LOCUS       NM_001352               2170 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens D-box binding PAR bZIP transcription factor (DBP),
            mRNA.
ACCESSION   NM_001352
VERSION     NM_001352.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2170)
  AUTHORS   Miao,D., Wang,Q., Shi,J., Lv,Q., Tan,D., Zhao,C., Xiong,Z. and
            Zhang,X.
  TITLE     N6-methyladenosine-modified DBT alleviates lipid accumulation and
            inhibits tumor progression in clear cell renal cell carcinoma
            through the ANXA2/YAP axis-regulated Hippo pathway
  JOURNAL   Cancer Commun (Lond) 43 (4), 480-502 (2023)
   PUBMED   36860124
  REMARK    GeneRIF: N6-methyladenosine-modified DBT alleviates lipid
            accumulation and inhibits tumor progression in clear cell renal
            cell carcinoma through the ANXA2/YAP axis-regulated Hippo pathway.
REFERENCE   2  (bases 1 to 2170)
  AUTHORS   Park,S.A., Lim,Y.J., Ku,W.L., Zhang,D., Cui,K., Tang,L.Y., Chia,C.,
            Zanvit,P., Chen,Z., Jin,W., Wang,D., Xu,J., Liu,O., Wang,F.,
            Cain,A., Guo,N., Nakatsukasa,H., Wu,C., Zhang,Y.E., Zhao,K. and
            Chen,W.
  TITLE     Opposing functions of circadian protein DBP and atypical E2F family
            E2F8 in anti-tumor Th9 cell differentiation
  JOURNAL   Nat Commun 13 (1), 6069 (2022)
   PUBMED   36241625
  REMARK    GeneRIF: Opposing functions of circadian protein DBP and atypical
            E2F family E2F8 in anti-tumor Th9 cell differentiation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2170)
  AUTHORS   Kratzer,T.B., Weinstein,S.J., Albanes,D. and Mondul,A.M.
  TITLE     Vitamin D binding protein and risk of renal cell carcinoma in the
            prostate, lung, colorectal and ovarian cancer screening trial
  JOURNAL   Int J Cancer 147 (3), 669-674 (2020)
   PUBMED   31659740
  REMARK    GeneRIF: Vitamin D binding protein and risk of renal cell carcinoma
            in the prostate, lung, colorectal and ovarian cancer screening
            trial.
REFERENCE   4  (bases 1 to 2170)
  AUTHORS   Ushijima,K., Suzuki,C., Kitamura,H., Shimada,K., Kawata,H.,
            Tanaka,A., Horie,H., Hosoya,Y., Imai,Y., Yamashita,C. and
            Fujimura,A.
  TITLE     Expression of clock gene Dbp in omental and mesenteric adipose
            tissue in patients with type 2 diabetes
  JOURNAL   BMJ Open Diabetes Res Care 8 (1) (2020)
   PUBMED   32816832
  REMARK    GeneRIF: Expression of clock gene Dbp in omental and mesenteric
            adipose tissue in patients with type 2 diabetes.
REFERENCE   5  (bases 1 to 2170)
  AUTHORS   Duan,G.Q., Zheng,X., Li,W.K., Zhang,W., Li,Z. and Tan,W.
  TITLE     The Association Between VDR and GC Polymorphisms and Lung Cancer
            Risk: A Systematic Review and Meta-Analysis
  JOURNAL   Genet Test Mol Biomarkers 24 (5), 285-295 (2020)
   PUBMED   32255717
  REMARK    GeneRIF: The Association Between VDR and GC Polymorphisms and Lung
            Cancer Risk: A Systematic Review and Meta-Analysis.
REFERENCE   6  (bases 1 to 2170)
  AUTHORS   Shutler,G., Glassco,T., Kang,X., Korneluk,R. and Mueller,C.R.
  TITLE     Genomic structure of the human D-site binding protein (DBP) gene
  JOURNAL   Genomics 34 (3), 334-339 (1996)
   PUBMED   8786133
REFERENCE   7  (bases 1 to 2170)
  AUTHORS   Nyunoya,H., Morita,T., Sato,T., Honma,S., Tsujimoto,A. and
            Shimotohno,K.
  TITLE     Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is
            specific for the tax-responsive enhancer of HTLV-I
  JOURNAL   Gene 148 (2), 371-373 (1994)
   PUBMED   7958972
  REMARK    Correction to:[Gene. 1993 Apr 30;126(2):251-5. doi:
            10.1016/0378-1119(93)90375-d. PMID: 8482542]
REFERENCE   8  (bases 1 to 2170)
  AUTHORS   Khatib,Z.A., Inaba,T., Valentine,M. and Look,A.T.
