LOCUS       NM_080759               5245 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens dachshund family transcription factor 1 (DACH1),
            transcript variant 1, mRNA.
ACCESSION   NM_080759
VERSION     NM_080759.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5245)
  AUTHORS   Lin,J., Li,B., Xu,Q., Liu,Y.S., Kang,Y.L., Wang,X., Wang,Y.,
            Lei,Y., Bai,Y.L., Li,X.M. and Zhou,J.
  TITLE     DACH1 attenuated PA-induced renal tubular injury through
            TLR4/MyD88/NF-kappaB and TGF-beta/Smad signalling pathway
  JOURNAL   J Endocrinol Invest 47 (6), 1531-1544 (2024)
   PUBMED   38147289
  REMARK    GeneRIF: DACH1 attenuated PA-induced renal tubular injury through
            TLR4/MyD88/NF-kappaB and TGF-beta/Smad signalling pathway.
REFERENCE   2  (bases 1 to 5245)
  AUTHORS   Lin,G.L., Chang,H.H., Lin,W.T., Liou,Y.S., Lai,Y.L., Hsieh,M.H.,
            Chen,P.K., Liao,C.Y., Tsai,C.C., Wang,T.F., Chu,S.C., Kau,J.H.,
            Huang,H.H., Hsu,H.L. and Sun,D.S.
  TITLE     Dachshund Homolog 1: Unveiling Its Potential Role in
            Megakaryopoiesis and Bacillus anthracis Lethal Toxin-Induced
            Thrombocytopenia
  JOURNAL   Int J Mol Sci 25 (6), 3102 (2024)
   PUBMED   38542074
  REMARK    GeneRIF: Dachshund Homolog 1: Unveiling Its Potential Role in
            Megakaryopoiesis and Bacillus anthracis Lethal Toxin-Induced
            Thrombocytopenia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5245)
  AUTHORS   Li,W., Xu,L., Cao,J., Ge,J., Liu,X., Liu,P., Teng,Y., Wang,S.,
            Sun,Y., Liu,M. and Tian,L.
  TITLE     DACH1 regulates macrophage activation and tumour progression in
            hypopharyngeal squamous cell carcinoma
  JOURNAL   Immunology 170 (2), 253-269 (2023)
   PUBMED   37243970
  REMARK    GeneRIF: DACH1 regulates macrophage activation and tumour
            progression in hypopharyngeal squamous cell carcinoma.
REFERENCE   4  (bases 1 to 5245)
  AUTHORS   Lu,Y., Tang,K., Wang,S., Tian,Z., Fan,Y., Li,B., Wang,M., Zhao,J.
            and Xie,J.
  TITLE     Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary
            fibrosis via modulating C-Jun/Bim activity
  JOURNAL   Transl Res 257, 54-65 (2023)
   PUBMED   36754276
  REMARK    GeneRIF: Dach1 deficiency drives alveolar epithelium apoptosis in
            pulmonary fibrosis via modulating C-Jun/Bim activity.
REFERENCE   5  (bases 1 to 5245)
  AUTHORS   Ayres,J.A., Shum,L., Akarsu,A.N., Dashner,R., Takahashi,K.,
            Ikura,T., Slavkin,H.C. and Nuckolls,G.H.
  TITLE     DACH: genomic characterization, evaluation as a candidate for
            postaxial polydactyly type A2, and developmental expression pattern
            of the mouse homologue
  JOURNAL   Genomics 77 (1-2), 18-26 (2001)
   PUBMED   11543628
REFERENCE   6  (bases 1 to 5245)
  AUTHORS   Kozmik,Z., Pfeffer,P., Kralova,J., Paces,J., Paces,V., Kalousova,A.
            and Cvekl,A.
  TITLE     Molecular cloning and expression of the human and mouse homologues
            of the Drosophila dachshund gene
  JOURNAL   Dev Genes Evol 209 (9), 537-545 (1999)
   PUBMED   10502110
REFERENCE   7  (bases 1 to 5245)
  AUTHORS   Kozmik,Z. and Cvekl,A.
  TITLE     Localization of the human homologue of the Drosophila dachshund
            gene (DACH) to chromosome 13q21
  JOURNAL   Genomics 59 (1), 110-111 (1999)
   PUBMED   10395809
REFERENCE   8  (bases 1 to 5245)
  AUTHORS   Hammond,K.L., Lettice,L.A., Hill,R.E., Lee,M., Boyle,S. and
            Hanson,I.M.
