LOCUS       NM_015397               3592 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 12 (DCAF12), mRNA.
ACCESSION   NM_015397
VERSION     NM_015397.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3592)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3592)
  AUTHORS   Lidak,T., Baloghova,N., Korinek,V., Sedlacek,R., Balounova,J.,
            Kasparek,P. and Cermak,L.
  TITLE     CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during
            Spermatogenesis and T Cell Activation
  JOURNAL   Int J Mol Sci 22 (10), 5394 (2021)
   PUBMED   34065512
  REMARK    GeneRIF: CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase
            during Spermatogenesis and T Cell Activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3592)
  AUTHORS   Ravichandran,R., Kodali,K., Peng,J. and Potts,P.R.
  TITLE     Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and
            nutrient availability
  JOURNAL   EMBO Rep 20 (7), e47352 (2019)
   PUBMED   31267705
REFERENCE   4  (bases 1 to 3592)
  AUTHORS   Koren,I., Timms,R.T., Kula,T., Xu,Q., Li,M.Z. and Elledge,S.J.
  TITLE     The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting
            C-Terminal Degrons
  JOURNAL   Cell 173 (7), 1622-1635 (2018)
   PUBMED   29779948
REFERENCE   5  (bases 1 to 3592)
  AUTHORS   Li,T., Robert,E.I., van Breugel,P.C., Strubin,M. and Zheng,N.
  TITLE     A promiscuous alpha-helical motif anchors viral hijackers and
            substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery
  JOURNAL   Nat Struct Mol Biol 17 (1), 105-111 (2010)
   PUBMED   19966799
REFERENCE   6  (bases 1 to 3592)
  AUTHORS   Olma,M.H., Roy,M., Le Bihan,T., Sumara,I., Maerki,S., Larsen,B.,
            Quadroni,M., Peter,M., Tyers,M. and Pintard,L.
  TITLE     An interaction network of the mammalian COP9 signalosome identifies
            Dda1 as a core subunit of multiple Cul4-based E3 ligases
  JOURNAL   J Cell Sci 122 (Pt 7), 1035-1044 (2009)
   PUBMED   19295130
REFERENCE   7  (bases 1 to 3592)
  AUTHORS   Soranzo,N., Rivadeneira,F., Chinappen-Horsley,U., Malkina,I.,
            Richards,J.B., Hammond,N., Stolk,L., Nica,A., Inouye,M., Hofman,A.,
            Stephens,J., Wheeler,E., Arp,P., Gwilliam,R., Jhamai,P.M.,
            Potter,S., Chaney,A., Ghori,M.J., Ravindrarajah,R., Ermakov,S.,
            Estrada,K., Pols,H.A., Williams,F.M., McArdle,W.L., van Meurs,J.B.,
            Loos,R.J., Dermitzakis,E.T., Ahmadi,K.R., Hart,D.J., Ouwehand,W.H.,
            Wareham,N.J., Barroso,I., Sandhu,M.S., Strachan,D.P., Livshits,G.,
            Spector,T.D., Uitterlinden,A.G. and Deloukas,P.
  TITLE     Meta-analysis of genome-wide scans for human adult stature
            identifies novel Loci and associations with measures of skeletal
            frame size
  JOURNAL   PLoS Genet 5 (4), e1000445 (2009)
   PUBMED   19343178
REFERENCE   8  (bases 1 to 3592)
  AUTHORS   Li,S., Hu,X., Cui,S. and He,D.
  TITLE     Novel centrosome protein, TCC52, is a cancer-testis antigen
  JOURNAL   Cancer Sci 99 (11), 2274-2279 (2008)
   PUBMED   18957058
  REMARK    GeneRIF: TCC52, as a novel CT antigen, would be a promising
            candidate for cancer immunotherapy.
REFERENCE   9  (bases 1 to 3592)
  AUTHORS   Bernstein,D., Williams,G.E., Eisen,H., Mital,S., Wohlgemuth,J.G.,
            Klingler,T.M., Fang,K.C., Deng,M.C. and Kobashigawa,J.
