LOCUS       NM_001013628            2791 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 12 like 2 (DCAF12L2),
            mRNA.
ACCESSION   NM_001013628 XM_293387
VERSION     NM_001013628.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2791)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
  REMARK    GeneRIF: Functionally characterizes other DDB1- and CUL4-associated
            factors, including the DCAF12 factor which most closely resembles
            the product of this gene.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445072.17, BC136674.1 and
            AY726580.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001013628.2.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD),
            which may facilitate formation of heterotrimeric or multi-protein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. This gene appears to
            represent an intronless retrocopy of a related multi-exon gene
            located on chromosome 9. However, the CDS of this intronless gene
            remains intact, it is conserved in other mammalian species, it is
            known to be transcribed, and it is therefore thought to encode a
            functional protein. [provided by RefSeq, May 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803612.100109.1, SRR1660809.50847.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360028.4/ ENSP00000353128.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AL445072.17        96641-96832         c
            193-337             BC136674.1         1-145
            338-338             AL445072.17        96495-96495         c
            339-1936            BC136674.1         147-1744
            1937-2289           AL445072.17        94544-94896         c
            2290-2791           AY726580.1         1-502
FEATURES             Location/Qualifiers
     source          1..2791
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq25"
     gene            1..2791
                     /gene="DCAF12L2"
                     /gene_synonym="WDR40C"
                     /note="DDB1 and CUL4 associated factor 12 like 2"
                     /db_xref="GeneID:340578"
                     /db_xref="HGNC:HGNC:32950"
     exon            1..2791
                     /gene="DCAF12L2"
                     /gene_synonym="WDR40C"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..1757
                     /gene="DCAF12L2"
                     /gene_synonym="WDR40C"
                     /note="WD repeat-containing protein 40C"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 12-like protein
                     2"
                     /protein_id="NP_001013650.1"
                     /db_xref="CCDS:CCDS43991.1"
                     /db_xref="GeneID:340578"
                     /db_xref="HGNC:HGNC:32950"
                     /translation="MAQQQTGSRKRKAPAVEAGAGSSSSQGLAAADGEGPLLPKKQKR
                     PATRRRLVHYLKGREVGARGPAGLQGFEGELRGYAVQRLPELLTERQLDLGTLNKVFA
                     SQWLNARQVVCGTKCNTLFVVDVQSGHITRIPLMRDKEAGLAQAHQGCGIHAIELNPS
                     KTLLATGGENPNSLAIYQLPTLDPLCLGDRHGHKDWIFAVAWLSDTVAVSGSRDGTVA
                     LWRMDPDMFNGSIAWHSEVGLPVYAHIRPRDVEAIPRASTNPSNRKVRALAFSGKNQE
                     LGAVSLDGYFHLWKARSTLSRLLSIRLPYCRENVCLTYCDELSLYAVGSQSHVSFLDP
                     RQRQQNIRPLCSREGGTGVRSLSFYQHIITVGTGHGSLLFYDIRAQKFLEERASSSLD
                     SMPGPAGRKLKLACGRGWLNQDDVWVNYFGGMGEFPNALYTHCYNWPEMKLFVAGGPL
                     PSGLHGNYAGLWS"
     regulatory      2765..2770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF12L2"
                     /gene_synonym="WDR40C"
                     /note="hexamer: AATAAA"
     polyA_site      2791
