LOCUS       NM_004938               5912 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens death associated protein kinase 1 (DAPK1), transcript
            variant 1, mRNA.
ACCESSION   NM_004938
VERSION     NM_004938.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5912)
  AUTHORS   Fu,M., Gu,J., Yu,D., Wang,M., Zhang,J., Ji,R., Jiang,P. and
            Zhang,X.
  TITLE     Circ1811 suppresses gastric cancer progression by regulating the
            miR-632/DAPK1 axis
  JOURNAL   Gene 910, 148331 (2024)
   PUBMED   38438055
  REMARK    GeneRIF: Circ1811 suppresses gastric cancer progression by
            regulating the miR-632/DAPK1 axis.
REFERENCE   2  (bases 1 to 5912)
  AUTHORS   Yang,J., Liu,Y., Geng,Q. and Wang,B.
  TITLE     Death associated protein kinase 1 predicts the prognosis and the
            immunotherapy response of various cancers
  JOURNAL   Mol Biol Rep 51 (1), 670 (2024)
   PUBMED   38787485
  REMARK    GeneRIF: Death associated protein kinase 1 predicts the prognosis
            and the immunotherapy response of various cancers.
            Erratum:[Mol Biol Rep. 2024 Jul 23;51(1):846. doi:
            10.1007/s11033-024-09709-w.. PMID: 39042224]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5912)
  AUTHORS   Wang,F., Hu,D., Lou,X., Wang,Y., Wang,L., Zhang,T., Yan,Z., Meng,N.
            and Zou,Y.
  TITLE     BNIP3 and DAPK1 methylation in peripheral blood leucocytes are
            noninvasive biomarkers for gastric cancer
  JOURNAL   Gene 898, 148109 (2024)
   PUBMED   38142898
  REMARK    GeneRIF: BNIP3 and DAPK1 methylation in peripheral blood leucocytes
            are noninvasive biomarkers for gastric cancer.
REFERENCE   4  (bases 1 to 5912)
  AUTHORS   Luo,Q.Q., Tian,Y., Qu,G.J., Huang,K., Hu,P.P., Xue,Y., Hu,B.F. and
            Luo,S.S.
  TITLE     The targeting of DAPK1 with miR-190a-3p promotes autophagy in
            trophoblast cells
  JOURNAL   Mol Reprod Dev 91 (1), e23724 (2024)
   PUBMED   38282318
  REMARK    GeneRIF: The targeting of DAPK1 with miR-190a-3p promotes autophagy
            in trophoblast cells.
REFERENCE   5  (bases 1 to 5912)
  AUTHORS   Takata,K., Miyata-Takata,T. and Sato,Y.
  TITLE     Frequent CDKN2B/P15 and DAPK1 methylation in duodenal follicular
            lymphoma is related to duodenal reactive lymphoid hyperplasia
  JOURNAL   J Clin Exp Hematop 64 (2), 129-137 (2024)
   PUBMED   38925973
  REMARK    GeneRIF: Frequent CDKN2B/P15 and DAPK1 methylation in duodenal
            follicular lymphoma is related to duodenal reactive lymphoid
            hyperplasia.
REFERENCE   6  (bases 1 to 5912)
  AUTHORS   Jin,Y., Blue,E.K., Dixon,S., Hou,L., Wysolmerski,R.B. and
            Gallagher,P.J.
  TITLE     Identification of a new form of death-associated protein kinase
            that promotes cell survival
  JOURNAL   J Biol Chem 276 (43), 39667-39678 (2001)
   PUBMED   11485996
REFERENCE   7  (bases 1 to 5912)
  AUTHORS   Tereshko,V., Teplova,M., Brunzelle,J., Watterson,D.M. and Egli,M.
  TITLE     Crystal structures of the catalytic domain of human protein kinase
            associated with apoptosis and tumor suppression
  JOURNAL   Nat Struct Biol 8 (10), 899-907 (2001)
   PUBMED   11573098
REFERENCE   8  (bases 1 to 5912)
  AUTHORS   Inbal,B., Shani,G., Cohen,O., Kissil,J.L. and Kimchi,A.
