LOCUS       NM_001387582            5599 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens DDB1 and CUL4 associated factor 1 (DCAF1), transcript
            variant 12, mRNA.
ACCESSION   NM_001387582
VERSION     NM_001387582.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5599)
  AUTHORS   Zhang,J., Shi,Y., Ding,K., Yu,W., He,J. and Sun,B.
  TITLE     DCAF1 interacts with PARD3 to promote hepatocellular carcinoma
            progression and metastasis by activating the Akt signaling pathway
  JOURNAL   J Exp Clin Cancer Res 43 (1), 136 (2024)
   PUBMED   38711082
  REMARK    GeneRIF: DCAF1 interacts with PARD3 to promote hepatocellular
            carcinoma progression and metastasis by activating the Akt
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5599)
  AUTHORS   Ghate,N.B., Kim,S., Shin,Y., Kim,J., Doche,M., Valena,S., Situ,A.,
            Kim,S., Rhie,S.K., Lenz,H.J., Ulmer,T.S., Mumenthaler,S.M. and
            An,W.
  TITLE     Phosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger
            aberrant gene silencing in colon cancer
  JOURNAL   Nat Commun 14 (1), 2140 (2023)
   PUBMED   37069142
  REMARK    GeneRIF: Phosphorylation and stabilization of EZH2 by DCAF1/VprBP
            trigger aberrant gene silencing in colon cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5599)
  AUTHORS   Zhang,C., Jiang,H., Yuan,L., Liao,Y., Liu,P., Du,Q., Pan,C.,
            Liu,T., Li,J., Chen,Y., Huang,J., Liang,Y., Xia,M., Xu,M., Qin,S.,
            Zou,Q., Liu,Y., Huang,H., Pan,Y., Li,J., Liu,J., Wang,W. and Yao,S.
  TITLE     CircVPRBP inhibits nodal metastasis of cervical cancer by impeding
            RACK1 O-GlcNAcylation and stability
  JOURNAL   Oncogene 42 (11), 793-807 (2023)
   PUBMED   36658304
  REMARK    GeneRIF: CircVPRBP inhibits nodal metastasis of cervical cancer by
            impeding RACK1 O-GlcNAcylation and stability.
REFERENCE   4  (bases 1 to 5599)
  AUTHORS   Poulose,N., Forsythe,N., Polonski,A., Gregg,G., Maguire,S.,
            Fuchs,M., Minner,S., Sauter,G., McDade,S.S. and Mills,I.G.
  TITLE     VPRBP Functions Downstream of the Androgen Receptor and OGT to
            Restrict p53 Activation in Prostate Cancer
  JOURNAL   Mol Cancer Res 20 (7), 1047-1060 (2022)
   PUBMED   35348747
  REMARK    GeneRIF: VPRBP Functions Downstream of the Androgen Receptor and
            OGT to Restrict p53 Activation in Prostate Cancer.
REFERENCE   5  (bases 1 to 5599)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 5599)
  AUTHORS   Borgne-Sanchez,A., Dupont,S., Langonne,A., Baux,L., Lecoeur,H.,
            Chauvier,D., Lassalle,M., Deas,O., Briere,J.J., Brabant,M.,
            Roux,P., Pechoux,C., Briand,J.P., Hoebeke,J., Deniaud,A.,
            Brenner,C., Rustin,P., Edelman,L., Rebouillat,D. and Jacotot,E.
  TITLE     Targeted Vpr-derived peptides reach mitochondria to induce
            apoptosis of alphaVbeta3-expressing endothelial cells
  JOURNAL   Cell Death Differ 14 (3), 422-435 (2007)
   PUBMED   16888644
  REMARK    GeneRIF: Hence, this chimeric peptide (TEAM-VP) constitutes the
            first example of a virus-derived mitochondriotoxic compound as a
            candidate to kill selectively tumor neo-endothelia.
REFERENCE   7  (bases 1 to 5599)
  AUTHORS   Jin,J., Arias,E.E., Chen,J., Harper,J.W. and Walter,J.C.
  TITLE     A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2,
            which is required for S phase destruction of the replication factor
            Cdt1
  JOURNAL   Mol Cell 23 (5), 709-721 (2006)
   PUBMED   16949367
REFERENCE   8  (bases 1 to 5599)
  AUTHORS   Zhao,L.J., Zhang,S. and Chinnadurai,G.
