LOCUS       NM_001014436            9869 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens drebrin like (DBNL), transcript variant 2, mRNA.
ACCESSION   NM_001014436
VERSION     NM_001014436.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9869)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 9869)
  AUTHORS   Ghosh,A., Enderlein,J. and Butkevich,E.
  TITLE     Dimerization of Human Drebrin-like Protein Governs Its Biological
            Activity
  JOURNAL   Biochemistry 59 (16), 1553-1558 (2020)
   PUBMED   32282191
  REMARK    GeneRIF: Dimerization of Human Drebrin-like Protein Governs Its
            Biological Activity.
REFERENCE   3  (bases 1 to 9869)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 9869)
  AUTHORS   Boateng,L.R., Bennin,D., De Oliveira,S. and Huttenlocher,A.
  TITLE     Mammalian Actin-binding Protein-1/Hip-55 Interacts with FHL2 and
            Negatively Regulates Cell Invasion
  JOURNAL   J Biol Chem 291 (27), 13987-13998 (2016)
   PUBMED   27129278
  REMARK    GeneRIF: findings show that mAbp1 and FHL2 are novel binding
            partners that differentially regulate Rho GTPase signaling and
            MTLn3 breast cancer cell invasion
REFERENCE   5  (bases 1 to 9869)
  AUTHORS   Coleman,K.M., Gudjonsson,J.E. and Stecher,M.
  TITLE     Open-Label Trial of MABp1, a True Human Monoclonal Antibody
            Targeting Interleukin 1alpha, for the Treatment of Psoriasis
  JOURNAL   JAMA Dermatol 151 (5), 555-556 (2015)
   PUBMED   25715176
  REMARK    GeneRIF: The results presented here indicate that targeting
            IL-1alpha with subcutaneous MABp1 adminisration has a strong
            potential therapeutic value in treating psoriasis and may provide a
            novel future treatment of this often devastating disease.
REFERENCE   6  (bases 1 to 9869)
  AUTHORS   Yamazaki,H., Takahashi,H., Aoki,T. and Shirao,T.
  TITLE     Molecular cloning and dendritic localization of rat SH3P7
  JOURNAL   Eur J Neurosci 14 (6), 998-1008 (2001)
   PUBMED   11595038
REFERENCE   7  (bases 1 to 9869)
  AUTHORS   Ensenat,D., Yao,Z., Wang,X.S., Kori,R., Zhou,G., Lee,S.C. and
            Tan,T.H.
  TITLE     A novel src homology 3 domain-containing adaptor protein, HIP-55,
            that interacts with hematopoietic progenitor kinase 1
  JOURNAL   J Biol Chem 274 (48), 33945-33950 (1999)
   PUBMED   10567356
  REMARK    Erratum:[J Biol Chem 2000 May 5;275(18):14004]
REFERENCE   8  (bases 1 to 9869)
  AUTHORS   Lee,C.G., Morse,H.C. 3rd, Kay,B.K. and Kozak,C.A.
  TITLE     Genetic mapping of eight SH3 domain genes on seven mouse
            chromosomes
  JOURNAL   Mamm Genome 10 (4), 402-404 (1999)
   PUBMED   10087302
REFERENCE   9  (bases 1 to 9869)
  AUTHORS   Larbolette,O., Wollscheid,B., Schweikert,J., Nielsen,P.J. and
            Wienands,J.
  TITLE     SH3P7 is a cytoskeleton adapter protein and is coupled to signal
            transduction from lymphocyte antigen receptors
  JOURNAL   Mol Cell Biol 19 (2), 1539-1546 (1999)
   PUBMED   9891087
REFERENCE   10 (bases 1 to 9869)
  AUTHORS   Gipson,I.K., Spurr-Michaud,S., Moccia,R., Zhan,Q., Toribara,N.,
            Ho,S.B., Gargiulo,A.R. and Hill,J.A. 3rd.
  TITLE     MUC4 and MUC5B transcripts are the prevalent mucin messenger
            ribonucleic acids of the human endocervix
  JOURNAL   Biol Reprod 60 (1), 58-64 (1999)
   PUBMED   9858486
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF077353.1, BC011677.2 and AC017116.7.
            
            On Jun 2, 2019 this sequence version replaced NM_001014436.2.
