LOCUS       NM_004394               2301 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens death associated protein (DAP), transcript variant 2,
            mRNA.
ACCESSION   NM_004394
VERSION     NM_004394.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2301)
  AUTHORS   Sui,L., Ye,L., Sanders,A.J., Yang,Y., Hao,C., Hargest,R. and
            Jiang,W.G.
  TITLE     Expression of Death Associated Proteins DAP1 and DAP3 in Human
            Pancreatic Cancer
  JOURNAL   Anticancer Res 41 (5), 2357-2362 (2021)
   PUBMED   33952460
  REMARK    GeneRIF: Expression of Death Associated Proteins DAP1 and DAP3 in
            Human Pancreatic Cancer.
REFERENCE   2  (bases 1 to 2301)
  AUTHORS   Wiedemann,C., Voigt,J., Jirschitzka,J., Hafner,S., Ohlenschlager,O.
            and Bordusa,F.
  TITLE     Backbone and nearly complete side-chain chemical shift assignments
            of the human death-associated protein 1 (DAP1)
  JOURNAL   Biomol NMR Assign 15 (1), 91-97 (2021)
   PUBMED   33263927
  REMARK    GeneRIF: Backbone and nearly complete side-chain chemical shift
            assignments of the human death-associated protein 1 (DAP1).
REFERENCE   3  (bases 1 to 2301)
  AUTHORS   Wazir,U., Sanders,A.J., Wazir,A., Baig,R.M., Jiang,W.G., Ster,I.C.,
            Sharma,A.K. and Mokbel,K.
  TITLE     Effect of the knockdown of death-associated protein 1 expression on
            cell adhesion, growth and migration in breast cancer cells
  JOURNAL   Oncol Rep 33 (3), 1450-1458 (2015)
   PUBMED   25530065
  REMARK    GeneRIF: DAP1 may have an important role in cell adhesion,
            migration and growth in the context of breast cancer and has
            significant associations with the apoptosis pathway.
REFERENCE   4  (bases 1 to 2301)
  AUTHORS   Jia,Y., Ye,L., Ji,K., Toms,A.M., Davies,M.L., Ruge,F., Ji,J.,
            Hargest,R. and Jiang,W.G.
  TITLE     Death associated protein 1 is correlated with the clinical outcome
            of patients with colorectal cancer and has a role in the regulation
            of cell death
  JOURNAL   Oncol Rep 31 (1), 175-182 (2014)
   PUBMED   24270644
  REMARK    GeneRIF: DAP1 was found to be correlated with disease progression
            and long-term survival of the colorectal patients. DAP1 is also a
            pivotal regulator of the growth and apoptosis and cellular response
            to chemotherapy agents.
REFERENCE   5  (bases 1 to 2301)
  AUTHORS   Yu,B., Zheng,Y., Alexander,D., Manolio,T.A., Alonso,A.,
            Nettleton,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association study of a heart failure related
            metabolomic profile among African Americans in the Atherosclerosis
            Risk in Communities (ARIC) study
  JOURNAL   Genet Epidemiol 37 (8), 840-845 (2013)
   PUBMED   23934736
REFERENCE   6  (bases 1 to 2301)
  AUTHORS   Zougman,A. and Wisniewski,J.R.
  TITLE     Beyond linker histones and high mobility group proteins: global
            profiling of perchloric acid soluble proteins
  JOURNAL   J Proteome Res 5 (4), 925-934 (2006)
   PUBMED   16602700
REFERENCE   7  (bases 1 to 2301)
  AUTHORS   Levy-Strumpf,N. and Kimchi,A.
  TITLE     Death associated proteins (DAPs): from gene identification to the
            analysis of their apoptotic and tumor suppressive functions
  JOURNAL   Oncogene 17 (25), 3331-3340 (1998)
   PUBMED   9916995
  REMARK    Review article
REFERENCE   8  (bases 1 to 2301)
  AUTHORS   Feinstein,E., Druck,T., Kastury,K., Berissi,H., Goodart,S.A.,
            Overhauser,J., Kimchi,A. and Huebner,K.