  TITLE     Sox9 transactivation and testicular expression of a novel human
            gene, KIAA0800
  JOURNAL   J Cell Biochem 86 (2), 277-289 (2002)
   PUBMED   12111997
  REMARK    GeneRIF: demonstration that a novel human gene, KIAA0800, is
            preferentially expressed in the testis and is transactivated by
            Sox9
REFERENCE   9  (bases 1 to 5599)
  AUTHORS   Zhang,S., Feng,Y., Narayan,O. and Zhao,L.J.
  TITLE     Cytoplasmic retention of HIV-1 regulatory protein Vpr by
            protein-protein interaction with a novel human cytoplasmic protein
            VprBP
  JOURNAL   Gene 263 (1-2), 131-140 (2001)
   PUBMED   11223251
REFERENCE   10 (bases 1 to 5599)
  AUTHORS   Zhao,L.J., Mukherjee,S. and Narayan,O.
  TITLE     Biochemical mechanism of HIV-I Vpr function. Specific interaction
            with a cellular protein
  JOURNAL   J Biol Chem 269 (22), 15577-15582 (1994)
   PUBMED   8195203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092037.2 and AC233756.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1849.1,
                                           SRR14038197.1114778.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AC092037.2         118333-118475       c
            144-261             AC092037.2         102179-102296       c
            262-338             AC092037.2         89389-89465         c
            339-409             AC092037.2         85266-85336         c
            410-523             AC092037.2         81574-81687         c
            524-661             AC092037.2         62226-62363         c
            662-1174            AC092037.2         59845-60357         c
            1175-1276           AC092037.2         59430-59531         c
            1277-1435           AC233756.2         30775-30933         c
            1436-1615           AC233756.2         27702-27881         c
            1616-1825           AC233756.2         26930-27139         c
            1826-1995           AC233756.2         25041-25210         c
            1996-2120           AC233756.2         19976-20100         c
            2121-3384           AC233756.2         17403-18666         c
            3385-3583           AC233756.2         16347-16545         c
            3584-3666           AC233756.2         15785-15867         c
            3667-3751           AC233756.2         14456-14540         c
            3752-3985           AC233756.2         12293-12526         c
            3986-4079           AC233756.2         11619-11712         c
            4080-4184           AC233756.2         10951-11055         c
            4185-4258           AC233756.2         10662-10735         c
            4259-4360           AC233756.2         10048-10149         c
            4361-4613           AC233756.2         812-1064            c
            4614-5599           AC092037.2         19717-20702         c
FEATURES             Location/Qualifiers
     source          1..5599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..5599
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /note="DDB1 and CUL4 associated factor 1"
                     /db_xref="GeneID:9730"
                     /db_xref="HGNC:HGNC:30911"
                     /db_xref="MIM:617259"
     exon            1..143
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            144..261
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..4672
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 12;
                     protein VPRBP; Vpr-binding protein; vpr-interacting
                     protein; HIV-1 Vpr-binding protein;
                     serine/threonine-protein kinase VPRBP; Vpr (HIV-1) binding
                     protein"
                     /codon_start=1