            
            Transcript Variant: This variant (2) uses two alternate in-frame
            splice sites compared to variant 3. The resulting isoform (b) has
            the same N- and C-termini but is shorter compared to isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2846193.1,
                                           SRR1803612.102836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448521.6/ ENSP00000411701.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1981              AF077353.1         3-1983
            1982-2129           BC011677.2         1970-2117
            2130-9869           AC017116.7         46525-54264
FEATURES             Location/Qualifiers
     source          1..9869
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..9869
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /note="drebrin like"
                     /db_xref="GeneID:28988"
                     /db_xref="HGNC:HGNC:2696"
                     /db_xref="MIM:610106"
     exon            1..119
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1329
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /note="isoform b is encoded by transcript variant 2; src
                     homology 3 domain-containing protein HIP-55; drebrin-like
                     protein; drebrin-F; cervical SH3P7; SH3 domain-containing
                     protein 7; cervical mucin-associated protein;
                     HPK1-interacting protein of 55 kDa; actin-binding protein
                     1"
                     /codon_start=1
                     /product="drebrin-like protein isoform b"
                     /protein_id="NP_001014436.1"
                     /db_xref="CCDS:CCDS34623.1"
                     /db_xref="GeneID:28988"
                     /db_xref="HGNC:HGNC:2696"
                     /db_xref="MIM:610106"
                     /translation="MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAG
                     TGEGGLEEMVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVS
                     TMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGS
                     VYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAA
                     RREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSP
                     QPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVY
                     EEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISF
                     DPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE"
     exon            120..175
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /inference="alignment:Splign:2.1.0"
     exon            176..288
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /inference="alignment:Splign:2.1.0"
     exon            289..363
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /inference="alignment:Splign:2.1.0"
     exon            364..510
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /inference="alignment:Splign:2.1.0"
     exon            511..588
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /inference="alignment:Splign:2.1.0"
     exon            589..740
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /inference="alignment:Splign:2.1.0"
     exon            741..789
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /inference="alignment:Splign:2.1.0"
     exon            790..871
