LOCUS       NM_014764               2064 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DAZ associated protein 2 (DAZAP2), transcript variant
            1, mRNA.
ACCESSION   NM_014764
VERSION     NM_014764.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2064)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2064)
  AUTHORS   Liebl,M.C., Moehlenbrink,J., Becker,H., Raddatz,G., Abdeen,S.K.,
            Aqeilan,R.I., Lyko,F. and Hofmann,T.G.
  TITLE     DAZAP2 acts as specifier of the p53 response to DNA damage
  JOURNAL   Nucleic Acids Res 49 (5), 2759-2776 (2021)
   PUBMED   33591310
  REMARK    GeneRIF: DAZAP2 acts as specifier of the p53 response to DNA
            damage.
REFERENCE   3  (bases 1 to 2064)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2064)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2064)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2064)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   7  (bases 1 to 2064)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   8  (bases 1 to 2064)
  AUTHORS   Shi,Y., Luo,S., Peng,J., Huang,C., Tan,D. and Hu,W.
  TITLE     The structure, expression and function prediction of DAZAP2, a
            down-regulated gene in multiple myeloma
  JOURNAL   Genomics Proteomics Bioinformatics 2 (1), 47-54 (2004)
   PUBMED   15629043
REFERENCE   9  (bases 1 to 2064)
  AUTHORS   Hamilton,M.H., Tcherepanova,I., Huibregtse,J.M. and McDonnell,D.P.
  TITLE     Nuclear import/export of hRPF1/Nedd4 regulates the
            ubiquitin-dependent degradation of its nuclear substrates
  JOURNAL   J Biol Chem 276 (28), 26324-26331 (2001)
   PUBMED   11342538
REFERENCE   10 (bases 1 to 2064)
  AUTHORS   Tsui,S., Dai,T., Roettger,S., Schempp,W., Salido,E.C. and Yen,P.H.
  TITLE     Identification of two novel proteins that interact with
            germ-cell-specific RNA-binding proteins DAZ and DAZL1
  JOURNAL   Genomics 65 (3), 266-273 (2000)
   PUBMED   10857750
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC341917.1, BC002334.2,
            AC139768.14 and BM982980.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014764.3.
            
            Summary: This gene encodes a proline-rich protein which interacts
            with the deleted in azoospermia (DAZ) and the deleted in
            azoospermia-like gene through the DAZ-like repeats. This protein
            also interacts with the transforming growth factor-beta signaling
            molecule SARA (Smad anchor for receptor activation), eukaryotic
            initiation factor 4G, and an E3 ubiquitinase that regulates its
            stability in splicing factor containing nuclear speckles. The
            encoded protein may function in various biological and pathological
            processes including spermatogenesis, cell signaling and
            transcription regulation, formation of stress granules during
            translation arrest, RNA splicing, and pathogenesis of multiple
            myeloma. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the predominant isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.590830.1,
                                           SRR3476690.853436.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000412716.8/ ENSP00000394699.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DC341917.1         104-119
            17-605              BC002334.2         1-589
            606-2032            AC139768.14        2054-3480           c
            2033-2064           BM982980.1         17-48               c
FEATURES             Location/Qualifiers
     source          1..2064
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..2064
                     /gene="DAZAP2"
                     /gene_synonym="PRTB"
                     /note="DAZ associated protein 2"
                     /db_xref="GeneID:9802"
                     /db_xref="HGNC:HGNC:2684"
                     /db_xref="MIM:607431"
     exon            1..95
                     /gene="DAZAP2"
                     /gene_synonym="PRTB"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..589
                     /gene="DAZAP2"
                     /gene_synonym="PRTB"
                     /note="isoform a is encoded by transcript variant 1;
                     proline-rich transcript in brain; proline-rich transcript,
                     brain-expressed protein; deleted in azoospermia associated