                     /product="DDB1- and CUL4-associated factor 1 isoform 2"
                     /protein_id="NP_001374511.1"
                     /db_xref="CCDS:CCDS74944.1"
                     /db_xref="GeneID:9730"
                     /db_xref="HGNC:HGNC:30911"
                     /db_xref="MIM:617259"
                     /translation="MTTVVVHVDSKAELTTLLEQWEKEHGSGQDMVPILTRMSQLIEK
                     ETEEYRKGDPDPFDDRHPGRADPECMLGHLLRILFKNDDFMNLVNAYVMTSREPPLNT
                     AACRLLLDIMPGLETAVVFQEKEGIVENLFKWAREADQPLRTYSTGLLGGAMENQDIA
                     ANYRDENSQLVAIVLRRLRELQLQEVALRQENKRPSPRKLSSEPLLPLDEEAVDMDYG
                     DMAVDVVDGDQEEASGDMEISFHLDSGHKTSSRVNSTTKPEDGGLKKNKSAKQGDREN
                     FRKAKQKLGFSSSDPDRMFVELSNSSWSEMSPWVIGTNYTLYPMTPAIEQRLILQYLT
                     PLGEYQELLPIFMQLGSRELMMFYIDLKQTNDVLLTFEALKHLASLLLHNKFATEFVA
                     HGGVQKLLEIPRPSMAATGVSMCLYYLSYNQDAMERVCMHPHNVLSDVVNYTLWLMEC
                     SHASGCCHATMFFSICFSFRAVLELFDRYDGLRRLVNLISTLEILNLEDQGALLSDDE
                     IFASRQTGKHTCMALRKYFEAHLAIKLEQVKQSLQRTEGGILVHPQPPYKACSYTHEQ
                     IVEMMEFLIEYGPAQLYWEPAEVFLKLSCVQLLLQLISIACNWKTYYARNDTVRFALD
                     VLAILTVVPKIQLQLAESVDVLDEAGSTVSTVGISIILGVAEGEFFIHDAEIQKSALQ
                     IIINCVCGPDNRISSIGKFISGTPRRKLPQNPKSSEHTLAKMWNVVQSNNGIKVLLSL
                     LSIKMPITDADQIRALACKALVGLSRSSTVRQIISKLPLFSSCQIQQLMKEPVLQDKR
                     SDHVKFCKYAAELIERVSGKPLLIGTDVSLARLQKADVVAQSRISFPEKELLLLIRNH
                     LISKGLGETATVLTKEADLPMTAASHSSAFTPVTAAASPVSLPRTPRIANGIATRLGS
                     HAAVGASAPSAPTAHPQPRPPQGPLALPGPSYAGNSPLIGRISFIRERPSPCNGRKIR
                     VLRQKSDHGAYSQSPAIKKQLDRHLPSPPTLDSIITEYLREQHARCKNPVATCPPFSL
                     FTPHQCPEPKQRRQAPINFTSRLNRRASFPKYGGVDGGCFDRHLIFSRFRPISVFREA
                     NEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDG
                     SLLLTSATWSQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDI
                     QTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDVRSAQAIHKFDKFNMNIS
                     GVFHPNGLEVIINTEIWDLRTFHLLHTVPALDQCRVVFNHTGTVMYGAMLQADDEDDL
                     MEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQGSMDALN
                     MDTVCRLYEVGRQRLAEDEDEEEDQEEEEQEEEDDDEDDDDTDDLDELDTDQLLEAEL
                     EEDDNNENAGEDGDNDFSPSDEELANLLEEGEDGEDEDSDADEEVELILGDTDSSDNS
                     DLEDDIILSLNE"
     exon            262..338
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            339..409
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            410..523
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            524..661
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            662..1174
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1276
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1435
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1615
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1825
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1995
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2120
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..3384
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3583
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3584..3666
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..3751
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3752..3985
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3986..4079
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4080..4184
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4185..4258
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4259..4360
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4361..4613
