LOCUS       NM_214462               2997 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens dishevelled binding antagonist of beta catenin 2
            (DACT2), transcript variant 1, mRNA.
ACCESSION   NM_214462 XM_001713778 XM_001713779 XM_001713780
VERSION     NM_214462.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2997)
  AUTHORS   Ghasemian,M., Rajabibazl,M., Poodineh,J., Sadeghi,H., Razavi,A.E.
            and Mirfakhraie,R.
  TITLE     Different expression of DACT1, DACT2, and CYCLIN D1 genes in human
            colorectal cancer tissues and its association with
            clinicopathological characteristics
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 43 (3), 203-213 (2024)
   PUBMED   37610179
  REMARK    GeneRIF: Different expression of DACT1, DACT2, and CYCLIN D1 genes
            in human colorectal cancer tissues and its association with
            clinicopathological characteristics.
REFERENCE   2  (bases 1 to 2997)
  AUTHORS   Yi,Z., Ouyang,J., Sun,W., Li,S., Xiao,X. and Zhang,Q.
  TITLE     Comparative exome sequencing reveals novel candidate genes for
            retinitis pigmentosa
  JOURNAL   EBioMedicine 56, 102792 (2020)
   PUBMED   32454406
  REMARK    GeneRIF: Comparative exome sequencing reveals novel candidate genes
            for retinitis pigmentosa.
            Erratum:[EBioMedicine. 2022 Mar;77:103913. doi:
            10.1016/j.ebiom.2022.103913.. PMID: 35248995]
REFERENCE   3  (bases 1 to 2997)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2997)
  AUTHORS   Fan,J., Zhang,Y., Mu,J., He,X., Shao,B., Zhou,D., Peng,W., Tang,J.,
            Jiang,Y., Ren,G. and Xiang,T.
  TITLE     TET1 exerts its anti-tumor functions via demethylating DACT2 and
            SFRP2 to antagonize Wnt/beta-catenin signaling pathway in
            nasopharyngeal carcinoma cells
  JOURNAL   Clin Epigenetics 10 (1), 103 (2018)
   PUBMED   30075814
  REMARK    GeneRIF: Studies suggested that DACT2 expression in nasopharyngeal
            carcinoma cells is restored by TET1 which demethylates its promotor
            region.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2997)
  AUTHORS   Zhang,Y., Fan,J., Fan,Y., Li,L., He,X., Xiang,Q., Mu,J., Zhou,D.,
            Sun,X., Yang,Y., Ren,G., Tao,Q. and Xiang,T.
  TITLE     The new 6q27 tumor suppressor DACT2, frequently silenced by CpG
            methylation, sensitizes nasopharyngeal cancer cells to paclitaxel
            and 5-FU toxicity via beta-catenin/Cdc25c signaling and G2/M arrest
  JOURNAL   Clin Epigenetics 10 (1), 26 (2018)
   PUBMED   30359298
  REMARK    GeneRIF: Results demonstrate that DACT2 is frequently inactivated
            epigenetically by CpG methylation in nasopharyngeal carcinoma
            (NPC), while it inhibits NPC cell proliferation and metastasis via
            suppressing beta-catenin/Cdc25c signaling. These findings suggest
            that DACT2 promoter methylation is a potential epigenetic biomarker
            for the detection of NPC.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2997)
  AUTHORS   Jia,Y., Yang,Y., Brock,M.V., Zhan,Q., Herman,J.G. and Guo,M.
  TITLE     Epigenetic regulation of DACT2, a key component of the Wnt
            signalling pathway in human lung cancer
  JOURNAL   J Pathol 230 (2), 194-204 (2013)
   PUBMED   22806826
  REMARK    GeneRIF: Epigenetic regulation of DACT2 is a key component of the
            Wnt signalling pathway in human lung cancer.
REFERENCE   7  (bases 1 to 2997)
  AUTHORS   Cheng,H., Lu,M., Mao,L.J., Wang,J.Q., Li,W., Wen,R.M. and Chen,J.C.
  TITLE     Relationships among MTHFR a1298c gene polymorphisms and methylation
            status of Dact1 gene in transitional cell carcinomas
  JOURNAL   Asian Pac J Cancer Prev 13 (10), 5069-5074 (2012)
   PUBMED   23244112
  REMARK    GeneRIF: Hypermethylation of Dact1 gene is associated with
            transitional cell carcinomas.
REFERENCE   8  (bases 1 to 2997)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2997)
  AUTHORS   Koga,Y., Yao,T., Hirahashi,M., Kumashiro,Y., Ohji,Y., Yamada,T.,
            Tanaka,M. and Tsuneyoshi,M.
  TITLE     Flat adenoma-carcinoma sequence with high-malignancy potential as
            demonstrated by CD10 and beta-catenin expression: a different
            pathway from the polypoid adenoma-carcinoma sequence
  JOURNAL   Histopathology 52 (5), 569-577 (2008)
   PUBMED   18370954
  REMARK    GeneRIF: Nuclear beta-catenin was more frequently expressed in
            non-polypoid growth low grade colorectal neoplasms than in polypoid
            growth neoplasms.