  TITLE     Gene expression profiling distinguishes a molecular signature for
            grade 1B mild acute cellular rejection in cardiac allograft
            recipients
  JOURNAL   J Heart Lung Transplant 26 (12), 1270-1280 (2007)
   PUBMED   18096478
  REMARK    GeneRIF: Of the classifier's 11 informative genes, expression of
            MIR and WDR40 showed statistically significant increases for both
            Grade 1B and Grade >or=3A rejection.
REFERENCE   10 (bases 1 to 3592)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM747928.1, AB067479.1,
            AL354989.13 and BM144957.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015397.3.
            
            Summary: This gene encodes a WD repeat-containing protein that
            interacts with the COP9 signalosome, a macromolecular complex that
            interacts with cullin-RING E3 ligases and regulates their activity
            by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul
            2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063823.1, DQ518909.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361264.9/ ENSP00000355114.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BM747928.1         76-80
            6-1954              AB067479.1         1-1949
            1955-3326           AL354989.13        98676-100047        c
            3327-3592           BM144957.1         18-283              c
FEATURES             Location/Qualifiers
     source          1..3592
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..3592
                     /gene="DCAF12"
                     /gene_synonym="CT102; KIAA1892; TCC52; WDR40A"
                     /note="DDB1 and CUL4 associated factor 12"
                     /db_xref="GeneID:25853"
                     /db_xref="HGNC:HGNC:19911"
                     /db_xref="MIM:620087"
     exon            1..345
                     /gene="DCAF12"
                     /gene_synonym="CT102; KIAA1892; TCC52; WDR40A"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1629
                     /gene="DCAF12"
                     /gene_synonym="CT102; KIAA1892; TCC52; WDR40A"
                     /note="cancer/testis antigen 102; WD repeat domain 40A; WD
                     repeat-containing protein 40A; testis cancer
                     centrosome-related protein; centrosome-related protein
                     TCC52"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 12"
                     /protein_id="NP_056212.1"
                     /db_xref="CCDS:CCDS6549.1"
                     /db_xref="GeneID:25853"
                     /db_xref="HGNC:HGNC:19911"
                     /db_xref="MIM:620087"
                     /translation="MARKVVSRKRKAPASPGAGSDAQGPQFGWDHSLHKRKRLPPVKR
                     SLVYYLKNREVRLQNETSYSRVLHGYAAQQLPSLLKEREFHLGTLNKVFASQWLNHRQ
                     VVCGTKCNTLFVVDVQTSQITKIPILKDREPGGVTQQGCGIHAIELNPSRTLLATGGD
                     NPNSLAIYRLPTLDPVCVGDDGHKDWIFSIAWISDTMAVSGSRDGSMGLWEVTDDVLT
                     KSDARHNVSRVPVYAHITHKALKDIPKEDTNPDNCKVRALAFNNKNKELGAVSLDGYF
                     HLWKAENTLSKLLSTKLPYCRENVCLAYGSEWSVYAVGSQAHVSFLDPRQPSYNVKSV
                     CSRERGSGIRSVSFYEHIITVGTGQGSLLFYDIRAQRFLEERLSACYGSKPRLAGENL
