LOCUS       NM_001917               1694 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens D-amino acid oxidase (DAO), transcript variant 2,
            mRNA.
ACCESSION   NM_001917
VERSION     NM_001917.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1694)
  AUTHORS   Dave,U., Narain,P., Mishra,D. and Gomes,J.
  TITLE     Aggregation of E121K mutant D-amino acid oxidase and
            ubiquitination-mediated autophagy mechanisms leading to amyotrophic
            lateral sclerosis
  JOURNAL   J Neurol Sci 456, 122845 (2024)
   PUBMED   38134563
  REMARK    GeneRIF: Aggregation of E121K mutant D-amino acid oxidase and
            ubiquitination-mediated autophagy mechanisms leading to amyotrophic
            lateral sclerosis.
REFERENCE   2  (bases 1 to 1694)
  AUTHORS   Dave,U., Khan,S. and Gomes,J.
  TITLE     Characterization of E121K mutation of D-amino acid oxidase -
            Insights into mechanisms leading to amyotrophic lateral sclerosis
  JOURNAL   Biochim Biophys Acta Proteins Proteom 1871 (6), 140947 (2023)
   PUBMED   37558109
  REMARK    GeneRIF: Characterization of E121K mutation of D-amino acid oxidase
            - Insights into mechanisms leading to amyotrophic lateral
            sclerosis.
REFERENCE   3  (bases 1 to 1694)
  AUTHORS   Lin,C.H. and Lane,H.Y.
  TITLE     Blood D-Amino Acid Oxidase Levels Increased With Cognitive Decline
            Among People With Mild Cognitive Impairment: A Two-Year Prospective
            Study
  JOURNAL   Int J Neuropsychopharmacol 25 (8), 660-665 (2022)
   PUBMED   35430632
  REMARK    GeneRIF: Blood D-Amino Acid Oxidase Levels Increased With Cognitive
            Decline Among People With Mild Cognitive Impairment: A Two-Year
            Prospective Study.
REFERENCE   4  (bases 1 to 1694)
  AUTHORS   Liu,T.H., Tsou,H.H., Chung,R.H., Liu,S.C., Wang,S.C., Kuo,H.W.,
            Fang,C.P., Chen,A.C.H. and Liu,Y.L.
  TITLE     Association of the D-amino acid oxidase gene with methadone dose in
            heroin dependent patients under methadone maintenance treatment
  JOURNAL   J Hum Genet 67 (5), 273-278 (2022)
   PUBMED   34983973
  REMARK    GeneRIF: Association of the D-amino acid oxidase gene with
            methadone dose in heroin dependent patients under methadone
            maintenance treatment.
REFERENCE   5  (bases 1 to 1694)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1694)
  AUTHORS   Chassande,O., Renard,S., Barbry,P. and Lazdunski,M.
  TITLE     The human gene for diamine oxidase, an amiloride binding protein.
            Molecular cloning, sequencing, and characterization of the promoter
  JOURNAL   J Biol Chem 269 (20), 14484-14489 (1994)
   PUBMED   8182053
REFERENCE   7  (bases 1 to 1694)
  AUTHORS   Siddique,N. and Siddique,T.
  TITLE     Amyotrophic Lateral Sclerosis Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301623
REFERENCE   8  (bases 1 to 1694)
  AUTHORS   Fukui,K. and Miyake,Y.
  TITLE     Molecular cloning and chromosomal localization of a human gene
            encoding D-amino-acid oxidase
  JOURNAL   J Biol Chem 267 (26), 18631-18638 (1992)
   PUBMED   1356107
REFERENCE   9  (bases 1 to 1694)
  AUTHORS   Momoi,K., Fukui,K., Watanabe,F. and Miyake,Y.
  TITLE     Molecular cloning and sequence analysis of cDNA encoding human
            kidney D-amino acid oxidase
  JOURNAL   FEBS Lett 238 (1), 180-184 (1988)
   PUBMED   2901986
REFERENCE   10 (bases 1 to 1694)
  AUTHORS   Perotti,M.E., Gavazzi,E., Trussardo,L., Malgaretti,N. and Curti,B.
  TITLE     Immunoelectron microscopic localization of D-amino acid oxidase in
            rat kidney and liver
  JOURNAL   Histochem J 19 (3), 157-169 (1987)
   PUBMED   2885296
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA085245.1, BC029057.1,
            BM932083.1 and AC087893.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001917.4.