  TITLE     Death-associated protein kinase-related protein 1, a novel
            serine/threonine kinase involved in apoptosis
  JOURNAL   Mol Cell Biol 20 (3), 1044-1054 (2000)
   PUBMED   10629061
REFERENCE   9  (bases 1 to 5912)
  AUTHORS   Feinstein,E., Druck,T., Kastury,K., Berissi,H., Goodart,S.A.,
            Overhauser,J., Kimchi,A. and Huebner,K.
  TITLE     Assignment of DAP1 and DAPK--genes that positively mediate
            programmed cell death triggered by IFN-gamma--to chromosome regions
            5p12.2 and 9q34.1, respectively
  JOURNAL   Genomics 29 (1), 305-307 (1995)
   PUBMED   8530096
REFERENCE   10 (bases 1 to 5912)
  AUTHORS   Deiss,L.P., Feinstein,E., Berissi,H., Cohen,O. and Kimchi,A.
  TITLE     Identification of a novel serine/threonine kinase and a novel 15-kD
            protein as potential mediators of the gamma interferon-induced cell
            death
  JOURNAL   Genes Dev 9 (1), 15-30 (1995)
   PUBMED   7828849
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR002874.1, AK295119.1,
            BC113660.1, CX872304.1, BG110813.1 and H77515.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004938.3.
            
            Summary: Death-associated protein kinase 1 is a positive mediator
            of gamma-interferon induced programmed cell death. DAPK1 encodes a
            structurally unique 160-kD calmodulin dependent serine-threonine
            kinase that carries 8 ankyrin repeats and 2 putative P-loop
            consensus sites. It is a tumor suppressor candidate. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3 and 4 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.202596.1,
                                           SRR1803617.102821.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408954.8/ ENSP00000386135.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                DR002874.1         145-226
            83-1209             AK295119.1         1-1127
            1210-4660           BC113660.1         934-4384
            4661-4995           AK295119.1         4579-4913
            4996-5496           CX872304.1         347-847
            5497-5742           BG110813.1         272-517
            5743-5912           H77515.1           15-184              c
FEATURES             Location/Qualifiers
     source          1..5912
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..5912
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /note="death associated protein kinase 1"
                     /db_xref="GeneID:1612"
                     /db_xref="HGNC:HGNC:2674"
                     /db_xref="MIM:600831"
     exon            1..241
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            242..411
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..4642
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /EC_number="2.7.11.1"
                     /note="DAP kinase 1"
                     /codon_start=1
                     /product="death-associated protein kinase 1"
                     /protein_id="NP_004929.2"
                     /db_xref="CCDS:CCDS43842.1"
                     /db_xref="GeneID:1612"
                     /db_xref="HGNC:HGNC:2674"
                     /db_xref="MIM:600831"
                     /translation="MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFI
                     KKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELF
                     DFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKII
                     DFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFL
                     GDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK
                     PKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSRSFLSRSNMSVARSD
                     DTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNI
                     QILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALH
                     VAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKN
                     REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQ
                     GCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILD
                     VVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHRGLFIQQLRPTQ
                     NLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSFFRRRRPRLSSTNSSRFPPSPLASKP
                     TVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAPTHHPHCSADDQSTKAIDI
                     QNAYLNGVGDFSVWEFSGNPVYFCCYDYFAANDPTSIHVVVFSLEEPYEIQLNQVIFW
                     LSFLKSLVPVEEPIAFGGKLKNPLQVVLVATHADIMNVPRPAGGEFGYDKDTSLLKEI
                     RNRFGNDLHISNKLFVLDAGASGSKDMKVLRNHLQEIRSQIVSVCPPMTHLCEKIIST
                     LPSWRKLNGPNQLMSLQQFVYDVQDQLNPLASEEDLRRIAQQLHSTGEINIMQSETVQ
                     DVLLLDPRWLCTNVLGKLLSVETPRALHHYRGRYTVEDIQRLVPDSDVEELLQILDAM
                     DICARDLSSGTMVDVPALIKTDNLHRSWADEEDEVMVYGGVRIVPVEHLTPFPCGIFH
                     KVQVNLCRWIHQQSTEGDADIRLWVNGCKLANRGAELLVLLVNHGQGIEVQVRGLETE
                     KIKCCLLLDSVCSTIENVMATTLPGLLTVKHYLSPQQLREHHEPVMIYQPRDFFRAQT
                     LKETSLTNTMGGYKESFSSIMCFGCHDVYSQASLGMDIHASDLNLLTRRKLSRLLDPP
                     DPLGKDWCLLAMNLGLPDLVAKYNTSNGAPKDFLPSPLHALLREWTTYPESTVGTLMS
                     KLRELGRRDAADFLLKASSVFKINLDGNGQEAYASSCNSGTSYNSISSVVSR"
     exon            412..633
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            634..772
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            773..902
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            903..951
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            952..978
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1131
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1177
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1267
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1360
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1480
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1579
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1678
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1777
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1975
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2173
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2272
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2350
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2573
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2762
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2960
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3099
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3220
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3409
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..5912
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5889..5894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /note="hexamer: AATAAA"
     polyA_site      5912
                     /gene="DAPK1"
                     /gene_synonym="DAPK; ROCO3"
                     /note="major polyA site"
ORIGIN      
        1 gcttcggagt gtgaggagga cagccggacc gagccaacgc cggggacttt gttccctccg
       61 cggaggggac tcggcaactc gcagcggcag ggtctggggc cggcgcctgg gagggatctg
      121 cgccccccac tcactcccta gctgtgttcc cgccgccgcc ccggctagtc tccggcgctg