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /inference="alignment:Splign:2.1.0"
     exon            872..967
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1083
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1189
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..9869
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2072
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /note="major polyA site"
     regulatory      2105..2110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /note="hexamer: AACAAA"
     polyA_site      2129
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /note="major polyA site"
     regulatory      9644..9649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
                     /note="hexamer: CATAAA"
     polyA_site      9666
                     /gene="DBNL"
                     /gene_synonym="ABP1; HIP-55; HIP55; SH3P7"
ORIGIN      
        1 agctacagca gcggcgcgga gactgcgggg cgggccatgg cggcgaacct gagccggaac
       61 gggccagcgc tgcaagaggc ctacgtgcgg gtggtcaccg agaagtcccc gaccgactgg
      121 gctctcttta cctatgaagg caacagcaat gacatccgcg tggctggcac aggggagggt
      181 ggcctggagg agatggtgga ggagctcaac agcgggaagg tgatgtacgc cttctgcaga
      241 gtgaaggacc ccaactctgg actgcccaaa tttgtcctca tcaactggac aggcgagggc
      301 gtgaacgatg tgcggaaggg agcctgtgcc agccacgtca gcaccatggc cagcttcctg
      361 aagggggccc atgtgaccat caacgcacgg gccgaggagg atgtggagcc tgagtgcatc
      421 atggagaagg tggccaaggc ttcaggtgcc aactacagct ttcacaagga gagtggccgc
      481 ttccaggacg tgggacccca ggccccagtg ggctctgtgt accagaagac caatgccgtg
      541 tctgagatta aaagggttgg taaagacagc ttctgggcca aagcagagaa ggaggaggag
      601 aaccgtcggc tggaggaaaa gcggcgggcc gaggaggcac agcggcagct ggagcaggag
      661 cgccgggagc gtgagctgcg tgaggctgca cgccgggagc agcgctatca ggagcagggt
      721 ggcgaggcca gcccccagag gacgtgggag cagcagcaag aagtggtttc aaggaaccga
      781 aatgagcagg agtctgccgt gcacccgagg gagattttca agcagaagga gagggccatg
      841 tccaccacct ccatctccag tcctcagcct ggcaagctga ggagcccctt cctgcagaag
      901 cagctcaccc aaccagagac ccactttggc agagagccag ctgctgccat ctcaaggccc
      961 agggcagatc tccctgctga ggagccggcg cccagcactc ctccatgtct ggtgcaggca
     1021 gaagaggagg ctgtgtatga ggaacctcca gagcaggaga ccttctacga gcagccccca
     1081 ctggtgcagc agcaaggtgc tggctctgag cacattgacc accacattca gggccagggg
     1141 ctcagtgggc aagggctctg tgcccgtgcc ctgtacgact accaggcagc cgacgacaca
     1201 gagatctcct ttgaccccga gaacctcatc acgggcatcg aggtgatcga cgaaggctgg
     1261 tggcgtggct atgggccgga tggccatttt ggcatgttcc ctgccaacta cgtggagctc
     1321 attgagtgag gctgagggca catcttgccc ttcccctctc agacatggct tccttattgc
     1381 tggaagagga ggcctgggag ttgacattca gcactcttcc aggaatagga cccccagtga
     1441 ggatgaggcc tcagggctcc ctccggcttg gcagactcag cctgtcaccc caaatgcagc
     1501 aatggcctgg tgattcccac acatccttcc tgcatccccc gaccctccca gacagcttgg
     1561 ctcttgcccc tgacaggata ctgagccaag ccctgcctgt ggccaagccc tgagtggcca
     1621 ctgccaagct gcggggaagg gtcctgagca ggggcatctg ggaggctctg gctgccttct
     1681 gcatttattt gccttttttc tttttctctt gcttctaagg ggtggtggcc accactgttt
     1741 agaatgaccc ttgggaacag tgaacgtaga gaattgtttt tagcagagtt tgtgaccaaa
     1801 gtcagagtgg atcatggtgg tttggcagca gggaatttgt cttgttggag cctgctctgt
     1861 gctccccact ccatttctct gtccctctgc ctgggctatg ggaagtgggg atgcagatgg