                     KLTTGKGWLNHDETWRNYFSDIDFFPNAVYTHCYDSSGTKLFVAGGPLPSGLHGNYAG
                     LWS"
     exon            346..600
                     /gene="DCAF12"
                     /gene_synonym="CT102; KIAA1892; TCC52; WDR40A"
                     /inference="alignment:Splign:2.1.0"
     exon            601..807
                     /gene="DCAF12"
                     /gene_synonym="CT102; KIAA1892; TCC52; WDR40A"
                     /inference="alignment:Splign:2.1.0"
     exon            808..868
                     /gene="DCAF12"
                     /gene_synonym="CT102; KIAA1892; TCC52; WDR40A"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1062
                     /gene="DCAF12"
                     /gene_synonym="CT102; KIAA1892; TCC52; WDR40A"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1128
                     /gene="DCAF12"
                     /gene_synonym="CT102; KIAA1892; TCC52; WDR40A"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1291
                     /gene="DCAF12"
                     /gene_synonym="CT102; KIAA1892; TCC52; WDR40A"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1470
                     /gene="DCAF12"
                     /gene_synonym="CT102; KIAA1892; TCC52; WDR40A"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..3592
                     /gene="DCAF12"
                     /gene_synonym="CT102; KIAA1892; TCC52; WDR40A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3572..3577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF12"
                     /gene_synonym="CT102; KIAA1892; TCC52; WDR40A"
                     /note="hexamer: AATAAA"
     polyA_site      3592
                     /gene="DCAF12"
                     /gene_synonym="CT102; KIAA1892; TCC52; WDR40A"
                     /note="major polyA site"
ORIGIN      
        1 gttctagccg ctcgccgtcc ttgcaggctc tgccgtcgga aagccgctca ttctcgcttc
       61 cccttccctt tcccggctca agtccttcct ctctctttcc tttctttccg cctatctttt
      121 ttctgctgcc gctccgggtc cgggccattt tccgggccgg gcgcactaag gtgcgcggcc
      181 ccggggccca gtatatgacc cgccgtcctg ctatccttcg cttcccccgc cccatgtggc
      241 tgcggggccg cggcggcgct gcccactatg gcccggaaag tagttagcag gaagcggaaa
      301 gcgcccgcct cgccgggagc tgggagcgac gctcagggcc cgcagtttgg ctgggatcac
      361 tcgcttcaca aaaggaaaag acttcctcct gtgaagagat ccttagtata ctacttgaag
      421 aaccgggaag tcaggctaca gaatgaaacc agctactctc gagtgttgca tggttatgca
      481 gcacagcaac ttcccagtct cctgaaggag agagagtttc accttgggac ccttaataaa
      541 gtgtttgcat ctcagtggtt gaatcatagg caagtggtgt gtggcacaaa atgcaacacg
      601 ctatttgtcg tagatgtcca gacaagccag atcaccaaga tccccattct gaaagaccgg
      661 gagcctggag gtgtgaccca gcagggctgt ggtatccatg ccatcgagct gaatccttct
      721 agaacactgc tagccactgg aggagacaac cccaacagtc ttgccatcta tcgactacct
      781 acgctggatc ctgtgtgtgt aggagatgat ggacacaagg actggatctt ttccatcgca
      841 tggatcagcg acactatggc agtgtctggc tcacgtgatg gttctatggg actctgggag
      901 gtgacagatg atgttttgac caaaagtgat gcgagacaca atgtgtcacg ggtccctgtg
      961 tatgcacaca tcactcacaa ggccttaaag gacatcccca aagaagacac aaaccctgac
     1021 aactgcaagg ttcgggctct ggccttcaac aacaagaaca aggaactggg agcagtgtct