REFERENCE   10 (bases 1 to 2997)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human DAPPER1 and DAPPER2
            genes in silico
  JOURNAL   Int J Oncol 22 (4), 907-913 (2003)
   PUBMED   12632086
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606970.12, BC092498.1, BC111790.1, AF318336.1 and BX377941.2.
            
            On Nov 23, 2018 this sequence version replaced NM_214462.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF318336.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366795.4/ ENSP00000355760.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AL606970.12        117871-117893       c
            24-98               BC092498.1         1-75
            99-124              BC111790.1         32-57
            125-882             AF318336.1         71-828
            883-2678            BC111790.1         293-2088
            2679-2950           BX377941.2         84-355
            2951-2997           AF318336.1         2896-2942
FEATURES             Location/Qualifiers
     source          1..2997
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..2997
                     /gene="DACT2"
                     /gene_synonym="bA503C24.7; C6orf116; DAPPER2; DPR2"
                     /note="dishevelled binding antagonist of beta catenin 2"
                     /db_xref="GeneID:168002"
                     /db_xref="HGNC:HGNC:21231"
                     /db_xref="MIM:608966"
     exon            1..390
                     /gene="DACT2"
                     /gene_synonym="bA503C24.7; C6orf116; DAPPER2; DPR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2469
                     /gene="DACT2"
                     /gene_synonym="bA503C24.7; C6orf116; DAPPER2; DPR2"
                     /note="isoform a is encoded by transcript variant 1;
                     dapper homolog 2, antagonist of beta-catenin; dapper
                     antagonist of catenin 2; dapper, antagonist of
                     beta-catenin, homolog 2"
                     /codon_start=1
                     /product="dapper homolog 2 isoform a"
                     /protein_id="NP_999627.2"
                     /db_xref="CCDS:CCDS47519.1"
                     /db_xref="GeneID:168002"
                     /db_xref="HGNC:HGNC:21231"
                     /db_xref="MIM:608966"
                     /translation="MWTPGGPPGSAGWDRRRLGARLRAAFAGLQELQGLRATQQERVR
                     GALALQPPPAPAAPCGPHGLHGPEQQLEAALAALQEQLSRLRQQDIGLKTHLDQLDLQ
                     ISKLQLDVGTASGEALDSDSRPSSGFYEMSDGGSCSLSTSCASVCSDHISPSLGSLLP
                     VAQAHKARPSMGDWRPRSVDETTVPAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVS
                     TGDLDRALPADTGLQKASADAELLGLLCQGVDIPLHVPDPKYRQDLVSQGGREVYPYP
                     SPLHAVALQSPLFVLTKETPQRGGPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYI
                     DRLLHLWGRETPAKGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGP
                     AQSRGAGRGGPQQQGYMPLEGPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTP
                     SAQDYGRGNIISPSRMLDKSPSPASGHFAHPSFAASLKMGPPKSKAEKIKRSPMDKVL
                     RFARQPLLLLDRPEGAHAAPQPSLEWDPAHWPTGRGGLQRRPALAWEAPGRSCSESTL
                     YPMPVLVPLAVAPQESHRTSAQALFPFEASLLTSVARRKHRRWQSTVEISARARLASC
                     PESNLGPPRPVARRAGGPLARGRPSLVRQDAYTRSDSEPSKHSAECDPRFPSVIPETS
                     EGESSDHTTNRFGDRESSSSDEEGGAQSRDCDLALGYVAAGHAELAWTQEAPVSSGPL
                     LSPVPKLCRIKASKALKKKIRRFQPTALKVMTMV"
     exon            391..523
                     /gene="DACT2"
                     /gene_synonym="bA503C24.7; C6orf116; DAPPER2; DPR2"
                     /inference="alignment:Splign:2.1.0"
     exon            524..802
                     /gene="DACT2"
                     /gene_synonym="bA503C24.7; C6orf116; DAPPER2; DPR2"
                     /inference="alignment:Splign:2.1.0"
     exon            803..2997
                     /gene="DACT2"
                     /gene_synonym="bA503C24.7; C6orf116; DAPPER2; DPR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2966..2971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DACT2"
