LOCUS       NM_001079520            3828 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens dishevelled binding antagonist of beta catenin 1
            (DACT1), transcript variant 2, mRNA.
ACCESSION   NM_001079520
VERSION     NM_001079520.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3828)
  AUTHORS   Ghasemian,M., Rajabibazl,M., Poodineh,J., Sadeghi,H., Razavi,A.E.
            and Mirfakhraie,R.
  TITLE     Different expression of DACT1, DACT2, and CYCLIN D1 genes in human
            colorectal cancer tissues and its association with
            clinicopathological characteristics
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 43 (3), 203-213 (2024)
   PUBMED   37610179
  REMARK    GeneRIF: Different expression of DACT1, DACT2, and CYCLIN D1 genes
            in human colorectal cancer tissues and its association with
            clinicopathological characteristics.
REFERENCE   2  (bases 1 to 3828)
  AUTHORS   Christians,A., Kesdiren,E., Hennies,I., Hofmann,A., Trowe,M.O.,
            Brand,F., Martens,H., Gjerstad,A.C., Gucev,Z., Zirngibl,M.,
            Geffers,R., Seeman,T., Billing,H., Bjerre,A., Tasic,V., Kispert,A.,
            Ure,B., Haffner,D., Dingemann,J. and Weber,R.G.
  TITLE     Heterozygous variants in the DVL2 interaction region of DACT1 cause
            CAKUT and features of Townes-Brocks syndrome 2
  JOURNAL   Hum Genet 142 (1), 73-88 (2023)
   PUBMED   36066768
  REMARK    GeneRIF: Heterozygous variants in the DVL2 interaction region of
            DACT1 cause CAKUT and features of Townes-Brocks syndrome 2.
REFERENCE   3  (bases 1 to 3828)
  AUTHORS   Hou,J., Huang,S., Long,Y., Feng,K., Shang,L., Zhou,Z., Yue,Y.,
            Huang,X., Chen,G. and Wu,Z.
  TITLE     Disheveled binding antagonist of beta-catenin 1 interacted with
            beta-catenin and connexin 43 in human-induced pluripotent stem
            cells-derived cardiomyocytes
  JOURNAL   Bioengineered 13 (5), 11594-11601 (2022)
   PUBMED   35510412
  REMARK    GeneRIF: Disheveled binding antagonist of beta-catenin 1 interacted
            with beta-catenin and connexin 43 in human-induced pluripotent stem
            cells-derived cardiomyocytes.
REFERENCE   4  (bases 1 to 3828)
  AUTHORS   Lv,D., Ding,S., Zhong,L., Tu,J., Li,H., Yao,H., Zou,Y., Zeng,Z.,
            Liao,Y., Wan,X., Wen,L. and Xie,X.
  TITLE     M6A demethylase FTO-mediated downregulation of DACT1 mRNA stability
            promotes Wnt signaling to facilitate osteosarcoma progression
  JOURNAL   Oncogene 41 (12), 1727-1741 (2022)
   PUBMED   35121825
  REMARK    GeneRIF: M(6)A demethylase FTO-mediated downregulation of DACT1
            mRNA stability promotes Wnt signaling to facilitate osteosarcoma
            progression.
REFERENCE   5  (bases 1 to 3828)
  AUTHORS   Zeng,L., Chen,C. and Yao,C.
  TITLE     Histone Deacetylation Regulated by KDM1A to Suppress DACT1 in
            Proliferation and Migration of Cervical Cancer
  JOURNAL   Anal Cell Pathol (Amst) 2021, 5555452 (2021)
   PUBMED   34350095
  REMARK    GeneRIF: Histone Deacetylation Regulated by KDM1A to Suppress DACT1
            in Proliferation and Migration of Cervical Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3828)
  AUTHORS   Zhang,L., Gao,X., Wen,J., Ning,Y. and Chen,Y.G.
  TITLE     Dapper 1 antagonizes Wnt signaling by promoting dishevelled
            degradation
  JOURNAL   J Biol Chem 281 (13), 8607-8612 (2006)
   PUBMED   16446366
  REMARK    GeneRIF: DACT1 antagonizes Wnt signaling by promoting DVL2
            degradation.