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4614..5599
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5575..5580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /note="hexamer: AATAAA"
     polyA_site      5599
                     /gene="DCAF1"
                     /gene_synonym="RIP; VPRBP"
                     /note="major polyA site"
ORIGIN      
        1 ataatatgtg ggccgctgtg gagccgtggt cgcgctgtgt gtgtgtgtga gtggagagtg
       61 agtgcgggac ctgaggctgt gtgtgtgtga actgtggcca ctggcggggt cggggggggg
      121 cagcggcgga gccgcctcgg acggcaaagc catgactaca gtagtggtac atgtggactc
      181 caaagctgag ctcactaccc tgctggagca gtgggaaaag gaacatggca gtgggcagga
      241 catggtacct atccttacca ggatgtctca attgattgaa aaagaaactg aagagtatcg
      301 taaaggggat ccagacccat ttgatgatcg acatcctggt cgagctgatc cagagtgtat
      361 gctgggccac ttgctgagaa tactcttcaa gaatgatgat ttcatgaatc tggtgaatgc
      421 atatgtgatg acaagccgag agcccccttt aaacactgca gcttgcagac tcctattaga
      481 catcatgcca gggctggaaa ctgctgtcgt ctttcaagaa aaggagggaa ttgtcgagaa
      541 tcttttcaaa tgggcccgag aggccgatca accattgagg acatattcta ctggactgtt
      601 aggaggtgct atggaaaatc aagacattgc tgccaactat agagatgaaa attcacagct
      661 ggtggcaata gtgcttcgaa gactgaggga gctacagcta caggaagtgg ctttgcggca
      721 ggaaaacaag cgtcccagtc cacggaagct ctcttctgaa ccccttttgc ctctggatga
      781 ggaggctgtg gatatggact atggtgacat ggctgtagat gtagtggatg gagaccaaga
      841 ggaagcttct ggagacatgg agatctcctt tcatcttgat tcaggccaca agactagtag
      901 cagagtgaac tcaacaacca aacctgagga tggaggatta aagaaaaaca agtcagcaaa
      961 acagggtgac agagagaact ttaggaaagc caagcaaaag ttgggtttct catcttctga
     1021 tccagatcgc atgtttgttg agctgtctaa tagcagttgg tcagaaatgt ctccctgggt
     1081 gattggcacc aattataccc tttatcctat gactcctgct atcgagcagc gactcattct
     1141 ccaatatttg acccctctag gagaatatca ggagctactt cccatattca tgcaacttgg
     1201 atcacgggag ctgatgatgt tctatattga cctgaagcaa actaatgatg tcctgcttac
     1261 atttgaggca ctaaagcacc tagcatctct cctgctccat aacaaatttg ccacagaatt
     1321 tgttgcgcat ggtggagtac agaaattact ggaaatacct cgtccttcta tggctgcaac
     1381 cggtgtgtct atgtgtttgt attacctatc ctacaatcag gatgccatgg aaagagtttg
     1441 catgcatccc cacaatgttc tgtctgatgt ggtgaactat accctgtggt taatggagtg
     1501 ttctcatgct tcaggatgct gccatgctac catgtttttt tcaatttgct tctcatttcg
     1561 ggccgtcttg gagctctttg accgctatga tggtcttcgt cgtctggtga acttgatcag
     1621 tactttggag attctaaatt tggaagatca gggtgcactt ctgagtgatg atgaaatatt
     1681 tgctagccgc caaactggga aacatacctg catggccttg cgcaaatact ttgaggctca
     1741 cctggccatt aaattggaac aagtgaagca gtcacttcag aggactgagg gtggcattct
     1801 tgtccaccca caacccccgt acaaggcatg ctcatatact catgaacaga ttgtggaaat
     1861 gatggaattt ttgatagaat atggcccagc gcagctatat tgggaaccag ctgaagtttt
     1921 cctcaaactt tcttgtgtgc aactcttgtt gcagcttatt tctattgcct gcaattggaa
     1981 gacctattat gcaaggaatg acactgtgcg ctttgctttg gatgtcctgg ctattcttac
     2041 tgtggtgcca aaaatccagc tccagttggc agaatcagtg gacgtgttgg atgaggctgg
     2101 atctacagtc tctactgtag gtatcagcat tattttggga gtggctgagg gtgagttctt
     2161 catccatgat gctgaaattc agaagtcagc acttcagatt atcatcaatt gtgtgtgtgg
     2221 cccagataac cgaatatcca gtattggtaa atttatctct ggtactcctc ggagaaagct
     2281 gcctcagaac cctaaaagca gtgagcacac cctggccaag atgtggaatg tggttcagtc
     2341 caacaacggc atcaaggtgc tcctgtcctt actgtccatt aagatgccca tcacagatgc
     2401 agaccaaatc cgggccctgg cctgcaaagc cctagtgggc ctgtctcgca gtagcactgt
     2461 ccggcagatc atcagtaaac tgcccctttt cagcagctgc cagatccagc agctgatgaa
     2521 ggagcctgtg ctgcaggaca agcgcagtga ccatgtcaag ttctgcaagt atgctgctga
     2581 actcattgaa cgggtgtcag gaaaaccact tctcattggc actgatgttt ccctagcacg