  TITLE     Assignment of DAP1 and DAPK--genes that positively mediate
            programmed cell death triggered by IFN-gamma--to chromosome regions
            5p12.2 and 9q34.1, respectively
  JOURNAL   Genomics 29 (1), 305-307 (1995)
   PUBMED   8530096
REFERENCE   9  (bases 1 to 2301)
  AUTHORS   Deiss,L.P., Feinstein,E., Berissi,H., Cohen,O. and Kimchi,A.
  TITLE     Identification of a novel serine/threonine kinase and a novel 15-kD
            protein as potential mediators of the gamma interferon-induced cell
            death
  JOURNAL   Genes Dev 9 (1), 15-30 (1995)
   PUBMED   7828849
REFERENCE   10 (bases 1 to 2301)
  AUTHORS   Belokrylov,G.A. and Zhitnukhin,Iu.L.
  TITLE     [Effect of antibodies to rat and human cerebral cortex and white
            matter on heterologous T- and B-cells]
  JOURNAL   Zh Mikrobiol Epidemiol Immunobiol (9), 66-70 (1976)
   PUBMED   1087798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC395850.1, BP265421.1 and
            BC002726.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_004394.2.
            
            Summary: This gene encodes a basic, proline-rich, 15-kD protein.
            The protein acts as a positive mediator of programmed cell death
            that is induced by interferon-gamma. Alternatively spliced
            transcript variants encoding distinct isoforms have been found for
            this gene. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (2) has an additional exon in the
            coding region, which causes a frameshift, compared to variant 1.
            The resulting isoform (2) has a shorter and distinct C-terminus,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002726.2, X76105.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230895.11/ ENSP00000230895.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               DC395850.1         42-205
            165-571             BP265421.1         167-573
            572-2301            BC002726.2         570-2299
FEATURES             Location/Qualifiers
     source          1..2301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.2"
     gene            1..2301
                     /gene="DAP"
                     /gene_synonym="DAP1"
                     /note="death associated protein"
                     /db_xref="GeneID:1611"
                     /db_xref="HGNC:HGNC:2672"
                     /db_xref="MIM:600954"
     exon            1..221
                     /gene="DAP"
                     /gene_synonym="DAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..475
                     /gene="DAP"
                     /gene_synonym="DAP1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     death-associated protein 1; DAP-1"
                     /codon_start=1
                     /product="death-associated protein 1 isoform 2"
                     /protein_id="NP_004385.1"
                     /db_xref="CCDS:CCDS3880.1"
                     /db_xref="GeneID:1611"
                     /db_xref="HGNC:HGNC:2672"
                     /db_xref="MIM:600954"
                     /translation="MSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHTGDTKEEKDKDD
                     QEWESPSPPKPTVFISGVIARGDKDFPPAAAQVAHQKPHASMDKHPSPRTQHIQQPRK
                     "
     exon            222..318
                     /gene="DAP"
                     /gene_synonym="DAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..361
                     /gene="DAP"