  TITLE     Human (DACH) and mouse (Dach) homologues of Drosophila dachshund
            map to chromosomes 13q22 and 14E3, respectively
  JOURNAL   Genomics 55 (2), 252-253 (1999)
   PUBMED   9933575
REFERENCE   9  (bases 1 to 5245)
  AUTHORS   Hammond,K.L., Hanson,I.M., Brown,A.G., Lettice,L.A. and Hill,R.E.
  TITLE     Mammalian and Drosophila dachshund genes are related to the Ski
            proto-oncogene and are expressed in eye and limb
  JOURNAL   Mech Dev 74 (1-2), 121-131 (1998)
   PUBMED   9651501
REFERENCE   10 (bases 1 to 5245)
  AUTHORS   Bardakjian,T., Weiss,A. and Schneider,A.
  TITLE     Microphthalmia/Anophthalmia/Coloboma Spectrum - RETIRED CHAPTER,
            FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301552
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139186.16, AMYH02028239.1,
            AL138698.15, AL163542.8 and AL354995.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_080759.5.
            
            Summary: This gene encodes a chromatin-associated protein that
            associates with other DNA-binding transcription factors to regulate
            gene expression and cell fate determination during development. The
            protein contains a Ski domain that is highly conserved from
            Drosophila to human. Expression of this gene is lost in some forms
            of metastatic cancer, and is correlated with poor prognosis.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) is the predominant transcript
            and it encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: The coding region has been updated to remove two codons
            that are not included in the GRCh38 reference genome allele.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF356492.1, AF102546.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000613252.5/ ENSP00000482245.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-651               AL139186.16        44064-44714
            652-679             AMYH02028239.1     127719-127746       c
            680-1283            AL139186.16        44749-45352
            1284-1399           AL138698.15        29874-29989         c
            1400-1561           AL163542.8         155572-155733       c
            1562-1734           AL163542.8         97856-98028         c
            1735-1870           AL163542.8         84836-84971         c
            1871-2005           AL163542.8         82040-82174         c
            2006-2157           AL163542.8         14013-14164         c
            2158-2305           AL163542.8         4185-4332           c
            2306-2449           AL163542.8         722-865             c
            2450-2518           AL163542.8         157-225             c
            2519-5245           AL354995.13        112464-115190       c
FEATURES             Location/Qualifiers
     source          1..5245
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q21.33"
     gene            1..5245
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /note="dachshund family transcription factor 1"
                     /db_xref="GeneID:1602"
                     /db_xref="HGNC:HGNC:2663"
                     /db_xref="MIM:603803"
     exon            1..1283
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..2556
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /note="isoform a is encoded by transcript variant 1;
                     dachshund homolog 1; dac homolog"
                     /codon_start=1
                     /product="dachshund homolog 1 isoform a"
