LOCUS       NM_018959               2184 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens DAZ associated protein 1 (DAZAP1), transcript variant
            2, mRNA.
ACCESSION   NM_018959
VERSION     NM_018959.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2184)
  AUTHORS   Mitamura,R., Nakano,M., Isono,M., Kurosawa,K., Fukami,T. and
            Nakajima,M.
  TITLE     NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to
            Negatively Regulate CYP3A4 Induction
  JOURNAL   Drug Metab Dispos 51 (10), 1230-1237 (2023)
   PUBMED   37349114
  REMARK    GeneRIF: NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with
            PXR to Negatively Regulate CYP3A4 Induction.
REFERENCE   2  (bases 1 to 2184)
  AUTHORS   Zhou,Y., Huangfu,S., Li,M., Tang,C., Qian,J., Guo,M., Zhou,Z.,
            Yang,Y. and Gu,C.
  TITLE     DAZAP1 facilitates the alternative splicing of KITLG to promote
            multiple myeloma cell proliferation via ERK signaling pathway
  JOURNAL   Aging (Albany NY) 14 (19), 7972-7985 (2022)
   PUBMED   36242590
  REMARK    GeneRIF: DAZAP1 facilitates the alternative splicing of KITLG to
            promote multiple myeloma cell proliferation via ERK signaling
            pathway.
REFERENCE   3  (bases 1 to 2184)
  AUTHORS   Deng,J.J., Li,G.P., Lu,W., Yan,Z. and Wang,Y.
  TITLE     DAZAP1 overexpression promotes growth of HCC cell lines: a primary
            study using CEUS
  JOURNAL   Clin Transl Oncol 24 (6), 1168-1176 (2022)
   PUBMED   35091997
  REMARK    GeneRIF: DAZAP1 overexpression promotes growth of HCC cell lines: a
            primary study using CEUS.
REFERENCE   4  (bases 1 to 2184)
  AUTHORS   Wang,Q., Guo,Y., Wang,W., Liu,B., Yang,G., Xu,Z., Li,J. and Liu,Z.
  TITLE     RNA binding protein DAZAP1 promotes HCC progression and regulates
            ferroptosis by interacting with SLC7A11 mRNA
  JOURNAL   Exp Cell Res 399 (1), 112453 (2021)
   PUBMED   33358859
  REMARK    GeneRIF: RNA binding protein DAZAP1 promotes HCC progression and
            regulates ferroptosis by interacting with SLC7A11 mRNA.
            Erratum:[Exp Cell Res. 2021 Nov 15;408(2):112867. doi:
            10.1016/j.yexcr.2021.112867.. PMID: 34648845]
REFERENCE   5  (bases 1 to 2184)
  AUTHORS   Chen,Y., Lu,Y., Ren,Y., Yuan,J., Zhang,N., Kimball,H., Zhou,L. and
            Yang,M.
  TITLE     Starvation-induced suppression of DAZAP1 by miR-10b integrates
            splicing control into TSC2-regulated oncogenic autophagy in
            esophageal squamous cell carcinoma
  JOURNAL   Theranostics 10 (11), 4983-4996 (2020)
   PUBMED   32308763
  REMARK    GeneRIF: Starvation-induced suppression of DAZAP1 by miR-10b
            integrates splicing control into TSC2-regulated oncogenic autophagy
            in esophageal squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2184)
  AUTHORS   Pan,H.A., Lin,Y.S., Lee,K.H., Huang,J.R., Lin,Y.H. and Kuo,P.L.
  TITLE     Expression patterns of the DAZ-associated protein DAZAP1 in rat and
            human ovaries
  JOURNAL   Fertil Steril 84 Suppl 2, 1089-1094 (2005)
   PUBMED   16209998
  REMARK    GeneRIF: This study shows expression patterns of DAZAP1 in human
            corpus luteum cells and demonstrates the in vivo interaction of
            DAZ-like protein (DAZL) with DAZAP1.
REFERENCE   7  (bases 1 to 2184)
  AUTHORS   Prima,V., Gore,L., Caires,A., Boomer,T., Yoshinari,M., Imaizumi,M.,
            Varella-Garcia,M. and Hunger,S.P.
  TITLE     Cloning and functional characterization of MEF2D/DAZAP1 and
            DAZAP1/MEF2D fusion proteins created by a variant
            t(1;19)(q23;p13.3) in acute lymphoblastic leukemia
  JOURNAL   Leukemia 19 (5), 806-813 (2005)
   PUBMED   15744350
  REMARK    GeneRIF: data suggest that MEF2D/DAZAP1 and/or DAZAP1/MEF2D
            contribute to leukemogenesis by altering signaling pathways
            normally regulated by wild-type MEF2D and DAZAP1
REFERENCE   8  (bases 1 to 2184)
  AUTHORS   Vera,Y., Dai,T., Hikim,A.P., Lue,Y., Salido,E.C., Swerdloff,R.S.
            and Yen,P.H.
