LOCUS       NM_001004329            2806 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens developing brain homeobox 2 (DBX2), mRNA.
ACCESSION   NM_001004329 XM_495922
VERSION     NM_001004329.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2806)
  AUTHORS   Hu,Y.T., Li,B.F., Zhang,P.J., Wu,D., Li,Y.Y., Li,Z.W., Shen,L.,
            Dong,B., Gao,J. and Zhu,X.
  TITLE     Dbx2 exhibits a tumor-promoting function in hepatocellular
            carcinoma cell lines via regulating Shh-Gli1 signaling
  JOURNAL   World J Gastroenterol 25 (8), 923-940 (2019)
   PUBMED   30833799
  REMARK    GeneRIF: DBX2 is obviously upregulated in hepatocellular carcinoma
            (HCC) tissues and strongly correlated with tumor size.
            Subsequently, both gain and loss of function assays indicated that
            DBX2 promoted HCC migration, invasion, and proliferation by
            facilitating the transition from G1 to S phase and attenuating
            apoptosis in vitro and in vivo.
REFERENCE   2  (bases 1 to 2806)
  AUTHORS   Kim,J., Choi,T.I., Park,S., Kim,M.H., Kim,C.H. and Lee,S.
  TITLE     Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains
  JOURNAL   Development 145 (17) (2018)
   PUBMED   30177510
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2806)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 2806)
  AUTHORS   Pierani,A., Moran-Rivard,L., Sunshine,M.J., Littman,D.R.,
            Goulding,M. and Jessell,T.M.
  TITLE     Control of interneuron fate in the developing spinal cord by the
            progenitor homeodomain protein Dbx1
  JOURNAL   Neuron 29 (2), 367-384 (2001)
   PUBMED   11239429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131230.1, AC089986.25 and AC079033.12.
            
            On May 17, 2019 this sequence version replaced NM_001004329.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131230.1, SRR1803616.119814.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332700.6/ ENSP00000331470.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-671               AK131230.1         1-671
            672-859             AC089986.25        9285-9472           c
            860-1050            AC089986.25        2006-2196           c
            1051-2722           AC079033.12        148452-150123       c
            2723-2806           AC079033.12        148368-148451       c
FEATURES             Location/Qualifiers
     source          1..2806
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..2806
                     /gene="DBX2"
                     /note="developing brain homeobox 2"
                     /db_xref="GeneID:440097"
                     /db_xref="HGNC:HGNC:33186"
                     /db_xref="MIM:620706"
     exon            1..575
                     /gene="DBX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1192
                     /gene="DBX2"
                     /note="developing brain homeobox protein 2"
                     /codon_start=1
                     /product="homeobox protein DBX2"
                     /protein_id="NP_001004329.2"
                     /db_xref="CCDS:CCDS31781.1"
                     /db_xref="GeneID:440097"
                     /db_xref="HGNC:HGNC:33186"
                     /db_xref="MIM:620706"
                     /translation="MLPSAVAAHAGAYWDVVASSALLNLPAAPGFGNLGKSFLIENLL
                     RVGGAPTPRLQPPAPHDPATALATAGAQLRPLPASPVPLKLCPAAEQVSPAGAPYGTR
                     WAFQVLSPSADSARLPGRAPGDRDCTFQPSAPAPSKPFLLSTPPFYSACCGGSCRRPA
                     SSTAFPREESMLPLLTQDSNSKARRGILRRAVFSEDQRKALEKMFQKQKYISKTDRKK
                     LAINLGLKESQVKIWFQNRRMKWRNSKEKEVLSNRCIQEVGLQEDPLSRSALGFPSPC
                     PSIWDVPQQHSSPRWRENSPEPSERLIQESSGAPPPEANSLQGALYLCSEEEAGSKGV
                     LTGAV"
     exon            576..671
                     /gene="DBX2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..859
                     /gene="DBX2"
                     /inference="alignment:Splign:2.1.0"
