LOCUS       NM_152654               1781 bp    mRNA    linear   PRI 29-JAN-2025
DEFINITION  Homo sapiens DAN domain BMP antagonist family member 5 (DAND5),
            mRNA.
ACCESSION   NM_152654
VERSION     NM_152654.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1781)
  AUTHORS   Ganapathi,M., Buchovecky,C.M., Cristo,F., Ahimaz,P.,
            Ruzal-Shapiro,C., Wou,K., Inacio,J.M., Iglesias,A., Belo,J.A. and
            Jobanputra,V.
  TITLE     A novel biallelic loss-of-function variant in DAND5 causes
            heterotaxy syndrome
  JOURNAL   Cold Spring Harb Mol Case Stud 8 (7), a006248 (2022)
   PUBMED   36316122
  REMARK    GeneRIF: A novel biallelic loss-of-function variant in DAND5 causes
            heterotaxy syndrome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1781)
  AUTHORS   Inacio,J.M., Almeida,M., Cristo,F. and Belo,J.A.
  TITLE     Generation of a gene-corrected human induced pluripotent stem cell
            line derived from a patient with laterality defects and congenital
            heart anomalies with a c.455G > A alteration in DAND5
  JOURNAL   Stem Cell Res 42, 101677 (2020)
   PUBMED   31869685
  REMARK    GeneRIF: Generation of a gene-corrected human induced pluripotent
            stem cell line derived from a patient with laterality defects and
            congenital heart anomalies with a c.455G > A alteration in DAND5.
REFERENCE   3  (bases 1 to 1781)
  AUTHORS   Mausner-Fainberg,K., Penn,M., Golan,M., Benhamou,M.,
            Wilf-Yarkoni,A., Gertel,S. and Karni,A.
  TITLE     Reduced levels of Coco in sera of multiple sclerosis patients: A
            potential role in neuro-regeneration failure
  JOURNAL   J Neuroimmunol 327, 36-40 (2019)
   PUBMED   30685069
  REMARK    GeneRIF: Coco may be a player in the bone morphogenetic protein
            dysregulation and the tissue repair failure in multiple sclerosis
REFERENCE   4  (bases 1 to 1781)
  AUTHORS   Cristo,F., Inacio,J.M., de Almeida,S., Mendes,P., Martins,D.S.,
            Maio,J., Anjos,R. and Belo,J.A.
  TITLE     Functional study of DAND5 variant in patients with Congenital Heart
            Disease and laterality defects
  JOURNAL   BMC Med Genet 18 (1), 77 (2017)
   PUBMED   28738792
  REMARK    GeneRIF: In this work, we report two patients with a DAND5
            heterozygous non-synonymous variant (c.455G > A) in the functional
            domain of the DAND5 protein (p.R152H), a master regulator of Nodal
            signaling. Patient 1 presents left isomerism, ventricular septal
            defect with overriding aorta and pulmonary atresia, while patient 2
            presents ventricular septal defect with overriding aorta, right
            ventricular hypertrophy
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1781)
  AUTHORS   Chi,Y., Yao,L., Hu,X., Huang,S., Huang,N., Li,S., Shao,Z. and Wu,J.
  TITLE     The BMP inhibitor DAND5 in serum predicts poor survival in breast
            cancer
  JOURNAL   Oncotarget 7 (12), 14951-14962 (2016)
   PUBMED   26908452
  REMARK    GeneRIF: High DAND5 expression is associated with tumor growth and
            angiogenesis in breast cancer.
REFERENCE   6  (bases 1 to 1781)
  AUTHORS   Gao,H., Chakraborty,G., Lee-Lim,A.P., Mo,Q., Decker,M., Vonica,A.,
            Shen,R., Brogi,E., Brivanlou,A.H. and Giancotti,F.G.
  TITLE     The BMP inhibitor Coco reactivates breast cancer cells at lung
            metastatic sites
  JOURNAL   Cell 150 (4), 764-779 (2012)
   PUBMED   22901808
  REMARK    GeneRIF: A gain-of-function cDNA screen reveals that Coco, a
            secreted antagonist of TGF-beta ligands, induces dormant breast
            cancer cells to undergo reactivation in the lung.