      181 gcgcctatgg tcggcctccg acagcgctcc ggagggaccg ggggagctcc caggcgcccg
      241 ggactggaga ctgatgcatg agggggctac ggaggcgcag gagcggtggt gatggtctgg
      301 gaagcggagc tgaagtgccc tgggctttgg tgaggcgtga cagtttatca tgaccgtgtt
      361 caggcaggaa aacgtggatg attactacga caccggcgag gaacttggca gtggacagtt
      421 tgcggttgtg aagaaatgcc gtgagaaaag caccggcctc cagtatgccg ccaaattcat
      481 caagaaaagg aggactaagt ccagccggcg gggtgtgagc cgcgaggaca tcgagcggga
      541 ggtcagcatc ctgaaggaga tccagcaccc caatgtcatc accctgcacg aggtctatga
      601 gaacaagacg gacgtcatcc tgatcttgga actcgttgca ggtggcgagc tgtttgactt
      661 cttagctgaa aaggaatctt taactgaaga ggaagcaact gaatttctca aacaaattct
      721 taatggtgtt tactacctgc actcccttca aatcgcccac tttgatctta agcctgagaa
      781 cataatgctt ttggatagaa atgtccccaa acctcggatc aagatcattg actttgggtt
      841 ggcccataaa attgactttg gaaatgaatt taaaaacata tttgggactc cagagtttgt
      901 cgctcctgag atagtcaact atgaacctct tggtcttgag gcagatatgt ggagtatcgg
      961 ggtaataacc tatatcctcc taagtggggc ctccccattt cttggagaca ctaagcaaga
     1021 aacgttagca aatgtatccg ctgtcaacta cgaatttgag gatgaatact tcagtaatac
     1081 cagtgcccta gccaaagatt tcataagaag acttctggtc aaggatccaa agaagagaat
     1141 gacaattcaa gatagtttgc agcatccctg gatcaagcct aaagatacac aacaggcact
     1201 tagtagaaaa gcatcagcag taaacatgga gaaattcaag aagtttgcag cccggaaaaa
     1261 atggaaacaa tccgttcgct tgatatcact gtgccaaaga ttatccaggt cattcctgtc
     1321 cagaagtaac atgagtgttg ccagaagcga tgatactctg gatgaggaag actcctttgt
     1381 gatgaaagcc atcatccatg ccatcaacga tgacaatgtc ccaggcctgc agcaccttct
     1441 gggctcatta tccaactatg atgttaacca acccaacaag cacgggacac ctccattact
     1501 cattgctgct ggctgtggga atattcaaat actacagttg ctcattaaaa gaggctcgag
     1561 aatcgatgtc caggataagg gcgggtccaa tgccgtctac tgggctgctc ggcatggcca
     1621 cgtcgatacc ttgaaatttc tcagtgagaa caaatgccct ttggatgtga aagacaagtc
     1681 tggagagatg gccctccacg tggcagctcg ctatggccat gctgacgtgg ctcagttact
     1741 gtgcagcttc ggctcaaatc ccaatatcca ggacaaggaa gaagaaaccc ccctgcactg
     1801 tgctgcttgg cacggctatt actctgtggc caaagccctt tgtgaagccg gctgtaacgt
     1861 gaacatcaag aaccgagaag gagagacgcc cctcctgaca gcctctgcca ggggctacca
     1921 cgacatcgtg gagtgtctgg ccgaacatgg agccgacctt aatgcttgcg acaaggacgg
     1981 acacattgcc cttcatctgg ctgtaagacg gtgtcagatg gaggtaatca agactctcct
     2041 cagccaaggg tgtttcgtcg attatcaaga caggcacggc aatactcccc tccatgtggc
     2101 atgtaaagat ggcaacatgc ctatcgtggt ggccctctgt gaagcaaact gcaatttgga
     2161 catctccaac aagtatgggc gaacgcctct gcaccttgcg gccaacaacg gaatcctaga
     2221 cgtggtccgg tatctctgtc tgatgggagc cagcgttgag gcgctgacca cggacggaaa
     2281 gacggcagaa gatcttgcta gatcggaaca gcacgagcac gtagcaggtc tccttgcaag
     2341 acttcgaaag gatacgcacc gaggactctt catccagcag ctccgaccca cacagaacct
     2401 gcagccaaga attaagctca agctgtttgg ccactcggga tccgggaaaa ccacccttgt
     2461 agaatctctc aagtgtgggc tgctgaggag ctttttcaga aggcgtcggc ccagactgtc
     2521 ttccaccaac tccagcaggt tcccaccttc acccctggct tctaagccca cagtctcagt
     2581 gagcatcaac aacctgtacc caggctgcga gaacgtgagt gtgaggagcc gcagcatgat
     2641 gttcgagccg ggtcttacca aagggatgct ggaggtgttt gtggccccga cccaccaccc
     2701 gcactgctcg gccgatgacc agtccaccaa ggccatcgac atccagaacg cttatttgaa
     2761 tggagttggc gatttcagcg tgtgggagtt ctctggaaat cctgtgtatt tctgctgtta
     2821 tgactatttt gctgcaaatg atcccacgtc aatccatgtt gttgtcttta gtctagaaga
     2881 gccctatgag atccagctga accaagtgat tttctggctc agtttcctga agtcccttgt
     2941 cccagttgaa gaacccatag ccttcggtgg caagctgaag aacccactcc aagttgtcct
     3001 ggtggccacc cacgctgaca tcatgaatgt tcctcgaccg gctggaggcg agtttggata
