LOCUS       NM_172370                785 bp    mRNA    linear   PRI 14-APR-2024
DEFINITION  Homo sapiens D-amino acid oxidase activator (DAOA), transcript
            variant 1, mRNA.
ACCESSION   NM_172370
VERSION     NM_172370.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 785)
  AUTHORS   Rabattoni,V., Motta,Z., Miceli,M., Molla,G., Fissore,A.,
            Adinolfi,S., Pollegioni,L. and Sacchi,S.
  TITLE     On the regulation of human D-aspartate oxidase
  JOURNAL   Protein Sci 32 (11), e4802 (2023)
   PUBMED   37805834
REFERENCE   2  (bases 1 to 785)
  AUTHORS   Cheng,Y.J., Lin,C.H. and Lane,H.Y.
  TITLE     d-Amino Acids and pLG72 in Alzheimer's Disease and Schizophrenia
  JOURNAL   Int J Mol Sci 22 (20), 10917 (2021)
   PUBMED   34681579
  REMARK    GeneRIF: d-Amino Acids and pLG72 in Alzheimer's Disease and
            Schizophrenia.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 785)
  AUTHORS   Su,W., Zhu,T., Xu,L., Wei,Y., Zeng,B., Zhang,T., Cui,H., Wang,J.,
            Jia,Y., Wang,J., Goff,D.C., Tang,Y. and Wang,J.
  TITLE     Effect of DAOA genetic variation on white matter alteration in
            corpus callosum in patients with first-episode schizophrenia
  JOURNAL   Brain Imaging Behav 15 (4), 1748-1759 (2021)
   PUBMED   32748316
  REMARK    GeneRIF: Effect of DAOA genetic variation on white matter
            alteration in corpus callosum in patients with first-episode
            schizophrenia.
REFERENCE   4  (bases 1 to 785)
  AUTHORS   Lin,C.H., Chiu,C.C., Huang,C.H., Yang,H.T. and Lane,H.Y.
  TITLE     pLG72 levels increase in early phase of Alzheimer's disease but
            decrease in late phase
  JOURNAL   Sci Rep 9 (1), 13221 (2019)
   PUBMED   31520071
  REMARK    GeneRIF: pLG72 levels increase in early phase of Alzheimer's
            disease but decrease in late phase.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 785)
  AUTHORS   Sacchi,S., Bernasconi,M., Martineau,M., Mothet,J.P., Ruzzene,M.,
            Pilone,M.S., Pollegioni,L. and Molla,G.
  TITLE     pLG72 modulates intracellular D-serine levels through its
            interaction with D-amino acid oxidase: effect on schizophrenia
            susceptibility
  JOURNAL   J Biol Chem 283 (32), 22244-22256 (2008)
   PUBMED   18544534
  REMARK    GeneRIF: a decrease in the synaptic concentration of d-serine as
            the result of an anomalous increase in hDAAO activity related to
            hypoexpression of pLG72 may represent a molecular mechanism by
            which hDAAO and pLG72 are involved in schizophrenia susceptibility
REFERENCE   6  (bases 1 to 785)
  AUTHORS   Addington,A.M., Gornick,M., Sporn,A.L., Gogtay,N., Greenstein,D.,
            Lenane,M., Gochman,P., Baker,N., Balkissoon,R., Vakkalanka,R.K.,
            Weinberger,D.R., Straub,R.E. and Rapoport,J.L.
  TITLE     Polymorphisms in the 13q33.2 gene G72/G30 are associated with
            childhood-onset schizophrenia and psychosis not otherwise specified
  JOURNAL   Biol Psychiatry 55 (10), 976-980 (2004)
   PUBMED   15121480
  REMARK    GeneRIF: Polymorphisms in the 13q33.2 gene G72/G30 are associated
            with childhood-onset schizophrenia and psychosis not otherwise
            specified.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 785)
  AUTHORS   Schumacher,J., Jamra,R.A., Freudenberg,J., Becker,T., Ohlraun,S.,
            Otte,A.C., Tullius,M., Kovalenko,S., Bogaert,A.V., Maier,W.,
            Rietschel,M., Propping,P., Nothen,M.M. and Cichon,S.