            Erratum:[Cell. 2012 Dec 7;151(6):1386-8]
REFERENCE   7  (bases 1 to 1781)
  AUTHORS   Tavares,A.T., Andrade,S., Silva,A.C. and Belo,J.A.
  TITLE     Cerberus is a feedback inhibitor of Nodal asymmetric signaling in
            the chick embryo
  JOURNAL   Development 134 (11), 2051-2060 (2007)
   PUBMED   17507406
REFERENCE   8  (bases 1 to 1781)
  AUTHORS   Marques,S., Borges,A.C., Silva,A.C., Freitas,S., Cordenonsi,M. and
            Belo,J.A.
  TITLE     The activity of the Nodal antagonist Cerl-2 in the mouse node is
            required for correct L/R body axis
  JOURNAL   Genes Dev 18 (19), 2342-2347 (2004)
   PUBMED   15466485
REFERENCE   9  (bases 1 to 1781)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human CKTSF1B2 and CKTSF1B3
            genes in silico
  JOURNAL   Oncol Rep 12 (2), 423-427 (2004)
   PUBMED   15254711
REFERENCE   10 (bases 1 to 1781)
  AUTHORS   Avsian-Kretchmer,O. and Hsueh,A.J.
  TITLE     Comparative genomic analysis of the eight-membered ring cystine
            knot-containing bone morphogenetic protein antagonists
  JOURNAL   Mol Endocrinol 18 (1), 1-12 (2004)
   PUBMED   14525956
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092069.2.
            
            On Jul 31, 2020 this sequence version replaced NM_152654.2.
            
            Summary: This gene encodes a member of the BMP (bone morphogenic
            protein) antagonist family. Like BMPs, BMP antagonists contain
            cystine knots and typically form homo- and heterodimers. The CAN
            (cerberus and dan) subfamily of BMP antagonists, to which this gene
            belongs, is characterized by a C-terminal cystine knot with an
            eight-membered ring. The antagonistic effect of the secreted
            protein encoded by this gene is likely due to its direct binding to
            BMP proteins. As an antagonist of BMP, this gene may play a role in
            regulating organogenesis, body patterning, and tissue
            differentiation. In mouse, this protein has been shown to bind
            Nodal and to inhibit the Nodal signaling pathway which patterns
            left/right body asymmetry. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095926.1, BC113476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317060.4/ ENSP00000323155.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-409               AC092069.2         19693-20101         c
            410-1781            AC092069.2         14917-16288         c
FEATURES             Location/Qualifiers
     source          1..1781
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..1781
                     /gene="DAND5"
                     /gene_synonym="CER2; CERL2; CKTSF1B3; COCO; CRL2; DANTE;
                     GREM3; HTX13; SP1"
                     /note="DAN domain BMP antagonist family member 5"
                     /db_xref="GeneID:199699"
                     /db_xref="HGNC:HGNC:26780"
                     /db_xref="MIM:609068"
     exon            1..409
                     /gene="DAND5"
                     /gene_synonym="CER2; CERL2; CKTSF1B3; COCO; CRL2; DANTE;
                     GREM3; HTX13; SP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..655
                     /gene="DAND5"
                     /gene_synonym="CER2; CERL2; CKTSF1B3; COCO; CRL2; DANTE;
                     GREM3; HTX13; SP1"
                     /note="cerberus-like 2; cerberus 2; cysteine knot
                     superfamily 1, BMP antagonist 3; cerl-2; gremlin-3;
                     cerberus-like protein 2; DAN domain family, member 5; DAN