     3061 tgacaaagac acatcgttgc tgaaagagat taggaacagg tttggaaatg atcttcacat
     3121 ttcaaataag ctgtttgttc tggatgctgg ggcttctggg tcaaaggaca tgaaggtact
     3181 tcgaaatcat ctgcaagaaa tacgaagcca gattgtttcg gtctgtcctc ccatgactca
     3241 cctgtgtgag aaaatcatct ccacgctgcc ttcctggagg aagctcaatg gacccaacca
     3301 gctgatgtcg ctgcagcagt ttgtgtacga cgtgcaggac cagctgaacc ccctggccag
     3361 cgaggaggac ctcaggcgca ttgctcagca gctccacagc acaggcgaga tcaacatcat
     3421 gcaaagtgaa acagttcagg acgtgctgct cctggacccc cgctggctct gcacaaacgt
     3481 cctggggaag ttgctgtccg tggagacccc acgggcgctg caccactacc ggggccgcta
     3541 caccgtggag gacatccagc gcctggtgcc cgacagcgac gtggaggagc tgctgcagat
     3601 cctcgatgcc atggacatct gcgcccggga cctgagcagc gggaccatgg tggacgtccc
     3661 agccctgatc aagacagaca acctgcaccg ctcctgggct gatgaggagg acgaggtgat
     3721 ggtgtatggt ggcgtgcgca tcgtgcccgt ggaacacctc acccccttcc catgtggcat
     3781 ctttcacaag gtccaggtga acctgtgccg gtggatccac cagcaaagca cagagggcga
     3841 cgcggacatc cgcctgtggg tgaatggctg caagctggcc aaccgtgggg ccgagctgct
     3901 ggtgctgctg gtcaaccacg gccagggcat tgaggtccag gtccgcggcc tggagacgga
     3961 gaagatcaag tgctgcctgc tgctggactc ggtgtgcagc accattgaga acgtcatggc
     4021 caccacgctg ccagggctcc tgaccgtgaa gcattacctg agcccccagc agctgcggga
     4081 gcaccatgag cccgtcatga tctaccagcc acgggacttc ttccgggcac agactctgaa
     4141 ggaaacctca ctgaccaaca ccatgggggg gtacaaggaa agcttcagca gcatcatgtg
     4201 cttcgggtgt cacgacgtct actcacaggc cagcctcggc atggacatcc atgcatcaga
     4261 cctgaacctc ctcactcgga ggaaactgag tcgcctgctg gacccgcccg accccctggg
     4321 gaaggactgg tgccttctcg ccatgaactt aggcctccct gacctcgtgg caaagtacaa
     4381 caccagtaac ggggctccca aggatttcct ccccagcccc ctccacgccc tgctgcggga
     4441 atggaccacc taccctgaga gcacagtggg caccctcatg tccaaactga gggagctggg
     4501 tcgccgggat gccgcagact ttttgctgaa ggcatcctct gtgttcaaaa tcaacctgga
     4561 tggcaatggc caggaggcct atgcctcgag ctgcaacagc ggcacctctt acaattccat
     4621 tagctctgtt gtatcccggt gagggcagcc tctggcttgg gcagggtctg tttggactgc
     4681 agaagcaagg gggtgatgta gcccatcctt ccctttggag atgctgaggg tgtttcttcc
     4741 tgcacccaca gccaggggga tgccactcct ccctccggct tgacctgttt ctctgccgct
     4801 acctccctcc ccgtctcatt ccgttgtctg tggatggtca ttgcagttta agagcagaac
     4861 agatctttta ctttggccgc ttgaaaagct agtgtacctc ctctcagtgt tttggactcc
     4921 atctctcatc ctccagtacc ttgcttctta ctgataattt tgctggaatt cctaactttt
     4981 caatgacatt ttttttaact actatattga ttgtccttta aaaaagaaaa gtgcatattt
     5041 atccaaaatg tgtatttctt atacgctttt ctttgttata ccatttcctc agcttatctc
     5101 ttttatattt gtaggagaaa ctcccatgta tggaatccca ctgtatgatt tataaacaga
     5161 caatatgtga gtgccttttg cagaagaggg tgtgtttgaa atcatcggag tcagccagga
     5221 gctgtcacca aggaaacgct acctctctgt cccttgctgt atgctgatca tcgccagagg
     5281 tgcttcaccc tgagttttgt tttgtattgt tttctgacag tttttctgtt ttgtttggca
     5341 aggaaagggg agaagggaat cctcctccag ggtgatttta tgatcagtgt tgttgctcta
     5401 ggaagacatt tttccgtttg cttttgttcc aatgtcaatg tgaacgtcca catgaaacct
     5461 acacactgtc atgcttcatc attccctctc atctcaggta gaaggttgac acagttgtag
     5521 ggttacagag acctatgtaa gaattcagaa gacccctgac tcatcatttg tggcagtccc
     5581 ttataattgg tgcatagcag atggtttcca catttagatc ctggtttcat aacttcctgt
     5641 acttgaagtc taaaagcaga aaataaagga agcaagtttt cttccatgat tttaaattgt
     5701 gatcgagttt taaattgata ggagggaaca tgtcctaatt cttctgtcct gagaagcatg
     5761 taatgttaat gttatatcat atgtatatat atatatgcac tatgtatata catatatatt
     5821 aatactggta tttttactta atctataaaa tgtcgttaaa aagttgtttg tttttttctt
     5881 tttttataaa taaactgttg ctcgttgcat ta
//