                     protein 2; proline-rich transcript in brain protein"
                     /codon_start=1
                     /product="DAZ-associated protein 2 isoform a"
                     /protein_id="NP_055579.1"
                     /db_xref="CCDS:CCDS8809.1"
                     /db_xref="GeneID:9802"
                     /db_xref="HGNC:HGNC:2684"
                     /db_xref="MIM:607431"
                     /translation="MNSKGQYPTQPTYPVQPPGNPVYPQTLHLPQAPPYTDAPPAYSE
                     LYRPSFVHPGAATVPTMSAAFPGASLYLPMAQSVAVGPLGSTIPMAYYPVGPIYPPGS
                     TVLVEGGYDAGARFGAGATAGNIPPPPPGCPPNAAQLAVMQGANVLVTQRKGNFFMGG
                     SDGGYTIW"
     exon            96..214
                     /gene="DAZAP2"
                     /gene_synonym="PRTB"
                     /inference="alignment:Splign:2.1.0"
     exon            215..460
                     /gene="DAZAP2"
                     /gene_synonym="PRTB"
                     /inference="alignment:Splign:2.1.0"
     exon            461..2064
                     /gene="DAZAP2"
                     /gene_synonym="PRTB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1868..1873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAZAP2"
                     /gene_synonym="PRTB"
                     /note="hexamer: AATAAA"
     polyA_site      1916
                     /gene="DAZAP2"
                     /gene_synonym="PRTB"
                     /note="major polyA site"
     regulatory      2040..2045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAZAP2"
                     /gene_synonym="PRTB"
                     /note="hexamer: AATAAA"
     polyA_site      2064
                     /gene="DAZAP2"
                     /gene_synonym="PRTB"
ORIGIN      
        1 gacacggaag tagctccgaa caggaagagg acgaaaaaaa taaccgtccg cgacgccgag
       61 acaaaccgga cccgcaacca ccatgaacag caaaggtcaa tatccaacac agccaaccta
      121 ccctgtgcag cctcctggga atccagtata ccctcagacc ttgcatcttc ctcaggctcc
      181 accctatacc gatgctccac ctgcctactc agagctctat cgtccgagct ttgtgcaccc
      241 aggggctgcc acagtcccca ccatgtcagc cgcatttcct ggagcctctc tgtatcttcc
      301 catggcccag tctgtggctg ttgggccttt aggttccaca atccccatgg cttattatcc
      361 agtcggtccc atctatccac ctggctccac agtgctggtg gaaggagggt atgatgcagg
      421 tgccagattt ggagctgggg ctactgctgg caacattcct cctccacctc ctggatgccc
      481 tcccaatgct gctcagcttg cagtcatgca gggagccaac gtcctcgtaa ctcagcggaa
      541 ggggaacttc ttcatgggtg gttcagatgg tggctacacc atctggtgag gaaccaaggc
      601 cacctctgtg ccgggaaaga catcacatac cttcagcact tctcacaatg taactgcttt
      661 agtcatatta acctgaagtt gcagtttaga cacatgttgt tggggtgtct ttctggtgcc
      721 caaactttca ggcacttttc aaatttaata aggaaccatg taatggtagc agtacctccc
      781 taaagcattt tgaggtaggg gaggtatcca ttcataaaat gaatgtgggt gaagccgccc
      841 taaggatttt cctttaattt ctctggagta atactgtacc atactggtct ttgcttttag
      901 taataaaaca tcaaattagg tttggaggga actttgatct tcctaagaat taaagttgcc
      961 aaattattct gattggtctt taatctcctt taagtctttg atatatatta cttgttataa
     1021 atggaacgca ttagttgtct gccttttcct ttccatccct tgccccaccc atcccatctc
     1081 caaccctagt cttccatttc ctcccgccag tctccattga atcaatggtg caggacagaa
     1141 agccagtcag actaatttcc ttctttcctc gcacttctcc ccactcgtca tcttttaact
     1201 agtgtttcac aaggatcctc tgaaaccctc tctgtgcccc aagtacagat gccattactt
     1261 ctgctttcgt atctcctcag gcaaaagtgg agggtgcctt atgggccctc ctcataggtt
     1321 gtctctgcat acacgaacct aacccaaatt tgctttggtg ccagaaaaac tgagctatgt
     1381 ttgaacaaag atgtcgtgca aactgtactg tgaacaacag ttggtttaaa atatgagggg
     1441 caaggaggag gatgcatttc aaaagcttga ttgatgtgtt cagagctaaa ttaagaggag
     1501 ttttcagatc aaaaactggt taccattttt tgtcagagtg tctgatgcgg ccactcattc
     1561 ggctccccag aattcctaga ctgggttaat agggtcatat tgtgaatgtc tcactacaaa
     1621 atgacttgag tccagtgaaa tctcattagg gtttaagaat atttcaggga tccttaatgt
     1681 tttgattttt gttttctgaa attggatttt attttatttt atcttataat ttcagttcat
     1741 ctaaattgtg tgttctgtac atgtgatgtt tgactgtacc attgactgtt atggaagttc
     1801 agcgttgtat gtctctctct acactgtggt gcacttaact tgtggaattt ttatactaaa
     1861 aatgtagaat aaagactatt ttgaagattt gaataaagtg atgaagttgc attacacctc
     1921 actgcaagga ttctttactt agcttgtttt tagatttctt ctatatatat tttatttata
     1981 tcccatctag aattcagcta ggtgctgctg ctgctctgtt tcctttgatg acgctttgaa
     2041 ataaaggcag gagtacaagc ctaa
//
