LOCUS       NM_001042610            2056 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens dysbindin domain containing 1 (DBNDD1), transcript
            variant 1, mRNA.
ACCESSION   NM_001042610
VERSION     NM_001042610.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2056)
  AUTHORS   Wiedemann,C., Obika,K.B., Liebscher,S., Jirschitzka,J.,
            Ohlenschlager,O. and Bordusa,F.
  TITLE     Backbone and side chain resonance assignment of the intrinsically
            disordered human DBNDD1 protein
  JOURNAL   Biomol NMR Assign 16 (2), 237-246 (2022)
   PUBMED   35474152
  REMARK    GeneRIF: Backbone and side chain resonance assignment of the
            intrinsically disordered human DBNDD1 protein.
REFERENCE   2  (bases 1 to 2056)
  AUTHORS   Nan,H., Kraft,P., Qureshi,A.A., Guo,Q., Chen,C., Hankinson,S.E.,
            Hu,F.B., Thomas,G., Hoover,R.N., Chanock,S., Hunter,D.J. and Han,J.
  TITLE     Genome-wide association study of tanning phenotype in a population
            of European ancestry
  JOURNAL   J Invest Dermatol 129 (9), 2250-2257 (2009)
   PUBMED   19340012
REFERENCE   3  (bases 1 to 2056)
  AUTHORS   Locke,M., Tinsley,C.L., Benson,M.A. and Blake,D.J.
  TITLE     TRIM32 is an E3 ubiquitin ligase for dysbindin
  JOURNAL   Hum Mol Genet 18 (13), 2344-2358 (2009)
   PUBMED   19349376
  REMARK    GeneRIF: TRIM32 is a widely expressed ubiquitin ligase and binds
            and ubiquitinates dysbindin.
REFERENCE   4  (bases 1 to 2056)
  AUTHORS   Luciano,M., Miyajima,F., Lind,P.A., Bates,T.C., Horan,M.,
            Harris,S.E., Wright,M.J., Ollier,W.E., Hayward,C., Pendleton,N.,
            Gow,A.J., Visscher,P.M., Starr,J.M., Deary,I.J., Martin,N.G. and
            Payton,A.
  TITLE     Variation in the dysbindin gene and normal cognitive function in
            three independent population samples
  JOURNAL   Genes Brain Behav 8 (2), 218-227 (2009)
   PUBMED   19077176
  REMARK    GeneRIF: Our results therefore support involvement of the dysbindin
            gene in cognitive function
REFERENCE   5  (bases 1 to 2056)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY166977.1, AK022644.1 and BC000700.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001042610.2.
            
            Transcript Variant: This variant (1) differs in its 5' UTR and
            initiates translation at an alternate start codon, compared to
            variant 4. The encoded isoform (1) has  a shorter and distinct
            N-terminus, compared to isoform 4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.728627.1,
                                           SRR1803616.163482.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000002501.11/ ENSP00000002501.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                HY166977.1         81-157
            78-190              AK022644.1         3-115
            191-2056            BC000700.2         210-2075
FEATURES             Location/Qualifiers
     source          1..2056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..2056
                     /gene="DBNDD1"
                     /note="dysbindin domain containing 1"
                     /db_xref="GeneID:79007"
                     /db_xref="HGNC:HGNC:28455"
                     /db_xref="MIM:620388"
     exon            1..146
                     /gene="DBNDD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..592
                     /gene="DBNDD1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dysbindin domain-containing protein 1; dysbindin
                     (dystrobrevin binding protein 1) domain containing 1"
                     /codon_start=1