  TITLE     Examination of G72 and D-amino-acid oxidase as genetic risk factors
            for schizophrenia and bipolar affective disorder
  JOURNAL   Mol Psychiatry 9 (2), 203-207 (2004)
   PUBMED   14966479
  REMARK    GeneRIF: The association of variation at G72 with schizophrenia as
            well as bipolar disorder provides molecular support for the
            hypothesis that these two major psychiatric disorders share some of
            their etiologic background
REFERENCE   8  (bases 1 to 785)
  AUTHORS   Hillman,R.T., Green,R.E. and Brenner,S.E.
  TITLE     An unappreciated role for RNA surveillance
  JOURNAL   Genome Biol 5 (2), R8 (2004)
   PUBMED   14759258
REFERENCE   9  (bases 1 to 785)
  AUTHORS   Hattori,E., Liu,C., Badner,J.A., Bonner,T.I., Christian,S.L.,
            Maheshwari,M., Detera-Wadleigh,S.D., Gibbs,R.A. and Gershon,E.S.
  TITLE     Polymorphisms at the G72/G30 gene locus, on 13q33, are associated
            with bipolar disorder in two independent pedigree series
  JOURNAL   Am J Hum Genet 72 (5), 1131-1140 (2003)
   PUBMED   12647258
  REMARK    GeneRIF: data suggest that a susceptibility variant for bipolar
            illness exists in the vicinity of the G72/G30 genes
REFERENCE   10 (bases 1 to 785)
  AUTHORS   Chumakov,I., Blumenfeld,M., Guerassimenko,O., Cavarec,L.,
            Palicio,M., Abderrahim,H., Bougueleret,L., Barry,C., Tanaka,H., La
            Rosa,P., Puech,A., Tahri,N., Cohen-Akenine,A., Delabrosse,S.,
            Lissarrague,S., Picard,F.P., Maurice,K., Essioux,L., Millasseau,P.,
            Grel,P., Debailleul,V., Simon,A.M., Caterina,D., Dufaure,I.,
            Malekzadeh,K., Belova,M., Luan,J.J., Bouillot,M., Sambucy,J.L.,
            Primas,G., Saumier,M., Boubkiri,N., Martin-Saumier,S., Nasroune,M.,
            Peixoto,H., Delaye,A., Pinchot,V., Bastucci,M., Guillou,S.,
            Chevillon,M., Sainz-Fuertes,R., Meguenni,S., Aurich-Costa,J.,
            Cherif,D., Gimalac,A., Van Duijn,C., Gauvreau,D., Ouellette,G.,
            Fortier,I., Raelson,J., Sherbatich,T., Riazanskaia,N., Rogaev,E.,
            Raeymaekers,P., Aerssens,J., Konings,F., Luyten,W., Macciardi,F.,
            Sham,P.C., Straub,R.E., Weinberger,D.R., Cohen,N. and Cohen,D.
  TITLE     Genetic and physiological data implicating the new human gene G72
            and the gene for D-amino acid oxidase in schizophrenia
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13675-13680 (2002)
   PUBMED   12364586
  REMARK    GeneRIF: The association of both DAAO and a new gene G72 from 13q34
            with schizophrenia together with activation of DAAO activity by a
            G72 protein product points to the involvement of this
            N-methyl-d-aspartate receptor regulation pathway in schizophrenia.
            Erratum:[Proc Natl Acad Sci U S A 2002 Dec 24;99(26):17221.
            Ouelette, G [corrected to Ouellette, G]; Realson, J [corrected to
            Raelson, J]]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359751.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 8, 2020 this sequence version replaced NM_172370.4.
            
            Summary: This gene encodes a protein that may function as an
            activator of D-amino acid oxidase, which degrades the
            gliotransmitter D-serine, a potent activator of
            N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also
            suggest that one encoded isoform may play a role in mitochondrial
            function and dendritic arborization. Polymorphisms in this gene
            have been implicated in susceptibility to schizophrenia and bipolar
            affective disorder. Alternatively spliced transcript variants
            encoding different isoforms have been identified.[provided by
            RefSeq, Mar 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: This CCDS ID represents the protein described in PMIDs:
            12364586 and 14966479. This transcript is supported by AY138546.1.
            It should be noted this transcript is predicted to undergo
            nonsense-mediated mRNA decay (NMD). However, the protein is
            represented because it was detected endogenously in PMID: 18544534.