                     /gene_synonym="bA503C24.7; C6orf116; DAPPER2; DPR2"
                     /note="hexamer: AATAAA"
     polyA_site      2997
                     /gene="DACT2"
                     /gene_synonym="bA503C24.7; C6orf116; DAPPER2; DPR2"
                     /note="major polyA site"
ORIGIN      
        1 agattccagc ccaccttggc gacctgcgga gccgggggcg gagagaggag gcgcaggagg
       61 acccgcgaca cagctcggga tccgcgcgcg ctgggcctcc ggcgccgctc gtggggttcg
      121 ggaggccggg accctgcccg ggagatgtgg acgccgggcg gacccccggg gtccgcgggc
      181 tgggaccgcc gtaggttggg cgcgaggttg cgcgcggcgt tcgcggggct gcaggagctg
      241 caggggctgc gagccacgca gcaggagcgg gtacggggcg ccctggccct gcagcccccg
      301 cccgcgcccg ccgcgccctg cggcccccac ggcctccacg gccccgagca gcagctggag
      361 gcggcgctgg ccgcgctgca ggagcagctg tcccggctga gacaacagga catcggcctg
      421 aagacccacc tggaccagct ggacctgcag attagcaagc tgcagctgga tgtgggcaca
      481 gcctcagggg aggccctgga cagcgacagc aggcccagct caggctttta cgagatgagc
      541 gacggtggat cctgctccct gtccacgtcc tgtgcctccg tctgcagtga ccacatctct
      601 ccctcgctgg gcagtttgtt gcctgtggcc caggcccaca aggccaggcc cagcatgggg
      661 gactggaggc cccggtcggt tgatgagact actgtgccag cgtggagacc ccaggctacc
      721 gaggagggcg ccaggccccc agggagcgtg gaggatgcag gccagccgtg gggcacattc
      781 tggcccaggc ctgtgtctac aggtgatctt gacagagccc tgccggcgga cacggggctc
      841 cagaaagcca gcgcggacgc cgagctcctc gggctcctct gccagggggt ggatatcccg
      901 ctgcacgtgc cggaccccaa gtatcggcag gacctggtgt cccagggcgg cagggaggtg
      961 tacccgtacc ccagccccct gcacgccgtg gctctacaga gccccctgtt tgtcctgact
     1021 aaggaaaccc cacagagagg tggcccctcg ttccctaggg agagccccag gggccccgca
     1081 ggtctgaaca ccatccagac tgggccggtc ctcgaggctg gcccggccag ggccagagct
     1141 tatatcgaca ggttgctgca tctgtggggc cgggagaccc cagcaaaggg tagcgaggga
     1201 gaacagggac ctctaaggca tgcagcgtcc ccatctccac agaggcaggg tggctggagt
     1261 acagacggtg gagggcgact gctggtcttc gccccaggga gggaggacga gggagggcca
     1321 gctcagagca ggggtgccgg caggggcggg ccccagcagc agggatacat gccccttgag
     1381 ggtccccagc agtctggcag ccttccagag gagggctcca agccctcaaa cagctgtgtc
     1441 ctcagggaga ccatggtgca ggcttctccc agctcaaagg cccagcagac accctcagct
     1501 caggactatg gacgaggcaa catcatatcc ccatccagga tgctggacaa gagcccctca
     1561 ccggcctctg ggcactttgc ccacccatcc tttgctgcca gcctgaaaat gggtcccccc
     1621 aagagcaagg ctgaaaaaat caagagaagt cccatggaca aggtgctgag gtttgcaagg
     1681 cagccgctgc ttctactgga caggcctgag ggagcccatg cagcccccca gccatccctg
     1741 gagtgggacc ctgcccactg gcccacaggg aggggcgggc tccagcggag gccagccctg
     1801 gcctgggagg cacccgggcg ctcctgttct gagtccaccc tctaccccat gcctgtcctc
     1861 gtccccttgg cagtggcccc gcaggagagc caccggacct cagcccaagc cctgttcccc
     1921 tttgaggcgt cactgctcac ctcagtggcc aggaggaagc atcgccgctg gcagtccacc
     1981 gtggagatct cggcccgggc ccgcctggcc agctgtcctg agtctaacct ggggcccccc
     2041 aggcccgtgg ccaggagagc aggtggccca ctggcccggg gccgtccctc actggtccgc
     2101 caggacgcct acaccaggag cgactcagag ccctccaagc actcggccga gtgtgacccg
     2161 cggttcccgt cagtcatccc ggagaccagc gagggagagt ccagtgacca caccaccaac
     2221 cgattcggag accgtgagtc cagcagcagc gacgaggagg gcggcgccca gagcagggac
     2281 tgtgacctgg cactgggcta tgtggcggcc gggcatgcgg agctggcctg gacccaggag
     2341 gccccggtca gctcggggcc actcctgtcc cccgtgccca agctgtgccg tattaaggcc
     2401 tccaaggccc tgaagaagaa gatccgcagg ttccagccga cggccctgaa ggtcatgacc
     2461 atggtgtgag gtgcagtgac tgcgtcaaga gaagcctgct gcacacaggg gccctttcca
     2521 tgcagtgtcc tgtgcatgtc tgggtttcag tgtcgtcttg ccaagtcgct ttatcttccg
     2581 aggccaccgt ttaacaggag tccccgcaga tgggttctgc cctgtggagt atggccgtga
     2641 gtccccgccc cagcaaagac ttccatgcgg agctctggtt tcagatgcca gcagcctccc
     2701 cggccgacct agtgtctctt ttcaaggtct gcccaggatg ctgcttcccg gcatgcacct
     2761 tgtttccatg ttgtcatcct cccatggctt cccctgccct cactcccctc tggctgggga
     2821 agtgtttccc aatcctttga ccattcctcc ccaaaagcat tttaaagagg cggttgcagg
     2881 actctgagct ggaaattgaa tttgagttta aactccacgt taagctgtca gcatacacaa
     2941 acacccaaat tatgccatga tctcaaataa aaggaacatt ttttttccct cttttaa
//
