LOCUS       NP_061832                407 aa            linear   PRI 27-APR-2025
DEFINITION  DAZ-associated protein 1 isoform b [Homo sapiens].
ACCESSION   NP_061832
VERSION     NP_061832.2
DBSOURCE    REFSEQ: accession NM_018959.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 407)
  AUTHORS   Mitamura,R., Nakano,M., Isono,M., Kurosawa,K., Fukami,T. and
            Nakajima,M.
  TITLE     NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to
            Negatively Regulate CYP3A4 Induction
  JOURNAL   Drug Metab Dispos 51 (10), 1230-1237 (2023)
   PUBMED   37349114
  REMARK    GeneRIF: NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with
            PXR to Negatively Regulate CYP3A4 Induction.
REFERENCE   2  (residues 1 to 407)
  AUTHORS   Zhou,Y., Huangfu,S., Li,M., Tang,C., Qian,J., Guo,M., Zhou,Z.,
            Yang,Y. and Gu,C.
  TITLE     DAZAP1 facilitates the alternative splicing of KITLG to promote
            multiple myeloma cell proliferation via ERK signaling pathway
  JOURNAL   Aging (Albany NY) 14 (19), 7972-7985 (2022)
   PUBMED   36242590
  REMARK    GeneRIF: DAZAP1 facilitates the alternative splicing of KITLG to
            promote multiple myeloma cell proliferation via ERK signaling
            pathway.
REFERENCE   3  (residues 1 to 407)
  AUTHORS   Deng,J.J., Li,G.P., Lu,W., Yan,Z. and Wang,Y.
  TITLE     DAZAP1 overexpression promotes growth of HCC cell lines: a primary
            study using CEUS
  JOURNAL   Clin Transl Oncol 24 (6), 1168-1176 (2022)
   PUBMED   35091997
  REMARK    GeneRIF: DAZAP1 overexpression promotes growth of HCC cell lines: a
            primary study using CEUS.
REFERENCE   4  (residues 1 to 407)
  AUTHORS   Wang,Q., Guo,Y., Wang,W., Liu,B., Yang,G., Xu,Z., Li,J. and Liu,Z.
  TITLE     RNA binding protein DAZAP1 promotes HCC progression and regulates
            ferroptosis by interacting with SLC7A11 mRNA
  JOURNAL   Exp Cell Res 399 (1), 112453 (2021)
   PUBMED   33358859
  REMARK    GeneRIF: RNA binding protein DAZAP1 promotes HCC progression and
            regulates ferroptosis by interacting with SLC7A11 mRNA.
            Erratum:[Exp Cell Res. 2021 Nov 15;408(2):112867. doi:
            10.1016/j.yexcr.2021.112867. PMID: 34648845]
REFERENCE   5  (residues 1 to 407)
  AUTHORS   Chen,Y., Lu,Y., Ren,Y., Yuan,J., Zhang,N., Kimball,H., Zhou,L. and
            Yang,M.
  TITLE     Starvation-induced suppression of DAZAP1 by miR-10b integrates
            splicing control into TSC2-regulated oncogenic autophagy in
            esophageal squamous cell carcinoma
  JOURNAL   Theranostics 10 (11), 4983-4996 (2020)
   PUBMED   32308763
  REMARK    GeneRIF: Starvation-induced suppression of DAZAP1 by miR-10b
            integrates splicing control into TSC2-regulated oncogenic autophagy
            in esophageal squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 407)
  AUTHORS   Pan,H.A., Lin,Y.S., Lee,K.H., Huang,J.R., Lin,Y.H. and Kuo,P.L.
  TITLE     Expression patterns of the DAZ-associated protein DAZAP1 in rat and
            human ovaries
  JOURNAL   Fertil Steril 84 Suppl 2, 1089-1094 (2005)
   PUBMED   16209998
  REMARK    GeneRIF: This study shows expression patterns of DAZAP1 in human
            corpus luteum cells and demonstrates the in vivo interaction of
            DAZ-like protein (DAZL) with DAZAP1.
REFERENCE   7  (residues 1 to 407)
  AUTHORS   Prima,V., Gore,L., Caires,A., Boomer,T., Yoshinari,M., Imaizumi,M.,
            Varella-Garcia,M. and Hunger,S.P.
  TITLE     Cloning and functional characterization of MEF2D/DAZAP1 and
            DAZAP1/MEF2D fusion proteins created by a variant
            t(1;19)(q23;p13.3) in acute lymphoblastic leukemia
  JOURNAL   Leukemia 19 (5), 806-813 (2005)
   PUBMED   15744350
  REMARK    GeneRIF: data suggest that MEF2D/DAZAP1 and/or DAZAP1/MEF2D
            contribute to leukemogenesis by altering signaling pathways
            normally regulated by wild-type MEF2D and DAZAP1
REFERENCE   8  (residues 1 to 407)
  AUTHORS   Vera,Y., Dai,T., Hikim,A.P., Lue,Y., Salido,E.C., Swerdloff,R.S.
            and Yen,P.H.
