LOCUS       NM_001141969            2558 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens death domain associated protein (DAXX), transcript
            variant 1, mRNA.
ACCESSION   NM_001141969
VERSION     NM_001141969.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2558)
  AUTHORS   Yasunaga,Y., Tanaka,M., Arita,J., Hasegawa,K. and Ushiku,T.
  TITLE     Loss of ATRX and DAXX in pancreatic neuroendocrine tumors:
            Association with recurrence risk, cellular phenotype, and
            heterogeneity
  JOURNAL   Hum Pathol 150, 51-57 (2024)
   PUBMED   38909708
  REMARK    GeneRIF: Loss of ATRX and DAXX in pancreatic neuroendocrine tumors:
            Association with recurrence risk, cellular phenotype, and
            heterogeneity.
REFERENCE   2  (bases 1 to 2558)
  AUTHORS   Pinto,L.M., Pailas,A., Bondarchenko,M., Sharma,A.B., Neumann,K.,
            Rizzo,A.J., Jeanty,C., Nicot,N., Racca,C., Graham,M.K.,
            Naughton,C., Liu,Y., Chen,C.L., Meakin,P.J., Gilbert,N.,
            Britton,S., Meeker,A.K., Heaphy,C.M., Larminat,F. and Van Dyck,E.
  TITLE     DAXX promotes centromeric stability independently of ATRX by
            preventing the accumulation of R-loop-induced DNA double-stranded
            breaks
  JOURNAL   Nucleic Acids Res 52 (3), 1136-1155 (2024)
   PUBMED   38038252
  REMARK    GeneRIF: DAXX promotes centromeric stability independently of ATRX
            by preventing the accumulation of R-loop-induced DNA
            double-stranded breaks.
REFERENCE   3  (bases 1 to 2558)
  AUTHORS   Ding,S., Wang,H., Liao,Y., Chen,R., Hu,Y., Wu,H., Shen,H. and
            Tang,S.
  TITLE     HPV16 E7 protein antagonizes TNF-alpha-induced apoptosis of
            cervical cancer cells via Daxx/JNK pathway
  JOURNAL   Microb Pathog 185, 106423 (2023)
   PUBMED   37871853
  REMARK    GeneRIF: HPV16 E7 protein antagonizes TNF-alpha-induced apoptosis
            of cervical cancer cells via Daxx/JNK pathway.
REFERENCE   4  (bases 1 to 2558)
  AUTHORS   Ali Naeem,H., Nazar Ibraheim,W. and Abdullah Alomar,S.A.
  TITLE     The Impact of Human Mammary Tumor Virus (HMTV) on the Expression of
            Epidermal Growth Factor Receptor (EGFR) and Death-Domain Associated
            Protein (DAXX) in Breast Carcinoma Tissues
  JOURNAL   Arch Razi Inst 78 (2), 689-699 (2023)
   PUBMED   37396746
  REMARK    GeneRIF: The Impact of Human Mammary Tumor Virus (HMTV) on the
            Expression of Epidermal Growth Factor Receptor (EGFR) and
            Death-Domain Associated Protein (DAXX) in Breast Carcinoma Tissues.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2558)
  AUTHORS   Carraro,M., Hendriks,I.A., Hammond,C.M., Solis-Mezarino,V.,
            Volker-Albert,M., Elsborg,J.D., Weisser,M.B., Spanos,C.,
            Montoya,G., Rappsilber,J., Imhof,A., Nielsen,M.L. and Groth,A.
  TITLE     DAXX adds a de novo H3.3K9me3 deposition pathway to the histone
            chaperone network
  JOURNAL   Mol Cell 83 (7), 1075-1092 (2023)
   PUBMED   36868228
  REMARK    GeneRIF: DAXX adds a de novo H3.3K9me3 deposition pathway to the
            histone chaperone network.
REFERENCE   6  (bases 1 to 2558)
  AUTHORS   Chang,H.Y., Nishitoh,H., Yang,X., Ichijo,H. and Baltimore,D.
  TITLE     Activation of apoptosis signal-regulating kinase 1 (ASK1) by the
            adapter protein Daxx
  JOURNAL   Science 281 (5384), 1860-1863 (1998)
   PUBMED   9743501
REFERENCE   7  (bases 1 to 2558)
  AUTHORS   Pluta,A.F., Earnshaw,W.C. and Goldberg,I.G.
  TITLE     Interphase-specific association of intrinsic centromere protein
            CENP-C with HDaxx, a death domain-binding protein implicated in
            Fas-mediated cell death
  JOURNAL   J Cell Sci 111 (Pt 14), 2029-2041 (1998)
   PUBMED   9645950
REFERENCE   8  (bases 1 to 2558)
  AUTHORS   Herberg,J.A., Beck,S. and Trowsdale,J.
