LOCUS       NM_001363541            3024 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens drebrin 1 (DBN1), transcript variant 3, mRNA.
ACCESSION   NM_001363541 XM_005265827
VERSION     NM_001363541.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3024)
  AUTHORS   Hironaka,T., Takizawa,N., Yamauchi,Y., Horii,Y. and Nakaya,M.
  TITLE     The well-developed actin cytoskeleton and Cthrc1 expression by
            actin-binding protein drebrin in myofibroblasts promote cardiac and
            hepatic fibrosis
  JOURNAL   J Biol Chem 299 (3), 102934 (2023)
   PUBMED   36690273
  REMARK    GeneRIF: The well-developed actin cytoskeleton and Cthrc1
            expression by actin-binding protein drebrin in myofibroblasts
            promote cardiac and hepatic fibrosis.
REFERENCE   2  (bases 1 to 3024)
  AUTHORS   Yu,Q., Tang,F., Cao,F., Tan,X., Weng,L. and Sun,L.
  TITLE     Drebrin promotes lung adenocarcinoma cell migration through
            inducing integrin beta1 endocytosis
  JOURNAL   Biochem Biophys Res Commun 630, 175-182 (2022)
   PUBMED   36155064
  REMARK    GeneRIF: Drebrin promotes lung adenocarcinoma cell migration
            through inducing integrin beta1 endocytosis.
REFERENCE   3  (bases 1 to 3024)
  AUTHORS   Dias,K.R., Carlston,C.M., Blok,L.E.R., De Hayr,L., Nawaz,U.,
            Evans,C.A., Bayrak-Toydemir,P., Htun,S., Zhu,Y., Ma,A., Lynch,S.A.,
            Moorwood,C., Stals,K., Ellard,S., Bainbridge,M.N., Friedman,J.,
            Pappas,J.G., Rabin,R., Nowak,C.B., Douglas,J., Wilson,T.E., Guillen
            Sacoto,M.J., Mullegama,S.V., Palculict,T.B., Kirk,E.P.,
            Pinner,J.R., Edwards,M., Montanari,F., Graziano,C., Pippucci,T.,
            Dingmann,B., Glass,I., Mefford,H.C., Shimoji,T., Suzuki,T.,
            Yamakawa,K., Streff,H., Schaaf,C.P., Slavotinek,A.M., Voineagu,I.,
            Carey,J.C., Buckley,M.F., Schenck,A., Harvey,R.J. and Roscioli,T.
  TITLE     De Novo ZMYND8 variants result in an autosomal dominant
            neurodevelopmental disorder with cardiac malformations
  JOURNAL   Genet Med 24 (9), 1952-1966 (2022)
   PUBMED   35916866
REFERENCE   4  (bases 1 to 3024)
  AUTHORS   Grintsevich,E.E.
  TITLE     Effects of neuronal drebrin on actin dynamics
  JOURNAL   Biochem Soc Trans 49 (2), 685-692 (2021)
   PUBMED   33739391
  REMARK    GeneRIF: Effects of neuronal drebrin on actin dynamics.
            Review article
REFERENCE   5  (bases 1 to 3024)
  AUTHORS   Maki,H., Yoshimi,A., Shimada,T., Arai,S., Morita,K., Kamikubo,Y.,
            Ikegawa,M. and Kurokawa,M.
  TITLE     Physical interaction between BAALC and DBN1 induces chemoresistance
            in leukemia
  JOURNAL   Exp Hematol 94, 31-36 (2021)
   PUBMED   33453340
  REMARK    GeneRIF: Physical interaction between BAALC and DBN1 induces
            chemoresistance in leukemia.
REFERENCE   6  (bases 1 to 3024)
  AUTHORS   Hayashi,K., Ishikawa,R., Kawai-Hirai,R., Takagi,T., Taketomi,A. and
            Shirao,T.
  TITLE     Domain analysis of the actin-binding and actin-remodeling
            activities of drebrin
  JOURNAL   Exp Cell Res 253 (2), 673-680 (1999)
   PUBMED   10585290
REFERENCE   7  (bases 1 to 3024)
  AUTHORS   Mammoto,A., Sasaki,T., Asakura,T., Hotta,I., Imamura,H.,
            Takahashi,K., Matsuura,Y., Shirao,T. and Takai,Y.
  TITLE     Interactions of drebrin and gephyrin with profilin
  JOURNAL   Biochem Biophys Res Commun 243 (1), 86-89 (1998)
   PUBMED   9473484
REFERENCE   8  (bases 1 to 3024)
  AUTHORS   Harigaya,Y., Shoji,M., Shirao,T. and Hirai,S.
  TITLE     Disappearance of actin-binding protein, drebrin, from hippocampal
            synapses in Alzheimer's disease
  JOURNAL   J Neurosci Res 43 (1), 87-92 (1996)
   PUBMED   8838578
REFERENCE   9  (bases 1 to 3024)
  AUTHORS   Shirao,T.
