LOCUS       NM_001348               2286 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens death associated protein kinase 3 (DAPK3), transcript
            variant 1, mRNA.
ACCESSION   NM_001348 XM_005259509
VERSION     NM_001348.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2286)
  AUTHORS   Park,J.E., Park,J.W., Sim,M.K., Kim,S.R. and Kim,K.S.
  TITLE     Inhibition of DAPK3 Suppresses Radiation-Induced Cellular
            Senescence by Activation of a PGC1alpha-Dependent Metabolism
            Pathway in Brain Endothelial Cells
  JOURNAL   J Gerontol A Biol Sci Med Sci 79 (5) (2024)
   PUBMED   38563090
  REMARK    GeneRIF: Inhibition of DAPK3 Suppresses Radiation-Induced Cellular
            Senescence by Activation of a PGC1alpha-Dependent Metabolism
            Pathway in Brain Endothelial Cells.
REFERENCE   2  (bases 1 to 2286)
  AUTHORS   Hyodo,T., Asano-Inami,E., Ito,S., Sugiyama,M., Nawa,A.,
            Rahman,M.L., Hasan,M.N., Mihara,Y., Lam,V.Q., Karnan,S., Ota,A.,
            Tsuzuki,S., Hamaguchi,M., Hosokawa,Y. and Konishi,H.
  TITLE     Leucine zipper protein 1 (LUZP1) regulates the constriction
            velocity of the contractile ring during cytokinesis
  JOURNAL   FEBS J 291 (5), 927-944 (2024)
   PUBMED   38009294
REFERENCE   3  (bases 1 to 2286)
  AUTHORS   Bai,X., Chen,J., Zhang,W., Zhou,S., Dong,L., Huang,J. and He,X.
  TITLE     YTHDF2 promotes gallbladder cancer progression and gemcitabine
            resistance via m6A-dependent DAPK3 degradation
  JOURNAL   Cancer Sci 114 (11), 4299-4313 (2023)
   PUBMED   37700438
  REMARK    GeneRIF: YTHDF2 promotes gallbladder cancer progression and
            gemcitabine resistance via m6A-dependent DAPK3 degradation.
REFERENCE   4  (bases 1 to 2286)
  AUTHORS   Turner,S.R., Al-Ghabkari,A., Carlson,D.A., Chappellaz,M.,
            Sutherland,C., Haystead,T.A.J., Cole,W.C. and MacDonald,J.A.
  TITLE     Death-associated protein kinase 3 regulates the myogenic reactivity
            of cerebral arteries
  JOURNAL   Exp Physiol 108 (7), 986-997 (2023)
   PUBMED   37084168
  REMARK    GeneRIF: Death-associated protein kinase 3 regulates the myogenic
            reactivity of cerebral arteries.
REFERENCE   5  (bases 1 to 2286)
  AUTHORS   Barman,M.K., Chand,K. and Mitra,D.
  TITLE     Zipper interacting protein kinase (ZIPK) is a negative regulator of
            HIV-1 replication that is restricted by viral Nef protein through
            proteasomal degradation
  JOURNAL   Biochem Biophys Res Commun 625, 122-127 (2022)
   PUBMED   35961135
  REMARK    GeneRIF: Zipper interacting protein kinase (ZIPK) is a negative
            regulator of HIV-1 replication that is restricted by viral Nef
            protein through proteasomal degradation.
REFERENCE   6  (bases 1 to 2286)
  AUTHORS   Page,G., Kogel,D., Rangnekar,V. and Scheidtmann,K.H.
  TITLE     Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP
            kinase and Par-4 results in cytoplasmic retention and apoptosis
  JOURNAL   Oncogene 18 (51), 7265-7273 (1999)
   PUBMED   10602480
REFERENCE   7  (bases 1 to 2286)
  AUTHORS   Page,G., Lodige,I., Kogel,D. and Scheidtmann,K.H.
  TITLE     AATF, a novel transcription factor that interacts with Dlk/ZIP
            kinase and interferes with apoptosis
  JOURNAL   FEBS Lett 462 (1-2), 187-191 (1999)
   PUBMED   10580117
REFERENCE   8  (bases 1 to 2286)
  AUTHORS   Murata-Hori,M., Suizu,F., Iwasaki,T., Kikuchi,A. and Hosoya,H.