     2641 actgcagaaa gcagatgttg ttgcccagtc aaggatctcc ttccctgaga aagagctgct
     2701 tttgttgata cgaaaccatc ttatttctaa agggcttgga gaaacagcaa ccgtgctgac
     2761 aaaagaggct gacctgccca tgactgctgc ctcccattct tctgccttta ccccagtcac
     2821 tgctgctgct tctcctgtct ctctaccccg aacccctcgt atcgctaatg gcattgcaac
     2881 tcgtctgggc agccatgctg ctgtgggtgc ctctgcgcct tctgccccta ctgctcatcc
     2941 tcagccacgg cccccccagg gtccgctagc tctgcccggc ccatcttatg caggcaactc
     3001 ccctttgatt ggtagaatca gttttatcag agagaggcca tcaccctgca atggcaggaa
     3061 aatcagagtg ttgcggcaga agtcggacca tggtgcctac agccaaagcc cagccataaa
     3121 aaaacagctg gacagacatc ttccttcccc acctacgctg gacagtataa tcacagagta
     3181 tcttagagaa caacatgctc gctgcaagaa tccagttgcc acctgcccac ctttctccct
     3241 ctttactcct caccaatgtc ctgagccaaa acagaggcgg caagcgccaa taaactttac
     3301 gtcaaggcta aaccgcaggg catcatttcc aaagtatgga ggggtggatg gcggatgctt
     3361 tgataggcac cttatcttta gcagattccg tcctatttca gtgttccggg aagccaatga
     3421 agatgagagt ggcttcacct gctgtgcatt ctcagcacgg gagcggttcc tgatgcttgg
     3481 cacctgcaca gggcagctga agctctataa tgtgtttagt ggacaggagg aggccagcta
     3541 taactgtcac aactcagcca tcacacatct tgaaccttcc agggatgggt ccttgctgct
     3601 gacatctgct acttggagcc agcctttgtc tgcactttgg ggaatgaagt cagtatttga
     3661 tatgaagcat tccttcacag aagatcacta tgttgagttc agtaagcact cccaggatcg
     3721 ggtcatcggc acaaaaggag acattgccca catttatgat attcagactg gcaacaagct
     3781 gttgactctg tttaacccag atcttgccaa caactacaag aggaactgtg ccacctttaa
     3841 tcctacagat gatcttgtct taaatgatgg cgtcctctgg gatgtccgct ctgcacaggc
     3901 catccacaag tttgacaagt tcaatatgaa catcagtggt gttttccatc caaatggact
     3961 ggaggtgatc attaatactg agatttggga ccttcgaact tttcatcttt tgcatactgt
     4021 tcccgctctg gatcagtgtc gcgtggtgtt caatcacacg ggaacagtga tgtatggagc
     4081 tatgttgcag gcagatgatg aagatgactt aatggaagag aggatgaaaa gcccctttgg
     4141 gtcatccttc cgaacattta atgcaactga ctacaaacct atagcaacca ttgatgtgaa
     4201 acggaacatc tttgacctgt gtacagacac caaagactgc tatcttgctg tcattgagaa
     4261 tcaaggcagc atggatgccc tgaacatgga cacagtatgc aggctgtatg aagtgggcag
     4321 gcagcgtctg gcagaggatg aggatgaaga ggaggaccag gaagaggaag aacaggagga
     4381 agaagatgat gatgaagatg atgatgacac cgatgattta gatgagcttg acactgacca
     4441 gttgctggag gcggagttgg aggaggacga caataatgag aacgcagggg aagatgggga
     4501 caatgacttc tctccctctg atgaggagct agcaaacctt ctagaggagg gagaggacgg
     4561 ggaggatgaa gactctgatg cagatgagga ggtggaactg atcctggggg acactgacag
     4621 ctctgacaac tctgatttgg aagatgacat catcttatct ctgaatgagt gaggagccat
     4681 cactgcttgg aagagattct tggcaggcga gaaactgagt caaatgaatt cagaacatat
     4741 tcccttctct ttctcccagg gctgtctgtc ttttaaggag ctgcatgccc tgcattcaga
     4801 agattatggc ttagagagcc tcattggcac ccgagggtcc ttccagaatc aataaccacc
     4861 acaaaaatga caacagggac taggccctac tctgcacccc ccacatccac cccccaccat
     4921 ttcctaggat ggacatatct ttcaagggga aaaaaaaacc atgtctctgg ggtatttcac
     4981 aatatatttt ctttgtatag tgttctttac ttaaagaaca agaaatagtt ttttataaaa
     5041 ctttaaaaag gaaaaaaaaa caggcattta taactgaggg tatgaactta tatccaccag
     5101 gtctcttgtc cctgcacttc attttctttg gaagaaaatg atgtctaaag aacaatatag
     5161 aggcattttt acatacgtat ttaaatgaaa aggaaaatcg tggtttctta aattgataag
     5221 gattaagaat attttattat aaatataata tatgattttt taacctgttt tgttgcctca
     5281 tatgctgtca ggttaatttg ttttccttcg tgccagaggt ggggaggaag gcactctgtc
     5341 tgctgggtaa atgcctaaat tcactcacct tcatggtttg ggggcagcat ggtcattgtg
     5401 gatattggtt ttgtggagtt gagggaactt aggatataag ttcactccct ctatttttct
     5461 ttgtgattca gtttttcaaa aatctttttt tcttcccttt ctccccattg tggaaattac
     5521 aaatcaaagg cctttttctt taatgtaaag tgtatttatt taaaaaaaat acaaaataaa
     5581 ctacaagtct gtctttgtt
//