     exon            860..2806
                     /gene="DBX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1508..1513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DBX2"
                     /note="hexamer: ATTAAA"
     polyA_site      1531
                     /gene="DBX2"
                     /note="major polyA site"
     polyA_site      2724
                     /gene="DBX2"
                     /note="major polyA site"
ORIGIN      
        1 atcgttccaa gtccgccgcc gtcccgggtg gcctttcctc cctgcctggc tccgcgcgct
       61 ccagccctgc gggaggcggc ggcgagaagc tgcggctctg ggtgcggtgc ggggcgcccg
      121 ggcgacaggc gggcgcaagg cgggcgcgca gcagaccggt tggcgccgca ctatgctccc
      181 cagcgcggtc gcagcccacg ccggtgcgta ctgggacgtt gtggcttcct ccgcgctcct
      241 caacctcccc gctgcgcccg gctttggcaa cctgggcaag agtttcctga tcgagaattt
      301 gctgcgggtc gggggcgccc caacgcccag gctgcagccg cccgcgcccc acgacccggc
      361 gaccgccctg gccaccgcgg gcgcgcagct ccggcccctg cctgctagcc cagttcccct
      421 aaagctgtgc cccgcagccg aacaagttag ccccgccggg gcgccctacg gaacgcggtg
      481 ggcttttcaa gtgctcagtc cctctgcgga cagtgcgagg ctgccgggcc gggctccggg
      541 ggaccgagac tgtaccttcc agccttcagc gccagcacct tccaaacctt tccttctgag
      601 caccccgcca ttctactcgg cgtgctgcgg tgggtcctgt cggcgccctg catcctccac
      661 tgcttttcca agagaagaga gcatgctgcc tctcctgaca caggactcta attccaaagc
      721 tcggaggggc attttaagaa gagctgtctt ttctgaggac cagagaaagg ctctggagaa
      781 aatgtttcag aaacagaaat atatcagcaa aacagaccga aagaaacttg ccatcaactt
      841 gggactaaag gaatcacagg tgaaaatttg gtttcagaac aggaggatga aatggcggaa
      901 ttccaaagaa aaggaagtgc tttccaacag gtgtatccaa gaagtaggtc ttcaagagga
      961 tcccctctca cggtctgctc tgggtttccc ttctccatgt ccttcaatat gggacgtccc
     1021 ccaacagcac tcaagtccaa gatggaggga gaattctcca gaaccttcag aaagactaat
     1081 ccaggagagt tcaggggcac cacccccaga agcaaattca ctgcaaggtg ccttatattt
     1141 atgttctgaa gaagaagctg gaagcaaggg tgtacttact ggggctgtct gaatggaagc
     1201 attcctccgt gttcatttaa aagaacgctt aatagtaaca tctggactct aatgccagct
     1261 agcttgtacc tcatcagtgc ttagagccta acaactttgg agcgatgtat gaactaatgc
     1321 tttaggaaac ccactctagt gttctcttgt ttggccctag actcaggctt aatttgtaag
     1381 tggaatagaa tctcccagca agtatgacag aactgaaaag aaggagagca acagctggct
     1441 cggtccctgc tctgagtatg tgtatatatg tgtttgtctc tatgtgtgtg tatatacata
     1501 aatatccatt aaaatgtatt agtagaaact agtttctctt taactattgc attgagtaaa
     1561 ttcacttcct tttatgtgaa gaaaactacc attgacagaa tgttattaac tttttgaaaa
     1621 taatgtaaaa tttggacttt agtgcaaact ttcatacccc aaaaacatgt ttttaaaaat
     1681 tctctatttt ctgacttctt ttggtatcca gctgtaagtg aattttaaca ccttagctca
     1741 gcagtcctca acaaatgagc cactgctaga tacatacact gagaatatat atttaaaatg
     1801 aacctaacaa gcaaattaga agaatttctg tatataacta ttagtatcct taatctccaa
     1861 gtctctggac catcgggcca tcatgaggga gagacccatt taactaataa ttattttttg
     1921 atctcttctc tgtaaagatg ggcctagacc agggtttgca aaataaaatg cctttaagag
     1981 cctgtcaggt aaatagaggg tatggcccac ccagagatat ttgagtcaag taatttttca
     2041 aatactgtat tggccaaaca aaatgtctat gccaagaagt ttgtgacctc tggctaagac
     2101 taaagaaagc cgtggtgtca cagttcttaa aatttttcta actggactta aaaccacaat
     2161 actaacagaa tcaatgatga tttctgtttg cgcttctagt tagggactca attttccact
     2221 taggtggcat acactttata tatcaggtta tttttatgta ttaacaaaca ccacacagat
     2281 gttttgtgtt ttttgactac cctgaaattg tatctttcta aaattgcatt tctggtaacg
     2341 atttgctgag ttaatccaga agtttttact ccaggaccaa gaagaaatta tgtttcactt
     2401 tgaaggaaat gaaacaaaaa taggaaatga tgtggttttg cattaaactc ttatcaatct
     2461 gtggacaaga aacactatca gaagttcatt aagtggcatt ttgttagtga gtaagctgca
     2521 taatgatggt ggcttctaat ttgctgaact ccactagagt ctgagaagtt aacgtctttt
     2581 gagggtttag tgtttagaaa agatatttca ggagataacg gttttaatca acagcaggaa
     2641 attattttgt acgaatagaa ttggacttgg tatgtcaacc tgtgtcttta ccacatgatc
     2701 ttttacttaa aagtcatttt agaagtgtgt ctcagtgcct cattgtgggg aatgggagca
     2761 gggatctgct gacaaaagtt aaaatttaaa acctgtctta aaatga
//