REFERENCE   7  (bases 1 to 3828)
  AUTHORS   Yau,T.O., Chan,C.Y., Chan,K.L., Lee,M.F., Wong,C.M., Fan,S.T. and
            Ng,I.O.
  TITLE     HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is
            frequently downregulated in hepatocellular carcinoma: involvement
            of methylation-mediated gene silencing
  JOURNAL   Oncogene 24 (9), 1607-1614 (2005)
   PUBMED   15580286
  REMARK    GeneRIF: Downregulation of HDPR1 is common in hepatic cellular
            carcinomas, frequently involves hypermethylation of the promoter
            region.
REFERENCE   8  (bases 1 to 3828)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human DAPPER1 and DAPPER2
            genes in silico
  JOURNAL   Int J Oncol 22 (4), 907-913 (2003)
   PUBMED   12632086
REFERENCE   9  (bases 1 to 3828)
  AUTHORS   Heilig,R., Eckenberg,R., Petit,J.L., Fonknechten,N., Da Silva,C.,
            Cattolico,L., Levy,M., Barbe,V., de Berardinis,V., Ureta-Vidal,A.,
            Pelletier,E., Vico,V., Anthouard,V., Rowen,L., Madan,A., Qin,S.,
            Sun,H., Du,H., Pepin,K., Artiguenave,F., Robert,C., Cruaud,C.,
            Bruls,T., Jaillon,O., Friedlander,L., Samson,G., Brottier,P.,
            Cure,S., Segurens,B., Aniere,F., Samain,S., Crespeau,H., Abbasi,N.,
            Aiach,N., Boscus,D., Dickhoff,R., Dors,M., Dubois,I., Friedman,C.,
            Gouyvenoux,M., James,R., Madan,A., Mairey-Estrada,B., Mangenot,S.,
            Martins,N., Menard,M., Oztas,S., Ratcliffe,A., Shaffer,T.,
            Trask,B., Vacherie,B., Bellemere,C., Belser,C., Besnard-Gonnet,M.,
            Bartol-Mavel,D., Boutard,M., Briez-Silla,S., Combette,S.,
            Dufosse-Laurent,V., Ferron,C., Lechaplais,C., Louesse,C.,
            Muselet,D., Magdelenat,G., Pateau,E., Petit,E.,
            Sirvain-Trukniewicz,P., Trybou,A., Vega-Czarny,N., Bataille,E.,
            Bluet,E., Bordelais,I., Dubois,M., Dumont,C., Guerin,T.,
            Haffray,S., Hammadi,R., Muanga,J., Pellouin,V., Robert,D.,
            Wunderle,E., Gauguet,G., Roy,A., Sainte-Marthe,L., Verdier,J.,
            Verdier-Discala,C., Hillier,L., Fulton,L., McPherson,J.,
            Matsuda,F., Wilson,R., Scarpelli,C., Gyapay,G., Wincker,P.,
            Saurin,W., Quetier,F., Waterston,R., Hood,L. and Weissenbach,J.
  TITLE     The DNA sequence and analysis of human chromosome 14
  JOURNAL   Nature 421 (6923), 601-607 (2003)
   PUBMED   12508121
  REMARK    Erratum:[Nature. 2023 Aug;620(7973):E17. doi:
            10.1038/s41586-023-06403-y.. PMID: 37491470]
REFERENCE   10 (bases 1 to 3828)
  AUTHORS   Cheyette,B.N., Waxman,J.S., Miller,J.R., Takemaru,K.,
            Sheldahl,L.C., Khlebtsova,N., Fox,E.P., Earnest,T. and Moon,R.T.
  TITLE     Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK
            signaling, is required for notochord formation
  JOURNAL   Dev Cell 2 (4), 449-461 (2002)
   PUBMED   11970895
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133312.3, CN304224.1,
            DR001289.1, DR157190.1 and BU742074.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001079520.1.
            
            Summary: The protein encoded by this gene belongs to the dapper
            family, characterized by the presence of PDZ-binding motif at the
            C-terminus. It interacts with, and positively regulates
            dishevelled-mediated signaling pathways during development.
            Depletion of this mRNA from xenopus embryos resulted in loss of
            notochord and head structures, and mice lacking this gene died
            shortly after birth from severe posterior malformations.
            Alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            acceptor splice site at the 3' terminal exon compared to variant 1.
