LOCUS       NM_014326               2791 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens death associated protein kinase 2 (DAPK2), transcript
            variant 1, mRNA.
ACCESSION   NM_014326
VERSION     NM_014326.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2791)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 2791)
  AUTHORS   Yang,X., Xu,J., Lan,S., Tong,Z., Chen,K., Liu,Z. and Xu,S.
  TITLE     Exosomal miR-133a-3p Derived from BMSCs Alleviates Cerebral
            Ischemia-Reperfusion Injury via Targeting DAPK2
  JOURNAL   Int J Nanomedicine 18, 65-78 (2023)
   PUBMED   36636640
  REMARK    GeneRIF: Exosomal miR-133a-3p Derived from BMSCs Alleviates
            Cerebral Ischemia-Reperfusion Injury via Targeting DAPK2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2791)
  AUTHORS   Jin,M., Li,G., Liu,W., Wu,X., Zhu,J., Zhao,D., Zeng,Z., Xiong,M.,
            Song,Y., He,X., Zhang,Q. and Hu,K.
  TITLE     Cigarette smoking induces aberrant N6-methyladenosine of DAPK2 to
            promote non-small cell lung cancer progression by activating
            NF-kappaB pathway
  JOURNAL   Cancer Lett 518, 214-229 (2021)
   PUBMED   34298122
  REMARK    GeneRIF: Cigarette smoking induces aberrant N(6)-methyladenosine of
            DAPK2 to promote non-small cell lung cancer progression by
            activating NF-kappaB pathway.
REFERENCE   4  (bases 1 to 2791)
  AUTHORS   Horvath,M., Petrvalska,O., Herman,P., Obsilova,V. and Obsil,T.
  TITLE     14-3-3 proteins inactivate DAPK2 by promoting its dimerization and
            protecting key regulatory phosphosites
  JOURNAL   Commun Biol 4 (1), 986 (2021)
   PUBMED   34413451
  REMARK    GeneRIF: 14-3-3 proteins inactivate DAPK2 by promoting its
            dimerization and protecting key regulatory phosphosites.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2791)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2791)
  AUTHORS   Chan,M.W., Chan,L.W., Tang,N.L., Tong,J.H., Lo,K.W., Lee,T.L.,
            Cheung,H.Y., Wong,W.S., Chan,P.S., Lai,F.M. and To,K.F.
  TITLE     Hypermethylation of multiple genes in tumor tissues and voided
            urine in urinary bladder cancer patients
  JOURNAL   Clin Cancer Res 8 (2), 464-470 (2002)
   PUBMED   11839665
  REMARK    GeneRIF: distinct methylation pattern in bladder cancer with
            frequent methylation of RARbeta, DAPK, E-cadherin, and p16.
REFERENCE   7  (bases 1 to 2791)
  AUTHORS   Wong,T.S., Chang,H.W., Tang,K.C., Wei,W.I., Kwong,D.L., Sham,J.S.,
            Yuen,A.P. and Kwong,Y.L.
  TITLE     High frequency of promoter hypermethylation of the death-associated
            protein-kinase gene in nasopharyngeal carcinoma and its detection
            in the peripheral blood of patients
  JOURNAL   Clin Cancer Res 8 (2), 433-437 (2002)
   PUBMED   11839660
  REMARK    GeneRIF: High frequency of promoter hypermethylation of the
            death-associated protein-kinase gene in nasopharyngeal carcinoma
            and its detection in the peripheral blood of patients
REFERENCE   8  (bases 1 to 2791)
  AUTHORS   Shani,G., Henis-Korenblit,S., Jona,G., Gileadi,O., Eisenstein,M.,
            Ziv,T., Admon,A. and Kimchi,A.
  TITLE     Autophosphorylation restrains the apoptotic activity of DRP-1
            kinase by controlling dimerization and calmodulin binding
  JOURNAL   EMBO J 20 (5), 1099-1113 (2001)
   PUBMED   11230133
REFERENCE   9  (bases 1 to 2791)
  AUTHORS   Inbal,B., Shani,G., Cohen,O., Kissil,J.L. and Kimchi,A.
