LOCUS       NP_001350470             695 aa            linear   PRI 07-APR-2024
DEFINITION  drebrin isoform c [Homo sapiens].
ACCESSION   NP_001350470 XP_005265884
VERSION     NP_001350470.2
DBSOURCE    REFSEQ: accession NM_001363541.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 695)
  AUTHORS   Hironaka,T., Takizawa,N., Yamauchi,Y., Horii,Y. and Nakaya,M.
  TITLE     The well-developed actin cytoskeleton and Cthrc1 expression by
            actin-binding protein drebrin in myofibroblasts promote cardiac and
            hepatic fibrosis
  JOURNAL   J Biol Chem 299 (3), 102934 (2023)
   PUBMED   36690273
  REMARK    GeneRIF: The well-developed actin cytoskeleton and Cthrc1
            expression by actin-binding protein drebrin in myofibroblasts
            promote cardiac and hepatic fibrosis.
REFERENCE   2  (residues 1 to 695)
  AUTHORS   Yu,Q., Tang,F., Cao,F., Tan,X., Weng,L. and Sun,L.
  TITLE     Drebrin promotes lung adenocarcinoma cell migration through
            inducing integrin beta1 endocytosis
  JOURNAL   Biochem Biophys Res Commun 630, 175-182 (2022)
   PUBMED   36155064
  REMARK    GeneRIF: Drebrin promotes lung adenocarcinoma cell migration
            through inducing integrin beta1 endocytosis.
REFERENCE   3  (residues 1 to 695)
  AUTHORS   Dias,K.R., Carlston,C.M., Blok,L.E.R., De Hayr,L., Nawaz,U.,
            Evans,C.A., Bayrak-Toydemir,P., Htun,S., Zhu,Y., Ma,A., Lynch,S.A.,
            Moorwood,C., Stals,K., Ellard,S., Bainbridge,M.N., Friedman,J.,
            Pappas,J.G., Rabin,R., Nowak,C.B., Douglas,J., Wilson,T.E., Guillen
            Sacoto,M.J., Mullegama,S.V., Palculict,T.B., Kirk,E.P.,
            Pinner,J.R., Edwards,M., Montanari,F., Graziano,C., Pippucci,T.,
            Dingmann,B., Glass,I., Mefford,H.C., Shimoji,T., Suzuki,T.,
            Yamakawa,K., Streff,H., Schaaf,C.P., Slavotinek,A.M., Voineagu,I.,
            Carey,J.C., Buckley,M.F., Schenck,A., Harvey,R.J. and Roscioli,T.
  TITLE     De Novo ZMYND8 variants result in an autosomal dominant
            neurodevelopmental disorder with cardiac malformations
  JOURNAL   Genet Med 24 (9), 1952-1966 (2022)
   PUBMED   35916866
REFERENCE   4  (residues 1 to 695)
  AUTHORS   Grintsevich,E.E.
  TITLE     Effects of neuronal drebrin on actin dynamics
  JOURNAL   Biochem Soc Trans 49 (2), 685-692 (2021)
   PUBMED   33739391
  REMARK    GeneRIF: Effects of neuronal drebrin on actin dynamics.
            Review article
REFERENCE   5  (residues 1 to 695)
  AUTHORS   Maki,H., Yoshimi,A., Shimada,T., Arai,S., Morita,K., Kamikubo,Y.,
            Ikegawa,M. and Kurokawa,M.
  TITLE     Physical interaction between BAALC and DBN1 induces chemoresistance
            in leukemia
  JOURNAL   Exp Hematol 94, 31-36 (2021)
   PUBMED   33453340
  REMARK    GeneRIF: Physical interaction between BAALC and DBN1 induces
            chemoresistance in leukemia.
REFERENCE   6  (residues 1 to 695)
  AUTHORS   Hayashi,K., Ishikawa,R., Kawai-Hirai,R., Takagi,T., Taketomi,A. and
            Shirao,T.
  TITLE     Domain analysis of the actin-binding and actin-remodeling
            activities of drebrin
  JOURNAL   Exp Cell Res 253 (2), 673-680 (1999)
   PUBMED   10585290
REFERENCE   7  (residues 1 to 695)
  AUTHORS   Mammoto,A., Sasaki,T., Asakura,T., Hotta,I., Imamura,H.,
            Takahashi,K., Matsuura,Y., Shirao,T. and Takai,Y.
