LOCUS       NM_001387583            5675 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 1 (DCAF1), transcript
            variant 13, mRNA.
ACCESSION   NM_001387583
VERSION     NM_001387583.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5675)
  AUTHORS   Zhang,J., Shi,Y., Ding,K., Yu,W., He,J. and Sun,B.
  TITLE     DCAF1 interacts with PARD3 to promote hepatocellular carcinoma
            progression and metastasis by activating the Akt signaling pathway
  JOURNAL   J Exp Clin Cancer Res 43 (1), 136 (2024)
   PUBMED   38711082
  REMARK    GeneRIF: DCAF1 interacts with PARD3 to promote hepatocellular
            carcinoma progression and metastasis by activating the Akt
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5675)
  AUTHORS   Ghate,N.B., Kim,S., Shin,Y., Kim,J., Doche,M., Valena,S., Situ,A.,
            Kim,S., Rhie,S.K., Lenz,H.J., Ulmer,T.S., Mumenthaler,S.M. and
            An,W.
  TITLE     Phosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger
            aberrant gene silencing in colon cancer
  JOURNAL   Nat Commun 14 (1), 2140 (2023)
   PUBMED   37069142
  REMARK    GeneRIF: Phosphorylation and stabilization of EZH2 by DCAF1/VprBP
            trigger aberrant gene silencing in colon cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5675)
  AUTHORS   Zhang,C., Jiang,H., Yuan,L., Liao,Y., Liu,P., Du,Q., Pan,C.,
            Liu,T., Li,J., Chen,Y., Huang,J., Liang,Y., Xia,M., Xu,M., Qin,S.,
            Zou,Q., Liu,Y., Huang,H., Pan,Y., Li,J., Liu,J., Wang,W. and Yao,S.
  TITLE     CircVPRBP inhibits nodal metastasis of cervical cancer by impeding
            RACK1 O-GlcNAcylation and stability
  JOURNAL   Oncogene 42 (11), 793-807 (2023)
   PUBMED   36658304
  REMARK    GeneRIF: CircVPRBP inhibits nodal metastasis of cervical cancer by
            impeding RACK1 O-GlcNAcylation and stability.
REFERENCE   4  (bases 1 to 5675)
  AUTHORS   Poulose,N., Forsythe,N., Polonski,A., Gregg,G., Maguire,S.,
            Fuchs,M., Minner,S., Sauter,G., McDade,S.S. and Mills,I.G.
  TITLE     VPRBP Functions Downstream of the Androgen Receptor and OGT to
            Restrict p53 Activation in Prostate Cancer
  JOURNAL   Mol Cancer Res 20 (7), 1047-1060 (2022)
   PUBMED   35348747
  REMARK    GeneRIF: VPRBP Functions Downstream of the Androgen Receptor and
            OGT to Restrict p53 Activation in Prostate Cancer.
REFERENCE   5  (bases 1 to 5675)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 5675)
  AUTHORS   Borgne-Sanchez,A., Dupont,S., Langonne,A., Baux,L., Lecoeur,H.,
            Chauvier,D., Lassalle,M., Deas,O., Briere,J.J., Brabant,M.,
            Roux,P., Pechoux,C., Briand,J.P., Hoebeke,J., Deniaud,A.,
            Brenner,C., Rustin,P., Edelman,L., Rebouillat,D. and Jacotot,E.
  TITLE     Targeted Vpr-derived peptides reach mitochondria to induce
            apoptosis of alphaVbeta3-expressing endothelial cells
  JOURNAL   Cell Death Differ 14 (3), 422-435 (2007)
   PUBMED   16888644
  REMARK    GeneRIF: Hence, this chimeric peptide (TEAM-VP) constitutes the
            first example of a virus-derived mitochondriotoxic compound as a
            candidate to kill selectively tumor neo-endothelia.
REFERENCE   7  (bases 1 to 5675)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
REFERENCE   8  (bases 1 to 5675)
  AUTHORS   Zhao,L.J., Zhang,S. and Chinnadurai,G.
  TITLE     Sox9 transactivation and testicular expression of a novel human
            gene, KIAA0800
  JOURNAL   J Cell Biochem 86 (2), 277-289 (2002)
   PUBMED   12111997
  REMARK    GeneRIF: demonstration that a novel human gene, KIAA0800, is
            preferentially expressed in the testis and is transactivated by
            Sox9
REFERENCE   9  (bases 1 to 5675)
  AUTHORS   Zhang,S., Feng,Y., Narayan,O. and Zhao,L.J.