  TITLE     Deleted in azoospermia associated protein 1 shuttles between
            nucleus and cytoplasm during normal germ cell maturation
  JOURNAL   J Androl 23 (5), 622-628 (2002)
   PUBMED   12185095
REFERENCE   9  (bases 1 to 2184)
  AUTHORS   Dai,T., Vera,Y., Salido,E.C. and Yen,P.H.
  TITLE     Characterization of the mouse Dazap1 gene encoding an RNA-binding
            protein that interacts with infertility factors DAZ and DAZL
  JOURNAL   BMC Genomics 2, 6 (2001)
   PUBMED   11604102
REFERENCE   10 (bases 1 to 2184)
  AUTHORS   Tsui,S., Dai,T., Roettger,S., Schempp,W., Salido,E.C. and Yen,P.H.
  TITLE     Identification of two novel proteins that interact with
            germ-cell-specific RNA-binding proteins DAZ and DAZL1
  JOURNAL   Genomics 65 (3), 266-273 (2000)
   PUBMED   10857750
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU557183.1, BC012062.1,
            AK124583.1 and AI802551.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_018959.3.
            
            Summary: In mammals, the Y chromosome directs the development of
            the testes and plays an important role in spermatogenesis. A high
            percentage of infertile men have deletions that map to regions of
            the Y chromosome. The DAZ (deleted in azoospermia) gene cluster
            maps to the AZFc region of the Y chromosome and is deleted in many
            azoospermic and severely oligospermic men. It is thought that the
            DAZ gene cluster arose from the transposition, amplification, and
            pruning of the ancestral autosomal gene DAZL also involved in germ
            cell development and gametogenesis. This gene encodes a RNA-binding
            protein with two RNP motifs that was originally identified by its
            interaction with the infertility factors DAZ and DAZL. Two isoforms
            are encoded by transcript variants of this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            3' coding region resulting in a novel 3' coding region and 3' UTR,
            compared to variant 1. It encodes isoform b, which is longer and
            has a distinct C-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF181719.1, BC012062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233078.9/ ENSP00000233078.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               BU557183.1         18-132
            116-1653            BC012062.1         1-1538
            1654-2181           AK124583.1         3413-3940
            2182-2184           AI802551.1         15-17               c
FEATURES             Location/Qualifiers
     source          1..2184
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2184
                     /gene="DAZAP1"
                     /note="DAZ associated protein 1"
                     /db_xref="GeneID:26528"
                     /db_xref="HGNC:HGNC:2683"
                     /db_xref="MIM:607430"
     exon            1..217
                     /gene="DAZAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1412
                     /gene="DAZAP1"
                     /note="isoform b is encoded by transcript variant 2;
                     deleted in azoospermia-associated protein 1; testicular
                     tissue protein Li 50"
                     /codon_start=1
                     /product="DAZ-associated protein 1 isoform b"
                     /protein_id="NP_061832.2"
                     /db_xref="CCDS:CCDS12065.1"
                     /db_xref="GeneID:26528"
                     /db_xref="HGNC:HGNC:2683"
                     /db_xref="MIM:607430"
                     /translation="MNNSGADEIGKLFVGGLDWSTTQETLRSYFSQYGEVVDCVIMKD
                     KTTNQSRGFGFVKFKDPNCVGTVLASRPHTLDGRNIDPKPCTPRGMQPERTRPKEGWQ
                     KGPRSDNSKSNKIFVGGIPHNCGETELREYFKKFGVVTEVVMIYDAEKQRPRGFGFIT
                     FEDEQSVDQAVNMHFHDIMGKKVEVKRAEPRDSKSQAPGQPGASQWGSRVVPNAANGW
                     AGQPPPTWQQGYGPQGMWVPAGQAIGGYGPPPAGRGAPPPPPPFTSYIVSTPPGGFPP
                     PQGFPQGYGAPPQFSFGYGPPPPPPDQFAPPGVPPPPATPGAAPLAFPPPPSQAAPDM