     1081 ctggatggct actttcatct ctggaaggct gaaaatacac tatctaagct cctctccacc
     1141 aaactgccat attgccgtga gaatgtgtgt ctggcttatg gtagtgaatg gtcagtttat
     1201 gcagtgggct cccaagctca tgtctccttc ttggatccac ggcagccatc atacaacgtc
     1261 aagtctgtct gttccaggga gcgaggcagt ggaatccggt cagtgagttt ctacgagcac
     1321 atcatcactg tgggaacagg gcagggctcc ctgctgttct atgacatccg agctcagaga
     1381 tttctggaag agaggctctc agcttgttat gggtccaagc ccagactagc aggggagaat
     1441 ctgaaactaa ccactggcaa aggctggctg aatcatgatg aaacctggag gaattacttt
     1501 tcagacattg acttcttccc caatgctgtt tacacccact gctacgactc gtctggaacg
     1561 aaactctttg tggcaggagg tcccctccct tcagggctcc atggaaacta tgctgggctc
     1621 tggagttaat gacaactccc caaatgcaga gatttacact aacttccatt ctcagtttcc
     1681 ttgtttcttt tgattttttt tttcctaatt gtgtgaggct cttgtgtttt agtgggaaca
     1741 ccaaagtttg cctatagttt aggcacttaa taggaagaag ctctgtacag aaatctgaaa
     1801 gttgttttgc tttttgtttt cccctttggt aatcaaaatt ttactatctt ttattatttc
     1861 tggcttttca accaaacatt gttgctaatc cctatttttc tttaagtgac acacattctc
     1921 ctgtctctgg cttcttcagg ctgaaatgac atagctcacc cttacttcac tcttgagagg
     1981 tagggctcct ttataattac atggttgctc tcagactttc tgtgaaagtt tgggagctgt
     2041 gtgtgtctgt gtgtgtgtga gagagagatc ttgtctgcgt gtgtgtgtgt gatcttgtgt
     2101 gcctgtaggt actgtgtgtc actgaaatta cctggagtga ggattacttg taattaaaat
     2161 atttataaaa gaaacaactt tattcacaga gtccagcttt gggactagtc tgtatcttgt
     2221 tttttaagtc taacaacact gataatagga agtaaaaaca gaaaggaaaa gaaattacca
     2281 ctgggaaaat ctttttagtt agattgtagg cttcctgggg cctcccatgc caggactgca
     2341 aagtgatcca gccctacctg tcttcccacc tgtgtgtccc ccgtgtggga agttggtgtc
     2401 acttcccctt cccaccctca catctgctta gccagtagcc acacccctaa aacatcagac
     2461 tcaccatcca ggtgcagctc cagaggctac aaaaggcttc atgggacttg aatccccatc
     2521 ctagcttctc tctccttccc ctcaagacct gatctggttt taaggggcct ggagctggga
     2581 gtctcaagtc tgctaagatt cacatccata gcccccatgg ctttgaggag aatcctctct
     2641 gccattcttc caatctcccc agtgggtttt gctattattt tctaaattgg gttaagtcta
     2701 agaaggtggg ggtgagcagg gggtttatct gtgtgtagtg agtgcttcat gtgtggaata
     2761 ttcattttct tactgcagtg ggacttgggg ttgaagccac ccctcctact ctgttggctt
     2821 agccctgaga tggtgacagg ctggcctgca gtcagcatca ttgtgcatgt gacagcatca
     2881 atgtgattag taatttgtct gttcctccct tgaactgtct gtttagtctg aggtttttaa
     2941 acttgcaggc agctgactgt gatgtccact tgttccctga tttttacaca tcatgtcaaa
     3001 gataacagct gttcccaccc accagttcct ctaagcacat actctgcttt tctgtcaaca
     3061 tcccattttg gggaaaggaa aagtcatatt tattcctgca ccccagtttt ttaacttgtt
     3121 ctcccagttg tccccctctt ctctgggtgt aagaagggaa attggaaaaa aaattatata
     3181 tatattctcc ttttaatggt ggggggctac tggagaggag agacagcaag tccaccctaa
     3241 cttgttacac agcacatacc acaggttctg gaattctcat cttcgaacct agagaaatag
     3301 gtgctataaa cagggaatta agcaaaatgc tggatgctat agatctttta attgtcttaa
     3361 ttttttttct attattaaac tacaggctgt agatttctta gttctcacag aacttctatc
     3421 attttaaact gacttgtata tttaaaaaaa aaatcttcag taggatgttt tgtactattg
     3481 ctagaccctc ttctgtaatg ggtaatgcgt ttgattgttt gagattttct gtttttaaaa
     3541 atgtagcact tgactttttg ccaaggaaaa aaataaaaat tattccagtg ca
//