  TITLE     The roles of microfilament-associated proteins, drebrins, in brain
            morphogenesis: a review
  JOURNAL   J Biochem 117 (2), 231-236 (1995)
   PUBMED   7608104
  REMARK    Review article
REFERENCE   10 (bases 1 to 3024)
  AUTHORS   Toda,M., Shirao,T., Minoshima,S., Shimizu,N., Toya,S. and
            Uyemura,K.
  TITLE     Molecular cloning of cDNA encoding human drebrin E and chromosomal
            mapping of its gene
  JOURNAL   Biochem Biophys Res Commun 196 (1), 468-472 (1993)
   PUBMED   8216329
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC145098.2.
            
            On May 21, 2020 this sequence version replaced NM_001363541.1.
            
            Summary: The protein encoded by this gene is a cytoplasmic
            actin-binding protein thought to play a role in the process of
            neuronal growth. It is a member of the drebrin family of proteins
            that are developmentally regulated in the brain. A decrease in the
            amount of this protein in the brain has been implicated as a
            possible contributing factor in the pathogenesis of memory
            disturbance in Alzheimer's disease. At least two alternative splice
            variants encoding different protein isoforms have been described
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) contains an alternate in-frame
            exon compared to variant 1. The resulting isoform (c) has the same
            N- and C-termini and is longer compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: LC369599.1, SRR11853567.25116.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393565.6/ ENSP00000377195.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               AC145098.2         110616-110814       c
            200-255             AC145098.2         106024-106079       c
            256-368             AC145098.2         105288-105400       c
            369-443             AC145098.2         104923-104997       c
            444-590             AC145098.2         104661-104807       c
            591-668             AC145098.2         104435-104512       c
            669-820             AC145098.2         104091-104242       c
            821-884             AC145098.2         103952-104015       c
            885-944             AC145098.2         97824-97883         c
            945-1068            AC145098.2         97612-97735         c
            1069-1206           AC145098.2         96783-96920         c
            1207-1377           AC145098.2         96278-96448         c
            1378-2027           AC145098.2         95238-95887         c
            2028-2130           AC145098.2         94835-94937         c
            2131-3024           AC145098.2         93790-94683         c
FEATURES             Location/Qualifiers
     source          1..3024
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..3024
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /note="drebrin 1"
                     /db_xref="GeneID:1627"
                     /db_xref="HGNC:HGNC:2695"
                     /db_xref="MIM:126660"
     exon            1..199
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2201
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /note="isoform c is encoded by transcript variant 3;
                     drebrin E2; developmentally-regulated brain protein;
                     drebrin A"
                     /codon_start=1
                     /product="drebrin isoform c"
                     /protein_id="NP_001350470.2"
                     /db_xref="CCDS:CCDS87354.1"
                     /db_xref="GeneID:1627"
                     /db_xref="HGNC:HGNC:2695"
                     /db_xref="MIM:126660"
                     /translation="MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLA
                     ASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHV
                     AKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVG
                     TTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQ
                     EERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEV
                     EEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGRPYCPFIKASDSGPS
                     SSSSSSSSPPRTPFPYITCHRTPNLSSSLPCSHLDSHRRMAPTPIPTRSPSDSSTAST
                     PVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEP
                     PQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADT
                     TVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPL
                     LPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPH
                     LLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDAD
                     PVPEEEEGFEGGD"
     exon            200..255
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     exon            256..368
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     exon            369..443
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     exon            444..590