                     /protein_id="NP_542937.3"
                     /db_xref="CCDS:CCDS41899.1"
                     /db_xref="GeneID:1602"
                     /db_xref="HGNC:HGNC:2663"
                     /db_xref="MIM:603803"
                     /translation="MAVPAALIPPTQLVPPQPPISTSASSSGTTTSTSSATSSPAPSI
                     GPPASSGPTLFRPEPIASAAAAAATVTSTGGGGGGGGSGGGGGSSGNGGGGGGGGGGS
                     NCNPNLAAASNGSGGGGGGISAGGGVASSTPINASTGSSSSSSSSSSSSSSSSSSSSS
                     SSSCGPLPGKPVYSTPSPVENTPQNNECKMVDLRGAKVASFTVEGCELICLPQAFDLF
                     LKHLVGGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAIQPGVNRCKLISRKDFETLY
                     NDCTNASSRPGRPPKRTQSVTSPENSHIMPHSVPGLMSPGIIPPTGLTAAAAAAAAAT
                     NAAIAEAMKVKKIKLEAMSNYHASNNQHGADSENGDMNSSVGLELPFMMMPHPLIPVS
                     LPPASVTMAMSQMNHLSTIANMAAAAQVQSPPSRVETSVIKERVPDSPSPAPSLEEGR
                     RPGSHPSSHRSSSVSSSPARTESSSDRIPVHQNGLSMNQMLMGLSPNVLPGPKEGDLA
                     GHDMGHESKRMHIEKDETPLSTPTARDSLDKLSLTGHGQPLPPGFPSPFLFPDGLSSI
                     ETLLTNIQGLLKVAIDNARAQEKQVQLEKTELKMDFLRERELRETLEKQLAMEQKNRA
                     IVQKRLKKEKKAKRKLQEALEFETKRREQAEQTLKQAASTDSLRVLNDSLTPEIEADR
                     SGGRTDAERTIQDGRLYLKTTVMY"
     exon            1284..1399
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1561
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1734
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1870
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2005
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2157
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2305
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2449
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2518
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..5245
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5225..5230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /note="hexamer: AATAAA"
     polyA_site      5245
                     /gene="DACH1"
                     /gene_synonym="DACH"
                     /note="major polyA site"
ORIGIN      
        1 attcccctct caatctttga tcaatgtact tgccagggag agcccaagtc cttcaaacct
       61 cctccttttc accttcatcc ttaactttgt gctagagcga gacccacaca acaacagccg
      121 accctccccg ccccaccccc acccccaaac cagccctcga tcccagcccc cggagaggac
      181 tcgcatttcg acttgcggga cacttttgtg cgttcctctc cagagcgcct ctcgtgctcg
      241 cccctcttgc gctcgctctt tattaccttc acctcctttt ctcccccttc tctccctttc
      301 tccttctcgt tctctcccgg agttgttgtt gcccccctcg ctccttctcc cccctttttt
      361 ccccttcccc tcccgggggt gtgtggcaac ttttcctctc gcttctcctc cgtctgtttc
      421 cccttatatg tgaccatggc agtgccggcg gctttgatcc ctccgaccca gctggtcccc
      481 cctcaacccc caatctccac gtctgcttcc tcctctggca ccaccacctc cacctcttcg
      541 gcgacttcgt ctccggctcc ttccatcgga cccccggcgt cctctgggcc aactctgttc
      601 cgcccggagc ccatcgcttc ggcggcggcg gcggcggcca cagtcacctc taccggcggc
      661 ggcggcggcg gcggcggcag cggaggcggc ggcggcagca gcggcaacgg aggcggcggt
      721 ggcggcggcg gcggtggcag caactgcaac cccaacctgg cggccgcgag caacggcagc
      781 ggcggcggcg gcggcggcat cagcgctggc ggcggcgtcg cttccagcac ccccatcaac
      841 gccagcaccg gcagcagcag cagcagcagt agcagcagca gcagcagcag cagtagtagc
      901 agcagcagca gtagcagcag cagctgcggc cccctccccg ggaaacccgt gtactcaacc
      961 ccgtccccag tggaaaacac ccctcagaat aatgagtgca aaatggtgga tctgaggggg
     1021 gccaaagtgg cttccttcac ggtggagggc tgcgagctga tctgcctgcc ccaggctttc
     1081 gacctgttcc tgaagcactt ggtggggggc ttgcatacgg tctacaccaa gctgaagcgg
