LOCUS       NM_178470               3345 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 12 like 1 (DCAF12L1),
            mRNA.
ACCESSION   NM_178470
VERSION     NM_178470.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3345)
  AUTHORS   Houston,B.J., Lopes,A.M., Laan,M., Nagirnaja,L., O'Connor,A.E.,
            Merriner,D.J., Nguyen,J., Punab,M., Riera-Escamilla,A., Krausz,C.,
            Aston,K.I., Conrad,D.F. and O'Bryan,M.K.
  TITLE     DDB1- and CUL4-associated factor 12-like protein 1 (Dcaf12l1) is
            not essential for male fertility in mice
  JOURNAL   Dev Biol 490, 66-72 (2022)
   PUBMED   35850260
REFERENCE   2  (bases 1 to 3345)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3345)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
  REMARK    GeneRIF: Functionally characterizes other DDB1- and CUL4-associated
            factors, including the DCAF12 factor which most closely resembles
            the product of this gene.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM563914.1, DN999337.1,
            BC035674.1 and AI139786.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_178470.4.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),
            which may facilitate formation of heterotrimeric or multiprotein
            complexes. Members of this family are involved in a variety of
            cellular processes, including cell cycle progression, signal
            transduction, apoptosis, and gene regulation. [provided by RefSeq,
            Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035674.1, ERR279842.10737.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371126.3/ ENSP00000360167.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               BM563914.1         58-318
            262-434             DN999337.1         269-441
            435-3342            BC035674.1         472-3379
            3343-3345           AI139786.1         14-16               c
FEATURES             Location/Qualifiers
     source          1..3345
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq25"
     gene            1..3345
                     /gene="DCAF12L1"
                     /gene_synonym="KIAA1892L; WDR40B"
                     /note="DDB1 and CUL4 associated factor 12 like 1"
                     /db_xref="GeneID:139170"
                     /db_xref="HGNC:HGNC:29395"
     exon            1..1620
                     /gene="DCAF12L1"
                     /gene_synonym="KIAA1892L; WDR40B"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1598
                     /gene="DCAF12L1"
                     /gene_synonym="KIAA1892L; WDR40B"
                     /note="WD repeat domain 40B; WD repeat-containing protein
                     40B"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 12-like protein
                     1"
                     /protein_id="NP_848565.2"
                     /db_xref="CCDS:CCDS14610.1"
                     /db_xref="GeneID:139170"
                     /db_xref="HGNC:HGNC:29395"
                     /translation="MAQQQTGSRKRKAPAVEADAESSPSQGLAAADGEGPLLLKRQRR
                     PATYRSMAHYLKVREVGGWGPARLQGFDGELRGYAVQRLPELLTERQLELGTVNKVFA
                     SQWLNSRQVVCGTKCNTLFVVDVESGHIARIPLLRDSEARLAQDQQGCGIHAIELNPS
                     KTLLATGGENPNSLAIYQLPSLDPLCLGDRHGHKDWIFAVAWLSDTVAVSGSRDGTVA
                     LWRMDPDKFDDTVAWHSEVGLPVYAHIRPRDVEAIPRAIINPSNRKVRALACGGKNQE
                     LGAVSLDGYFHLWKAGSALSRLLSIRLPYFRDNVCLTYCDDMSVYAVGSHSHVSFLDL
                     RQDQQNIRPLCSREGGTGVRSLSFYRHIITVGTGQGSLLFYDVRAQKFLEERASATLE
                     SSSGPARRKLRLACGRGWLNHNDFWVNYFGGMEVFPNALYTHCYNWPEMKLFVAGGPL
                     PAGLHGNYAGLWS"
     exon            1621..3345
                     /gene="DCAF12L1"
                     /gene_synonym="KIAA1892L; WDR40B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3323..3328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF12L1"
                     /gene_synonym="KIAA1892L; WDR40B"
                     /note="hexamer: AATAAA"
     polyA_site      3345
                     /gene="DCAF12L1"
                     /gene_synonym="KIAA1892L; WDR40B"
                     /note="major polyA site"
ORIGIN      