  TITLE     Death-associated protein kinase-related protein 1, a novel
            serine/threonine kinase involved in apoptosis
  JOURNAL   Mol Cell Biol 20 (3), 1044-1054 (2000)
   PUBMED   10629061
REFERENCE   10 (bases 1 to 2791)
  AUTHORS   Kawai,T., Nomura,F., Hoshino,K., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Akira,S.
  TITLE     Death-associated protein kinase 2 is a new
            calcium/calmodulin-dependent protein kinase that signals apoptosis
            through its catalytic activity
  JOURNAL   Oncogene 18 (23), 3471-3480 (1999)
   PUBMED   10376525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021541.7, AF052941.1, AB018001.1 and AC015914.8.
            
            On Jun 2, 2019 this sequence version replaced NM_014326.4.
            
            Summary: This gene encodes a protein that belongs to the
            serine/threonine protein kinase family. This protein contains a
            N-terminal protein kinase domain followed by a conserved
            calmodulin-binding domain with significant similarity to that of
            death-associated protein kinase 1 (DAPK1), a positive regulator of
            programmed cell death. Overexpression of this gene was shown to
            induce cell apoptosis.  It uses multiple polyadenylation sites.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018001.1, AF052941.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000457488.6/ ENSP00000408277.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AC021541.7         137940-138102       c
            164-914             AF052941.1         1-751
            915-1903            AB018001.1         751-1739
            1904-2791           AC015914.8         55357-56244
FEATURES             Location/Qualifiers
     source          1..2791
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..2791
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /note="death associated protein kinase 2"
                     /db_xref="GeneID:23604"
                     /db_xref="HGNC:HGNC:2675"
                     /db_xref="MIM:616567"
     exon            1..188
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..286
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1307
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; DAP
                     kinase 2"
                     /codon_start=1
                     /product="death-associated protein kinase 2 isoform 1"
                     /protein_id="NP_055141.2"
                     /db_xref="CCDS:CCDS10188.1"
                     /db_xref="GeneID:23604"
                     /db_xref="HGNC:HGNC:2675"
                     /db_xref="MIM:616567"
                     /translation="MFQASMRSPNMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKS
                     TGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLI
                     LELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDK
                     NIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITY
                     ILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTI
                     QEALRHPWITPVDNQQAMVRRESVVNLENFRKQYVRRRWKLSFSIVSLCNHLTRSLMK
                     KVHLRPDEDLRNCESDTEEDIARRKALHPRRRSSTS"
     exon            287..508
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..647
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..777
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..826
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..853
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1006
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1052
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1142
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1226
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..2791
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1883..1888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /note="hexamer: ATTAAA"