            This results in a shorter isoform (2) missing an internal protein
            segment compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.444163.1,
                                           SRR1803612.482533.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395153.8/ ENSP00000378582.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AL133312.3         123281-123357
            78-94               CN304224.1         1-17
            95-718              DR001289.1         1-624
            719-1476            DR157190.1         20-777
            1477-3166           AL133312.3         131289-132978
            3167-3828           BU742074.1         16-677              c
FEATURES             Location/Qualifiers
     source          1..3828
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.1"
     gene            1..3828
                     /gene="DACT1"
                     /gene_synonym="DAPPER; DAPPER1; DPR1; FRODO; HDPR1; TBS2;
                     THYEX3"
                     /note="dishevelled binding antagonist of beta catenin 1"
                     /db_xref="GeneID:51339"
                     /db_xref="HGNC:HGNC:17748"
                     /db_xref="MIM:607861"
     exon            1..586
                     /gene="DACT1"
                     /gene_synonym="DAPPER; DAPPER1; DPR1; FRODO; HDPR1; TBS2;
                     THYEX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..2641
                     /gene="DACT1"
                     /gene_synonym="DAPPER; DAPPER1; DPR1; FRODO; HDPR1; TBS2;
                     THYEX3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     heptacellular carcinoma novel gene 3; hepatocellular
                     carcinoma novel gene 3 protein; dapper antagonist of
                     catenin 1; dapper, antagonist of beta-catenin, homolog 1"
                     /codon_start=1
                     /product="dapper homolog 1 isoform 2"
                     /protein_id="NP_001072988.1"
                     /db_xref="CCDS:CCDS41961.1"
                     /db_xref="GeneID:51339"
                     /db_xref="HGNC:HGNC:17748"
                     /db_xref="MIM:607861"
                     /translation="MKPSPAGTAKELEPPAPARGEQRTAEPEGRWREKGEADTERQRT
                     RERQEATLAGLAELEYLRQRQELLVRGALRGAGGAGAAAPRAGELLGEAAQRSRLEEK
                     FLEENILLLRKQLNCLRRRDAGLLNQLQELDKQISDLRLDVEKTSEEHLETDSRPSSG
                     FYELSDGASGSLSNSSNSVFSECLSSCHSSTCFCSPLEATLSLSDGCPKSADVNPKYQ
                     CDLVSKNGNDVYRYPSPLHAVAVQSPMFLLCLTGNPLREEDRLGNHASDICGGSELDA
                     VKTDSSLPSPSSLWSASHPSSSKKMDGYILSLVQKKTHPVRTNKPRTSVNADPTKGLL
                     RNGSVCVRAPGGVSQGNSVNLKNSKQACLPSGGIPSLNNGTFSPPKQWSKESKAEQAE
                     SKRVPLPEGCPSGAASDLQSKHLPKTAKPASQEHARCSAIGTGESPKESAQLSGASPK
                     ESPSRGPAPPQENKVVQPLKKMSQKNSLQGVPPATPPLLSTAFPVEERPALDFKSEGS
                     SQSLEEAHLVKAQFIPGQQPSVRLHRGHRNMGVVKNSSLKHRGPALQGLENGLPTVRE
                     KTRAGSKKCRFPDDLDTNKKLKKASSKGRKSGGGPEAGVPGRPAGGGHRAGSRAHGHG
                     REAVVAKPKHKRTDYRRWKSSAEISYEEALRRARRGRRENVGLYPAPVPLPYASPYAY
                     VASDSEYSAECESLFHSTVVDTSEDEQSNYTTNCFGDSESSVSEGEFVGESTTTSDSE