                     SKPPTAQPDFPYGQYAGYGQDLSGFGQGFSDPSQQPPSYGGPSVPGSGGPPAGGSGFG
                     RGQNHNVQGFHPYRR"
     exon            218..258
                     /gene="DAZAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            259..425
                     /gene="DAZAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..491
                     /gene="DAZAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..602
                     /gene="DAZAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..651
                     /gene="DAZAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..734
                     /gene="DAZAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..888
                     /gene="DAZAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..918
                     /gene="DAZAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1059
                     /gene="DAZAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1236
                     /gene="DAZAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..2184
                     /gene="DAZAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2156..2161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAZAP1"
                     /note="hexamer: AATAAA"
     polyA_site      2184
                     /gene="DAZAP1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcggtgac cgttggcgcc gaggggagga ggcagccgcc gccgccgccg ccgccgccgc
       61 cgccgccgcc gccgccgttg cgcagatccg ggccgcggct gtggggaggg cgacggagcg
      121 ggtgaccttc cggaggcggg agcgagcgag gaggcccggg agcgccgagc gtcgccgccg
      181 ccgccgccat gaacaactcg ggcgccgacg agatcgggaa gctcttcgtg ggcggtcttg
      241 actggagcac gacccaagag actctgcgca gctacttttc ccaatatgga gaagtcgtag
      301 attgtgttat catgaaagat aaaaccacca accagtctcg aggctttggg tttgtcaaat
      361 ttaaagaccc aaactgtgtg gggacggtgc tggccagcag accgcacacg ctagatggcc
      421 gaaacatcga ccccaagcca tgcacacccc gggggatgca gccggagaga acacggccga
      481 aggaaggatg gcagaaagga cccaggagcg ataacagtaa atcaaataag atatttgtcg
      541 gtggaattcc tcacaattgt ggtgagacag agctcaggga atacttcaag aagttcggag
      601 tggtcacgga ggtagtcatg atctatgacg ccgagaagca gaggccccga ggttttggat
      661 ttattacttt cgaggacgaa caatcagtgg accaggctgt caacatgcat tttcacgaca
      721 tcatgggcaa aaaagtggaa gttaaacgag ctgagcctcg ggacagcaag agccaagcgc
      781 cgggacagcc aggtgccagc cagtggggga gccgggttgt gcccaacgct gccaatggct
      841 gggcaggcca gcccccgccc acgtggcagc aaggatatgg cccgcaagga atgtgggtgc
      901 cggcaggaca ggcgattggt ggctatggac cgccccctgc aggaagagga gcccccccgc
      961 cacccccacc gttcacctcc tacatcgtgt ccacccctcc tggaggcttt ccccctcccc
     1021 agggcttccc tcagggctac ggtgccccgc cacagttcag ttttggctac gggcctccac
     1081 ctccaccgcc agatcagttt gcccctccgg gggttcctcc tccaccagcc actcccgggg
     1141 cagcacctct ggctttccca ccgcctccgt ctcaggctgc cccggacatg agcaagcccc
     1201 cgacagctca gccagacttc ccctatggtc agtatgcagg ttacgggcag gacttgagtg
     1261 gcttcggaca gggcttctca gaccccagcc agcagcctcc ttcctacggg ggtccctccg
     1321 tgccagggtc ggggggcccc cccgccggcg gcagcggctt tggacgaggg cagaaccaca
     1381 acgtgcaagg gttccacccc taccgacgct agcccgcggc gccgcgacgt ctgcacggcc
     1441 cagacccagg attccaaact tgtgaactcg tgacaatcac aaacttggcg gcaaagtggc
     1501 gactcaacct tggggggggg ggcgggggga gggcgcgagg cttttggagc ggctgtgggt
     1561 gtcgtctgga ctgaggtttt taaatatttc tttctctaac ccatcagcac aataaaaaaa
     1621 agtcactggt tcaacaacag ggtttaaaaa aaatgtcttc agctttaatt caaaacttca
     1681 ggtttctttt tcttcctttt ttttggaaat tattttcctg agccttttgt tttacggtat
     1741 attgtaaact tttatgttaa agaaaaaata tacatttaca aattgtgaga tttttaagag
     1801 aaattttcta cgatgtatac tggcttattt tttaatttaa aacggggttt ccgtcggcac
     1861 tggtggaggg ggtgcgctgt tagtcccctc gctcctggct ttgggggttg ggacttggtg
     1921 gtccagaaac tctgggagct tctagaagaa atctactgag tgtatttctg ttttttgttt
     1981 aattccttgc ttttgtcgac tgacctgctt ggtagtgtct gaggtgaact gtgggggttg
     2041 cgcacagcca gccgcgtgga tcccacgcag cgctgaaccg aaccgagtag gaagcctttc
     2101 tccccaggca cgtggcttca gggcgtttcc cattgaccag tttgaccctg gtttgaataa
     2161 agagaagtgc gtttggatta gaaa
//