                     /gene="DCAF12L2"
                     /gene_synonym="WDR40C"
                     /note="major polyA site"
ORIGIN      
        1 acactgactt cgctcccgca gccatccaga cagacactct tcccgctctc gcctaggtct
       61 gcaccgccac tgccgccctt gccgccgcgc ttcgccccgg ctctgctacg tcaggccgcg
      121 catctctggc caggacgacc gctgccgccg ccgccgccgc cgagcctcag actgaagtct
      181 gggcgcccgc gatcgcacca gcttcttggt cttagagatc ctgagctctc ggctgacgcg
      241 gaagcgcagc catccccacc accgccgcca cggccaacac gggtgccacg cgccgccacc
      301 gccgccgggc cgccgccgcc gccgccgccg ccgccgccgc tgctgcagat cgcccgccgc
      361 ccaccatggc ccagcagcaa acaggtagca ggaaacggaa agcgcccgcg gtcgaggcgg
      421 gagccgggag ctcgtcgtcg cagggtttag cggcggcgga cggagagggg cctctgctac
      481 ccaagaagca gaagcggccg gcgacgcgtc gcaggctggt gcactatctg aagggccggg
      541 aggtaggagc gcggggccca gccgggctcc agggcttcga gggcgagctg cggggctacg
      601 ccgtccagag gctgcccgag ctgctgacgg agcgccagct ggacctgggc accctcaaca
      661 aggtgttcgc gtcacagtgg ctgaacgcca ggcaggtggt gtgcggcacc aagtgtaata
      721 cgctgtttgt ggtggacgtg cagtcaggcc acatcacgcg catccccctc atgcgggaca
      781 aggaggccgg gctggcccag gcccaccagg gctgcggcat ccatgccatc gagctgaatc
      841 cctccaagac gcttctggcc accggcggcg aaaaccccaa cagcctggcc atctaccagc
      901 tgcccaccct ggaccccctg tgcctgggcg accgccatgg ccacaaggac tggatcttcg
      961 cagtcgcctg gctgagtgac accgtagctg tgagcggctc ccgcgacggc accgtggctc
     1021 tgtggcggat ggacccagac atgtttaatg gcagcattgc ctggcacagc gaggtgggtc
     1081 tcccagtata tgcccacatc cgtccgaggg atgtggaggc catccccagg gccagcacca
     1141 accccagcaa ccgcaaggta cgggccctgg ccttcagcgg caagaaccag gagctgggag
     1201 cggtgtcctt ggacggctac ttccacctgt ggaaagcccg gagcacacta tccaggctcc
     1261 tgtccatcag gctgccctac tgccgagaga atgtgtgcct gacctactgt gatgagttgt
     1321 ccctgtacgc tgtgggctct cagtcccacg tctccttcct ggatccgcgc cagcgccagc
     1381 agaacatccg gcccctgtgc tctcgagagg gtggcacagg cgtgcggtcg ctgagcttct
     1441 accagcacat catcactgtg ggcaccggcc atggttccct gctcttctat gacatccgcg
     1501 cccagaagtt cctggaggag agggcctctt ccagcctgga ctccatgccg gggcccgcag
     1561 ggaggaagct caagcttgcc tgcggcagag gctggctcaa ccaagatgac gtctgggtga
     1621 actactttgg tggcatggga gagttcccca atgcgctcta cacccactgc tacaactggc
     1681 cggagatgaa gctctttgtg gctggggggc ctctcccttc aggcctccat gggaactacg
     1741 caggcctctg gagttaagga tggacgcctt gttctcaaag tgcacaggtt tacctttcag
     1801 ttccgcctga ctttccttct tcatgctgca tttgtgcttt taactttgtg tggcttttgt
     1861 cttccaggtg gaaccagtcc aacttacgtg tgcttaatgt attaggcaga gaaagaaaga
     1921 gagagagcgg gagcgagaga gcacaagtgg tcctttcggc agtcaaaact ttggctttaa
     1981 aactctcatt cacgtttccc aacagcagta tatttttgcc ttctcattca aagagttttg
     2041 gctaaacctt aattgtgttc tgtctttcag tgattcacat accctccttc tttaggttga
     2101 tgtagtcata gtcttcacta ctattcagta cgttagtttt atcaatattg caatagtgtt
     2161 cagatctttt acacatgtta gatgtgtggt gttttgggga aatgtgagct acaaagcatc
     2221 tttggggttg ttttgaggaa ctacccatca tttatagcct tactctaatt acaaaatgca
     2281 gttcaggttc tagattgcca ccattctaga gtgtggcaca caccattcta gggcgtgatt
     2341 catttggatg ttggaaactc aatgtctgtt gtttgtatag tgttgatgtg taaaatgctt
     2401 taaaaatatg ttctgttagt tagaaatctt acaatgttgt tcatactatt aatcaacatt
     2461 tttggttatt cagtaaaact ttactatcct caggccctcc gtgttcttat ttaaagccgc
     2521 tgtattatgg cctgcttttc tatgctacag attttcagaa ctactcaatt ctggtctata
     2581 tatgtggtag tgcaatcagg gaggtatttt tgggggtata tggggtacac atctctttaa
     2641 attcaggtag ctatttacag tgaaaagcca gttgtggcag ttgtgctcag agtaggtgtt
     2701 gattttttat tactgtatac atggataatt ctggatccag tatgtgatgt gttgcagaaa
     2761 aataaataaa atgtgttcat catcttagca a
//