                     domain family member 5, BMP antagonist"
                     /codon_start=1
                     /product="DAN domain family member 5 precursor"
                     /protein_id="NP_689867.1"
                     /db_xref="CCDS:CCDS12291.1"
                     /db_xref="GeneID:199699"
                     /db_xref="HGNC:HGNC:26780"
                     /db_xref="MIM:609068"
                     /translation="MLLGQLSTLLCLLSGALPTGSGRPEPQSPRPQSWAAANQTWALG
                     PGALPPLVPASALGSWKAFLGLQKARQLGMGRLQRGQDEVAAVTLPLNPQEVIQGMCK
                     AVPFVQVFSRPGCSAIRLRNHLCFGHCSSLYIPGSDPTPLVLCNSCMPARKRWAPVVL
                     WCLTGSSASRRRVKISTMLIEGCHCSPKA"
     exon            410..1781
                     /gene="DAND5"
                     /gene_synonym="CER2; CERL2; CKTSF1B3; COCO; CRL2; DANTE;
                     GREM3; HTX13; SP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1755..1760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAND5"
                     /gene_synonym="CER2; CERL2; CKTSF1B3; COCO; CRL2; DANTE;
                     GREM3; HTX13; SP1"
                     /note="hexamer: CATAAA"
     polyA_site      1781
                     /gene="DAND5"
                     /gene_synonym="CER2; CERL2; CKTSF1B3; COCO; CRL2; DANTE;
                     GREM3; HTX13; SP1"
                     /note="major polyA site"
ORIGIN      
        1 actcaccaga cagcagggtc gactgctagt gaccttgagc ccagtccgga cagacagaca
       61 ggcagacaga cgcacggaca agcagatgct ccttggccag ctatccactc ttctgtgcct
      121 gcttagcggg gccctgccta caggctcagg gaggcctgaa ccccagtctc ctcgacctca
      181 gtcctgggct gcagccaatc agacctgggc tctgggccca ggggccctgc ccccactggt
      241 gccagcttct gcccttggga gctggaaggc cttcttgggc ctgcagaaag ccaggcagct
      301 ggggatgggc aggctgcagc gtgggcaaga cgaggtggct gctgtgactc tgccgctgaa
      361 ccctcaggaa gtgatccagg ggatgtgtaa ggctgtgccc ttcgttcagg tgttctcccg
      421 gcccggctgc tcagccatac gcctccgaaa tcatctgtgc tttggtcatt gctcctctct
      481 ctacatccct ggctcggacc ccaccccact agtcctgtgc aacagctgta tgcctgctcg
      541 caagcgttgg gcacccgtgg tcctgtggtg tctcactggc agctcagcct cccgtcgacg
      601 ggtgaagata tccaccatgc tgatcgaggg gtgtcactgc agcccaaaag catgaactga
      661 gcatcgtgga tgggtgcacg gagacacgca ccttggagaa atgaggggag atggaccaag
      721 aaagacgtgg acctggatga tgtactctgg gtcaagagac cagggatgca gggttaggca
      781 gacaggtccc cagagtcctc accctgctcc ccagacagta gacacagtgc ccgtcctgga
      841 gttgcaccac tgatagtcac agcacacaat gattgacaac tcactttttt tttttttttt
      901 tgagatggag tctcgctctg tcgcccaggc tggagtgcag tggcgcaatc tcagctcact
      961 gcaagctcca cctcccgggt ttatgccatt ctcctgtctc agcctcccga gtagctggga
     1021 ctacaggcac ccgccaacac gcccggctaa ttttttgtat ttttagtaaa gacagggttt
     1081 caccgtgtta gccaggatgg tctctatctc ctgacctcgt gatctgcctg ccttggcctt
     1141 attatttttt ttttttaagg acagagtctc tctctgtcac ccaggctgga gtgcaatggc
     1201 gcgatcttgg ctcactgtaa cttccacttg ccaggctcaa gcagttctcc tgcctcagcc
     1261 tcctgagtag ctgggactac aggcacccgc caccatgccc agctaatttt tgtattttta
     1321 gtagagacag agtttcacca tattagcctg gctggtctca aactcctggc ctcaggtgat
     1381 ctgcccacct cggcctccca aagtgctggg atcaaatcca ctgttaatca ttaggctgaa
     1441 ctgtctctta tagaatgagg tcaaagacac tcccagttgc agggagggta gatggcccca
     1501 cccagaccga gagacacagt gatgacctca gcctagggac accaaaaaag aaaaaaaaaa
     1561 aaacccaaac caaaaacgca aaccaaagca ggcaggcaga cagctgctgg gggaaatcct
     1621 ggggtccttg agacagaggc aggaccctcg tgttcccagc tgcctcttgc cttgatagtg
     1681 gtgctgtgtc cctctcagac cccccacctg agtctccaca gagccccacg cctggcatgg
     1741 cattccacag aaaccataaa ggttggctga gtccagctgt c
//