     1921 ccaagctccc accctgggta ttcaaaaacg gcagacacaa catgttcctc cacgcggctc
     1981 actcgatgcc tgcaggcccc agtgtgtgcc tcaactgatt ctgacttcag gaaaagtaac
     2041 acagagtggc cttggcctgt tgtcttcccc tattttctgt cccagctcat ccgtgtctct
     2101 gaagaacaaa tatgcttttg gaccacgaat tcccagtttg gtctacacag gctcgcagct
     2161 ctcacctgtc ctgctgtagc ctgaatgctc ccatgtggga atagcacccc accacctgcc
     2221 cagtgtctgc ctctgctccg tgtctggggt gagcaccctc accctgagac tgtggctgat
     2281 gatgatcagc caccaggaag aggctaaatg ttaagatggg actgaagttg gagccttcct
     2341 gcgttccagt tcctctagga gaggccaagg gctgccctgc tcccagcttc agggagcctc
     2401 tgcctacatg ggatggccca ctgtgtggcg tcaggtacct ggcacccact gagcatccgg
     2461 ggaattaggt ccctcctgtg ccccagagct gctaggcaga ctgctaggcg gttgactcaa
     2521 ggtgttacct gctagtgcct ggggtgaagg ctgcatggag cccaaccttg ctcctggcct
     2581 tcctgtgctc aggcctctcc ccttttcgcc agggcttcct ggtgcctctc ccatgaagag
     2641 ggaacttccc ctccactccc atggaagacc caggtttggg ctgttgccag ctttgaggcc
     2701 ccctgtgggc ttgcctgtcc caacccaaga ggcagggctc aaagtgccac ccgggggttg
     2761 caaggacagc agaggaccac ctgccctctg caggaagctg tccaggaagc cgtgtcctgg
     2821 gctgtggtcc ttgctcccca tggggagagc tgggtcactt ggcctcttct aactggcccc
     2881 aagcacgcca attctggagc atggttacta agtggctctg aagcttcagg gtcaccacag
     2941 gcttgtcctg actgcaaact catggagtgg ttgcagccct ggctcagtgt cctgatgact
     3001 aggtgtgggt actaggctcc tgcccctggt gacacacgta tggagtgggg gagggtgggt
     3061 ggctgcaccc ctggttctgg agtccccaca gctgatggcg gtgtgagcct ggcatgcacg
     3121 gctgcgctgg actccaggct gttgggggag gtgcctttat tgcccaagcc cacccctcac
     3181 ttggccttgc cctgggcagc cacagcctcc atggccttcc gcaccgtttc ctcatcaccc
     3241 aggaactgca tgggcttggt gggcttcagc tccttgttca gctcatacac aatggggatc
     3301 cccgtgggca ggttcagctc catgatcgcc tggtctgaca tccctatgcc ggaaggaata
     3361 ggtgtcctta gcccctctgt ccccagcctg tttacacagc agacactatg tgacctttat
     3421 ggtccacaga gccagttccc ctggcaccaa ttccttccca gccctgagaa cgaggccaca
     3481 gaaatgttgc caaaggtcaa ggagtaactg agttagacca agcagcctac agaaatagcc
     3541 cagtggtgaa aaaaatgggg acttcagccc cacccaagtg gctgtgatct gtggtggtgc
     3601 tgtccatagt tccctcagcc cagtgtgact ccagccagac tgaagttgag ggtcaggaag
     3661 ggacactcac cctttgtttt ttttttttct tttctttttc tttttctttt ttttgagatg
     3721 gagttttact cctcttgccc aggctggagt gcagtggcac gatcttggct cactgcaacc
     3781 tccatctcct gggttgaagt gattctgcct cagcctccca agtagctggg attacaggtg
     3841 agcgccacca cacccggcta attttgtatt tttagtagaa acgggtttta ccatgttggt
     3901 caggctggtc tcaaactcct gacctcaggt gatctgcctg cctcagcctc ccaaagtgct
     3961 gggattacag gagtgagcca ccgtgcccag caccctttgg tttctaaagt gctctaaatt
     4021 ctagacatcc tgaacagagg agcaagtgcg gaatggagct ggaggaggga cagggaggcc
     4081 gagcctggtc gaaacctgac cctgcctgcc tcctgcagcc cctgagctgg gaatagcagc
     4141 tcgacctttg atgttcgcgc cactccaccc ctgctccgtg caggagggtt taagaaaatg
     4201 ttctctgggg agtcagagtg aaatccctca tattcaccac caaaagtgcg tcccctttcc
     4261 ccaaaccagg ctgtgggagg gtcatggggc tgcatgaagt ctccggaagg gagaggaggc
     4321 aggtggtcct tccctctgcc tggccccagt gccaggtgcc aggtgtccgt gtttggagcg
     4381 ggcaggcttg gggctggctg ggtctccggg gcctgccggt ctgggtgctc tggccaactg
     4441 cccaacggcc ctaggagcag gaggtctggg gcacaccctt ctagcctttc caggactcaa
     4501 caagctttaa ggtcattcag atgctaattt agactgccct tgtgtcagaa tactaaggtg
