LOCUS       NM_025230               4304 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 11 (DCAF11),
            transcript variant 1, mRNA.
ACCESSION   NM_025230
VERSION     NM_025230.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4304)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4304)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4304)
  AUTHORS   Zhang,X., Luukkonen,L.M., Eissler,C.L., Crowley,V.M., Yamashita,Y.,
            Schafroth,M.A., Kikuchi,S., Weinstein,D.S., Symons,K.T.,
            Nordin,B.E., Rodriguez,J.L., Wucherpfennig,T.G., Bauer,L.G.,
            Dix,M.M., Stamos,D., Kinsella,T.M., Simon,G.M., Baltgalvis,K.A. and
            Cravatt,B.F.
  TITLE     DCAF11 Supports Targeted Protein Degradation by Electrophilic
            Proteolysis-Targeting Chimeras
  JOURNAL   J Am Chem Soc 143 (13), 5141-5149 (2021)
   PUBMED   33783207
  REMARK    GeneRIF: DCAF11 Supports Targeted Protein Degradation by
            Electrophilic Proteolysis-Targeting Chimeras.
REFERENCE   4  (bases 1 to 4304)
  AUTHORS   Siswanto,F.M., Oguro,A., Arase,S. and Imaoka,S.
  TITLE     WDR23 regulates the expression of Nrf2-driven drug-metabolizing
            enzymes
  JOURNAL   Drug Metab Pharmacokinet 35 (5), 441-455 (2020)
   PUBMED   32839090
  REMARK    GeneRIF: WDR23 regulates the expression of Nrf2-driven
            drug-metabolizing enzymes.
REFERENCE   5  (bases 1 to 4304)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4304)
  AUTHORS   Jager,S., Cimermancic,P., Gulbahce,N., Johnson,J.R., McGovern,K.E.,
            Clarke,S.C., Shales,M., Mercenne,G., Pache,L., Li,K., Hernandez,H.,
            Jang,G.M., Roth,S.L., Akiva,E., Marlett,J., Stephens,M., D'Orso,I.,
            Fernandes,J., Fahey,M., Mahon,C., O'Donoghue,A.J., Todorovic,A.,
            Morris,J.H., Maltby,D.A., Alber,T., Cagney,G., Bushman,F.D.,
            Young,J.A., Chanda,S.K., Sundquist,W.I., Kortemme,T.,
            Hernandez,R.D., Craik,C.S., Burlingame,A., Sali,A., Frankel,A.D.
            and Krogan,N.J.
  TITLE     Global landscape of HIV-human protein complexes
  JOURNAL   Nature 481 (7381), 365-370 (2011)
   PUBMED   22190034
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4304)
  AUTHORS   Choe,K.P., Przybysz,A.J. and Strange,K.
  TITLE     The WD40 repeat protein WDR-23 functions with the CUL4/DDB1
            ubiquitin ligase to regulate nuclear abundance and activity of
            SKN-1 in Caenorhabditis elegans
  JOURNAL   Mol Cell Biol 29 (10), 2704-2715 (2009)
   PUBMED   19273594
  REMARK    GeneRIF: Includes the functional characterization of a similar
            protein in C. elegans and comparison to the human protein.
REFERENCE   8  (bases 1 to 4304)
  AUTHORS   Olma,M.H., Roy,M., Le Bihan,T., Sumara,I., Maerki,S., Larsen,B.,
            Quadroni,M., Peter,M., Tyers,M. and Pintard,L.
  TITLE     An interaction network of the mammalian COP9 signalosome identifies
            Dda1 as a core subunit of multiple Cul4-based E3 ligases
  JOURNAL   J Cell Sci 122 (Pt 7), 1035-1044 (2009)
   PUBMED   19295130
REFERENCE   9  (bases 1 to 4304)
  AUTHORS   Scrima,A., Konickova,R., Czyzewski,B.K., Kawasaki,Y., Jeffrey,P.D.,
            Groisman,R., Nakatani,Y., Iwai,S., Pavletich,N.P. and Thoma,N.H.
  TITLE     Structural basis of UV DNA-damage recognition by the DDB1-DDB2
            complex
  JOURNAL   Cell 135 (7), 1213-1223 (2008)
   PUBMED   19109893
REFERENCE   10 (bases 1 to 4304)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP245093.1, AK074296.1,
            AK094478.1, BX406971.2 and AB209073.1.
            
            On Nov 30, 2019 this sequence version replaced NM_025230.4.