  TITLE     Cytoplasmic retention of HIV-1 regulatory protein Vpr by
            protein-protein interaction with a novel human cytoplasmic protein
            VprBP
  JOURNAL   Gene 263 (1-2), 131-140 (2001)
   PUBMED   11223251
REFERENCE   10 (bases 1 to 5675)
  AUTHORS   Zhao,L.J., Mukherjee,S. and Narayan,O.
  TITLE     Biochemical mechanism of HIV-I Vpr function. Specific interaction
            with a cellular protein
  JOURNAL   J Biol Chem 269 (22), 15577-15582 (1994)
   PUBMED   8195203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092037.2 and AC233756.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR14038197.895883.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AC092037.2         118333-118475       c
            144-190             AC092037.2         115194-115240       c
            191-290             AC092037.2         110849-110948       c
            291-408             AC092037.2         102179-102296       c
            409-485             AC092037.2         89389-89465         c
            486-599             AC092037.2         81574-81687         c
            600-737             AC092037.2         62226-62363         c
            738-1250            AC092037.2         59845-60357         c
            1251-1352           AC092037.2         59430-59531         c
            1353-1511           AC233756.2         30775-30933         c
            1512-1691           AC233756.2         27702-27881         c
            1692-1901           AC233756.2         26930-27139         c
            1902-2071           AC233756.2         25041-25210         c
            2072-2196           AC233756.2         19976-20100         c
            2197-3460           AC233756.2         17403-18666         c
            3461-3659           AC233756.2         16347-16545         c
            3660-3742           AC233756.2         15785-15867         c
            3743-3827           AC233756.2         14456-14540         c
            3828-4061           AC233756.2         12293-12526         c
            4062-4155           AC233756.2         11619-11712         c
            4156-4260           AC233756.2         10951-11055         c
            4261-4334           AC233756.2         10662-10735         c
            4335-4436           AC233756.2         10048-10149         c
            4437-4689           AC233756.2         812-1064            c
            4690-5675           AC092037.2         19717-20702         c
FEATURES             Location/Qualifiers
     source          1..5675
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..5675
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /note="DDB1 and CUL4 associated factor 1"
                     /db_xref="GeneID:9730"
                     /db_xref="HGNC:HGNC:30911"
                     /db_xref="MIM:617259"
     exon            1..143
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            144..190
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            191..290
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            291..408
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            409..485
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             471..4748
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /EC_number="2.7.11.1"
                     /note="isoform 3 is encoded by transcript variant 13;
                     protein VPRBP; Vpr-binding protein; vpr-interacting
                     protein; HIV-1 Vpr-binding protein;
                     serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding
                     protein"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 1 isoform 3"
                     /protein_id="NP_001374512.1"
                     /db_xref="GeneID:9730"
                     /db_xref="HGNC:HGNC:30911"
                     /db_xref="MIM:617259"
                     /translation="MIDILLVNAYVMTSREPPLNTAACRLLLDIMPGLETAVVFQEKE
                     GIVENLFKWAREADQPLRTYSTGLLGGAMENQDIAANYRDENSQLVAIVLRRLRELQL
                     QEVALRQENKRPSPRKLSSEPLLPLDEEAVDMDYGDMAVDVVDGDQEEASGDMEISFH
                     LDSGHKTSSRVNSTTKPEDGGLKKNKSAKQGDRENFRKAKQKLGFSSSDPDRMFVELS
                     NSSWSEMSPWVIGTNYTLYPMTPAIEQRLILQYLTPLGEYQELLPIFMQLGSRELMMF
                     YIDLKQTNDVLLTFEALKHLASLLLHNKFATEFVAHGGVQKLLEIPRPSMAATGVSMC
                     LYYLSYNQDAMERVCMHPHNVLSDVVNYTLWLMECSHASGCCHATMFFSICFSFRAVL
                     ELFDRYDGLRRLVNLISTLEILNLEDQGALLSDDEIFASRQTGKHTCMALRKYFEAHL
                     AIKLEQVKQSLQRTEGGILVHPQPPYKACSYTHEQIVEMMEFLIEYGPAQLYWEPAEV
                     FLKLSCVQLLLQLISIACNWKTYYARNDTVRFALDVLAILTVVPKIQLQLAESVDVLD
                     EAGSTVSTVGISIILGVAEGEFFIHDAEIQKSALQIIINCVCGPDNRISSIGKFISGT
                     PRRKLPQNPKSSEHTLAKMWNVVQSNNGIKVLLSLLSIKMPITDADQIRALACKALVG
                     LSRSSTVRQIISKLPLFSSCQIQQLMKEPVLQDKRSDHVKFCKYAAELIERVSGKPLL
                     IGTDVSLARLQKADVVAQSRISFPEKELLLLIRNHLISKGLGETATVLTKEADLPMTA
                     ASHSSAFTPVTAAASPVSLPRTPRIANGIATRLGSHAAVGASAPSAPTAHPQPRPPQG
                     PLALPGPSYAGNSPLIGRISFIRERPSPCNGRKIRVLRQKSDHGAYSQSPAIKKQLDR
                     HLPSPPTLDSIITEYLREQHARCKNPVATCPPFSLFTPHQCPEPKQRRQAPINFTSRL
                     NRRASFPKYGGVDGGCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLMLGT
                     CTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVF
                     DMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCA
                     TFNPTDDLVLNDGVLWDVRSAQAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFH
                     LLHTVPALDQCRVVFNHTGTVMYGAMLQADDEDDLMEERMKSPFGSSFRTFNATDYKP
                     IATIDVKRNIFDLCTDTKDCYLAVIENQGSMDALNMDTVCRLYEVGRQRLAEDEDEEE
                     DQEEEEQEEEDDDEDDDDTDDLDELDTDQLLEAELEEDDNNENAGEDGDNDFSPSDEE
                     LANLLEEGEDGEDEDSDADEEVELILGDTDSSDNSDLEDDIILSLNE"
     exon            486..599
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            600..737
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1250
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1352
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1511
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1691
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1901
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2071
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2196
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..3460
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3659
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3660..3742
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..3827
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..4061
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4062..4155
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4156..4260
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4261..4334
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4335..4436
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4437..4689
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4690..5675
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5651..5656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /note="hexamer: AATAAA"
     polyA_site      5675
