LOCUS       NM_004632               2056 bp    mRNA    linear   PRI 19-FEB-2025
DEFINITION  Homo sapiens death associated protein 3 (DAP3), transcript variant
            2, mRNA.
ACCESSION   NM_004632
VERSION     NM_004632.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2056)
  AUTHORS   Tan,S., Zhang,X., Guo,X., Pan,G., Yan,L., Ding,Z., Li,R., Wang,D.,
            Yan,Y., Dong,Z. and Li,T.
  TITLE     DAP3 promotes mitochondrial activity and tumour progression in
            hepatocellular carcinoma by regulating MT-ND5 expression
  JOURNAL   Cell Death Dis 15 (7), 540 (2024)
   PUBMED   39080251
  REMARK    GeneRIF: DAP3 promotes mitochondrial activity and tumour
            progression in hepatocellular carcinoma by regulating MT-ND5
            expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2056)
  AUTHORS   Sui,L., Zeng,J., Zhao,H., Ye,L., Martin,T.A., Sanders,A.J.,
            Ruge,F., Jiang,A., Dou,Q.P., Hargest,R., Song,X. and Jiang,W.G.
  TITLE     Death associated protein-3 (DAP3) and DAP3 binding cell death
            enhancer-1 (DELE1) in human colorectal cancer, and their impacts on
            clinical outcome and chemoresistance
  JOURNAL   Int J Oncol 62 (1) (2023)
   PUBMED   36382667
  REMARK    GeneRIF: Death associated protein3 (DAP3) and DAP3 binding cell
            death enhancer1 (DELE1) in human colorectal cancer, and their
            impacts on clinical outcome and chemoresistance.
REFERENCE   3  (bases 1 to 2056)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 2056)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2056)
  AUTHORS   Sui,L., Ye,L., Sanders,A.J., Yang,Y., Hao,C., Hargest,R. and
            Jiang,W.G.
  TITLE     Expression of Death Associated Proteins DAP1 and DAP3 in Human
            Pancreatic Cancer
  JOURNAL   Anticancer Res 41 (5), 2357-2362 (2021)
   PUBMED   33952460
  REMARK    GeneRIF: Expression of Death Associated Proteins DAP1 and DAP3 in
            Human Pancreatic Cancer.
REFERENCE   6  (bases 1 to 2056)
  AUTHORS   Han,M.J., Chiu,D.T. and Koc,E.C.
  TITLE     Regulation of mitochondrial ribosomal protein S29 (MRPS29)
            expression by a 5'-upstream open reading frame
  JOURNAL   Mitochondrion 10 (3), 274-283 (2010)
   PUBMED   20079882
REFERENCE   7  (bases 1 to 2056)
  AUTHORS   Morgan,C.J., Jacques,C., Savagner,F., Tourmen,Y., Mirebeau,D.P.,
            Malthiery,Y. and Reynier,P.
  TITLE     A conserved N-terminal sequence targets human DAP3 to mitochondria
  JOURNAL   Biochem Biophys Res Commun 280 (1), 177-181 (2001)
   PUBMED   11162496
REFERENCE   8  (bases 1 to 2056)
  AUTHORS   Hulkko,S.M., Wakui,H. and Zilliacus,J.
  TITLE     The pro-apoptotic protein death-associated protein 3 (DAP3)
            interacts with the glucocorticoid receptor and affects the receptor
            function
  JOURNAL   Biochem J 349 Pt 3 (Pt 3), 885-893 (2000)
   PUBMED   10903152
REFERENCE   9  (bases 1 to 2056)
  AUTHORS   Kissil,J.L. and Kimchi,A.
  TITLE     Assignment of death associated protein 3 (DAP3) to human chromosome
            1q21 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 77 (3-4), 252 (1997)
   PUBMED   9284927
REFERENCE   10 (bases 1 to 2056)
  AUTHORS   Kissil,J.L., Deiss,L.P., Bayewitch,M., Raveh,T., Khaspekov,G. and
            Kimchi,A.