        1 agacgcactt cccgccttcg cctaggtctg caccgccacc gccgccctct cccgcgcgtc
       61 cctcacccgg tccgccactg ccgcgcctca gaatccgaag gctcggttcc agcgcagcca
      121 tccacgccgc cgccacgacc gactccggag ccacgcgctg caaccgccac caacgccttg
      181 ccgccgccgc tcgcccgccg cccaccatgg cccagcagca aacaggtagc aggaaacgga
      241 aagcgcccgc ggtcgaggcg gacgccgaga gctcgccgtc gcagggcttg gcggcagcgg
      301 acggtgaggg gccgctgcta ctcaagaggc agaggcggcc ggcgacgtat cgctcgatgg
      361 cgcactatct gaaggttcgg gaggtaggcg ggtggggccc cgccaggctc cagggcttcg
      421 atggcgagct gcggggctac gcggtacaga ggctgcccga gctgctgacg gagcgccaac
      481 tggagctggg cacggtcaac aaggtgttcg cgtcacagtg gctgaactcc aggcaggtgg
      541 tgtgcggcac caagtgtaac acgcttttcg tggtggacgt ggagtcaggc cacatcgcgc
      601 gcattcccct cttgcgggac agtgaggcca ggctggccca ggaccaacag ggctgcggca
      661 tccatgccat cgagctgaat ccctccaaga cgcttctggc caccggcggc gaaaacccca
      721 acagcctggc catctaccag ctgccctccc tggatcccct gtgcctgggc gaccgccatg
      781 gccacaagga ctggatcttc gccgtcgcct ggctgagtga caccgtagcc gtgagcggct
      841 cccgcgacgg cactgtggcg ctgtggcgga tggacccgga caagttcgat gacactgttg
      901 cctggcatag cgaggtgggt ctccccgtat atgcccacat ccgtccgagg gatgtggagg
      961 ccatccccag ggccatcatc aaccccagta accgcaaggt gcgggccctg gcctgcggcg
     1021 gcaagaacca ggaactggga gcggtgtcct tggacggcta cttccacctg tggaaagccg
     1081 ggagcgcact atccaggctg ctgtccatca ggctgcccta cttccgggat aatgtgtgcc
     1141 tgacctactg tgatgatatg tctgtgtacg ccgtgggctc ccattcccac gtctctttcc
     1201 tggatctgcg ccaggaccag cagaacatcc ggcccctgtg ttctcgagag ggtggcacag
     1261 gcgtgcggtc gctgagcttc taccgccaca tcatcactgt gggcaccggt cagggctccc
     1321 tgctcttcta tgacgtccgg gcccagaaat tcctggagga aagagcctcc gccaccctgg
     1381 agtcctcttc gggacctgca aggaggaagc tcaggcttgc ctgtggcaga ggctggctca
     1441 accacaatga tttctgggtg aattactttg gtggcatgga agtgtttccc aatgcgctct
     1501 acacccactg ctacaactgg cctgagatga agctctttgt ggctgggggg cctctccctg
     1561 caggcctcca tgggaactat gcaggcctct ggagctaagg atgaccgcct tgtactccag
     1621 gtggaaccag cccagcttaa tttgtactcc tccaagcaga gagagtgagt ggtcctttgg
     1681 tcaatgaaaa cttggcttta agactttttg actcctttcc aacaccatct tttggaattt
     1741 tcatacaaag aaatttggtt aatcgttaat ctttagttgc attctctctt tgagtgattc
     1801 atacattctg tttctttaag aagatgcagt catggtcttt cagttatgta tatttgtttt
     1861 ccttgttttt cctcgttacc aatattacaa cagcattgtt ttcagttatt tttcattgca
     1921 gatacgaaga gaaaattttc tagtaagcaa ggtgttccta catcttttct ggagagctta
     1981 ccatagtttt atagcattgt tcaattggaa aagtacattc caagttctag attacctacg
     2041 tttggaaaca cttaatttac aaattgtgat cttagtgtat atagttttta cgttgttggt
     2101 gctaaagtgc ttttttgaag tttattctct ttcaaaataa gttatcatag aatcttgtgc
     2161 ttgtatcaaa ctcctaattg gtcggaacac tttaggagtg caggggttct gcttcattgc
     2221 attttcagaa ttaacctgaa agttgaaaca accatttttt tttatttcaa aacttattta
     2281 agttgttatc acctgtcctt aaatagataa aagaatgtgt attttttcac ttgttgcctt
     2341 agtactatca agacttgtga atatatttga atgtatgttg tttgaaaaac ttgcacaggg
     2401 cattggagcc atcatgaaaa gcaggaaatg taaacgtgga atgtatggca ggctgggcag
     2461 aatgtatact gatccagggt atagactaga tatttttgct gttgctgttt ttattataaa
     2521 atgttatatt tgaggatatt taacattttc caattctgct taagaggtaa ttcacaataa
     2581 aaaaaacaaa gaccaaaaat agcacattct gaaaaaaaga ttcttaataa gattttattt
     2641 tgtgaagttc aaagattctt tcctaaagta taacgtgttg ttaaaaagta gtggtgttat
     2701 aactctcaat gtaatagtat gcaatatcaa gaacacagga agttcgtttc aagataggtg
     2761 agatttaaaa taaataggat gaggttgaag aaaagtatat tggagcgcag ataaatataa
     2821 attgtggact gctatgaaaa caggttgtac ttctccatat gtgagactac tggaagtgag
     2881 aagcaatatt tgtcatttct aaaactggcc aggctgtgct gacccaggat tagtaatttg
     2941 ttatgtctgt tttcccttag atgtttgggc actcagatgc tatcttggtg cacacacaca
     3001 acattgctgt tcagtcacaa atccgaacaa cttaatataa taaattgtac taaaagtcat
     3061 ttaagaaata ccaaaaagta agcttttgtt tctaaccatt gttataaagg ctaatataat
     3121 tgttgttata tagcagtaag atatatttgt gtgcatgcgt ctccaagtca gttgtaaatg
     3181 tcttgagaac agagaataca attgtcatct ttatattgcc tcatttctcc actaatactt
     3241 agcaaataaa aggcaataag taaatatgta ctggttgaat gcctctggag acctagagtt
     3301 taaagtttta agtcaataaa taaataaata tttactctta aataa
//