  TITLE     TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form
            a dense cluster at the centromeric end of the MHC
  JOURNAL   J Mol Biol 277 (4), 839-857 (1998)
   PUBMED   9545376
REFERENCE   9  (bases 1 to 2558)
  AUTHORS   Kiriakidou,M., Driscoll,D.A., Lopez-Guisa,J.M. and Strauss,J.F.
            3rd.
  TITLE     Cloning and expression of primate Daxx cDNAs and mapping of the
            human gene to chromosome 6p21.3 in the MHC region
  JOURNAL   DNA Cell Biol 16 (11), 1289-1298 (1997)
   PUBMED   9407001
REFERENCE   10 (bases 1 to 2558)
  AUTHORS   Yang,X., Khosravi-Far,R., Chang,H.Y. and Baltimore,D.
  TITLE     Daxx, a novel Fas-binding protein that activates JNK and apoptosis
  JOURNAL   Cell 89 (7), 1067-1076 (1997)
   PUBMED   9215629
  REMARK    GeneRIF: A partial human cDNA clone was identified by its
            interaction with murine Fas in a yeast two-hybrid screening. The
            human clone was then used to clone the murine Daxx, which was
            further characterized.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC359186.1, BC073776.1,
            AK223404.1 and BM997178.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001141969.1.
            
            Summary: This gene encodes a multifunctional protein that resides
            in multiple locations in the nucleus and in the cytoplasm. It
            interacts with a wide variety of proteins, such as apoptosis
            antigen Fas, centromere protein C, and transcription factor
            erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the
            encoded protein functions as a potent transcription repressor that
            binds to sumoylated transcription factors. Its repression can be
            relieved by the sequestration of this protein into promyelocytic
            leukemia nuclear bodies or nucleoli. This protein also associates
            with centromeres in G2 phase. In the cytoplasm, the encoded protein
            may function to regulate apoptosis. The subcellular localization
            and function of this protein are modulated by post-translational
            modifications, including sumoylation, phosphorylation and
            polyubiquitination. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript but encodes the shorter isoform (a). Variants 1 and 2
            encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223404.1, SRR1803614.195016.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374542.10/ ENSP00000363668.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DC359186.1         58-71
            15-1337             BC073776.1         1-1323
            1338-2503           AK223404.1         1393-2558
            2504-2558           BM997178.1         18-72               c
FEATURES             Location/Qualifiers
     source          1..2558
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..2558
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1; SMIM40"
                     /note="death domain associated protein"
                     /db_xref="GeneID:1616"
                     /db_xref="HGNC:HGNC:2681"
                     /db_xref="MIM:603186"
     exon            1..98
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1; SMIM40"
                     /inference="alignment:Splign:2.1.0"
     exon            99..357
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1; SMIM40"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..2373
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1; SMIM40"
                     /note="isoform a is encoded by transcript variant 1;
                     death-associated protein 6; Fas-binding protein; CENP-C
                     binding protein; ETS1-associated protein 1; death
                     domain-associated protein 6; fas death domain-associated
                     protein"
                     /codon_start=1
                     /product="death domain-associated protein 6 isoform a"
                     /protein_id="NP_001135441.1"
                     /db_xref="CCDS:CCDS4776.1"
                     /db_xref="GeneID:1616"
                     /db_xref="HGNC:HGNC:2681"
                     /db_xref="MIM:603186"
                     /translation="MATANSIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEP
                     HGARGSSSSGGKKCYKLENEKLFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLAS
                     AEFCNILSRVLSRARSRPAKLYVYINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNP
                     PTHLSLDPTNAENTASQSPRTRGSRRQIQRLEQLLALYVAEIRRLQEKELDLSELDDP
                     DSAYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLIN
                     KPGPDTFPDYGDVLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIY
                     NFGCHLTDDYRPGVDPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERK
                     KRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEE
                     EEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNL
                     EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQL
                     FELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGD
                     SGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICTLPSPPSPLASLAPVADS
                     STRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVATQCDPEEIIVLSDSD
                     "
     exon            358..1189
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1; SMIM40"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1401
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1; SMIM40"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1615
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1; SMIM40"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..2090
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1; SMIM40"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2313
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1; SMIM40"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2558
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1; SMIM40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2529..2534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1; SMIM40"
                     /note="hexamer: AATAAA"
     polyA_site      2558
                     /gene="DAXX"
                     /gene_synonym="BING2; DAP6; EAP1; SMIM40"
                     /note="major polyA site"
ORIGIN      
        1 gtagtggggc ctgcggtggg agtgggaagg aaggcggagg gaaccatgcg aggttctgag
       61 aattgcggcg agggtcgcct cgagagacgg tttctgagca ggaattctga aatccccacc
      121 acttcctccc tccgggggat ttgatcccct atggccaccg ctaacagcat catcgtgctg
      181 gatgatgatg acgaagatga agcagctgct cagccagggc cctcccaccc actccccaat
      241 gcggcctcac ctggggcaga agcccctagc tcctctgagc ctcatggggc cagaggaagc
      301 agtagttcgg gcggcaagaa atgctacaag ctggagaatg agaagctgtt cgaagagttc
      361 cttgaacttt gtaagatgca gacagcagac caccctgagg tggtcccatt cctctataac
      421 cggcagcaac gtgcccactc tctgtttttg gcctcggcgg agttctgcaa catcctctct
      481 agggtcctgt ctcgggcccg gagccggcca gccaagctct atgtctacat caatgagctc
      541 tgcactgttc tcaaggccca ctcagccaaa aagaagctga acttggcccc tgccgccacc
      601 acctccaatg agccctctgg gaataaccct cccacacacc tctccttgga ccccacaaat
      661 gctgaaaaca ctgcctctca gtctccaagg acccgtggtt cccggcggca gatccagcgt
      721 ttggagcagc tgctggcgct ctatgtggca gagatccggc ggctgcagga aaaggagttg
      781 gatctctcag aattggatga cccagactcc gcatacctgc aggaggcacg gttgaagcgt
      841 aagctgatcc gcctctttgg gcgactatgt gagctgaaag actgctcttc actgaccggc
      901 cgtgtcatag agcagcgcat cccctaccgt ggcacccgct acccagaggt taacaggcgc
      961 attgagcggc tcatcaacaa gccagggcct gataccttcc ctgactatgg ggatgtgctt
     1021 cgggctgtag agaaggcagc tgcccgacac agccttggcc tcccccgaca gcagctccag
     1081 ctcatggctc aggatgcctt ccgagatgtg ggcatcaggt tacaggagcg acgtcacctc
     1141 gatctcatct acaactttgg ctgccacctc acagatgact ataggccagg cgttgaccct
     1201 gcactatcag atcctgtgtt ggcccggcgc cttcgggaaa accggagttt ggccatgagt
     1261 cggctggatg aggtcatctc caaatatgca atgttgcaag acaaaagtga ggagggcgag
     1321 agaaaaaaga gaagagctcg gctccaaggc acctcttccc actctgcaga cacccccgaa
     1381 gcctccttgg attctggtga gggccctagt ggaatggcat cccaggggtg cccttctgcc
     1441 tccagagctg agacagatga cgaagacgat gaggagagtg atgaggaaga ggaggaggag
     1501 gaggaagaag aagaggagga ggccacagat tctgaagagg aggaggatct ggaacagatg
     1561 caggagggtc aggaggatga tgaagaggag gacgaagagg aagaagcagc agcaggtaaa
     1621 gatggagaca agagccccat gtcctcacta cagatctcca atgaaaagaa cctggaacct
     1681 ggcaaacaga tcagcagatc ttcaggggag cagcaaaaca aaggacgcat agtgtcacca
     1741 tcgttactgt cagaagaacc cctggccccc tccagcatag atgctgaaag caatggagaa
     1801 cagcctgagg agctgaccct ggaggaagaa agccctgtgt ctcagctctt tgagctagag
     1861 attgaagctt tgcccctgga taccccttcc tctgtggaga cggacatttc ctcttccagg
     1921 aagcaatcag aggagccctt caccactgtc ttagagaatg gagcaggcat ggtctcttct
     1981 acttccttca atggaggcgt ctctcctcac aactggggag attctggtcc cccctgcaaa
     2041 aaatctcgga aggagaagaa gcaaacagga tcagggccat taggaaacag ctatgtggaa
     2101 aggcaaaggt cagtgcatga gaagaatggg aaaaagatat gtaccctgcc cagcccacct
     2161 tcccccttgg cttccttggc cccagttgct gattcctcca cgagggtgga ctctcccagc
     2221 catggcctgg tgaccagctc cctctgcatc ccttctccag cccggctgtc ccaaaccccc
     2281 cattcacagc ctcctcggcc tggtacttgc aagacaagtg tggccacaca atgcgatcca
     2341 gaagagatca tcgtgctctc agactctgat tagctgcctc cccttctccc tgcctccaga
     2401 atgttctggg ataacatttg gaggaaggtg ggaagcagat gactgaggaa gggatggact
     2461 aagctaatcc ccttttggtg gtgtttcttt aaaaaaaaaa aaaagcttaa gttttacaca
     2521 gaaacattaa taaacaataa agttcttttc ttactgta
//