  TITLE     Deleted in azoospermia associated protein 1 shuttles between
            nucleus and cytoplasm during normal germ cell maturation
  JOURNAL   J Androl 23 (5), 622-628 (2002)
   PUBMED   12185095
REFERENCE   9  (residues 1 to 407)
  AUTHORS   Dai,T., Vera,Y., Salido,E.C. and Yen,P.H.
  TITLE     Characterization of the mouse Dazap1 gene encoding an RNA-binding
            protein that interacts with infertility factors DAZ and DAZL
  JOURNAL   BMC Genomics 2, 6 (2001)
   PUBMED   11604102
REFERENCE   10 (residues 1 to 407)
  AUTHORS   Tsui,S., Dai,T., Roettger,S., Schempp,W., Salido,E.C. and Yen,P.H.
  TITLE     Identification of two novel proteins that interact with
            germ-cell-specific RNA-binding proteins DAZ and DAZL1
  JOURNAL   Genomics 65 (3), 266-273 (2000)
   PUBMED   10857750
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU557183.1, BC012062.1,
            AK124583.1 and AI802551.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2002 this sequence version replaced NP_061832.1.
            
            Summary: In mammals, the Y chromosome directs the development of
            the testes and plays an important role in spermatogenesis. A high
            percentage of infertile men have deletions that map to regions of
            the Y chromosome. The DAZ (deleted in azoospermia) gene cluster
            maps to the AZFc region of the Y chromosome and is deleted in many
            azoospermic and severely oligospermic men. It is thought that the
            DAZ gene cluster arose from the transposition, amplification, and
            pruning of the ancestral autosomal gene DAZL also involved in germ
            cell development and gametogenesis. This gene encodes a RNA-binding
            protein with two RNP motifs that was originally identified by its
            interaction with the infertility factors DAZ and DAZL. Two isoforms
            are encoded by transcript variants of this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            3' coding region resulting in a novel 3' coding region and 3' UTR,
            compared to variant 1. It encodes isoform b, which is longer and
            has a distinct C-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF181719.1, BC012062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233078.9/ ENSP00000233078.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..407
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     Protein         1..407
                     /product="DAZ-associated protein 1 isoform b"
                     /note="deleted in azoospermia-associated protein 1;
                     testicular tissue protein Li 50"
                     /calculated_mol_wt=43252
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine. /evidence=ECO:0000269|Ref.3,
                     ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895;
                     propagated from UniProtKB/Swiss-Prot (Q96EP5.1)"
     Region          11..92
                     /region_name="RRM1_DAZAP1"
                     /note="RNA recognition motif 1 (RRM1) found in Deleted in
                     azoospermia-associated protein 1 (DAZAP1) and similar
                     proteins; cd12574"
                     /db_xref="CDD:409988"
     Region          74..117
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96EP5.1)"
     Region          111..190
                     /region_name="RRM2_DAZAP1"
                     /note="RNA recognition motif 2 (RRM2) found in Deleted in
                     azoospermia-associated protein 1 (DAZAP1) and similar
                     proteins; cd12327"
                     /db_xref="CDD:409765"
     Site            150
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:22001406; propagated from
                     UniProtKB/Swiss-Prot (Q96EP5.1)"
     Region          185..407
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96EP5.1)"
     Site            253
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (Q96EP5.1)"
     CDS             1..407
                     /gene="DAZAP1"
                     /coded_by="NM_018959.4:189..1412"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS12065.1"
                     /db_xref="GeneID:26528"
                     /db_xref="HGNC:HGNC:2683"
                     /db_xref="MIM:607430"
ORIGIN      
        1 mnnsgadeig klfvggldws ttqetlrsyf sqygevvdcv imkdkttnqs rgfgfvkfkd
       61 pncvgtvlas rphtldgrni dpkpctprgm qpertrpkeg wqkgprsdns ksnkifvggi
      121 phncgetelr eyfkkfgvvt evvmiydaek qrprgfgfit fedeqsvdqa vnmhfhdimg
      181 kkvevkraep rdsksqapgq pgasqwgsrv vpnaangwag qppptwqqgy gpqgmwvpag
      241 qaiggygppp agrgappppp pftsyivstp pggfpppqgf pqgygappqf sfgygppppp
      301 pdqfappgvp pppatpgaap lafppppsqa apdmskppta qpdfpygqya gygqdlsgfg
      361 qgfsdpsqqp psyggpsvpg sggppaggsg fgrgqnhnvq gfhpyrr
//