                     /product="dysbindin domain-containing protein 1 isoform 1"
                     /protein_id="NP_001036075.1"
                     /db_xref="CCDS:CCDS42223.1"
                     /db_xref="GeneID:79007"
                     /db_xref="HGNC:HGNC:28455"
                     /db_xref="MIM:620388"
                     /translation="MEPPEGAGTGEIVKEAEVPQAALGVPAQGTGDNGHTPVEEEVGG
                     IPVPAPGLLQVTERRQPLSSVSSLEVHFDLLDLTELTDMSDQELAEVFADSDDENLNT
                     ESPAGLHPLPRAGYLRSPSWTRTRAEQSHEKQPLGDPERQATVLDTFLTVERPQED"
     exon            147..293
                     /gene="DBNDD1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..434
                     /gene="DBNDD1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..2056
                     /gene="DBNDD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2032..2037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DBNDD1"
                     /note="hexamer: ATTAAA"
     polyA_site      2056
                     /gene="DBNDD1"
                     /note="major polyA site"
ORIGIN      
        1 gctgccccga tgcgctgcgc ccggagccgg ggccgagtcg ctgccgcagc tgttggggcg
       61 cccgggccag gcgacgccgc cgtcgcccgt gcccctccca gaccgcaccg gccgcatgga
      121 gcccccggag ggcgccggca ccggagagat cgttaaggag gctgaggtgc cgcaggctgc
      181 gctgggcgtc ccagcccagg ggacagggga caatggccac acgcctgtgg aggaggaggt
      241 cgggggcatc ccagtaccag caccggggct cctgcaggtc acggagagga ggcagcctct
      301 gagcagcgtc tcctctctgg aggtccactt cgacctcctg gacctcactg agctcaccga
      361 catgtcggac caggagctgg ccgaggtctt tgctgactcg gacgacgaga acctcaacac
      421 cgagtcccca gcaggtctgc acccgctgcc ccgggccggc tacctgcgct ccccttcctg
      481 gacgaggaca agggctgagc agagccacga gaagcagccc ctaggcgacc ccgagcggca
      541 ggccacagtc ctggacacgt ttctcactgt ggagaggccc caggaggact agaccatctc
      601 cacctgcccc agctcctgca gggatggggt ccgaacacga tggcagatct gggcagtgct
      661 gacccagcag acacacttca cccgcccacg aggctccagc cgtcacctcc tgacacacac
      721 cctgggggca gctctctgcc agccccgaga ccggccttgt ctgctgggca cgggtcttcg
      781 cctcacttgg agaccagccg gctttcctgg gggacacacg gggcccccgg atgcctctgg
      841 gagccccagc acaagcacag cccagtggcc ttacgtccag ctcgttcctg ggccccgagt
      901 caggaagaca gcgtcacgga gtcactgcca ggaacgtgct gaggaatgga gtggcccacg
      961 gcggccttgg ggtgaagggg acccaggcct gtgacagcca ctccaggaac tcctgggggt
     1021 gctccaacct ccgcgttttc ctgtgctgcc aagctcagaa gccagaggcg ggtttggtag
     1081 tggctaatgg gacaatgtgc tgtccagcaa agcacacatg gagaagcggc cccaaaattc
     1141 ccaccttgat ttccatcctg ccccttcttc tactccacgg aggcgctgtc tcactagggt
     1201 cccctcccca aggctcagct ctaagacctg cacctgcttc tcttggcccc tgcgtgacag
     1261 acaagtccat tccctcctta gctcagaaca ccaaatatca ccagactgcc taagagactt
     1321 gatgacacct cccggaatgc tctcggggtg gggttcacct ctccttgtcc tgcacccact
     1381 gctaggccac attctcgttt ctgctcacat cccattgccc ggctacaagg cctgcccacg
     1441 gcccttaaac ttgctgggca ggtttggagc ccatgggacc ccgtgggtct ctgtccagga
     1501 gcagcagagg aggctgacag gccctgctcc ctctgctctg ggggtgtctg ggagccccag
     1561 ctcacaccct cccaatgctt atatgctgaa gctcacagaa tgggcttctt gcctgacagc
     1621 aagtcaaaga atgagtttaa tatcaaagtg taagcttact ttccatcccc aagccagcct
     1681 gccccctgcc ccatttccca tgagcacact tctggggaag gaaaacaggc tcctggcctt
     1741 cactctcagc agagctttgg agatgcccca ggcatgccct gagctccttc tgtgtacctg
     1801 ctcccacttc tgagccaccc gctgcccctc cgcactgctg gcaaacccag ttcctgcctc
     1861 agccaggtct ccttccctgg tttccagtca cacagagccc agcagctttc tctttcagtc
     1921 ccataagggc agccttgtgt ccctggccac acttccaccc gccagggtct tcctccccat
     1981 ctttccatcc ttcctgctga gcttccacag agctcgtttg caaacagggg gattaaagca
     2041 tcactgcgca ttcgaa
//