     polyA_site      1904
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /note="major polyA site"
     regulatory      2768..2773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /note="hexamer: AATAAA"
     polyA_site      2791
                     /gene="DAPK2"
                     /gene_synonym="DRP-1; DRP1"
                     /note="major polyA site"
ORIGIN      
        1 ctcggctcct aggctgctcg gcgggcgggt gccgggcgct ctgggaggag aggactgcag
       61 ggccgagccc agcgcacccc gccgcgtccc ccgttcccgc cgcgcccgcc gcgcccgccg
      121 cgcccgccgc gcccgccgct cccgccgcgc ctgccgcggc cgcgaccgcg gcagctcagc
      181 ctcccgccga ttgtatgttc caggcctcaa tgaggagtcc aaacatggag ccattcaagc
      241 agcagaaggt ggaggacttt tatgacatcg gagaggagct ggggagtggc cagtttgcca
      301 tcgtgaagaa gtgccgggag aagagcacgg ggcttgagta tgcagccaag ttcatcaaga
      361 agcggcagag ccgggcgagc cggcgcggtg tgagccggga ggagatcgag cgggaggtga
      421 gcatcctgcg gcaggtgctg caccacaatg tcatcacgct gcacgacgtc tatgagaacc
      481 gcaccgacgt ggtgctcatc cttgagctag tgtctggagg agagctcttc gatttcctgg
      541 cccagaagga gtcactgagt gaggaggagg ccaccagctt cattaagcag atcctggatg
      601 gggtgaacta ccttcacaca aagaaaattg ctcactttga tctcaagcca gaaaacatta
      661 tgttgttaga caagaatatt cccattccac acatcaagct gattgacttt ggtctggctc
      721 acgaaataga agatggagtt gaatttaaga atatttttgg gacgccggaa tttgttgctc
      781 cagaaattgt gaactacgag cccctgggtc tggaggctga catgtggagc ataggcgtca
      841 tcacctacat cctcttaagt ggagcatccc ctttcctggg agacacgaag caggaaacac
      901 tggcaaatat cacagcagtg agttacgact ttgatgagga attcttcagc cagacgagcg
      961 agctggccaa ggactttatt cggaagcttc tggttaaaga gacccggaaa cggctcacaa
     1021 tccaagaggc tctcagacac ccctggatca cgccggtgga caaccagcaa gccatggtgc
     1081 gcagggagtc tgtggtcaat ctggagaact tcaggaagca gtatgtccgc aggcggtgga
     1141 agctttcctt cagcatcgtg tccctgtgca accacctcac ccgctcgctg atgaagaagg
     1201 tgcacctgag gccggatgag gacctgagga actgtgagag tgacactgag gaggacatcg
     1261 ccaggaggaa agccctccac ccacggagga ggagcagcac ctcctaactg gcctgacctg
     1321 cagtggccgc cagggaggtc tgggcccagc ggggctccct tctgtgcaga cttttggacc
     1381 cagctcagca ccagcacccg ggcgtcctga gcactttgca agagagatgg gcccaaggaa
     1441 ttcagaagag cttgcaggca agccaggaga ccctgggagc tgtggctgtc ttctgtggag
     1501 gaggctccag cattcccaaa gctcttaatt ctccataaaa tgggctttcc tctgtctgcc
     1561 atcctcagag tctggggtgg gagtgtggac ttaggaaaac aatataaagg acatcctcat
     1621 catcacgggg tgaaggtcag actaaggcag ccttcttcac aggctgaggg ggttcagaac
     1681 cagcctggcc aaaaattaca ccagagagac agagtcctcc ccattgggaa cagggtgatt
     1741 gaggaaagtg aaccttgggt gtgagggacc aatcctgtga cctcccagaa ccatggaagc
     1801 caggacgtca ggctgaccaa cacctcagac cttctgaagc agcccattgc tggcccgcca
     1861 tgttgtaatt ttgctcattt ttattaaact tctggtttac ctgatgcttg gcttctttta
     1921 gggctacccc catctcattt cctttagccc gtgtgcctgt aactctgagg gggggcaccc
     1981 agtggggtgc tgagtgggca gaatctcaga aggtcctcct gaaccgtccg cgcaggcctg
     2041 cagtgggcct gcctcctcct tgcttcccta acaggaaggt gtccagttca agagaaccca
     2101 cccagagact gggagtggtg gctcacgcct ataatccctg cgctttggca gtccgaggca
     2161 ggggaattgc ttgaactcag gagttggaga ccagcctggg caacatggca aaacgcagtc
     2221 tgtacaaaaa atacaaaaaa ttagccaggt gtaggggtag gcacctggca tcccagctac
     2281 tccaggggct gaggtgacag cattgcttaa gcccagaagg tcgaggctgc agtgagctga
     2341 gatcacgcca ctgcactcca gtctgggtga cagagagaga ccatatccaa aaaaaaaaaa
     2401 agttgccaga gacgagtatg cccatgctcc ctctacctca ctgccaccac tcctgctgtt
     2461 aggagctgag tgtgtctccc taaaatttct atgttgaagt cttaaccctt ggtaccacag
     2521 aatatcactg tatttggaga tggggtcttt agaaaggcac ttaaattaaa atgagctcac
     2581 tgatatgggc cccgatgcaa tataattggt gtccttataa gaaggggagg ttaggacacg
     2641 caggaaagac cacatgaagg cccaggagtg ggagggggaa tagccatcga caaactaagg
     2701 gggcctcaga ggaaaccaac cctgctgaca cctcaatctt agactctggc ctcaaaaatt
     2761 gtaagaaaat aaacttctgt cttttaagcc a
//
