,G.H., Wajid,M. and Naz,S.
  TITLE     A biallelic variant of DCAF13 implicated in a neuromuscular
            disorder in humans
  JOURNAL   Eur J Hum Genet 31 (6), 629-637 (2023)
   PUBMED   36797467
  REMARK    GeneRIF: A biallelic variant of DCAF13 implicated in a
            neuromuscular disorder in humans.
REFERENCE   4  (bases 1 to 1970)
  AUTHORS   Wei,S., Lu,K., Xing,J. and Yu,W.
  TITLE     A multidimensional pan-cancer analysis of DCAF13 and its
            protumorigenic effect in lung adenocarcinoma
  JOURNAL   FASEB J 37 (4), e22849 (2023)
   PUBMED   36884358
  REMARK    GeneRIF: A multidimensional pan-cancer analysis of DCAF13 and its
            protumorigenic effect in lung adenocarcinoma.
REFERENCE   5  (bases 1 to 1970)
  AUTHORS   Yan,X., Rong,M., Zhou,Q. and Zhang,C.
  TITLE     DCAF13 is essential for the pathogenesis of preeclampsia through
            its involvement in endometrial decidualization
  JOURNAL   Mol Cell Endocrinol 556, 111741 (2022)
   PUBMED   35932979
  REMARK    GeneRIF: DCAF13 is essential for the pathogenesis of preeclampsia
            through its involvement in endometrial decidualization.
REFERENCE   6  (bases 1 to 1970)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 1970)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 1970)
  AUTHORS   Urano,T., Shiraki,M., Usui,T., Sasaki,N., Ouchi,Y. and Inoue,S.
  TITLE     Identification of non-synonymous polymorphisms in the WDSOF1 gene
            as novel susceptibility markers for low bone mineral density in
            Japanese postmenopausal women
  JOURNAL   Bone 47 (3), 636-642 (2010)
   PUBMED   20601284
  REMARK    GeneRIF: This study suggests that non-synonymous WDSOF1
            polymorphisms play a role in the genetic susceptibility to
            osteoporosis.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1970)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
REFERENCE   10 (bases 1 to 1970)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK027799.1, AC012213.8 and CA429438.1.
            
            On Jul 12, 2018 this sequence version replaced NM_015420.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.743504.1,
                                           SRR1803613.2471.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000612750.5/ ENSP00000484962.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               AK027799.1         674-857
            185-185             AC012213.8         98476-98476         c
            186-1489            AK027799.1         859-2162
            1490-1970           CA429438.1         16-496              c
FEATURES             Location/Qualifiers
     source          1..1970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..1970
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /note="DDB1 and CUL4 associated factor 13"
                     /db_xref="GeneID:25879"
                     /db_xref="HGNC:HGNC:24535"
                     /db_xref="MIM:616196"
     exon            1..131
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1399
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeats and SOF1 domain containing; WD repeat and SOF
                     domain-containing protein 1"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 13 isoform 1"
                     /protein_id="NP_056235.5"
                     /db_xref="CCDS:CCDS34934.2"
                     /db_xref="GeneID:25879"
                     /db_xref="HGNC:HGNC:24535"
                     /db_xref="MIM:616196"
                     /translation="MKVKMLSRNPDNYVRETKLDLQRVPRNYDPALHPFEVPREYIRA
                     LNATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCI
                     RTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYT
                     GIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASD
                     RNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVM
                     VHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWT
                     SDSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIKRIAR
                     HRHLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVPLVSEKKKHVVAVVK"
     exon            132..331
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /inference="alignment:Splign:2.1.0"
     exon            332..439
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /inference="alignment:Splign:2.1.0"
     exon            440..529
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..685
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..763
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..846
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1011
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1147
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1311
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1970
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1461..1466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /note="hexamer: AATAAA"
     polyA_site      1492
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /note="major polyA site"
     regulatory      1617..1622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /note="hexamer: AATACA"
     polyA_site      1636
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
     regulatory      1945..1950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
                     /note="hexamer: ATTAAA"
     polyA_site      1970
                     /gene="DCAF13"
                     /gene_synonym="GM83; HSPC064; Sof1; WDSOF1"
ORIGIN      
        1 gtggcggtgg gcggaactcc tagcggacac ctcgtggagt ccggccggaa gagcaaccga
       61 gatgaaggtg aagatgctga gccggaatcc ggacaattat gtccgcgaaa ccaagttgga
      121 cttacagaga gttccaagaa actatgatcc tgctttacat ccttttgagg tcccacgaga
      181 atatataaga gctttaaatg ctaccaaact ggaacgagta tttgcaaaac cattccttgc
      241 ttcgctggat ggtcaccgtg atggagtcaa ttgcttggca aagcatccag agaagctggc
      301 tactgtcctt tctggggcgt gtgatggaga ggttagaatt tggaatctaa ctcagcggaa
      361 ttgtatccgt acaatacaag cacatgaagg ctttgtacga ggaatatgta ctcgcttttg
      421 tgggacttct tttttcactg ttggtgatga caaaactgtg aagcagtgga aaatggatgg
      481 gccaggctat ggagacgagg aagagccatt acatacaata ttaggaaaga cagtgtatac
      541 tgggattgat catcactgga aagaagctgt ttttgccaca tgtggacagc aagtagacat
      601 ttgggatgaa caaagaacta atcctatatg ttcaatgacc tggggatttg acagtataag
      661 tagtgttaaa tttaacccaa ttgagacatt tctcttggga agttgtgcat ctgacaggaa
      721 tatagtactg tacgatatga ggcaagctac tcctttgaaa aaggttatct tagatatgag
      781 aacaaataca atctgttgga accctatgga agctttcatt tttacagcag caaatgaaga
      841 ttataactta tatacttttg atatgcgtgc actggacact cctgtaatgg tccatatgga
      901 tcatgtatct gcagtgcttg atgtggatta ctctcccact gggaaggagt ttgtgtctgc
      961 tagtttcgat aaatctattc gaatctttcc tgtagacaaa agtcgaagca gggaggtata
     1021 tcatacaaag agaatgcaac atgttatctg tgtaaaatgg acttctgaca gcaagtatat
     1081 tatgtgtgga tctgatgaaa tgaacattcg cctgtggaaa gctaatgctt ctgaaaaatt
     1141 gggtgtgctt acatcacgag aaaaagcagc caaggattat aaccagaaat tgaaggagaa
     1201 atttcagcat tatcctcata taaaacgtat agctcgtcat cgacatctac caaaatctat
     1261 ctatagccag attcaggaac agcgcatcat gaaagaagct cgtcgacgaa aggaagtgaa
     1321 tcgtattaaa cacagcaagc ctggatctgt gccacttgtg tcagagaaga agaaacacgt
     1381 agtggcagtt gtaaaataat tggtattcct aacaatcctg atgtataatt atttgttact
     1441 tttgatttga gaactctaca aataaaagtg ctgggactag attaattgca aacattttag
     1501 ttatatgtgt agagctttat tgttactcct tttagctacc ctgaaaaatg atccttaaag
     1561 gtggcctagt tggtaagact gttttatcct taatctgcat tcttctttca ttgtagaata
     1621 cagtatttgc aactcatttt ttcttgtttt tattacagat atacttactt tctctttgat
     1681 ctattattgt agacactata cattcaaatt gacatttaag accaaacatc tcttatgtta
     1741 tctttaatat tactttgaat aatgattgca atgatgtttc ttcctgtgat tccacataac
     1801 atttagaata atgatgtcaa ttttttacaa ctgaatttat ttctagtgct ttacttatat
     1861 ttggcttttt gactctttta aaacaatcag cctgcattta tataactttt ataaataata
     1921 atataatttg ggtcaagtta agatattaaa agttcctttc agcattgaaa
//