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /note="major polyA site"
ORIGIN      
        1 ataatatgtg ggccgctgtg gagccgtggt cgcgctgtgt gtgtgtgtga gtggagagtg
       61 agtgcgggac ctgaggctgt gtgtgtgtga actgtggcca ctggcggggt cggggggggg
      121 cagcggcgga gccgcctcgg acgataagga aattgagatt tggagaagtt aaataaccaa
      181 gacttcacag gccggtgtgc attggggtaa tctcggctga ctgcaacctc cgtcccctcc
      241 gagttcaagt gattctcctg cctcaacctc ccgagtagct gggattacag gcaaagccat
      301 gactacagta gtggtacatg tggactccaa agctgagctc actaccctgc tggagcagtg
      361 ggaaaaggaa catggcagtg ggcaggacat ggtacctatc cttaccagga tgtctcaatt
      421 gattgaaaaa gaaactgaag agtatcgtaa aggggatcca gacccatttg atgatcgaca
      481 tcctgctggt gaatgcatat gtgatgacaa gccgagagcc ccctttaaac actgcagctt
      541 gcagactcct attagacatc atgccagggc tggaaactgc tgtcgtcttt caagaaaagg
      601 agggaattgt cgagaatctt ttcaaatggg cccgagaggc cgatcaacca ttgaggacat
      661 attctactgg actgttagga ggtgctatgg aaaatcaaga cattgctgcc aactatagag
      721 atgaaaattc acagctggtg gcaatagtgc ttcgaagact gagggagcta cagctacagg
      781 aagtggcttt gcggcaggaa aacaagcgtc ccagtccacg gaagctctct tctgaacccc
      841 ttttgcctct ggatgaggag gctgtggata tggactatgg tgacatggct gtagatgtag
      901 tggatggaga ccaagaggaa gcttctggag acatggagat ctcctttcat cttgattcag
      961 gccacaagac tagtagcaga gtgaactcaa caaccaaacc tgaggatgga ggattaaaga
     1021 aaaacaagtc agcaaaacag ggtgacagag agaactttag gaaagccaag caaaagttgg
     1081 gtttctcatc ttctgatcca gatcgcatgt ttgttgagct gtctaatagc agttggtcag
     1141 aaatgtctcc ctgggtgatt ggcaccaatt atacccttta tcctatgact cctgctatcg
     1201 agcagcgact cattctccaa tatttgaccc ctctaggaga atatcaggag ctacttccca
     1261 tattcatgca acttggatca cgggagctga tgatgttcta tattgacctg aagcaaacta
     1321 atgatgtcct gcttacattt gaggcactaa agcacctagc atctctcctg ctccataaca
     1381 aatttgccac agaatttgtt gcgcatggtg gagtacagaa attactggaa atacctcgtc
     1441 cttctatggc tgcaaccggt gtgtctatgt gtttgtatta cctatcctac aatcaggatg
     1501 ccatggaaag agtttgcatg catccccaca atgttctgtc tgatgtggtg aactataccc
     1561 tgtggttaat ggagtgttct catgcttcag gatgctgcca tgctaccatg tttttttcaa
     1621 tttgcttctc atttcgggcc gtcttggagc tctttgaccg ctatgatggt cttcgtcgtc
     1681 tggtgaactt gatcagtact ttggagattc taaatttgga agatcagggt gcacttctga
     1741 gtgatgatga aatatttgct agccgccaaa ctgggaaaca tacctgcatg gccttgcgca
     1801 aatactttga ggctcacctg gccattaaat tggaacaagt gaagcagtca cttcagagga
     1861 ctgagggtgg cattcttgtc cacccacaac ccccgtacaa ggcatgctca tatactcatg
     1921 aacagattgt ggaaatgatg gaatttttga tagaatatgg cccagcgcag ctatattggg
     1981 aaccagctga agttttcctc aaactttctt gtgtgcaact cttgttgcag cttatttcta
     2041 ttgcctgcaa ttggaagacc tattatgcaa ggaatgacac tgtgcgcttt gctttggatg
     2101 tcctggctat tcttactgtg gtgccaaaaa tccagctcca gttggcagaa tcagtggacg
     2161 tgttggatga ggctggatct acagtctcta ctgtaggtat cagcattatt ttgggagtgg
     2221 ctgagggtga gttcttcatc catgatgctg aaattcagaa gtcagcactt cagattatca
     2281 tcaattgtgt gtgtggccca gataaccgaa tatccagtat tggtaaattt atctctggta
     2341 ctcctcggag aaagctgcct cagaacccta aaagcagtga gcacaccctg gccaagatgt
     2401 ggaatgtggt tcagtccaac aacggcatca aggtgctcct gtccttactg tccattaaga
     2461 tgcccatcac agatgcagac caaatccggg ccctggcctg caaagcccta gtgggcctgt
     2521 ctcgcagtag cactgtccgg cagatcatca gtaaactgcc ccttttcagc agctgccaga
     2581 tccagcagct gatgaaggag cctgtgctgc aggacaagcg cagtgaccat gtcaagttct
     2641 gcaagtatgc tgctgaactc attgaacggg tgtcaggaaa accacttctc attggcactg
     2701 atgtttccct agcacgactg cagaaagcag atgttgttgc ccagtcaagg atctccttcc
     2761 ctgagaaaga gctgcttttg ttgatacgaa accatcttat ttctaaaggg cttggagaaa