     4561 ggaggcggag cggaggtgcc agtcactctg ggcgaggcct tactgcgccc atgcatcccg
     4621 ggcccatttg tcagcccttg ctcttcagtg ggagcccagc tgcaagccca gagtctggcc
     4681 actccatagt cctgcacccc tcttttgatt ggtctttcct ttgcccagag aggggctcca
     4741 gagggagata ggtggtgaag ctcatgcagg gattctgagg acctgatggg ggagggccct
     4801 gcgaggggtc caagcctaca tcaagaggaa ttcagtacca gggggagctc cccaccaccc
     4861 cggaaaaggg agaggcccag agatggaggt ggcttgtcca gggccccaca gtaagttggg
     4921 atttggagcc agatgctcta agcccagccc ttccgtttcc tagctgggtg tcccttggca
     4981 gatgccacct ttggagcctg ccccacctcg ggacacagcg agcttcgagt gcagtcagcc
     5041 cctgtggagt gtgtcccagt tacacagaaa tggggaaaat ttcacaaaac taaaaaatgg
     5101 cttctcagcc ctcctttttc agtgaatgat gtggagcccc acgcctagaa agcctggtcc
     5161 atgggcgaga gactttgctg agatgagaag ccagctgggg ctgctgccca cccaccctgc
     5221 ccaggctcct gaaggtggcc tcaccttcca ggtgcttgac aatgccccgc aggctgttcc
     5281 cgtgggctgc aatgagcact cgcttgccgg ccttgatctg gggaacaatc tcctcgttcc
     5341 agaagggcag ggcccgggca atggtgtcct tgaggctctc gcaggtgggg agttccccgg
     5401 gcttcaggcc tgcgtaccga cgctcctggg ggacacaggc acgctgcttt ccctcccaag
     5461 ccagtgggcc cccacccgac tccccactct gcagcttccc agaggccttc ccagcaaagg
     5521 cagcccacct tgctaatgga gttgtagtag gggtgcttct cgtccatcgg gggcggcggg
     5581 atgtcgaagg agcgcctcca gatcttcacc tgctcctccc cgtgcttggc ggccgtttct
     5641 gccttgttga ggcctgtgag gcccccgtaa tgccgctcat tgaggcgcca agtgcgcacc
     5701 acaggcagcc acatctggtc cgtgccgtcc aggatggccc agagggtgcg gatggcccgc
     5761 ttcagcactg acgtgtagca gatgtcaaac tccatcttgg catccttgat ggccttggct
     5821 ccccgcttgg cctcctcggt ccccttttca ctcagctctg catcgaacca gccacagaaa
     5881 cggttctcct ggttccatgt gctctcgccg tgccggacca tcacgaggcg gtgagtggcc
     5941 atggtggcag cagggaccac agaggactct ggacggggac ggctgcttcc caacactccc
     6001 agctttataa tagtgtcttc ccagccccca cccaccccag ccaactgcca atcagcattc
     6061 caggcggtgg caggtgacca gtagctgagc tgctgggggc tgggggccag gggagtgtgc
     6121 aggccaagag gctgtgctta aaatagcccc acgcatccac cagctcctgg cctgggttca
     6181 ggtggcatgt ctataaccag ctggcaccca gagcccagac tgagtggggc tgctggtcag
     6241 ggatgggcgt gaagggcaga agtctgggcc aggggagatg gggatagcag ggacagaggg
     6301 gctctccagg gcaacgctca gtggcctatc agccattctc tgctcagaca gaggcacaaa
     6361 caaaatccca acccctttct cctgtgattg gcagccaggc taggaggcgg ccctcagcag
     6421 gcagaggagg agagccagag gagctggtgc agaccacagc tttgtggaga ggagtctggc
     6481 cttgtggaag gtaccaggca gcagcagcag aatgggcaag ggctggggct gagccgggtt
     6541 tccaggacaa agggggaaag ggcccctgtc tttcctccgg ggtccctttg tcaaggtctc
     6601 atccatacat gccccatgct cccaccctat ctgccctcac ccaagccacg ctcactctcc
     6661 tagccgaaac caccttgaaa aagagaaatc caagggggtt tgggggcagg actgaggact
     6721 gtcagaagtc ttgattgtta ggtaaatgct cagcttagca ggaacccaca acgtaggctg
     6781 aagggtggca cggagttgag tctaggacca agacttctgc attcaggttt gggggatgag
     6841 agccaccaag gcagggaaga gactatgagc aataaagtca caattggggc cctaatgaag
     6901 gggccatggc cagacccttg ggcatgggcc ccatccaggg cctcccattt cctcccaccc
     6961 cagtgaccac actgtcacct gcgacacttc tgataacagg agcgggtagg tgagaggcca
     7021 gcagagggac caccactctg agacttggat ctgagtgtgc aagaaaccct cgacaggcct
     7081 ccctccatcc ctgctggcct acctggggag gggctcctgg cttggggcct gtgaagctaa
     7141 ggctctgtac ccaaaggttg gcagacaagt cccagtgggc aaagtcctgt cggctgccag
