LOCUS       NM_145056               2939 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens dishevelled binding antagonist of beta catenin 3
            (DACT3), transcript variant 1, mRNA.
ACCESSION   NM_145056
VERSION     NM_145056.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2939)
  AUTHORS   Gao,Q., Hou,L., Wang,H. and Xun,L.
  TITLE     DACT3 has a tumor-inhibiting role in acute myeloid leukemia via the
            suppression of Wnt/beta-catenin signaling by DVL2
  JOURNAL   J Biochem Mol Toxicol 36 (5), e23014 (2022)
   PUBMED   35187752
  REMARK    GeneRIF: DACT3 has a tumor-inhibiting role in acute myeloid
            leukemia via the suppression of Wnt/beta-catenin signaling by DVL2.
REFERENCE   2  (bases 1 to 2939)
  AUTHORS   Lenoir,M., Martin,R., Torres-Maravilla,E., Chadi,S.,
            Gonzalez-Davila,P., Sokol,H., Langella,P., Chain,F. and
            Bermudez-Humaran,L.G.
  TITLE     Butyrate mediates anti-inflammatory effects of Faecalibacterium
            prausnitzii in intestinal epithelial cells through Dact3
  JOURNAL   Gut Microbes 12 (1), 1-16 (2020)
   PUBMED   33054518
  REMARK    GeneRIF: Butyrate mediates anti-inflammatory effects of
            Faecalibacterium prausnitzii in intestinal epithelial cells through
            Dact3.
REFERENCE   3  (bases 1 to 2939)
  AUTHORS   Jiang,X., Tan,J., Li,J., Kivimae,S., Yang,X., Zhuang,L., Lee,P.L.,
            Chan,M.T., Stanton,L.W., Liu,E.T., Cheyette,B.N. and Yu,Q.
  TITLE     DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in
            colorectal cancer and is a therapeutic target of histone
            modifications
  JOURNAL   Cancer Cell 13 (6), 529-541 (2008)
   PUBMED   18538736
  REMARK    GeneRIF: Epigenetic repression of DACT3 leads to aberrant
            Wnt-beta-catenin signaling in colorectal cancer cells.
REFERENCE   4  (bases 1 to 2939)
  AUTHORS   Fisher,D.A., Kivimae,S., Hoshino,J., Suriben,R., Martin,P.M.,
            Baxter,N. and Cheyette,B.N.
  TITLE     Three Dact gene family members are expressed during embryonic
            development and in the adult brains of mice
  JOURNAL   Dev Dyn 235 (9), 2620-2630 (2006)
   PUBMED   16881060
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093503.2.
            
            On Nov 22, 2018 this sequence version replaced NM_145056.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1966682,
                              SAMEA1968189 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391916.7/ ENSP00000375783.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC093503.2         102315-102358       c
            45-367              AC093503.2         101992-102314       c
            368-464             AC093503.2         94155-94251         c
            465-617             AC093503.2         93836-93988         c
            618-2878            AC093503.2         88788-91048         c
            2879-2939           AC093503.2         88727-88787         c
FEATURES             Location/Qualifiers
     source          1..2939
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2939
                     /gene="DACT3"
                     /gene_synonym="DAPPER3; RRR1"
                     /note="dishevelled binding antagonist of beta catenin 3"
                     /db_xref="GeneID:147906"
