LOCUS       NM_001079862             564 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens diazepam binding inhibitor, acyl-CoA binding protein
            (DBI), transcript variant 3, mRNA.
ACCESSION   NM_001079862
VERSION     NM_001079862.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 564)
  AUTHORS   Montegut,L., Liu,P., Zhao,L., Perez-Lanzon,M., Chen,H., Mao,M.,
            Zhang,S., Derosa,L., Naour,J.L., Lambertucci,F., Mingoia,S.,
            Nogueira-Recalde,U., Mena-Osuna,R., Herranz-Montoya,I., Djouder,N.,
            Baulande,S., Pan,H., Joseph,A., Messaoudene,M., Routy,B.,
            Fidelle,M., Ben Ahmed,T., Caron,O., Busson,P., Boulate,D.,
            Deschasaux-Tanguy,M., Arnault,N., Pol,J.G., Piaggio,E., Touvier,M.,
            Zitvogel,L., Delaloge,S., Martins,I. and Kroemer,G.
  TITLE     Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer
            diagnosis and an inhibitor of immunosurveillance
  JOURNAL   Mol Cancer 23 (1), 187 (2024)
   PUBMED   39242519
  REMARK    GeneRIF: Acyl-coenzyme a binding protein (ACBP) - a risk factor for
            cancer diagnosis and an inhibitor of immunosurveillance.
            Erratum:[Mol Cancer. 2024 Oct 17;23(1):231. doi:
            10.1186/s12943-024-02152-2.. PMID: 39420364]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 564)
  AUTHORS   Montegut,L., Abdellatif,M., Motino,O., Madeo,F., Martins,I.,
            Quesada,V., Lopez-Otin,C. and Kroemer,G.
  TITLE     Acyl coenzyme A binding protein (ACBP): An aging- and
            disease-relevant 'autophagy checkpoint'
  JOURNAL   Aging Cell 22 (9), e13910 (2023)
   PUBMED   37357988
  REMARK    GeneRIF: Acyl coenzyme A binding protein (ACBP): An aging- and
            disease-relevant 'autophagy checkpoint'.
            Review article
REFERENCE   3  (bases 1 to 564)
  AUTHORS   Duman,C., Di Marco,B., Nevedomskaya,E., Ulug,B., Lesche,R.,
            Christian,S. and Alfonso,J.
  TITLE     Targeting fatty acid oxidation via Acyl-CoA binding protein hinders
            glioblastoma invasion
  JOURNAL   Cell Death Dis 14 (4), 296 (2023)
   PUBMED   37120445
  REMARK    GeneRIF: Targeting fatty acid oxidation via Acyl-CoA binding
            protein hinders glioblastoma invasion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 564)
  AUTHORS   Piras,M., Gerosa,C., Fanni,D., Cau,F., Coni,P., Murru,R.,
            Denotti,G., Orru,G., Scano,A., Ledda,F., Van Eyken,P., Coghe,F.,
            Faa,G. and Castagnola,M.
  TITLE     Acyl-CoA binding protein (ACBP) is highly expressed in the
            developing human kidney
  JOURNAL   Eur Rev Med Pharmacol Sci 26 (9), 3301-3309 (2022)
   PUBMED   35587082
  REMARK    GeneRIF: Acyl-CoA binding protein (ACBP) is highly expressed in the
            developing human kidney.
REFERENCE   5  (bases 1 to 564)
  AUTHORS   Conti,E., Andreoni,S., Tomaselli,D., Storti,B., Brovelli,F.,
            Acampora,R., Da Re,F., Appollonio,I., Ferrarese,C. and
            Tremolizzo,L.
  TITLE     Serum DBI and biomarkers of neuroinflammation in Alzheimer's
            disease and delirium
  JOURNAL   Neurol Sci 42 (3), 1003-1007 (2021)
   PUBMED   32705487
  REMARK    GeneRIF: Serum DBI and biomarkers of neuroinflammation in
            Alzheimer's disease and delirium.
REFERENCE   6  (bases 1 to 564)
  AUTHORS   Nitz,I., Doring,F., Schrezenmeir,J. and Burwinkel,B.
  TITLE     Identification of new acyl-CoA binding protein transcripts in human
            and mouse
  JOURNAL   Int J Biochem Cell Biol 37 (11), 2395-2405 (2005)
   PUBMED   16055366
  REMARK    GeneRIF: Results identify new acyl-CoA binding protein transcripts
            in human and mouse tissues, generated by alternative first exon
            usage.
REFERENCE   7  (bases 1 to 564)
  AUTHORS   Todd,S. and Naylor,S.L.
  TITLE     New chromosomal mapping assignments for argininosuccinate
            synthetase pseudogene 1, interferon-beta 3 gene, and the diazepam
            binding inhibitor gene
  JOURNAL   Somat Cell Mol Genet 18 (4), 381-385 (1992)
   PUBMED   1440058
REFERENCE   8  (bases 1 to 564)
  AUTHORS   DeBernardi,M.A., Crowe,R.R., Mocchetti,I., Shows,T.B., Eddy,R.L.
            and Costa,E.
  TITLE     Chromosomal localization of the human diazepam binding inhibitor
            gene
  JOURNAL   Proc Natl Acad Sci U S A 85 (17), 6561-6565 (1988)
   PUBMED   3413112
REFERENCE   9  (bases 1 to 564)
  AUTHORS   Webb,N.R., Rose,T.M., Malik,N., Marquardt,H., Shoyab,M.,
            Todaro,G.J. and Lee,D.C.