     2821 cagcaaccgt gctgacaaaa gaggctgacc tgcccatgac tgctgcctcc cattcttctg
     2881 cctttacccc agtcactgct gctgcttctc ctgtctctct accccgaacc cctcgtatcg
     2941 ctaatggcat tgcaactcgt ctgggcagcc atgctgctgt gggtgcctct gcgccttctg
     3001 cccctactgc tcatcctcag ccacggcccc cccagggtcc gctagctctg cccggcccat
     3061 cttatgcagg caactcccct ttgattggta gaatcagttt tatcagagag aggccatcac
     3121 cctgcaatgg caggaaaatc agagtgttgc ggcagaagtc ggaccatggt gcctacagcc
     3181 aaagcccagc cataaaaaaa cagctggaca gacatcttcc ttccccacct acgctggaca
     3241 gtataatcac agagtatctt agagaacaac atgctcgctg caagaatcca gttgccacct
     3301 gcccaccttt ctccctcttt actcctcacc aatgtcctga gccaaaacag aggcggcaag
     3361 cgccaataaa ctttacgtca aggctaaacc gcagggcatc atttccaaag tatggagggg
     3421 tggatggcgg atgctttgat aggcacctta tctttagcag attccgtcct atttcagtgt
     3481 tccgggaagc caatgaagat gagagtggct tcacctgctg tgcattctca gcacgggagc
     3541 ggttcctgat gcttggcacc tgcacagggc agctgaagct ctataatgtg tttagtggac
     3601 aggaggaggc cagctataac tgtcacaact cagccatcac acatcttgaa ccttccaggg
     3661 atgggtcctt gctgctgaca tctgctactt ggagccagcc tttgtctgca ctttggggaa
     3721 tgaagtcagt atttgatatg aagcattcct tcacagaaga tcactatgtt gagttcagta
     3781 agcactccca ggatcgggtc atcggcacaa aaggagacat tgcccacatt tatgatattc
     3841 agactggcaa caagctgttg actctgttta acccagatct tgccaacaac tacaagagga
     3901 actgtgccac ctttaatcct acagatgatc ttgtcttaaa tgatggcgtc ctctgggatg
     3961 tccgctctgc acaggccatc cacaagtttg acaagttcaa tatgaacatc agtggtgttt
     4021 tccatccaaa tggactggag gtgatcatta atactgagat ttgggacctt cgaacttttc
     4081 atcttttgca tactgttccc gctctggatc agtgtcgcgt ggtgttcaat cacacgggaa
     4141 cagtgatgta tggagctatg ttgcaggcag atgatgaaga tgacttaatg gaagagagga
     4201 tgaaaagccc ctttgggtca tccttccgaa catttaatgc aactgactac aaacctatag
     4261 caaccattga tgtgaaacgg aacatctttg acctgtgtac agacaccaaa gactgctatc
     4321 ttgctgtcat tgagaatcaa ggcagcatgg atgccctgaa catggacaca gtatgcaggc
     4381 tgtatgaagt gggcaggcag cgtctggcag aggatgagga tgaagaggag gaccaggaag
     4441 aggaagaaca ggaggaagaa gatgatgatg aagatgatga tgacaccgat gatttagatg
     4501 agcttgacac tgaccagttg ctggaggcgg agttggagga ggacgacaat aatgagaacg
     4561 caggggaaga tggggacaat gacttctctc cctctgatga ggagctagca aaccttctag
     4621 aggagggaga ggacggggag gatgaagact ctgatgcaga tgaggaggtg gaactgatcc
     4681 tgggggacac tgacagctct gacaactctg atttggaaga tgacatcatc ttatctctga
     4741 atgagtgagg agccatcact gcttggaaga gattcttggc aggcgagaaa ctgagtcaaa
     4801 tgaattcaga acatattccc ttctctttct cccagggctg tctgtctttt aaggagctgc
     4861 atgccctgca ttcagaagat tatggcttag agagcctcat tggcacccga gggtccttcc
     4921 agaatcaata accaccacaa aaatgacaac agggactagg ccctactctg caccccccac
     4981 atccaccccc caccatttcc taggatggac atatctttca aggggaaaaa aaaaccatgt
     5041 ctctggggta tttcacaata tattttcttt gtatagtgtt ctttacttaa agaacaagaa
     5101 atagtttttt ataaaacttt aaaaaggaaa aaaaaacagg catttataac tgagggtatg
     5161 aacttatatc caccaggtct cttgtccctg cacttcattt tctttggaag aaaatgatgt
     5221 ctaaagaaca atatagaggc atttttacat acgtatttaa atgaaaagga aaatcgtggt
     5281 ttcttaaatt gataaggatt aagaatattt tattataaat ataatatatg attttttaac
     5341 ctgttttgtt gcctcatatg ctgtcaggtt aatttgtttt ccttcgtgcc agaggtgggg
     5401 aggaaggcac tctgtctgct gggtaaatgc ctaaattcac tcaccttcat ggtttggggg
     5461 cagcatggtc attgtggata ttggttttgt ggagttgagg gaacttagga tataagttca
     5521 ctccctctat ttttctttgt gattcagttt ttcaaaaatc tttttttctt ccctttctcc
     5581 ccattgtgga aattacaaat caaaggcctt tttctttaat gtaaagtgta tttatttaaa
     5641 aaaaatacaa aataaactac aagtctgtct ttgtt
//