            
            Summary: This gene encodes a WD repeat-containing protein that
            interacts with the COP9 signalosome, a macromolecular complex that
            interacts with cullin-RING E3 ligases and regulates their activity
            by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Jul 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.793745.1,
                                           SRR14038195.2619888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446197.8/ ENSP00000415556.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BP245093.1         1-35
            36-2707             AK074296.1         1-2672
            2708-3804           AK094478.1         1155-2251
            3805-4265           BX406971.2         26-486              c
            4266-4304           AB209073.1         4164-4202
FEATURES             Location/Qualifiers
     source          1..4304
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..4304
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /note="DDB1 and CUL4 associated factor 11"
                     /db_xref="GeneID:80344"
                     /db_xref="HGNC:HGNC:20258"
                     /db_xref="MIM:613317"
     exon            1..517
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     exon            518..885
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     CDS             731..2371
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat domain 23; WD repeat-containing protein 23"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 11 isoform 1"
                     /protein_id="NP_079506.3"
                     /db_xref="CCDS:CCDS9610.1"
                     /db_xref="GeneID:80344"
                     /db_xref="HGNC:HGNC:20258"
                     /db_xref="MIM:613317"
                     /translation="MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQ
                     VLAYLLRRGQVRLVQGGGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTR
                     ELEFNEIKTQVELATGQLGLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHF
                     LPNDLGFTDSYSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVG
                     WSVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSD
                     GREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKV
                     WDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFSSREG
                     MEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHS
                     TGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLR
                     LWQYRQAEYFQDDMPESEECASAPAPVPQSSTPFSSPQ"
     exon            886..1013
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1141
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1206
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1307
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1454
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1509
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1578
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1636
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1822
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1976
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2129
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2236
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..4304
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3071..3076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /note="hexamer: AATAAA"
     polyA_site      3091
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /note="major polyA site"
     regulatory      4291..4296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
                     /note="hexamer: AATAAA"
     polyA_site      4304
                     /gene="DCAF11"
                     /gene_synonym="GL014; PRO2389; WDR23"
ORIGIN      
        1 gtgtgacgtt tgcagcccgc cggccaggaa gccgcgagat gcgtgacgag cgaagcgcgt
       61 gacggaggag cggttggcca acgcagtggc ggcagtcggt gtaaacaagg cctcgcgccg
      121 ctgcgggtcc tgcgaccgct cctggctggt gggtggtctc gcgtggggcg gttaccgccg
      181 gcttcagtgg gaggtgcttc tcggcttcct ccccctcatg gcgtacacac ccccggcgca
      241 ccacgtgggc gtgaggcgag gaaggagggg tgttaggcca aattctattt tcattggctg
      301 tcactgctgc cggcctttgt aagggggcgc tctgattggt cgataaggtg ggggcgtcga
      361 gggtctttga gtcctaaggc ttctaattgg ttagatgaga taagctagtg aagcgctttc
      421 ttccgagagg gatttcgatt ggtcggtcag agaggttacc tggaaatcca acaccgccca
      481 acacccctcc cgctccccag tccggggact tcgataggat tggagaaggt ttgtgttccc
      541 gacgccttgg tagttggcat aggctaaaga aaagggatct cagccccgag gaagggtcac