  TITLE     Bovine and human cDNA sequences encoding a putative benzodiazepine
            receptor ligand
  JOURNAL   DNA 6 (1), 71-79 (1987)
   PUBMED   2881742
REFERENCE   10 (bases 1 to 564)
  AUTHORS   Gray,P.W., Glaister,D., Seeburg,P.H., Guidotti,A. and Costa,E.
  TITLE     Cloning and expression of cDNA for human diazepam binding
            inhibitor, a natural ligand of an allosteric regulatory site of the
            gamma-aminobutyric acid type A receptor
  JOURNAL   Proc Natl Acad Sci U S A 83 (19), 7547-7551 (1986)
   PUBMED   3020548
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016736.6.
            
            On Aug 30, 2020 this sequence version replaced NM_001079862.3.
            
            Summary: This gene encodes diazepam binding inhibitor, a protein
            that is regulated by hormones and is involved in lipid metabolism
            and the displacement of beta-carbolines and benzodiazepines, which
            modulate signal transduction at type A gamma-aminobutyric acid
            receptors located in brain synapses. The protein is conserved from
            yeast to mammals, with the most highly conserved domain consisting
            of seven contiguous residues that constitute the hydrophobic
            binding site for medium- and long-chain acyl-Coenzyme A esters.
            Diazepam binding inhibitor is also known to mediate the feedback
            regulation of pancreatic secretion and the postprandial release of
            cholecystokinin, in addition to its role as a mediator in
            corticotropin-dependent adrenal steroidogenesis. Three pseudogenes
            located on chromosomes 6, 8 and 16 have been identified. Multiple
            transcript variants encoding different isoforms have been described
            for this gene. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP211979.1, BP209651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355857.8/ ENSP00000348116.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC016736.6         108165-108248
            85-202              AC016736.6         109376-109493
            203-265             AC016736.6         111928-111990
            266-564             AC016736.6         113433-113731
FEATURES             Location/Qualifiers
     source          1..564
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.2"
     gene            1..564
                     /gene="DBI"
                     /gene_synonym="ACBD1; ACBP; CCK-RP; EP"
                     /note="diazepam binding inhibitor, acyl-CoA binding
                     protein"
                     /db_xref="GeneID:1622"
                     /db_xref="HGNC:HGNC:2690"
                     /db_xref="MIM:125950"
     exon            1..84
                     /gene="DBI"
                     /gene_synonym="ACBD1; ACBP; CCK-RP; EP"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..339
                     /gene="DBI"
                     /gene_synonym="ACBD1; ACBP; CCK-RP; EP"
                     /EC_number="3.4.17.3"
                     /note="isoform 3 is encoded by transcript variant 3;
                     diazepam binding inhibitor (GABA receptor modulator,
                     acyl-Coenzyme A binding protein); acyl-Coenzyme A binding
                     domain containing 1; cholecystokinin-releasing peptide,
                     trypsin-sensitive; endozepine; acyl coenzyme A binding
                     protein; epididymis secretory sperm binding protein;
                     acyl-CoA-binding protein; diazepam-binding inhibitor;
                     diazepam binding inhibitor (GABA receptor modulator,
                     acyl-CoA binding protein)"
                     /codon_start=1
                     /product="acyl-CoA-binding protein isoform 3"
                     /protein_id="NP_001073331.1"
                     /db_xref="CCDS:CCDS42740.1"
                     /db_xref="GeneID:1622"
                     /db_xref="HGNC:HGNC:2690"
                     /db_xref="MIM:125950"
                     /translation="MSQAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTER
                     PGMLDFTGKAKWDAWNELKGTSKEDAMKAYINKVEELKKKYGI"
     exon            85..202
                     /gene="DBI"
                     /gene_synonym="ACBD1; ACBP; CCK-RP; EP"
                     /inference="alignment:Splign:2.1.0"
     exon            203..265
                     /gene="DBI"
                     /gene_synonym="ACBD1; ACBP; CCK-RP; EP"
                     /inference="alignment:Splign:2.1.0"
     exon            266..564
                     /gene="DBI"
                     /gene_synonym="ACBD1; ACBP; CCK-RP; EP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      539..544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DBI"
                     /gene_synonym="ACBD1; ACBP; CCK-RP; EP"
                     /note="hexamer: ATTAAA"
     polyA_site      564
                     /gene="DBI"
                     /gene_synonym="ACBD1; ACBP; CCK-RP; EP"
                     /note="major polyA site"
ORIGIN      
        1 agtgcaatct gggcgatcgc ttcctggtcc tcgcctcctc cgctgtctcc ctggagttct
       61 tgcaagtcgg ccaggatgtc tcaggctgag tttgagaaag ctgcagagga ggttaggcac
      121 cttaagacca agccatcgga tgaggagatg ctgttcatct atggccacta caaacaagca
      181 actgtgggcg acataaatac agaacggccc gggatgttgg acttcacggg caaggccaag
      241 tgggatgcct ggaatgagct gaaagggact tccaaggaag atgccatgaa agcttacatc
      301 aacaaagtag aagagctaaa gaaaaaatac gggatatgag agactggatt tggttactgt
      361 gccatgtgtt tatcctaaac tgagacaatg ccttgttttt ttctaatacc gtggatggtg
      421 ggaattcggg aaaataacca gttaaaccag ctactcaagg ctgctcacca tacggctcta
      481 acagattagg ggctaaaacg attactgact ttccttgagt agtttttatc tgaaatcaat
      541 taaaagtgta tttgttactt taaa
//