     7201 gacccccaag gctggcaggt ggaacccatc cctcctagca gtgccatgcg caggtctcac
     7261 tgttccacac tgatcctgat tgaagccaca tctcctcatc tgcttttgtc cctttgacca
     7321 agagttgatt cactagccca actaaacatg actgaggacc aggctctggc agtcccacag
     7381 gggccagaca tgaagcccat atttcagtgg aggagggatc gtaccagcag ctaaacatgc
     7441 ctaccgtaga tagcaccaga tgctaggaag gaaggaccat aatgtactgg gagagatggg
     7501 aaaggagagg ccggggacag ccctgaggtg acatgtgagt ggaaagagcg gagtgcaaag
     7561 gcctcagcta tgatgagtcc tacagggaga gcaattcagg tagaggggtt ggcaaagacc
     7621 caagccctac agaaagcaaa caagctgggg cagcgaccat caggggcaca tggcagagag
     7681 gtgggctttg tgtcccaaca cagtgggaat cactggagac tttgaagcat ggtcatattt
     7741 tcaagtcact tgcagctgtg taggagtgga agtagaagct gagtaccctg caggtctcgg
     7801 cagctttgat gagaacaagg ccgcttagcc agggctgggt gcagaagcag tggcaaggat
     7861 cccccagacc tgggagacct cactgccaac caagcaggag gtgtcaaaaa ggaaagggga
     7921 gcccaaagaa gggctggact tcggggaagc aagcccctgc ttctgaccct tggctccggc
     7981 ttgactttcc tttgattcat ttgacaagta gttgctggcc tctgcagtgt gccagagctt
     8041 tcttggaggg gtacaggggt aggaaaacca aaagccaccc tcagggcctc catccaggaa
     8101 ggcatagcat ggtgggcggc gaggaaggct gctgagtcaa caaggtggtc ccaggaaggt
     8161 ggagggagca tcttcccatg tctctcccac tgacagccac caatcctgga cagatgcagg
     8221 agcagctgtc agtagacaga taagaaaagg agatcagatt caaagttccg cagagaagtg
     8281 gtgaggtaac aagtattgcc tagcctggac acacaggcgg cttgaaacct caagtgcacc
     8341 aacagaaaga gctccaggaa gaatcagagg agtgggatgt gaagcccctc gaagtcagtg
     8401 agttggggga atccctccaa tttttctttt cttctctacc ccagctcctg ggcagtaaca
     8461 tggaggtggc agtggtggca cagtgacggt agtgtgagct gggtacgcac ttgaaacctg
     8521 agagggtaac gctaccctct gtctagagga gccatggccc caaaagcatg gggcaaccac
     8581 cttctgcagc tcctttctgc ccccctgcgc tgggccctgg atgcagtttc agggagtatg
     8641 cagcagggta ggtagggaaa gagccccaga tttgtggctg gaggtcttgg tagggatgtt
     8701 gcagggagct gttgtgtttc agggagagta cagagaaggg agagatgaag tgagtgatcc
     8761 gataaagtga tatgtgaagt cattggcttg ctgccaagct gcgcacaggg ctgaccctag
     8821 atgcacattg caggtcccag actgaccggt gtagatacag gactaatatg actagtagtg
     8881 caaacacttt aaacagtcaa cattctgctt aggatttaaa caaggtccag agtctcaaca
     8941 taatatttaa aatatccagg ttatccaaaa taacccagtg tatgaaaacc aggaaaatct
     9001 taacatggga gaaaagaaga tgatcaatac atgcccatcc tgagatgatt caactattgg
     9061 aatgatcaga tacagacttc aaagcagcta tttataacca gccttcagaa agtattggtg
     9121 aatattctta aacagaatgg aaatgacaaa gcatggagtc cataaattag atgatagttt
     9181 ggaaaaagat ataaacttac aaaccaagaa gctcagtgaa ccacacaact ggataaatta
     9241 acaacaaaag tccaagctta gacacatcat aaagaaactt ctgaaaacta aagaccaaga
     9301 aaaataagat cagccagaga aaaacgatac atttcattca ggtgaacaat tctttgaaag
     9361 actggatctt caccagaaac tatagaggcc agaaagaagt ggaacatttt tagttttgaa
     9421 ataactgtca cccaagaatt ctatatccag taaaaatttc tattttactg gaataaaaga
     9481 atgaaataaa gacattctca aatgaaggca agctgaggaa attcataacc aaagaatctg
     9541 ctttaaaaaa atgttaaacc aagttcttca gacagaagag attactgggg gcaattcaaa
     9601 actttgggaa tgcaggaaga acatcataaa tggcaaaagt ccacataaat atgaaactat
     9661 tctttacttc tttaagagtt atgtgatggt tgaattaagt catgatactg tctgatggag
     9721 gcttcagtgt atacagatgt aagacaacta gaacatgagg ggagaagggt gaagggacct
     9781 agatggtagt gaggtttcta catgctactt gaaatggcaa aacattaatc taaattgact
     9841 gtaagagtat gtgtatttgg ccgggcagg
//