      601 cctcctagag atagctacta ccccgtctca ggagaccctg gtatttctag agcacgcttt
      661 gctttcacca aacccaagga ggtgacagga ggagcccccg cacaggacct aagaatgctg
      721 tgaccagaag atgggatcgc ggaacagcag cagtgcagga tccgggtccg gagacccctc
      781 cgagggcttg ccccgaagag gggctggcct gcgtcggagt gaggaagagg aagaagagga
      841 tgaagatgtg gatctggccc aggtactggc ctatctcctc cgcagaggcc aagtgaggtt
      901 ggtgcaggga ggaggtgcag caaatttaca attcattcag gccctcttgg actcagagga
      961 agagaatgac agagcttggg atggtcgtct tggggatcga tacaacccac ctgtggatgc
     1021 tacccctgac acccgggagc tggaattcaa tgagatcaag acacaagtgg aactggccac
     1081 agggcagctg gggcttaggc gggccgccca gaagcacagc tttcctcgaa tgttgcacca
     1141 gagagaacgg ggcctctgcc atcggggaag cttctccctt ggagaacagt ctcgagtgat
     1201 atctcacttc ttgcccaatg atctgggctt cactgatagc tactctcaga aggctttctg
     1261 tggcatctac agcaaagatg gtcaaatatt catgtctgct tgccaagacc agacaatccg
     1321 actctatgac tgccgatatg gccgtttccg taaattcaag agcatcaagg cccgcgacgt
     1381 aggctggagc gtcttggatg tggccttcac ccctgatggg aaccacttcc tctactctag
     1441 ctggtctgat tacattcata tctgcaatat ctatggtgag ggagatacac acactgccct
     1501 ggatctcagg ccagatgagc gtcgctttgc tgtcttctcc attgctgtct cctcagatgg
     1561 acgagaagta ctaggagggg ccaatgatgg ctgcctgtat gtctttgacc gagaacagaa
     1621 ccggcgcacc cttcagattg agtcccatga ggatgatgtg aatgcagtgg cctttgctga
     1681 tataagctcc caaatcctgt tctctggggg agatgatgcc atctgcaaag tgtgggatcg
     1741 acgcaccatg cgggaggatg accccaagcc tgtgggtgca ctggctggac accaggatgg
     1801 catcaccttc attgacagca agggtgatgc ccggtatctg atctccaact ctaaagacca
     1861 gaccatcaaa ctctgggata tccgacgctt ttccagccgg gaaggcatgg aagcttcacg
     1921 ccaggctgcc acacagcaaa actgggacta tcggtggcag caagtgccca aaaaagcctg
     1981 gcggaagctg aagctcccag gggacagctc cttgatgacc taccggggcc acggagtgct
     2041 gcacaccctc atccgctgcc ggttctcccc cattcatagc actggccagc agttcatcta
     2101 cagtggctgc tccactggca aagtggttgt gtacgacctt ctaagtggcc acattgtgaa
     2161 gaagctgacc aaccacaagg cctgtgtgcg tgacgtcagt tggcacccct ttgaagagaa
     2221 gattgtcagc agttcgtggg acgggaacct gcgtctgtgg cagtaccgcc aggctgagta
     2281 cttccaggat gacatgccag aatctgagga atgtgccagc gcccctgccc cagtgcccca
     2341 atcctctaca cccttttcct caccccagta gatccaacct ccagccccat atagggtgaa
     2401 cctcttgata agctctctgc ctcctcctcc ctttctccct tgtggggaat gtttggagga
     2461 atcactggca tttgatgggg aataacataa gcctgggctc tgagcctcag ctgagccctg
     2521 gaagattctc cccatggggc agagtggtct ccttacgtgc tcacacccag tcagcttggg
     2581 tccctatctc tggccagagt ttggcaggac tgccattatc tggggtgtgg cctctgccag
     2641 caagagaagt gtcctgggtg tttttaatca tgtttgaatg ttaggggttg gatcctagag
     2701 tagatgcctg aggccacatc tgaacagacc tgtcagccag gcctgccagg tcttcacgtt
     2761 gaggattcaa ctggccaatc acaggacagg tgtcctggcc tttcttcctg aggtctctag
     2821 gggaggggca tgggtaaggg tgtttcctca gcaccctcct ggggtgggga ttatgtctgc
     2881 tgtcatgtct gggtctttag ggtaggacag gctgtggtat gagaggcagg agtctccaca
     2941 aggcttcatg tggcccctta tagggcaggc cctgccctct gggaaggtcc cttcatgctg
     3001 gaggcacaca gctttaagga agtaggttga agtaggactc cttcgtcctc tcactggctt
     3061 tggctccctc aataaactgt gtgggaacct ggctcagtgt ctgtctctct ctctcactct
     3121 ctgtttttcc tatctgaggt ctttcatctc ctcacttcag gaaaacacag ttcagcaaag
     3181 tcttcagatg cgatcctgtg taggagaaaa tacccttctg gtgccccatg aaaaagggaa
     3241 ataccaaaac catttgttca ctgagccttg caataggtgc tcccttacca atttcagaag
     3301 cttccctgca agtagatatc gagagagcac actttccatt agagcctggt aatacccata
     3361 tcacctctgc tctgaggctg ggcctgcagc tgtgtagtct ttggaagagg tagcccctga
     3421 acgcagagcc taagagaagc aagtcggccc tgacgccagg ccccagtggg cgcctcacac
     3481 tcagaacctc ataccccaga gcaaaccgat ggtcagggag agggctagag ctcacaccca
     3541 gctcggaata gatcttccct gatgacattt catgccctct aaggcagttt ttaaatgaag
     3601 gtacacacat ccaggggtgt tcacaggctt tcacagcaag ggtacctatt tcatggcaaa
     3661 ataggcagtt ttaaaagaat aaacaagcta ggtgtggtgg ctcatgcctg taatcctagc
     3721 actttgggaa gccaaagctg atggatcgct tgagcccagg agtttgagac cagcctgggc
     3781 aacatggcaa aaccccatct ctacaaaaaa tacaaaaagt aggccgggca cggtggttca
     3841 cacctgtaat cccggcattt tgggaggccg agataggtgg atcacctgaa gtcaggtgtt
     3901 tgagaccagc ctggccaaca tggtggaacc caatctctac taaaaataca aaaaaactag
     3961 ccggatatgg tggcgggtgc ctgtaatctc agctacttga gaggctgagg caggagaatc
     4021 gcttgaactt gggagcagag gtgagctgag tgcagtgagc caagaccatg ccattacact
     4081 caagcttggg caacgagagc aaaactctgt ctcaaaaaaa aaattagcca gatgtggtga
     4141 cgcatgcctg tagtcctagc tactcaggag gctgaggtgg gaggatcacc taaggccagg
     4201 aggtcaaggc tgcggtgagc cgtgattgtg ccaatgtact ccagcctagg tgacagagtg
     4261 agaccctgtc tcaaaaataa ataataaata aataaatgtt caga
//