  TITLE     ZIP kinase identified as a novel myosin regulatory light chain
            kinase in HeLa cells
  JOURNAL   FEBS Lett 451 (1), 81-84 (1999)
   PUBMED   10356987
REFERENCE   9  (bases 1 to 2286)
  AUTHORS   Kawai,T., Matsumoto,M., Takeda,K., Sanjo,H. and Akira,S.
  TITLE     ZIP kinase, a novel serine/threonine kinase which mediates
            apoptosis
  JOURNAL   Mol Cell Biol 18 (3), 1642-1651 (1998)
   PUBMED   9488481
REFERENCE   10 (bases 1 to 2286)
  AUTHORS   Saito,T., Seki,N., Ohira,M., Hayashi,A., Kozuma,S., Hattori,A. and
            Hori,T.
  TITLE     Assignment of the ZIP kinase gene to human chromosome 19p13.3 by
            somatic hybrid analysis and fluorescence in-situ hybridization
  JOURNAL   J Hum Genet 43 (3), 209-211 (1998)
   PUBMED   9747039
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA748997.1, HY104892.1,
            AK027590.1, AK074799.1 and AI654829.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001348.2.
            
            Summary: Death-associated protein kinase 3 (DAPK3) induces
            morphological changes in apoptosis when overexpressed in mammalian
            cells.  These results suggest that DAPK3 may play a role in the
            induction of apoptosis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027590.1, SRR14038191.3357018.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000545797.7/ ENSP00000442973.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DA748997.1         25-44
            21-59               HY104892.1         2-40
            60-1005             AK027590.1         1-946
            1006-2283           AK074799.1         802-2079
            2284-2286           AI654829.1         20-22               c
FEATURES             Location/Qualifiers
     source          1..2286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2286
                     /gene="DAPK3"
                     /gene_synonym="DLK; ZIP; ZIPK"
                     /note="death associated protein kinase 3"
                     /db_xref="GeneID:1613"
                     /db_xref="HGNC:HGNC:2676"
                     /db_xref="MIM:603289"
     exon            1..179
                     /gene="DAPK3"
                     /gene_synonym="DLK; ZIP; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            180..335
                     /gene="DAPK3"
                     /gene_synonym="DLK; ZIP; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1638
                     /gene="DAPK3"
                     /gene_synonym="DLK; ZIP; ZIPK"
                     /EC_number="2.7.11.1"
                     /note="ZIP-kinase; DAP kinase 3; DAP-like kinase;
                     zipper-interacting protein kinase; MYPT1 kinase"
                     /codon_start=1
                     /product="death-associated protein kinase 3"
                     /protein_id="NP_001339.1"
                     /db_xref="CCDS:CCDS12116.1"
                     /db_xref="GeneID:1613"
                     /db_xref="HGNC:HGNC:2676"
                     /db_xref="MIM:603289"
                     /translation="MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFI
                     KKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELF
                     DFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLI
                     DFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFL
                     GETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK
                     AIRRRNVRGEDSGRKPERRRLKTTRLKEYTIKSHSSLPPNNSYADFERFSKVLEEAAA
                     AEEGLRELQRSRRLCHEDVEALAAIYEEKEAWYREESDSLGQDLRRLRQELLKTEALK
                     RQAQEEAKGALLGTSGLKRRFSRLENRYEALAKQVASEMRFVQDLVRALEQEKLQGVE
                     CGLR"
     exon            336..696
                     /gene="DAPK3"
                     /gene_synonym="DLK; ZIP; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            697..826
                     /gene="DAPK3"