                     /gene_synonym="DAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..2301
                     /gene="DAP"
                     /gene_synonym="DAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2277..2282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAP"
                     /gene_synonym="DAP1"
                     /note="hexamer: AATAAA"
     polyA_site      2301
                     /gene="DAP"
                     /gene_synonym="DAP1"
                     /note="major polyA site"
ORIGIN      
        1 aacggcagtg gcactcaccc ggctcgcgcg gccccggcgc cccacgcgcg cgcgtcgttc
       61 tcccgcccgc tcgctccccg gcgctcacac ctgagctcac tcgcgcacgc ccgcccggcc
      121 cgagaaccgc gccgccgcct cggccccgcg gaagccccgc cgcgtcatgt cttcgcctcc
      181 cgaagggaaa ctagagacta aagctggaca cccgcccgcc gtgaaagctg gtggaatgcg
      241 aattgtgcag aaacacccac atacaggaga caccaaagaa gagaaagaca aggatgacca
      301 ggaatgggaa agccccagtc cacctaaacc cactgtgttc atctctgggg tcatcgcccg
      361 gggtgacaaa gatttccccc cggcggctgc gcaggtggct caccagaagc cgcatgcctc
      421 catggacaag catccttccc caagaaccca gcacatccag cagccacgca agtgagcctg
      481 gagtccacca gcctgcccca tggccccggc tctgctgcac ttggtatttc cctgacagag
      541 agaaccagca gtttcgccca aatcctactc tgctgggaaa tctaaggcaa aaccaagtgc
      601 tctgtccttt gccttacatt tccatattta aaactagaaa cagctccagc ccaaaccttg
      661 tttatgggga gtctggttgg atgtcatttg aggatcattg tgcccctaga ggtgccatta
      721 gcagaatttg ccaagatccg agaaaaattt tagctttagt tctatttcag cagtcacctg
      781 acgtccttgt ctatggtctt aaaaacaaga aggcacacat ttgagaagat gagattaagg
      841 ttaggagaaa acctcagtca ttgcatgctt tttagtatgg gccaataaaa tctcaacacc
      901 tgtgggagag taagaactaa gggaatgagt ttgggcggcc cctcataaag gaccttagag
      961 gcagggaaca gcaatgccaa atttccctct ctcgtgagat gggggatcct gtgcaggctg
     1021 atgaggcacc catgagaaaa gccgaaaaag catgcatctt agaaatagcc cctcaattcc
     1081 aggagtcaac atgccaaaga atgaggctgg agacaggtag ctccgaggga ggacttctgg
     1141 catgagatct cggcacggca agcccagcat cgcctcagcc cagacaggct ccaccaggag
     1201 atcaagcaag ggctgccttt caggagtcac ctcctgagcc acttcagagt tctggaagtg
     1261 accacggacc agggtggagg aatagacttc tagttcattc tgggacactt gagccagaga
     1321 gttgaaagct tggaaagacc agataagaaa cctgcccttt gtctccctag ggacatgaga
     1381 caccacattc catttgtgct agaaaaacct atccactgat gagtctaact gttccaaacg
     1441 cctcccacct ggtgtgcaca gctgcctggg tccattgtca cttgggtgca tcaggttgtc
     1501 ctccgatttt tagatgagtt tcctgtctag agatgtccta gtctgctcac tggctggtgg
     1561 cagtagggta ccctgcgtcc tcgaaaagcc agagggttca cctagtcaga cgaaactcca
     1621 gaacagtgct tgtggagggc ctgactgtcc tgctcaccca cagccgatct gctgcaggtc
     1681 agcaactgtg tcgtgagcag ctgccaacca ccagcctttc tggtgctgtt ctccagttca
     1741 cgtctgccag ctggtgaggg cagaggcaga cctggtcaga cccagcgccc ctcctccctg
     1801 agggagcatg gcacagcctc acacttgaaa gacggtgttt ggtttcccat ctaatcaact
     1861 taagggaagc cggcatgtac ccttcaaggc cctgtcacca cctatttcct gatcagttgg
     1921 tataaactga gggtggcttt tagagaccca gacttggttg gcagcgctgc catggaacac
     1981 cccagcaagc acctcccagc ctgcctttcg gagcagcacc caggagggga tgccgcgctc
     2041 cagcaacacc aggtcaggcc tgtgcagacc cctgccctgc cgctgcagaa atccagaagc
     2101 atccttaatg cttctcagtc ttcagccaga gggagggctg ttatttccag aggtgcgctt
     2161 tttatgtact tttagctaga tgtggcatgc atctgtgagc tttagatcat taaatccaaa
     2221 atgtttgcct aaatgagttt atcagttgtt aacttcaaga atattaaatg atttataata
     2281 aagctcctgc atttctctcc a
//