  TITLE     Interactions of drebrin and gephyrin with profilin
  JOURNAL   Biochem Biophys Res Commun 243 (1), 86-89 (1998)
   PUBMED   9473484
REFERENCE   8  (residues 1 to 695)
  AUTHORS   Harigaya,Y., Shoji,M., Shirao,T. and Hirai,S.
  TITLE     Disappearance of actin-binding protein, drebrin, from hippocampal
            synapses in Alzheimer's disease
  JOURNAL   J Neurosci Res 43 (1), 87-92 (1996)
   PUBMED   8838578
REFERENCE   9  (residues 1 to 695)
  AUTHORS   Shirao,T.
  TITLE     The roles of microfilament-associated proteins, drebrins, in brain
            morphogenesis: a review
  JOURNAL   J Biochem 117 (2), 231-236 (1995)
   PUBMED   7608104
  REMARK    Review article
REFERENCE   10 (residues 1 to 695)
  AUTHORS   Toda,M., Shirao,T., Minoshima,S., Shimizu,N., Toya,S. and
            Uyemura,K.
  TITLE     Molecular cloning of cDNA encoding human drebrin E and chromosomal
            mapping of its gene
  JOURNAL   Biochem Biophys Res Commun 196 (1), 468-472 (1993)
   PUBMED   8216329
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC145098.2.
            
            On May 21, 2020 this sequence version replaced NP_001350470.1.
            
            Summary: The protein encoded by this gene is a cytoplasmic
            actin-binding protein thought to play a role in the process of
            neuronal growth. It is a member of the drebrin family of proteins
            that are developmentally regulated in the brain. A decrease in the
            amount of this protein in the brain has been implicated as a
            possible contributing factor in the pathogenesis of memory
            disturbance in Alzheimer's disease. At least two alternative splice
            variants encoding different protein isoforms have been described
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) contains an alternate in-frame
            exon compared to variant 1. The resulting isoform (c) has the same
            N- and C-termini and is longer compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: LC369599.1, SRR11853567.25116.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393565.6/ ENSP00000377195.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..695
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     Protein         1..695
                     /product="drebrin isoform c"
                     /note="drebrin E2; developmentally-regulated brain
                     protein; drebrin A"
                     /calculated_mol_wt=76169
     Region          4..139
                     /region_name="ADF_drebrin_like"
                     /note="ADF homology domain of drebrin and actin-binding
                     protein 1 (abp1); cd11281"
                     /db_xref="CDD:200437"
     Site            order(79,93,120,123)
                     /site_type="other"
                     /note="putative F-actin interface [polypeptide binding]"
                     /db_xref="CDD:200437"
     Region          <277..606
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     CDS             1..695
                     /gene="DBN1"
                     /gene_synonym="D0S117E"
                     /coded_by="NM_001363541.2:114..2201"
                     /note="isoform c is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS87354.1"
                     /db_xref="GeneID:1627"
                     /db_xref="HGNC:HGNC:2695"
                     /db_xref="MIM:126660"
ORIGIN      
        1 magvsfsghr lellaayeev ireesaadwa lytyedgsdd lklaasgegg lqelsghfen
       61 qkvmygfcsv kdsqaalpky vlinwvgedv pdarkcacas hvakvaeffq gvdvivnass
      121 vedidagaig qrlsnglarl sspvlhrlrl redenaepvg ttyqktdaav emkrinreqf
      181 weqakkeeel rkeeerkkal derlrfeqer meqerqeqee rerryrereq qieehrrkqq
      241 tleaeeakrr lkeqsifgdh rdeeeethmk kseseveeaa aiiaqrpdnp reffkqqerv
      301 asasagscdv pspfnhrpgr pycpfikasd sgpsssssss sspprtpfpy itchrtpnls
      361 sslpcshlds hrrmaptpip trspsdssta stpvaeqier aldevtssqp pplppppppa
      421 qetqepspil dseetraaap qawagpmeep pqaqapprgp gspaedlmfm esaeqavlaa
      481 pvepatadat eihdaadtie tdtatadttv annvppaats lidlwpgnge gastlqgepr
      541 aptppsgtev tlaevpllde vapepllpag egcatllnfd elpeppatfc dpeevegesl
      601 aapqtptlps aleeleqeqe pephlltnge ttqkegtqas egyfsqsqee efaqseelca
      661 kapppvfynk ppeiditcwd adpvpeeeeg feggd
//