  TITLE     Chromosomal localization and cDNA cloning of the human DBP and TEF
            genes
  JOURNAL   Genomics 23 (2), 344-351 (1994)
   PUBMED   7835883
REFERENCE   9  (bases 1 to 2170)
  AUTHORS   Nyunoya,H., Morita,T., Sato,T., Honma,S., Tsujimoto,A. and
            Shimotohno,K.
  TITLE     Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is
            specific for the tax-responsive enhancer of HTLV-I
  JOURNAL   Gene 126 (2), 251-255 (1993)
   PUBMED   8482542
  REMARK    Erratum:[Gene. 1994 Oct 21;148(2):371-3. doi:
            10.1016/0378-1119(94)90716-1. PMID: 7958972]
REFERENCE   10 (bases 1 to 2170)
  AUTHORS   Szpirer,C., Riviere,M., Cortese,R., Nakamura,T., Islam,M.Q.,
            Levan,G. and Szpirer,J.
  TITLE     Chromosomal localization in man and rat of the genes encoding the
            liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1
            (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of
            the hepatocyte growth factor/scatter factor gene (HGF)
  JOURNAL   Genomics 13 (2), 293-300 (1992)
   PUBMED   1535333
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA068934.1, BC011965.1,
            CA425431.1 and AC022154.4.
            
            On May 17, 2019 this sequence version replaced NM_001352.4.
            
            Summary: The protein encoded by this gene is a member of the PAR
            bZIP transcription factor family and binds to specific sequences in
            the promoters of several genes, such as albumin, CYP2A4, and
            CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer
            and is involved in the regulation of some circadian rhythm genes.
            [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.333055.1,
                                           SRR7346977.851635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222122.10/ ENSP00000222122.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                DA068934.1         172-219
            49-1515             BC011965.1         1-1467
            1516-1640           CA425431.1         16-140              c
            1641-2170           AC022154.4         31474-32003         c
FEATURES             Location/Qualifiers
     source          1..2170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2170
                     /gene="DBP"
                     /gene_synonym="DABP; taxREB302"
                     /note="D-box binding PAR bZIP transcription factor"
                     /db_xref="GeneID:1628"
                     /db_xref="HGNC:HGNC:2697"
                     /db_xref="MIM:124097"
     exon            1..524
                     /gene="DBP"
                     /gene_synonym="DABP; taxREB302"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..1363
                     /gene="DBP"
                     /gene_synonym="DABP; taxREB302"
                     /note="albumin D box-binding protein; albumin
                     D-element-binding protein; tax-responsive enhancer
                     element-binding protein 302; D site of albumin promoter
                     (albumin D-box) binding protein"
                     /codon_start=1
                     /product="D site-binding protein"
                     /protein_id="NP_001343.2"
                     /db_xref="CCDS:CCDS12728.1"
                     /db_xref="GeneID:1628"
                     /db_xref="HGNC:HGNC:2697"
                     /db_xref="MIM:124097"
                     /translation="MARPVSDRTPAPLLLGGPAGTPPGGGALLGLRSLLQGTSKPKEP
                     ASCLLKEKERKAALPAATTPGPGLETAGPADAPAGAVVGGGSPRGRPGPVPAPGLLAP
                     LLWERTLPFGDVEYVDLDAFLLEHGLPPSPPPPGGPSPEPSPARTPAPSPGPGSCGSA
                     SPRSSPGHAPARAALGTASGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIP
                     GHETFDPRRHRFSEEELKPQPIMKKARKIQVPEEQKDEKYWSRRYKNNEAAKRSRDAR
                     RLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGAL"
     exon            525..935
                     /gene="DBP"