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     exon            591..668
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     exon            669..820
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     exon            821..884
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     exon            885..944
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1068
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1206
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1377
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..2027
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2130
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..3024
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2677..2682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /note="hexamer: AATAAA"
     polyA_site      2714
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /note="major polyA site"
     regulatory      3003..3008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /note="hexamer: AATAAA"
     polyA_site      3024
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
ORIGIN      
        1 gcgacgctgc agaggctccg aggcggcggc ggcgactccc tctttccctc cctcctcctc
       61 cgtccgcccg tccgtccgcg cgtctgtccg ttcggcccgg tccggcccga agcatggccg
      121 gcgtcagctt cagcggccac cgcctggagc tgctggcggc ttacgaggag gtgatccgag
      181 aggagagcgc ggccgactgg gctctgtaca catatgaaga tggctccgat gacctcaagc
      241 ttgcagcatc aggagaaggg ggcttgcagg agctttcggg acactttgag aaccagaagg
      301 tgatgtacgg cttctgcagt gtcaaggact cccaagctgc tctgccaaaa tacgtgctca
      361 tcaactgggt gggcgaagat gtgcctgatg cccgcaagtg cgcttgtgcc agccacgtgg
      421 ctaaggtggc ggagttcttc cagggtgtcg acgtgatcgt gaacgccagc agcgtggaag
      481 acatagacgc gggtgccatc gggcagcggc tctctaacgg gctggcgcga ctctccagcc
      541 ctgtgctgca ccgactgcgg ctgcgagagg atgagaacgc agagcccgtg ggcaccacct
      601 accagaagac ggatgcagct gtggaaatga agcggattaa ccgagagcag ttctgggagc
      661 aggccaagaa ggaagaagag ctgcggaagg aggaggagcg gaagaaggcc ctggatgaga
      721 ggctcaggtt cgagcaggag cggatggagc aggagcggca ggagcaagag gagcgcgagc
      781 ggcgctaccg ggagcgggag cagcagatcg aggagcacag gaggaaacag cagactttag
      841 aagcggaaga ggccaagagg cggttgaagg agcagtctat ctttggtgac catcgggatg
      901 aggaggaaga gacccacatg aagaagtcag agtcggaggt ggaggaggca gcagctatta
      961 ttgcccagcg gcctgacaac ccaagggagt tcttcaagca gcaggaaaga gtcgcatcgg
     1021 cctctgcggg cagctgtgat gtaccctcgc ccttcaacca tcgaccaggt cgtccgtact
     1081 gccctttcat aaaggcatcg gacagtgggc cttcctcctc ctcctcttcc tcctcctccc
     1141 ctccacggac tccctttccc tatatcacct gccaccgcac cccaaacctc tcttcctccc
     1201 tcccatgcag ccacctggac agccaccgga ggatggcgcc cactcccatc cccacgcgga
     1261 gcccgtctga ctccagcacc gcctccaccc ctgtcgctga gcagatagag cgggccctgg
     1321 atgaggtcac ctcctcgcag cctccaccac tgccaccgcc acccccacca gcccaagaga
     1381 cccaggagcc cagccccatc ctagacagtg aggagaccag agcagcagcc cctcaggcct
     1441 gggccggccc catggaggag ccccctcagg cacaggcgcc tccccggggg ccaggcagcc
     1501 ctgcagagga cttgatgttc atggagtctg cagagcaggc tgtcctggct gctcccgtgg
     1561 agcctgccac agctgacgcc acggagatcc acgatgcagc tgacaccatt gaaactgaca
     1621 ctgccactgc tgacaccact gttgccaaca acgtaccccc cgccgccacc agcctcattg
     1681 acctatggcc tggcaacggg gaaggggcct ccacactcca gggtgagccc agggccccca
     1741 cgccaccctc gggtactgag gtcaccctgg cagaggtgcc cctgctggat gaggtggctc
     1801 cggagccact gctgccagca ggcgaaggct gtgccaccct tctcaacttt gatgagctgc
     1861 ctgagccgcc agccaccttc tgtgacccag aggaagtgga aggggagtcc ctggctgccc
     1921 cccagacccc aactctgccc tcagcccttg aggagctgga gcaagagcag gagccggagc
     1981 cccacctgct aaccaatggc gagaccaccc agaaggaggg gacccaggcc agtgaggggt
     2041 acttcagtca atcacaggag gaggagtttg cccaatcgga agagctctgt gccaaggctc
     2101 cgcctcctgt gttctacaac aagcctccag agatcgacat cacatgctgg gatgcagacc
     2161 cagttccaga agaggaggag ggcttcgagg gtggtgatta gcggtggcgc cagccctagg
     2221 ctacccttgc caaggccgcc cacctgcatc agcctctggc cagacggccc gccgtgcctg
     2281 cattcgcagc agctccgcct ggcacccact ccggattccg gccctggctg gggacttggc
     2341 cgcttcccta cccacagggc ctgactttta cagcttttct ctttttttaa aaagttgata
     2401 ggagacttgt acagttgact ggctttcctc tcgttggtag ttgagacgct gttgcaaatt
     2461 ccacccctcc ttccctggtc cagattgtag ctcttagtcc tccctgctca gctggccggg
     2521 ttggaggcct caccctgctt ggggcctggc gtggggggag ctctggtggg aaaatgtccc
     2581 ccacctcttt tcctagtttt atgtttcttg ggaaaatatc actttgtatt ctctgtccag
     2641 ggcttcagat attttgcacg aattttaaaa catggcaata aatggctcgt gggctctggc
     2701 tccctgggac cccctccccg cccttctttt gaccccttcc tgtctggccc aaaggaagta
     2761 gcaggcccag ctggggcccc tcggctaccc cccgtctcct gccgggcagg tcccaggttg
     2821 gaggccctag gcgcggttca ggtcagggct atggatgggg cccaggggct ttggtggccc
     2881 ctccccaact ccttcctctt tgcttgggtt cctttttcac gtttagtaac tgtttttttt
     2941 tttttttttt tttttttttt ggaaagcaca aacttctgta acgggtcgtg ctcatgtctg
     3001 ttaataaaga aatccagatc cctt
//