            
            Summary: This gene encodes the peroxisomal enzyme D-amino acid
            oxidase. The enzyme is a flavoprotein which uses flavin adenine
            dinucleotide (FAD) as its prosthetic group. Its substrates include
            a wide variety of D-amino acids, but it is inactive on the
            naturally occurring L-amino acids. Its biological function is not
            known; it may act as a detoxifying agent which removes D-amino
            acids that accumulate during aging. In mice, it degrades D-serine,
            a co-agonist of the NMDA receptor. This gene may play a role in the
            pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.254102.1,
                                           SRR3476690.493112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228476.8/ ENSP00000228476.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA085245.1         12-30
            20-1572             BC029057.1         1-1553
            1573-1585           BM932083.1         324-336
            1586-1694           AC087893.15        168795-168903
FEATURES             Location/Qualifiers
     source          1..1694
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..1694
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /note="D-amino acid oxidase"
                     /db_xref="GeneID:1610"
                     /db_xref="HGNC:HGNC:2671"
                     /db_xref="MIM:124050"
     exon            1..133
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /inference="alignment:Splign:2.1.0"
     exon            134..336
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1186
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /EC_number="1.4.3.3"
                     /note="isoform a is encoded by transcript variant 2"
                     /codon_start=1
                     /product="D-amino-acid oxidase isoform a"
                     /protein_id="NP_001908.3"
                     /db_xref="CCDS:CCDS9122.1"
                     /db_xref="GeneID:1610"
                     /db_xref="HGNC:HGNC:2671"
                     /db_xref="MIM:124050"
                     /translation="MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTT
                     TDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAI
                     PDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFF
                     QRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHD
                     PERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARII
                     GERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRIL
                     EEKKLSRMPPSHL"
     exon            337..451
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /inference="alignment:Splign:2.1.0"
     exon            452..528
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /inference="alignment:Splign:2.1.0"
     exon            529..594
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /inference="alignment:Splign:2.1.0"
     exon            595..649
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /inference="alignment:Splign:2.1.0"
     exon            650..754
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /inference="alignment:Splign:2.1.0"
     exon            755..837
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /inference="alignment:Splign:2.1.0"
     exon            838..955
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1054
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1694
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1548..1553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /note="hexamer: ATTAAA"
     polyA_site      1577
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /note="major polyA site"
     polyA_site      1694
                     /gene="DAO"
                     /gene_synonym="DAAO; DAMOX; OXDA"
                     /note="major polyA site"
ORIGIN      
        1 gcactccagt ccgggctggc ggacagaggg ctggaaacaa gacgctccag aatcaggagc
       61 ttcccctcag gaaatagcat cctgtgtccc cgcactgcag ttgtctggtc tctccagcag
      121 tttggtactt ccggctgctg caatgcgtgt ggtggtgatt ggagcaggag tcatcgggct
      181 gtccaccgcc ctctgcatcc atgagcgcta ccactcagtc ctgcagccac tggacataaa
      241 ggtctacgcg gaccgcttca ccccactcac caccaccgac gtggctgccg gcctctggca
      301 gccctacctt tctgacccca acaacccaca ggaggcggac tggagccaac agacctttga
      361 ctatctcctg agccatgtcc attctcccaa cgctgaaaac ctgggcctgt tcctaatctc
      421 gggctacaac ctcttccatg aagccattcc ggacccttcc tggaaggaca cagttctggg
      481 atttcggaag ctgaccccca gagagctgga tatgttccca gattacggct atggctggtt
      541 ccacacaagc ctaattctgg agggaaagaa ctatctacag tggctgactg aaaggttaac
      601 tgagagggga gtgaagttct tccagcggaa agtggagtct tttgaggagg tggcaagaga
      661 aggcgcagac gtgattgtca actgcactgg ggtatgggct ggggcgctac aacgagaccc
      721 cctgctgcag ccaggccggg ggcagatcat gaaggtggac gccccttgga tgaagcactt
      781 cattctcacc catgacccag agagaggcat ctacaattcc ccgtacatca tcccagggac
      841 ccagacagtt actcttggag gcatcttcca gttgggaaac tggagtgaac taaacaatat
      901 ccaggaccac aacaccattt gggaaggctg ctgcagactg gagcccacac tgaagaatgc
      961 aagaattatt ggtgaacgaa ctggcttccg gccagtacgc ccccagattc ggctagaaag
     1021 agaacagctt cgcactggac cttcaaacac agaggtcatc cacaactatg gccatggagg
     1081 ctacgggctc accatccact ggggatgtgc cctggaggca gccaagctct ttgggagaat
     1141 cctggaagaa aagaaattgt ccagaatgcc accatcccac ctctgaagac tccagtgact
     1201 gctgcctccc cccacaagaa ctcccttctc ccctcagcca atgaatcaat gtgctccttc
     1261 ataagccatt gcttctccct cacttctttc ctcaaagaag catgaggtga gagaaagcca
     1321 caaagtcagt gcctggagaa gggttcagcc caacatgggg cccctctcat cactgaaatc
     1381 cctctacctt ctctgggtct ggcattataa agaacagctg aggctgtcat tccatgagtc
     1441 ttcagaagaa aggacagctc agaaaatcaa agaggccaac tgcccagagc cacagaaaat
     1501 ggaggataat tgaggctaag taacctgatt acaagttgta ctaacatatt aaaggttctg
     1561 aaaagtcctg cagcaaagac aactatctga tgttgtttaa cccagtgctt gctaaaccta
     1621 tctggctatg gaactctttt gcccagagca cccatgaatg ccatgacaca aatctgagaa
     1681 aatgctggaa caga
//
