LOCUS       NM_001048225            1132 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens dysbindin domain containing 2 (DBNDD2), transcript
            variant 5, mRNA.
ACCESSION   NM_001048225
VERSION     NM_001048225.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1132)
  AUTHORS   Elsholz,L., Wasser,Y., Ziegler,P., Habib,P. and Voigt,A.
  TITLE     CK1BP Reduces alpha-Synuclein Oligomerization and Aggregation
            Independent of Serine 129 Phosphorylation
  JOURNAL   Cells 10 (11), 2830 (2021)
   PUBMED   34831053
  REMARK    GeneRIF: CK1BP Reduces alpha-Synuclein Oligomerization and
            Aggregation Independent of Serine 129 Phosphorylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1132)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   3  (bases 1 to 1132)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   4  (bases 1 to 1132)
  AUTHORS   Yin,H., Laguna,K.A., Li,G. and Kuret,J.
  TITLE     Dysbindin structural homologue CK1BP is an isoform-selective
            binding partner of human casein kinase-1
  JOURNAL   Biochemistry 45 (16), 5297-5308 (2006)
   PUBMED   16618118
  REMARK    GeneRIF: CK1BP is an isoform-selective binding partner of human
            casein kinase-1
REFERENCE   5  (bases 1 to 1132)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 1132)
  AUTHORS   Lucas,T., Pratscher,B., Fink,D., Wolschek,M., Samorapoompichit,P.,
            Schofer,C., Pehamberger,H., Muller,M., Sorensen,P. and Jansen,B.
  TITLE     The human orthologue of a novel apoptosis response gene induced
            during rat myelomonocytic stem cell apoptosis maps to 20q13.12
  JOURNAL   Stem Cells Dev 14 (5), 556-563 (2005)
   PUBMED   16305340
REFERENCE   7  (bases 1 to 1132)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL021578.4, AY113697.1 and BC023562.2.
            
            On May 20, 2020 this sequence version replaced NM_001048225.3.
            
            Transcript Variant: This variant (5) differs in the 5' UTR and 5'
            coding region, and uses an alternate start codon, compared to
            variant 1. The encoded isoform (c) has a distinct and longer
            N-terminus, compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX384644.2, BG706414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372710.5/ ENSP00000361795.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AL021578.4         119559-119606
            49-456              AY113697.1         1-408
            457-459             BC023562.2         635-637
            460-1130            AY113697.1         412-1082
            1131-1132           AL021578.4         121876-121877
FEATURES             Location/Qualifiers
     source          1..1132
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..1132
                     /gene="DBNDD2"
                     /gene_synonym="C20orf35; CK1BP; HSMNP1"
                     /note="dysbindin domain containing 2"
                     /db_xref="GeneID:55861"
                     /db_xref="HGNC:HGNC:15881"
                     /db_xref="MIM:611453"
     exon            1..318
                     /gene="DBNDD2"
                     /gene_synonym="C20orf35; CK1BP; HSMNP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..665
                     /gene="DBNDD2"
                     /gene_synonym="C20orf35; CK1BP; HSMNP1"
                     /note="isoform a is encoded by transcript variant 5; SCF
                     apoptosis response protein 1; casein kinase-1 binding
                     protein; dysbindin (dystrobrevin binding protein 1) domain
                     containing 2"
                     /codon_start=1
                     /product="dysbindin domain-containing protein 2 isoform a"
                     /protein_id="NP_001041690.3"
                     /db_xref="CCDS:CCDS42880.1"
                     /db_xref="GeneID:55861"
                     /db_xref="HGNC:HGNC:15881"
                     /db_xref="MIM:611453"
                     /translation="MDPNPRAALERQQLRLRERQKFFEDILQPETEFVFPLSHLHLES
                     QRPPIGSISSMEVNVDTLEQVELIDLGDPDAADVFLPCEDPPPTPQSSGMDNHLEELS
                     LPVPTSDRTTSRTSSSSSSDSSTNLHSPNPSDDGADTPLAQSDEEEERGDGGAEPGAC
                     S"
     exon            319..456
                     /gene="DBNDD2"
                     /gene_synonym="C20orf35; CK1BP; HSMNP1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..1132
                     /gene="DBNDD2"
                     /gene_synonym="C20orf35; CK1BP; HSMNP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1109..1114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DBNDD2"
                     /gene_synonym="C20orf35; CK1BP; HSMNP1"
                     /note="hexamer: AATAAA"
     polyA_site      1132
                     /gene="DBNDD2"
                     /gene_synonym="C20orf35; CK1BP; HSMNP1"
                     /note="major polyA site"
ORIGIN      
        1 acacttggtt tcagggaagg ggaaagaggt caccaagggc agaggtgtcc aggccggagc
       61 caggggcccc actgttggga tgctggctgc agtggggcgc cccaagccca ggtcccctct
      121 gtcttctctt tcgactttgc agctgtactt gttttgctcc tctacccgca ggagctgaca
      181 tggacccaaa tcctcgggcc gccctggagc gccagcagct ccgccttcgg gagcggcaaa
      241 aattcttcga ggacatttta cagccagaga cagagtttgt ctttcctctg tcccatctgc
      301 atctcgagtc gcagagaccc cccataggta gtatctcatc catggaagtg aatgtggaca
      361 cactggagca agtagaactt attgaccttg gggacccgga tgcagcagat gtgttcttgc
      421 cttgcgaaga tcctccacca accccccagt cgtctgggat ggacaaccat ttggaggagc
      481 tgagcctgcc ggtgcctaca tcagacagga ccacatctag gacctcctcc tcctcctcct
      541 ccgactcctc caccaacctg catagcccaa atccaagtga tgatggagca gatacgccct
      601 tggcacagtc ggatgaagag gaggaaaggg gtgatggagg ggcagagcct ggagcctgca
      661 gctagcagtg ggcccctgcc tacagactga ccacgctggc tattctccac atgagaccac
      721 aggcccagcc agagcctgtc gggagaagac cagactcttt acttgcagta ggcaccagag
      781 gtgggaagga tggtgggatt gtgtaccttt ctaagaatta accctctcct gctttactgc
      841 taattttttc ctgctgcaac cctcccacca gtttttggct tactcctgag atatgatttg
      901 caaatgagga gagagaagat gaggttggac aagatgccac tgcttttctt agcactcttc
      961 cctcccctaa accatcccgt agtcttctaa tacagtctct cagacaagtg tctctagatg
     1021 gatgtgaact ccttaactca tcaagtaagg tggtactcaa gccatgctgc ctccttacat
     1081 cctttttgga acagagcacg gtataaataa taaactaata ataatatgcc aa
//
