LOCUS       NM_014395               2935 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dual adaptor of phosphotyrosine and
            3-phosphoinositides 1 (DAPP1), transcript variant 1, mRNA.
ACCESSION   NM_014395
VERSION     NM_014395.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2935)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2935)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2935)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2935)
  AUTHORS   Ortner,D., Grabher,D., Hermann,M., Kremmer,E., Hofer,S. and
            Heufler,C.
  TITLE     The adaptor protein Bam32 in human dendritic cells participates in
            the regulation of MHC class I-induced CD8+ T cell activation
  JOURNAL   J Immunol 187 (8), 3972-3978 (2011)
   PUBMED   21930970
  REMARK    GeneRIF: we propose a role for Bam32 in the signaling of MHC class
            I molecules in professional Ag-presenting DC for the regulation of
            CD8(+) T cell activation.
            Erratum:[J Immunol. 2011 Dec 15;187(12):6584]
REFERENCE   5  (bases 1 to 2935)
  AUTHORS   Manna,D., Albanese,A., Park,W.S. and Cho,W.
  TITLE     Mechanistic basis of differential cellular responses of
            phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol
            3,4,5-trisphosphate-binding pleckstrin homology domains
  JOURNAL   J Biol Chem 282 (44), 32093-32105 (2007)
   PUBMED   17823121
REFERENCE   6  (bases 1 to 2935)
  AUTHORS   Dowler,S., Currie,R.A., Campbell,D.G., Deak,M., Kular,G.,
            Downes,C.P. and Alessi,D.R.
  TITLE     Identification of pleckstrin-homology-domain-containing proteins
            with novel phosphoinositide-binding specificities
  JOURNAL   Biochem J 351 (Pt 1), 19-31 (2000)
   PUBMED   11001876
REFERENCE   7  (bases 1 to 2935)
  AUTHORS   Ferguson,K.M., Kavran,J.M., Sankaran,V.G., Fournier,E.,
            Isakoff,S.J., Skolnik,E.Y. and Lemmon,M.A.
  TITLE     Structural basis for discrimination of 3-phosphoinositides by
            pleckstrin homology domains
  JOURNAL   Mol Cell 6 (2), 373-384 (2000)
   PUBMED   10983984
REFERENCE   8  (bases 1 to 2935)
  AUTHORS   Dowler,S., Montalvo,L., Cantrell,D., Morrice,N. and Alessi,D.R.
  TITLE     Phosphoinositide 3-kinase-dependent phosphorylation of the dual
            adaptor for phosphotyrosine and 3-phosphoinositides by the Src
            family of tyrosine kinase
  JOURNAL   Biochem J 349 (Pt 2), 605-610 (2000)
   PUBMED   10880360
REFERENCE   9  (bases 1 to 2935)
  AUTHORS   Marshall,A.J., Niiro,H., Lerner,C.G., Yun,T.J., Thomas,S.,
            Disteche,C.M. and Clark,E.A.
  TITLE     A novel B lymphocyte-associated adaptor protein, Bam32, regulates
            antigen receptor signaling downstream of phosphatidylinositol
            3-kinase
  JOURNAL   J Exp Med 191 (8), 1319-1332 (2000)
   PUBMED   10770799
REFERENCE   10 (bases 1 to 2935)
  AUTHORS   Dowler,S., Currie,R.A., Downes,C.P. and Alessi,D.R.
  TITLE     DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides
  JOURNAL   Biochem J 342 (Pt 1) (Pt 1), 7-12 (1999)
   PUBMED   10432293
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN995752.1, AF163254.1, BC012924.1, BM968883.1 and CA428013.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014395.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.261143.1,
                                           SRR1660803.51428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000512369.2/ ENSP00000423602.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DN995752.1         15-33
            20-1440             AF163254.1         4-1424
            1441-1711           BC012924.1         1369-1639
            1712-1915           BM968883.1         297-500
            1916-2316           BC012924.1         1843-2243
            2317-2935           CA428013.1         16-634              c
FEATURES             Location/Qualifiers
     source          1..2935
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q23"
     gene            1..2935
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /note="dual adaptor of phosphotyrosine and
                     3-phosphoinositides 1"
                     /db_xref="GeneID:27071"
                     /db_xref="HGNC:HGNC:16500"
                     /db_xref="MIM:605768"
     exon            1..188
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..930
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /note="isoform 1 is encoded by transcript variant 1; dual
                     adapter for phosphotyrosine and 3-phosphotyrosine and
                     3-phosphoinositide; hDAPP1; B-cell adapter molecule of 32
                     kDa; b lymphocyte adapter protein Bam32"
                     /codon_start=1
                     /product="dual adapter for phosphotyrosine and
                     3-phosphotyrosine and 3-phosphoinositide isoform 1"
                     /protein_id="NP_055210.2"
                     /db_xref="CCDS:CCDS47112.1"
                     /db_xref="GeneID:27071"
                     /db_xref="HGNC:HGNC:16500"
                     /db_xref="MIM:605768"
                     /translation="MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHA
                     AEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSL
                     KDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPT
                     APSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQF
                     DYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIKILRWKLSQIRKQLNQGEGTIRSRS
                     FIFK"
     exon            189..311
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            312..445
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            446..576
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            577..624
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            625..687
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            688..773
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            774..861
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /inference="alignment:Splign:2.1.0"
     exon            862..2935
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2336..2341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /note="hexamer: GATAAA"
     polyA_site      2359
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /note="major polyA site"
     regulatory      2862..2867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /note="hexamer: ATTAAA"
     polyA_site      2891
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /note="major polyA site"
     regulatory      2902..2907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /note="hexamer: ATTAAA"
     polyA_site      2935
                     /gene="DAPP1"
                     /gene_synonym="BAM32"
                     /note="major polyA site"
ORIGIN      
        1 gccatagcag gctgctgtct cacagagcga gaaggtgtca ggagcagccc agttgtgtct
       61 ctctctctac ctctgtgaag ggcgcgaatg ggcagagcag aacttctaga agggaagatg
      121 agcacccagg atccctcaga tctgtggagc agatccgatg gagaggctga gctgctccag
      181 gacttggggt ggtatcacgg caacctcaca cgccatgctg ctgaagctct tctcctctca
      241 aatggatgtg acggcagcta ccttctgagg gacagcaatg agaccaccgg gctgtactct
      301 ctctctgtga gggccaaaga ttctgttaaa cactttcatg ttgaatatac tggatattca
      361 tttaaatttg gctttaatga attctcatct ttgaaggatt ttgtcaagca ttttgcaaat
      421 cagcctttga ttggaagcga gacaggcact ctgatggttc taaaacatcc ctacccaaga
      481 aaagtggaag aaccctccat ttatgaatct gtccgggttc acacagcaat gcagacagga
      541 agaacagaag atgaccttgt gcccacagca ccttctctgg gcaccaaaga aggttacctc
      601 accaaacagg gaggcctggt caagacctgg aaaacaagat ggtttactct gcacaggaat
      661 gaactgaaat acttcaaaga ccagatgtca ccagaaccaa ttcggatcct agacctaaca
      721 gaatgttcag ctgtacaatt cgattattca caagaaaggg taaactgttt ttgtttggta
      781 tttccattca ggacatttta tctctgtgca aagaccggag tagaagctga tgagtggatc
      841 aagatattac gctggaaatt gtcacaaata agaaaacagc tcaaccaagg ggaaggcacg
      901 atccgatctc ggtcgttcat ctttaaatag atctttcttg ccaaggaatg ctctggccca
      961 ggagcaaggt ggaatgtttc cctgacgctg tgatctgcag caggcttcaa atgaaaaccg
     1021 actaaggatt ttctttcaaa aacaaatcag aagcagatgc tgattgggac ccatatacca
     1081 cgttgctgac tcacgttgct gcccttccat gatgttgcca tctccttgag aacactgaag
     1141 caatcaccat tctgatagaa agtgcttaaa ccaccactct taggtctgct cactcttaga
     1201 acacacaatg gaagaggaag ggtttttgtt ttcactcatt gtggtcccca agcctattga
     1261 cactagttgc ctagagtccc actgtgagtc atggtcagcc tgtctgacat ccaggttgtg
     1321 ctattaacca agaaggaaac agatacttgg aggcttagat gacttctgca ggatttatat
     1381 tcagatagaa aacatcaaat attttcaggg gagaggtttt tttttttaat ttttccccct
     1441 ttatacaaaa aaaaaagaac atttccaaaa ctaaaataga aaatgcttgt ggcatttatt
     1501 ttctcttttt aaaaggttca gaaatttggc aggtcctttg cttctaatga caaaactgtg
     1561 agagctagat gtcctatggg caattaggta gtataataaa ggtaaatgaa ggtacaattt
     1621 ttaaaccatt attttcaccc tgttggggta aatgttttaa agagtgagaa aacataaatt
     1681 gagaaagggt gataaagtaa tagataactt ttagtttaat aataattatt gttattatac
     1741 tactaataat agagcacttg taagcactaa gttatcttta tccaacattt ctccaaatgg
     1801 actgaaagaa acttttcaag gacagtgtat tataacaatc cctttcccag aattagttgt
     1861 atagggttgg cccaagagat gtaagaaaaa tctcgcattg ctccctaagc accctgggcc
     1921 ttattaaaga gcaacttcta tttccagtcg ggggagtaac actaaagcta caagaaatat
     1981 gtaataatga taggtaataa tgtgttccaa agctttttca aactagaata aggaggcaaa
     2041 tagaagaatg agatactgat gtccacagtt cattggcaga atctaacccc ttctgttatc
     2101 ttttttaata ctatttttgt ttagatagaa gtttcaaaga agataaaaat gcttgaagag
     2161 cctgagagta aaaagattat gctgcaaagc tatgatataa actgctcttg cagtccaaag
     2221 ggatacctga ttaaagaagt ttcttattta aacatctcag acgcaaaaat tacattaaat
     2281 ttttgtatat ttcaacaaca ttttaaatgt attttgttat gtttgtatta tataggataa
     2341 agcaaatgtc aagttaaaat gtattgtgtt gtttgtaaag taagaagtta ctggccagga
     2401 gcggcggctc atgcctgtaa tcccaggact ttggtaggcc aagacaagca gatcacttga
     2461 ggtcaggagt tcaacatcag cctggccaac atgatgaaac cttgtcttta ctaaaaatac
     2521 aaaaattagc tgggcatggt ggcaggcgcc tgtaatccca gctactcagg aggctgaggc
     2581 aggagaattg cttgaacccg ggaggtggag gttgcagtga accaagatcg cggcgctgca
     2641 ctctagcctg ggtgacagag tcagactccg tcccaaaaaa acaaacaaac aaaacaaaac
     2701 aaaaaaaaac agaagttaca aatgaatact cacggatatg tatagtttta tgtttgtttt
     2761 cttagaaaca aatgtgtttc tttgggtggg taatattgtg ttttactatg tttacctttt
     2821 ataaaacata acctgtttat ttatattctt tggctttgtt tattaaaaag catgattttg
     2881 ctgtgcatgt accattttgc tattaaaatt tatttttaat atttgtaact tgaaa
//