                     ESGGLIWSQFVQTLPIQTVTAPDLHNHPAKTFVKIKASHNLKKKILRFRSGSLKLMTT
                     V"
     exon            587..719
                     /gene="DACT1"
                     /gene_synonym="DAPPER; DAPPER1; DPR1; FRODO; HDPR1; TBS2;
                     THYEX3"
                     /inference="alignment:Splign:2.1.0"
     exon            720..875
                     /gene="DACT1"
                     /gene_synonym="DAPPER; DAPPER1; DPR1; FRODO; HDPR1; TBS2;
                     THYEX3"
                     /inference="alignment:Splign:2.1.0"
     exon            876..3828
                     /gene="DACT1"
                     /gene_synonym="DAPPER; DAPPER1; DPR1; FRODO; HDPR1; TBS2;
                     THYEX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3759..3764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DACT1"
                     /gene_synonym="DAPPER; DAPPER1; DPR1; FRODO; HDPR1; TBS2;
                     THYEX3"
                     /note="hexamer: AATAAA"
     polyA_site      3781
                     /gene="DACT1"
                     /gene_synonym="DAPPER; DAPPER1; DPR1; FRODO; HDPR1; TBS2;
                     THYEX3"
                     /note="major polyA site"
     regulatory      3801..3806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DACT1"
                     /gene_synonym="DAPPER; DAPPER1; DPR1; FRODO; HDPR1; TBS2;
                     THYEX3"
                     /note="hexamer: TATAAA"
     polyA_site      3828
                     /gene="DACT1"
                     /gene_synonym="DAPPER; DAPPER1; DPR1; FRODO; HDPR1; TBS2;
                     THYEX3"
                     /note="major polyA site"
ORIGIN      
        1 gttatcagct gccgggccgc ggcgagggac gcgcggcgac agcggacggc gctgcccggg
       61 ccgggacagc agcagccggc ggtcgcgcgc aggactcgag ggcttctagc caccgtcccc
      121 gccagcgccg cgccccgcca cagggcggca tgagcccacc cgcggccgca gccctagcgc
      181 cctgctcctc cgcctgggcg gcccggctgc ggtgacggct ctcgctgccc gactgggggc
      241 catgaagccg agtccggccg ggacggcgaa ggagctggag cctccggcgc cggcccgagg
      301 cgagcagcgc acggcggagc ccgaggggcg ctggcgggag aagggcgagg cagacaccga
      361 gcggcagcgc acccgggagc ggcaggaggc cacgctggcc gggctggcgg agctggagta
      421 cctgcgccag cgccaagagc tgctggtcag gggcgccctg cgcggcgccg ggggtgcggg
      481 agccgctgcg ccccgcgctg gggagctact gggggaggcg gcgcagcgca gtcgcctgga
      541 ggagaagttc ttggaggaga acatcttgct gctaagaaag caattgaact gtttgaggcg
      601 aagagatgct ggtttgttga atcagttgca agagcttgac aagcagataa gtgacctgag
      661 actggatgta gaaaagacat ctgaagagca cctggagaca gacagtcggc ctagctcagg
      721 gttttatgag ctgagtgatg gggcttcagg atccctttcc aattcctcta actcggtgtt
      781 cagtgagtgt ttatccagtt gtcattccag cacctgcttt tgcagcccct tggaggcgac
      841 cttgagtctc tcagatggtt gccccaaatc tgcagatgtg aatcccaagt accagtgtga
      901 tctggtgtct aaaaacggga atgatgtata tcgctatccc agtccacttc atgctgtggc
      961 tgtgcagagc ccaatgtttc tcctttgtct gacgggcaac cctctgaggg aagaggacag
     1021 gcttggaaac catgccagtg acatttgcgg tggatctgag ctagatgccg tcaaaacaga
     1081 cagttcctta ccgtccccaa gcagtctgtg gtctgcttcc catccttcat ccagcaagaa
     1141 aatggatggc tacattctga gcctggtcca gaaaaaaaca caccctgtaa ggaccaacaa
     1201 accaagaacc agcgtgaacg ctgaccccac gaaagggctt ctgaggaacg ggagcgtttg