                     /db_xref="HGNC:HGNC:30745"
                     /db_xref="MIM:611112"
     exon            1..367
                     /gene="DACT3"
                     /gene_synonym="DAPPER3; RRR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..2008
                     /gene="DACT3"
                     /gene_synonym="DAPPER3; RRR1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     arginine-rich region 1 protein; antagonist of beta-catenin
                     Dapper homolog 3; dapper, antagonist of beta-catenin,
                     homolog 3"
                     /codon_start=1
                     /product="dapper homolog 3 isoform 1"
                     /protein_id="NP_659493.2"
                     /db_xref="CCDS:CCDS12688.2"
                     /db_xref="GeneID:147906"
                     /db_xref="HGNC:HGNC:30745"
                     /db_xref="MIM:611112"
                     /translation="MIRAFSFPVSPERGRLRGWLEGSLAGLCELHWLRERQEYRVQQA
                     LRLAQPGMGGAEAEDEEDADEDEDAAAARRAAAALEEQLEALPGLVWDLGQQLGDLSL
                     ESGGLEQESGRSSGFYEDPSSTGGPDSPPSTFCGDSGFSGSSSYGRLGPSEPRGIYAS
                     ERPKSLGDASPSAPEVVGARAAVPRSFSAPYPTAGGSAGPEACSSAERRARAGPFLTP
                     SPLHAVAMRSPRPCGRPPTDSPDAGGAGRPLDGYISALLRRRRRRGAGQPRTSPGGAD
                     GGPRRQNSVRQRPPDASPSPGSARPAREPSLERVGGHPTSPAALSRAWASSWESEAAP
                     EPAAPPAAPSPPDSPAEGRLVKAQYIPGAQAATRGLPGRAARRKPPPLTRGRSVEQSP
                     PRERPRAAGRRGRMAEASGRRGSPRARKASRSQSETSLLGRASAVPSGPPKYPTAERE
                     EPRPPRPRRGPAPTLAAQAAGSCRRWRSTAEIDAADGRRVRPRAPAARVPGPGPSPSA
                     PQRRLLYGCAGSDSECSAGRLGPLGRRGPAGGVGGGYGESESSASEGESPAFSSASSD
                     SDGSGGLVWPQQLVAATAASGGGAGAGAPAGPAKVFVKIKASHALKKKILRFRSGSLK
                     VMTTV"
     exon            368..464
                     /gene="DACT3"
                     /gene_synonym="DAPPER3; RRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..617
                     /gene="DACT3"
                     /gene_synonym="DAPPER3; RRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..2939
                     /gene="DACT3"
                     /gene_synonym="DAPPER3; RRR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2857..2862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DACT3"
                     /gene_synonym="DAPPER3; RRR1"
                     /note="hexamer: AATAAA"
     polyA_site      2878
                     /gene="DACT3"
                     /gene_synonym="DAPPER3; RRR1"
                     /note="major polyA site"
     regulatory      2901..2906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DACT3"
                     /gene_synonym="DAPPER3; RRR1"
                     /note="hexamer: ATTAAA"
     polyA_site      2939
                     /gene="DACT3"
                     /gene_synonym="DAPPER3; RRR1"
ORIGIN      
        1 agatgagacg gtgacagccc ggccagcggg cgggcgggca ggctgctggg gcggggaggt
       61 gggaccggga gaggggtggc cgcggggccc ggccgggctg gggcgggggg ccgcagccat
      121 gatccgggcc ttctcgttcc cggtgagccc tgagcggggc cggctgcggg gctggctgga
      181 gggtagcctg gccgggctct gcgagttaca ttggctccgg gagaggcagg agtaccgcgt
      241 gcagcaggcg ctgcggctgg cccagcccgg aatggggggc gccgaggccg aggacgagga