                     /gene_synonym="DLK; ZIP; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            827..875
                     /gene="DAPK3"
                     /gene_synonym="DLK; ZIP; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            876..902
                     /gene="DAPK3"
                     /gene_synonym="DLK; ZIP; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1055
                     /gene="DAPK3"
                     /gene_synonym="DLK; ZIP; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1101
                     /gene="DAPK3"
                     /gene_synonym="DLK; ZIP; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..2286
                     /gene="DAPK3"
                     /gene_synonym="DLK; ZIP; ZIPK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2264..2269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAPK3"
                     /gene_synonym="DLK; ZIP; ZIPK"
                     /note="hexamer: AATAAA"
     polyA_site      2286
                     /gene="DAPK3"
                     /gene_synonym="DLK; ZIP; ZIPK"
                     /note="major polyA site"
ORIGIN      
        1 ggcaggggcg cggggcttct ggaggcggcg gcggtggcca gcgcggcggc gccggccgta
       61 ttctccgggc tgcggagggt aaagagcggg ctcgggccga ggctggaggg ctgggtgggg
      121 ccagagcggc gcttcggggg cccgcggagg acgagggagg gagagaatct gaggagctgg
      181 gttgccatta ggggactcct gaggtcctat ctccaggctg cggtgactgc actttccctg
      241 gagtggaagc tgctggaagg cggaccggcc gccatgtcca cgttcaggca ggaggacgtg
      301 gaggaccatt atgagatggg ggaggagctg ggcagcggcc agtttgcgat cgtgcggaag
      361 tgccggcaga agggcacggg caaggagtac gcagccaagt tcatcaagaa gcgccgcctg
      421 tcatccagcc ggcgtggggt gagccgggag gagatcgagc gggaggtgaa catcctgcgg
      481 gagatccggc accccaacat catcaccctg cacgacatct tcgagaacaa gacggacgtg
      541 gtcctcatcc tggagctggt ctctggcggg gagctctttg acttcctggc ggagaaggag
      601 tcgctgacgg aggacgaggc cacccagttc ctcaagcaga tcctggacgg cgttcactac
      661 ctgcactcta agcgcatcgc acactttgac ctgaagccgg aaaacatcat gctgctggac
      721 aagaacgtgc ccaacccacg aatcaagctc atcgacttcg gcatcgcgca caagatcgag
      781 gcggggaacg agttcaagaa catcttcggc accccggagt ttgtggcccc agagattgtg
      841 aactatgagc cgctgggcct ggaggcggac atgtggagca tcggtgtcat cacctatatc
      901 ctcctgagcg gtgcatcccc gttcctgggc gagaccaagc aggagacgct caccaacatc
      961 tcagccgtga actacgactt cgacgaggag tacttcagca acaccagcga gctggccaag
     1021 gacttcattc gccggctgct cgtcaaagat cccaagcgga gaatgaccat tgcccagagc
     1081 ctggaacatt cctggattaa ggcgatccgg cggcggaacg tgcgtggtga ggacagcggc
     1141 cgcaagcccg agcggcggcg cctgaagacc acgcgtctga aggagtacac catcaagtcg
     1201 cactccagct tgccgcccaa caacagctac gccgacttcg agcgcttctc caaggtgctg
     1261 gaggaggcgg cggccgccga ggagggcctg cgcgagctgc agcgcagccg gcggctctgc
     1321 cacgaggacg tggaggcgct ggccgccatc tacgaggaga aggaggcctg gtaccgcgag
     1381 gagagcgaca gcctgggcca ggacctgcgg aggctacggc aggagctgct caagaccgag
     1441 gcgctcaagc ggcaggcgca ggaggaggcc aagggcgcgc tgctggggac cagcggcctc
     1501 aagcgccgct tcagccgcct ggagaaccgc tacgaggcgc tggccaagca agtagcctcc
     1561 gagatgcgct tcgtgcagga cctcgtgcgc gccctggagc aggagaagct gcagggcgtg
     1621 gagtgcgggc tgcgctaggc gcagtggggt gggccaggcc ccaggacagc cggagctcgg
     1681 cctgcggtgg gggcgcttcc tgtggacgct gcgcctccca tcgcccgggt gcctgtcctt
     1741 gcccagcgcc accaggctgg aggcggagtg ggaggagctg gagccaggcc cgtaagttcg
     1801 caggcagggg tgggtgtggg acggggctgc ttctctacac agcctccacg ctggccttca
     1861 ccttcacccc tgcatcgtcg gtgaccctgg gaccctccag gcagcgtggc ctgtggcacc
     1921 gtgagggttg ggacccaccg aggcgcagag gcggcccgaa tgcagccctg gttcaggccc
     1981 ggaggagggt ttgcgggtag ttgcacggac aattcggcgg ggtgctgcct gttgctgcca
     2041 ttagcccagg aggaggtcgt gggacgggga gggtgggatg gacggcggac aggcagtccc
     2101 cacgctgctg ggtggcgccg ggcttggtgg ggtcttccac tgtgtgccct tctcgccgag
     2161 gccggtcccc cgggtgtggg gtgccctgct gcggactcct ccgcgagccc catcgtcgcg
     2221 cctgtggacg cctaggcaag agcggccctc tgcagccaag agaaataaaa tactggcttc
     2281 cagata
//