     1261 tgtcagagcc ccgggcggtg tctcacaggg caacagtgtg aaccttaaga attcgaaaca
     1321 ggcgtgtctg ccctctggcg ggataccttc tctgaacaat gggacattct ccccaccgaa
     1381 gcagtggtcg aaagaatcaa aggccgaaca agccgaaagc aagagggtgc ccctgccaga
     1441 gggctgcccc tcaggcgctg cctccgacct tcagagtaag cacctgccaa aaacggccaa
     1501 gccagcctcg caagaacatg ctcggtgttc cgccattggg acaggggagt cccctaagga
     1561 aagcgctcag ctctcagggg cctctccaaa agagagtcct agcagaggcc ctgccccgcc
     1621 gcaggagaac aaagttgtac agcccctgaa aaagatgtca cagaaaaaca gcctgcaggg
     1681 cgtccccccg gccactcctc ccctgctgtc tacagctttc cccgtggaag agaggcctgc
     1741 cttggatttc aagagcgagg gctcttccca aagcctggag gaagcgcacc tggtcaaggc
     1801 ccagtttatc ccggggcagc agcccagtgt caggctccac cggggccaca ggaacatggg
     1861 cgtcgtgaag aactccagcc tgaagcaccg cggcccagcc ctccaggggc tggagaacgg
     1921 cttgcccacc gtcagggaga aaacgcgggc cgggagcaag aagtgtcgct tcccagatga
     1981 cttggataca aataagaaac tcaagaaagc ctcctccaag gggaggaaga gtgggggcgg
     2041 gcccgaggct ggtgttcccg gcaggcccgc gggcgggggc cacagggcgg ggagcagggc
     2101 gcatggccac ggacgggagg cggtggtggc caaacctaag cacaagcgaa ctgactaccg
     2161 gcggtggaag tcctcggccg agatttccta cgaagaggcc ctgaggaggg cccggcgcgg
     2221 tcgccgggag aatgtggggc tgtaccccgc gcctgtgcct ctgccctacg ccagccccta
     2281 cgcctacgtg gctagcgact ccgagtactc ggccgagtgc gagtccctgt tccactccac
     2341 cgtggtggac accagtgagg acgagcagag caattacacc accaactgct tcggggacag
     2401 cgagtcgagt gtgagcgagg gcgagttcgt gggggagagc acaaccacca gcgactctga
     2461 agaaagcggg ggcttaattt ggtcccagtt tgtccagact ctgcccattc aaacggtaac
     2521 ggccccagac cttcacaacc accccgcaaa aacctttgtc aaaattaagg cctcacataa
     2581 cctcaagaag aagatcctcc gctttcggtc tggctctttg aaactgatga cgacggtttg
     2641 agtgacatca ttggtgtaga aagtttgtgt gttttttttt cttctcccta gttgccaaaa
     2701 ttaaaaaggt ggtgttttca tttttgtata atactttaat ggaatgcttt ttaaaaaaat
     2761 ataaaaccaa ggtaaattat tgtttcatct tcacgtatgg atgctagtgc ctttaatgga
     2821 aggtaaagaa tgttttgcta gttagaagta catattgagg ttttaatggt ggtgatagtg
     2881 agttttgtgg caccagctgt tttttatttt aaactttctg agcatccggc aaggtacagg
     2941 ttttgatgtt caagttttat tgggataaga tcttttgatc ccaaggtcag gtggatggaa
     3001 tttttggatt tatatttgtt ccttgagtct tcagggcagt gtctccatga gggttttcct
     3061 gttgaggggc accacataca atagtgtgaa gtaggtatga ggggcagtca ttgtattcta
     3121 tagttttttt atgtagtcta catttctcag atgtatcccc attcggtttt attctcagaa
     3181 ctgttactag actcatgact tggaggccaa accttaaatc cagagatagc agcctcgata
     3241 gggaccttaa aaggattcac aaaaactttt gccacacttg gtgcctaggc cctgttccta
     3301 ataacccctt ctagggccgt ttatccaaca tttagatgcc ttcttttccc tccctaattt
     3361 gtagccagtc caacctttca ttccttggag gatttagttt tgggataaaa ttttggtcct
     3421 tgggcacaga gacattcact attaatgaag taacccttgg gcatgactcc aatcccagaa
     3481 ttgctcactg agcgctatgc caccgaagcg ttgacctgaa catattagtg caatccagtc
     3541 cagattggac ctttgatcct atgtggaagg gctgtttttt aagaaaaaat ttttggtaaa
     3601 cagtattgtg taaaattgct ttttgtatac caatatatgc atgttttgtg catgagtagt
     3661 acttgtgttg atactcctgt tgatgttaaa ttactatata atataaacag tatgtgtttt
     3721 tatatatcat tgtgtaaatt taatataaca tatgcagtaa taaaccattt gttttactgc
     3781 tgttaagttt gttatttggg tataaaacca gatgtttaca cctgtaaa
//