                     /gene_synonym="DABP; taxREB302"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1147
                     /gene="DBP"
                     /gene_synonym="DABP; taxREB302"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..2170
                     /gene="DBP"
                     /gene_synonym="DABP; taxREB302"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1491..1496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DBP"
                     /gene_synonym="DABP; taxREB302"
                     /note="hexamer: AATACA"
     polyA_site      1515
                     /gene="DBP"
                     /gene_synonym="DABP; taxREB302"
     regulatory      1619..1624
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DBP"
                     /gene_synonym="DABP; taxREB302"
                     /note="hexamer: AATAAA"
     polyA_site      1638
                     /gene="DBP"
                     /gene_synonym="DABP; taxREB302"
                     /note="major polyA site"
     regulatory      1802..1807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DBP"
                     /gene_synonym="DABP; taxREB302"
                     /note="hexamer: AATGAA"
     polyA_site      1825
                     /gene="DBP"
                     /gene_synonym="DABP; taxREB302"
ORIGIN      
        1 gcacacctct cggtgcagat tgcaaagcgc cttccgttgc gagagctgca gattttgcaa
       61 gagccaggct cgcccacctt gtagaaggag cgccttgagt cccctctcac cctcggttgc
      121 aaagagccga ccgcttgatc tggacacccc ctcgcccaga ttgcatgatc tcccgggacc
      181 ctcttgagtt gcacgtttct gcaccgagga cctcaaatcc ccgtcgctcc taggatttgc
      241 agcgttctgg atactggagg gttgcaggct acactcgccc gcccctgggc agacactcgt
      301 ccaaaccact ggagtgtgct ggtgactggc aggccagccc ttcgcctctc catgaacccg
      361 tgagcctggg ggcaggtgcc aggcgatggc gcggcctgtg agcgacagga ccccggcccc
      421 tctgctgctg ggcggcccgg ccgggacacc ccctggcggg ggagcgctgc ttgggttgcg
      481 gagccttctg caggggacca gcaagcccaa agagccggcc agctgtctcc tgaaggaaaa
      541 ggagcgcaag gcggccctgc ctgcagccac aacccctggg ccaggcctgg agactgcggg
      601 cccggcggat gccccggctg gggcagtggt gggcggaggg tccccgcggg ggcgcccggg
      661 gccggtgccc gccccgggtc tgttggcgcc actgctgtgg gagcgcacgc tgccgttcgg
      721 cgatgtggag tacgtagacc tggacgcctt cctgctggag cacgggctcc cgcccagccc
      781 gccgcccccc ggtggcccgt cgccggagcc gtcgcccgcg cggacgcccg caccctcccc
      841 agggccgggt tcgtgcggct cggcttcccc ccgctcctct cctgggcacg cccccgcccg
      901 ggctgccctc gggaccgcca gcggccaccg cgcaggcctg acctctcggg acacacccag
      961 ccctgtggac ccagacaccg tggaggtgtt gatgaccttt gaacccgacc cagctgatct
     1021 tgccctatca agcattcctg gccacgagac ctttgaccct cgaagacatc gcttctcaga
     1081 agaggaactt aagccccagc caatcatgaa gaaggcaaga aaaatccagg tgccggagga
     1141 gcagaaggat gagaaatact ggagccggcg gtacaagaac aacgaggcag ccaagcggtc
     1201 ccgtgacgcc cggcggctca aggagaacca gatatcggtg cgggcggcct tcctggagaa
     1261 ggagaacgcc ctgctgcggc aggaagttgt ggccgtgcgc caggagctgt cccactaccg
     1321 cgccgtgctg tcccgatacc aggcccagca cggggccctg tgaggctgcc ccacatcccc
     1381 acctggcgga gctctcctcc gccttgctga gacttacgcc ctgttccctt cctgccctgt
     1441 ggcccacggg ccggccagct gggtgcccca gggacgtgat aatgcagata aatacattta
     1501 tatttttaag aaaaagcgag cctcccccct cccttgcggg ggcggggagg gttctctgtg
     1561 tgtgtccccg gcacgtcagg gaccctatcc tcccaccgcc tccgttaaca cgatcctgaa
     1621 taaatcttga gaaccccaga gccagctgtt gtggaagaag agggcagctc cctggcatac
     1681 tggctgcagc ccgtgggcag ctccgggctg tcgtccatag agggcaggcg ctgctggaag
     1741 tgctggagtc tgagtcctcc cgcgggctgt cggatggagg aagggcagaa ggtctgagag
     1801 gaatgaagcg actgccttta ttgcatagac cttttcaatt gctttttaga ttggggacgg
     1861 aggacgcgca tgagacgaac aggggatatg aatttccccg cccccacccg cggggagagg
     1921 aacattagtg caaatcctag cgccggcccc ggggaacctg cccctcctgg gctgattggc
     1981 cagctaaatg gaggcaccgg agtggatggg gcgaggctgc gggccctgac cggccgactc
     2041 actgaggcct accccagcca gtacattcca ggtcctgtca ttgggcgacg cgtaaaatag
     2101 actccgccct cagccatcct ggccgggtag gagcaggtgg caagcgtcag gactgagccc
     2161 tgccccgtaa
//