  TITLE     Isolation of DAP3, a novel mediator of interferon-gamma-induced
            cell death
  JOURNAL   J Biol Chem 270 (46), 27932-27936 (1995)
   PUBMED   7499268
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162734.15, BC107487.1 and
            BQ183744.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004632.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 28S subunit protein that also
            participates in apoptotic pathways which are initiated by tumor
            necrosis factor-alpha, Fas ligand, and gamma interferon. This
            protein potentially binds ATP/GTP and might be a functional partner
            of the mitoribosomal protein S27. Multiple alternatively spliced
            transcript variants encoding distinct isoforms have been found for
            this gene. Pseudogenes corresponding to this gene are found on
            chromosomes 1q and 2q. [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (1). Variants 1, 2 and 3 encode the same isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.210349.1,
                                           SRR1163655.119506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000368336.10/
                                                  ENSP00000357320.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL162734.15        31265-31267
            4-1408              BC107487.1         1-1405
            1409-1851           AL162734.15        80537-80979
            1852-2056           BQ183744.1         13-217              c
FEATURES             Location/Qualifiers
     source          1..2056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2056
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /note="death associated protein 3"
                     /db_xref="GeneID:7818"
                     /db_xref="HGNC:HGNC:2673"
                     /db_xref="MIM:602074"
     exon            1..84
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            85..136
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1288
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /note="isoform 1 is encoded by transcript variant 2;
                     mitochondrial 28S ribosomal protein S29; 28S ribosomal
                     protein S29, mitochondrial; ionizing radiation resistance
                     conferring protein; mitochondrial small ribosomal subunit
                     protein mS29"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS29 isoform 1"
                     /protein_id="NP_004623.1"
                     /db_xref="CCDS:CCDS1120.1"
                     /db_xref="GeneID:7818"
                     /db_xref="HGNC:HGNC:2673"
                     /db_xref="MIM:602074"
                     /translation="MMLKGITRLISRIHKLDPGRFLHMGTQARQSIAAHLDNQVPVES
                     PRAISRTNENDPAKHGDQHEGQHYNISPQDLETVFPHGLPPRFVMQVKTFSEACLMVR
                     KPALELLHYLKNTSFAYPAIRYLLYGEKGTGKTLSLCHVIHFCAKQDWLILHIPDAHL
                     WVKNCRDLLQSSYNKQRFDQPLEASTWLKNFKTTNERFLNQIKVQEKYVWNKRESTEK
                     GSPLGEVVEQGITRVRNATDAVGIVLKELKRQSSLGMFHLLVAVDGINALWGRTTLKR
                     EDKSPIAPEELALVHNLRKMMKNDWHGGAIVSALSQTGSLFKPRKAYLPQELLGKEGF
                     DALDPFIPILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLE
                     RHCAYL"
     exon            137..259
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            260..361
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            362..470
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            471..563
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            564..694
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            695..775
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            776..934
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            935..994
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1084
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1202
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..2056
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1557..1562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /note="hexamer: AATAAA"
     polyA_site      1575
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /note="major polyA site"
     regulatory      2036..2041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /note="hexamer: AATAAA"
     regulatory      2040..2045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
                     /note="hexamer: AATAAA"
     polyA_site      2052
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
     polyA_site      2056
                     /gene="DAP3"
                     /gene_synonym="bMRP-10; DAP-3; MRP-S29; MRPS29; mS29;
                     PRLTS7; S29mt"
ORIGIN      
        1 gcagtctcag gacgggcgct ttggagccgg ccccaggcag cgtgtgtcgg tcgcctagtc
       61 tggagaacta gtcctcgact cacgtgcaag gatgatgctg aaaggaataa caaggcttat
      121 ctctaggatc cataagttgg accctgggcg ttttttacac atggggaccc aggctcgcca
      181 aagcattgct gctcacctag ataaccaggt tccagttgag agtccgagag ctatttcccg
      241 caccaatgag aatgacccgg ccaagcatgg ggatcagcac gagggtcagc actacaacat
      301 ctccccccag gatttggaga ctgtatttcc ccatggcctt cctcctcgct ttgtgatgca
      361 ggtgaagaca ttcagtgaag cttgcctgat ggtaaggaaa ccagccctag aacttctgca
      421 ttacctgaaa aacaccagtt ttgcttatcc agctatacga tatcttctgt atggagagaa
      481 gggaacagga aaaaccctaa gtctttgcca tgttattcat ttctgtgcaa aacaggactg
      541 gctgatacta catattccag atgctcatct ttgggtgaaa aattgtcggg atcttctgca
      601 gtccagctac aacaaacagc gctttgatca acctttagag gcttcaacct ggctgaagaa
      661 tttcaaaact acaaatgagc gcttcctgaa ccagataaaa gttcaagaga agtatgtctg
      721 gaataagaga gaaagcactg agaaagggag tcctctggga gaagtggttg aacagggcat
      781 aacacgggtg aggaacgcca cagatgcagt tggaattgtg ctgaaagagc taaagaggca
      841 aagttctttg ggtatgtttc acctcctagt ggccgtggat ggaatcaatg ctctttgggg
      901 aagaaccact ctgaaaagag aagataaaag cccgattgcc cccgaggaat tagcacttgt
      961 tcacaacttg aggaaaatga tgaaaaatga ttggcatgga ggcgccattg tgtcggcttt
     1021 gagccagact gggtctctct ttaagccccg gaaagcctat ctgccccagg agttgctggg
     1081 aaaggaagga tttgatgccc tggatccctt tattcccatc ctggtttcca actataaccc
     1141 aaaggaattt gaaagttgta ttcagtatta tttggaaaac aattggcttc aacatgagaa
     1201 agctcctaca gaagaaggga aaaaagagct gctgttccta agtaacgcga acccctcgct
     1261 gctggagcgg cactgtgcct acctctaagc caagatcaca gcatgtgagg aagacagtgg
     1321 acatctgctt tatgctggac ccagtaagat gaggaagtcg ggcagtacac aggaagagga
     1381 gccaggccct tgtacctatg ggattggaca ggactgcagt tggctctgga cctgcattaa
     1441 aatgggtttc actgtgaatg cgtgacaata agatattccc ttgttcctaa aactttatat
     1501 cagtttattg gatgtggttt ttcacattta agataattat ggctcttttc ctaaaaaata
     1561 aaatatcttt ctaaagtgtt gtgttagatt aataatatgg aaggagtctt tagattggcc
     1621 aaattgcatt tctctgatat tcctcttgtt gcaggtcaga agagatcaat tctacagaaa
     1681 tttccagtgg ttctgttgag gctttatgga attcagcatg tcaaaattca cagctggctg
     1741 ggcacagtgg ctcatgcctg taatcccagc actttggaag cccaaggcgg gcagactgct
     1801 tgagttcagg agtttgcaac cagcctgggc aacatggtga aaacctgtct ctactaaaaa
     1861 tacaaaaatt agccgggcac ggtggcatgc gcctgtaatc caagctactt gggaggctga
     1921 ggcaggagaa ttgcttcaac ttgggaggcg gatgttgcag tgagccaaaa ttgcaccact
     1981 gcactccagc ctgggcagca gagcaagact ccgtctcaaa ataaataaat aaataaataa
     2041 ataaataaat aataaa
//
