LOCUS       NM_001029865            1242 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens developing brain homeobox 1 (DBX1), mRNA.
ACCESSION   NM_001029865 XM_061930
VERSION     NM_001029865.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1242)
  AUTHORS   Kim,J., Choi,T.I., Park,S., Kim,M.H., Kim,C.H. and Lee,S.
  TITLE     Rnf220 cooperates with Zc4h2 to specify spinal progenitor domains
  JOURNAL   Development 145 (17) (2018)
   PUBMED   30177510
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1242)
  AUTHORS   Gray,P.A., Hayes,J.A., Ling,G.Y., Llona,I., Tupal,S., Picardo,M.C.,
            Ross,S.E., Hirata,T., Corbin,J.G., Eugenin,J. and Del Negro,C.A.
  TITLE     Developmental origin of preBotzinger complex respiratory neurons
  JOURNAL   J Neurosci 30 (44), 14883-14895 (2010)
   PUBMED   21048147
  REMARK    GeneRIF: Dbx1-derived neurons are essential for the transgenic
            expression and generation of respiratory behavior both in vitro and
            in vivo.
REFERENCE   3  (bases 1 to 1242)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 1242)
  AUTHORS   Pierani,A., Moran-Rivard,L., Sunshine,M.J., Littman,D.R.,
            Goulding,M. and Jessell,T.M.
  TITLE     Control of interneuron fate in the developing spinal cord by the
            progenitor homeodomain protein Dbx1
  JOURNAL   Neuron 29 (2), 367-384 (2001)
   PUBMED   11239429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068860.9.
            
            On May 17, 2019 this sequence version replaced NM_001029865.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on cross-species transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1059583.1,
                                           SRR14372080.1510593.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2148874,
                                           SAMEA2162946 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524983.3/ ENSP00000436881.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-518               AC068860.9         36823-37340         c
            519-620             AC068860.9         36056-36157         c
            621-823             AC068860.9         33902-34104         c
            824-1242            AC068860.9         33020-33438         c
FEATURES             Location/Qualifiers
     source          1..1242
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..1242
                     /gene="DBX1"
                     /gene_synonym="HLX1"
                     /note="developing brain homeobox 1"
                     /db_xref="GeneID:120237"
                     /db_xref="HGNC:HGNC:33185"
                     /db_xref="MIM:619830"
     exon            1..518
                     /gene="DBX1"
                     /gene_synonym="HLX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1183
                     /gene="DBX1"
                     /gene_synonym="HLX1"
                     /note="developing brain homeobox protein 1"
                     /codon_start=1
                     /product="homeobox protein DBX1"
                     /protein_id="NP_001025036.2"
                     /db_xref="CCDS:CCDS31443.2"
                     /db_xref="GeneID:120237"
                     /db_xref="HGNC:HGNC:33185"
                     /db_xref="MIM:619830"
                     /translation="MMFPGLLAPPAGYPSLLRPTPTLTLPQSLQSAFSGHSSFLVEDL
                     IRISRPPAYLPRSVPTASMSPPRQGAPTALTDTGASDLGSPGPGSRRGGSPPTAFSPA
                     SETTFLKFGVNAILSSGPRTETSPALLQSVPPKTFAFPYFEGSFQPFIRSSYFPASSS
                     VVPIPGTFSWPLAARGKPRRGMLRRAVFSDVQRKALEKMFQKQKYISKPDRKKLAAKL
                     GLKDSQVKIWFQNRRMKWRNSKERELLSSGGCREQTLPTKLNPHPDLSDVGQKGPGNE
                     EEEEGPGSPSHRLAYHASSDPQHLRDPRLPGPLPPSPAHSSSPGKPSDFSDSEEEEEG
                     EEQEEITVS"
     exon            519..620
                     /gene="DBX1"
                     /gene_synonym="HLX1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..823
                     /gene="DBX1"
                     /gene_synonym="HLX1"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1242
                     /gene="DBX1"
                     /gene_synonym="HLX1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggactcg cagacgccca agtgggattg ttacttggag acgtttgcta agcccaagag
       61 agaggacact gtgggggcgg gaggggcggg aagcgaggcg tttaccctcc ggccactgaa
      121 agaagggtta tttcgcccgc ccgcgcctac catgatgttc cccggcctcc tcgcgccccc
      181 cgccgggtac cctagcctcc tgcggcccac gcccaccttg acgctgcccc agtccttgca
      241 gtcggcattt tccggccact ccagcttcct ggtggaggat ctgatccgca tcagccgacc
      301 ccccgcctac ctgccccgca gcgtgcccac cgccagcatg tcgccgccca ggcagggggc
      361 ccccacggcc ctcaccgaca cgggggcctc ggacctgggc tccccgggtc ccggcagccg
      421 acggggcggc tctccgccga ctgccttctc ccctgccagc gagacgacgt ttctgaagtt
      481 tggagtgaac gccatcctct cctcggggcc cagaacagaa acatccccag ccttgctcca
      541 gagcgtccct cccaagacct tcgcctttcc ctacttcgaa gggtcttttc agcctttcat
      601 cagatcttct tatttcccag cttcctccag cgtggtgccc atccccggga ccttctcctg
      661 gccgctggcc gcgcgcggga agcctcggcg gggcatgctg cgtcgagcag tcttctccga
      721 cgtgcagcgg aaggcgctgg agaagatgtt ccagaagcag aagtacatca gcaagcccga
      781 ccgcaagaag ctggcggcca agctgggcct gaaagactcg caggtgaaaa tctggttcca
      841 gaaccgacgc atgaaatggc ggaactccaa ggagcgcgaa ctcctgtcta gcgggggctg
      901 tcgcgagcag accctgccca ccaagctcaa tccgcacccg gacctcagcg acgtgggcca
      961 gaagggccct gggaacgaag aggaggagga gggcccgggc agccccagcc accgcctggc
     1021 ctaccacgcg tcctccgacc cccagcacct gcgggacccg cggctgccag ggccgctgcc
     1081 cccctcgccc gcgcactcga gcagtcccgg gaaaccttcg gacttctcag attccgagga
     1141 ggaagaggag ggcgaggaac aggaggaaat caccgtgtcc tagaagccgc tcgcacgcca
     1201 gagtactatt tttaagtgct ttgaaatcga agaggtgggg tc
//