            It is likely that the majority of transcripts representing this
            variant will undergo NMD, while some low level of NMD escape may
            allow for the expression of this protein. It is likely that the
            majority of transcripts representing this variant will undergo NMD,
            while some low level of NMD escape may allow for the expression of
            this protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY138546.1, BC121091.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000375936.9/ ENSP00000365103.3
            NMD candidate             :: PMID: 18544534
            RefSeq Select criteria    :: based on manual assertion, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL359751.12        16215-16230
            17-133              AL359751.12        16386-16502
            134-222             AL359751.12        17223-17311
            223-370             AL359751.12        22708-22855
            371-662             AL359751.12        40071-40362
            663-785             AL359751.12        41082-41204
FEATURES             Location/Qualifiers
     source          1..785
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q33.2"
     gene            1..785
                     /gene="DAOA"
                     /gene_synonym="LG72; SG72"
                     /note="D-amino acid oxidase activator"
                     /db_xref="GeneID:267012"
                     /db_xref="HGNC:HGNC:21191"
                     /db_xref="MIM:607408"
     exon            1..16
                     /gene="DAOA"
                     /gene_synonym="LG72; SG72"
                     /inference="alignment:Splign:2.1.0"
     exon            17..133
                     /gene="DAOA"
                     /gene_synonym="LG72; SG72"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..551
                     /gene="DAOA"
                     /gene_synonym="LG72; SG72"
                     /note="isoform 1 is encoded by transcript variant 1;
                     schizophrenia- and bipolar disorder-associated protein
                     G72; D-amino acid oxidase regulator"
                     /codon_start=1
                     /product="D-amino acid oxidase regulator isoform 1"
                     /protein_id="NP_758958.3"
                     /db_xref="CCDS:CCDS41905.1"
                     /db_xref="GeneID:267012"
                     /db_xref="HGNC:HGNC:21191"
                     /db_xref="MIM:607408"
                     /translation="MLEKLMGADSLQLFRSRYTLGKIYFIGFQRSILLSKSENSLNSI
                     AKETEEGRETVTRKEGWKRRHEDGYLEMAQRHLQRSLCPWVSYLPQPYAELEEVSSHV
                     GKVFMARNYEFLAYEASKDRRQPLERMWTCNYNQQKDQSCNHKEITSTKAE"
     exon            134..222
                     /gene="DAOA"
                     /gene_synonym="LG72; SG72"
                     /inference="alignment:Splign:2.1.0"
     exon            223..370
                     /gene="DAOA"
                     /gene_synonym="LG72; SG72"
                     /inference="alignment:Splign:2.1.0"
     exon            371..662
                     /gene="DAOA"
                     /gene_synonym="LG72; SG72"
                     /inference="alignment:Splign:2.1.0"
     exon            663..785
                     /gene="DAOA"
                     /gene_synonym="LG72; SG72"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcaagtaat gtgtgtgatt tggaaagggc atggcaggag gtctcatctc tgcttcacaa
       61 tgccgatgat ttagctggga ggacccaaaa tgctggaaaa gctgatgggt gctgattctc
      121 tccagctttt cagatccaga tatacattgg gtaaaatcta cttcataggt tttcaaagga
      181 gcattcttct gagcaaatct gaaaactctc taaactctat tgcaaaggag acagaagaag
      241 gaagagagac ggtaacaagg aaagaaggat ggaagagaag gcatgaggac ggctatttgg
      301 aaatggcaca gaggcattta cagagatcat tatgtccttg ggtctcttac cttcctcagc
      361 cctatgcaga gcttgaagaa gtaagcagcc atgttggaaa agtcttcatg gcaagaaact
      421 atgagttcct tgcctatgag gcctctaagg accgcaggca gcctctagaa cgaatgtgga
      481 cctgcaacta caaccagcaa aaagaccagt catgcaacca caaggaaata acttctacca
      541 aagctgaatg agtttggaag cagattcttc ccagccaatc cttctgatga caatgtagtc
      601 tggccaacat cttcactgga ctctgacgga ctctgtgtct gggacccagc tgataacacg
      661 tggtgatggg attgtatttg caactctctg gtcagtaagt gataaaatgc catttctatg
      721 cacccacctg gcctgtgtga ctgggagaat ctctcttttt attaaatgtg cttcaagttt
      781 taaca
//