      301 ggacgccgat gaggatgaag atgcggcggc ggcgcgccgg gccgcagcgg ccctggagga
      361 gcagctggag gccctgcctg gtctcgtctg ggacctggga cagcagctgg gagacctgag
      421 cctggagtct gggggcctgg aacaggagag cgggcgtagc tcgggcttct atgaagatcc
      481 cagctctaca ggaggtccag attcaccacc ctcaaccttc tgtggggaca gtggcttctc
      541 tggatccagc tcctatggtc gcctgggtcc ctctgagccc cggggcatct atgccagtga
      601 gaggcccaag tccctaggag acgccagtcc cagcgctccg gaggtggtgg gcgcgcgggc
      661 agcggtgccg cggtccttct cagcgcccta cccgacggca ggggggtccg ccggcccgga
      721 ggcctgctcc tcggcggagc ggcgggcccg cgccgggccc tttctgacgc ccagccccct
      781 gcacgccgtg gcgatgcgca gcccgcggcc ctgcggccgc cctcccaccg actcgcccga
      841 cgcggggggc gcagggcggc ccctggacgg ctacatctcg gcgctcctgc gcaggcgccg
      901 ccgccggggg gcgggccagc cccggaccag tcccgggggc gcggacggcg gcccgcggcg
      961 ccagaacagc gtgcgccagc ggccgcccga cgcgtctccg tcccccggca gcgcgcgacc
     1021 cgcgcgggag ccctcgttgg agcgcgtcgg gggccacccc accagccctg ccgccttgag
     1081 ccgcgcctgg gcgtcgtcgt gggagtcgga ggcggcaccc gagcccgctg cgccgcccgc
     1141 cgccccctca ccccccgaca gcccggctga gggccgcttg gtgaaggcgc agtacatccc
     1201 gggcgcgcag gcggccaccc gaggcctccc tggccgcgcc gcccgccgca aaccgccgcc
     1261 actgacccgc ggccgcagcg tggagcagtc accaccccgg gagcgtcccc gggccgccgg
     1321 ccgccgtgga cgcatggccg aggcttcggg ccgccgcggc tcgcccaggg cccgcaaggc
     1381 ctcgcgctcc cagtctgaga ccagcctgct gggccgcgcc tccgcggtcc cttcggggcc
     1441 ccctaagtac cccacggcgg agcgggaaga gcctcggcct ccacggccac gccgcggccc
     1501 agcgcccacg ctggcggccc aggccgcagg gtcctgccgt cgctggcgct ccactgcgga
     1561 gatcgacgct gccgatgggc gccgcgtgcg gccccgagcc cctgcggcgc gtgttcccgg
     1621 ccccggcccg tccccgtcag ctccccagcg tcgtctgctt tacggctgcg cgggcagcga
     1681 ctccgagtgc tcggctgggc gcctggggcc cctgggacgc cgggggcctg cgggaggcgt
     1741 cggcgggggt tacggggaga gcgaatcgag cgccagcgag ggagaatcgc ctgccttcag
     1801 ctctgcctcc agcgactcag acggcagcgg tggcctcgtg tggccgcagc agctggtggc
     1861 ggccaccgcg gcctctgggg gtggagcagg tgcaggggcg cccgcaggcc ccgccaaagt
     1921 cttcgtgaaa atcaaagctt cccacgcgct caagaaaaag atactgcgtt tccgttcggg
     1981 ttctctcaag gtcatgacta cagtgtgagt ttggggattt gcttgggctc ccccttcatg
     2041 gcctctgcac ctccacactc ccaaccactg acccttccac atctaccttc caaagaccat
     2101 cgttttctct gcttccaaag acccccctca ctctccccac tcctaacagt cttggttgaa
     2161 aaggctcccc caccaccacc gagaggaatg gggaggagcc ctgtttgacc cagttcagct
     2221 tctagcttgg aagcccttgg gcaagacagt tccccttctc tgggcgtcac tttcctcatc
     2281 tgtacagtaa gtgtccatgt atgcaaaagg ggtaattcgg tttgaatttc cccgttttag
     2341 tttagaagcc tagtctgttt gttcccctcc accgctctcc ctctcattcc tgatgagccc
     2401 tctcattcct cctttccttg cccagctatg gccccctctc attcacaaag tgccccctcc
     2461 atgtccctgg acccttaaga tatccccttg gcaccctggt cagagactct gtgtctgact
     2521 caggtggtcc ctgcagagtg ccctgggaag ggaaggagca ctgatttggg ggttttgagg
     2581 gtcaagtagg ggttggtaac acctggaaag aaggactctt tcacttcgat ccctggacaa
     2641 ttatggagga ttcggaggta gaagagggga aggaagatgg tttctatctc atgaccccca
     2701 ctccctgtga gagggaatgg gggaagcctg atgaccctca gctgttccaa tctagtattt
     2761 tttttctttt ttaaaattac tgtatttatt atgacgatgg tgactcccca gtgcaaaggg
     2821 gggccagatt ctgtgtgttt ctctaacctc tttgtaaata aatgcacagt gtaacatatg
     2881 tggtggactc tcactgaatg attaaatggg agaaatgctc tttttccttt ggactaaca
//