     1141 ctggagatca cgccggtggt gtgcaatgtg gaacaagttc gcatcctgag gggactgggc
     1201 gccatccagc caggagtgaa ccgctgcaaa ctcatctcca ggaaggactt cgagaccctc
     1261 tacaatgact gcaccaacgc aagttctaga cctggaaggc ctcctaagag gactcaaagt
     1321 gtcacctccc cagagaactc tcacatcatg ccgcattctg tccctggtct catgtctcct
     1381 gggataattc caccaacagg tctgacagca gccgctgcag cagctgctgc tgctaccaat
     1441 gcagctattg ctgaagcaat gaaggtgaaa aaaatcaaat tagaagccat gagcaactat
     1501 catgccagta ataaccaaca tggagcagac tctgaaaacg gggacatgaa ttcaagtgtc
     1561 ggactggaac ttccttttat gatgatgccc caccctctaa ttcctgtcag cctacctcca
     1621 gcatctgtca ccatggcaat gagccagatg aaccacctca gcaccattgc aaatatggca
     1681 gcagcagcac aagttcagag tcccccatcc agagttgaga catcagttat taaggagcgt
     1741 gttcctgata gcccctcacc tgccccctct ctggaggagg ggagaaggcc tggcagtcac
     1801 ccatcatcac atcgcagcag cagcgtgtcc agctcccctg ctcggactga gagctcttct
     1861 gacagaatcc cggtccatca gaatgggttg tccatgaacc agatgctgat gggcttatca
     1921 ccaaatgtac ttcctgggcc caaagaggga gatttggccg gtcatgacat gggacatgag
     1981 tcaaaaagga tgcatattga aaaagatgag accccgcttt ctacaccaac cgcaagagac
     2041 agccttgaca aactctctct aactgggcat ggacaaccac tgcctccagg ttttccatct
     2101 ccttttctgt ttcctgatgg actgtcttcc atcgagactc ttctgactaa catacagggg
     2161 ctgttgaaag ttgccataga taatgccaga gctcaagaga aacaggtcca actggaaaaa
     2221 actgagctga agatggattt tttaagggaa agagaactaa gggaaacact tgagaagcag
     2281 ttggctatgg aacaaaagaa tagagccata gttcaaaaga ggctaaagaa ggagaagaag
     2341 gcaaagagaa aattgcagga agcacttgag tttgagacga aacggcgtga acaagcagaa
     2401 cagacgctaa aacaggcagc ttcaacagat agtctcaggg tcttaaatga ctctctgacc
     2461 ccagagatag aggctgaccg cagtggcggc agaacagatg ctgaaaggac aatacaagat
     2521 ggaagactgt atttgaaaac tactgtcatg tactgaatct ttcctgttga agaaatccat
     2581 gttatagaaa agaactttgc agtcagacat tcgtcatggg aaagttcaga aaaaaataaa
     2641 gtccttttaa gggaacttcc tgaattttgt gtattaatgt tctttaaaag tttaagtatt
     2701 ctacaaaaaa aaaaaaagtt ttctccattg attttcacct gtggttcata ccagagacct
     2761 gagaatgttt gtaaatgtac aagtatcaaa gttcttacag ttaattactg caacttgctg
     2821 ctggacaatt gtatacagag ttaaaggcag gtctgaataa gacctagctt tgtttttttc
     2881 taatggaatg aaccattttc ctcttctgaa aattctgtat ctgagcacat caagagactc
     2941 ttgtagcagt ggttacccag acttacagaa ttatgtcctc cagaaaccag caagaacact
     3001 tggaatgaac gaatgaactt gtagggggca tagaggattc ttgaaaaaaa aaaatgcaag
     3061 agtgattttc tgttacattc aatttcaaac tctctaattg tgggttttct cctgaagaat
     3121 tttttttcac atactttcca aaagaccaac aaatggatgt tgacaacaac ccaatgaaat
     3181 aacattttgc atatctgaaa agaagcattg aatataagcc aaaagctttc actgaaggtt
     3241 tttttttctt aaaaataaaa aaaaatatat aagtgtaaca tgttttcatt ccaaactggt
     3301 agtggtatgt agaattaaag ataataatgt tgcttcttat tcaaactgtt ggtcatatgt
     3361 acagtatata aacataaaac acacaaggaa ggtattatgt atgcagtagt atactagagt
     3421 ttaggaaaat gaaaatttta gaaaatatgt tttgtcaccc tgttggtcag aaagatgtct
     3481 ttctggtttt aacgcatgca ggcatgtaaa tatttgtctg gagtcacagt attaatgaat
     3541 gagatcttaa gcatctggtg acatcagaac tctgtgtcag ccacttttat ttgtatattg
     3601 aaccctagct agtgccccaa gctgcactat tgggaatgga ttgtggctga acagcaaatc
     3661 aaaacaccag aaatattttt atatgttaac gtcatattat gttaatgttg ctgaaaacaa
     3721 aacctaacaa accttgatgt accagtccaa taccatgtag cgctgagtga taaagttaaa
     3781 atgtgctgtg cttcccaccc ttgtcagagg gaagggtggc tatgtgttat tttcactgtc
     3841 tttttgaaag ttacagtatg tgttttcact ttcgtgcaga taactggaag taaagcggca
     3901 aacagtgctt attacatgct aaagttacct tctctttgtt ttttgcatat ctggaattac
     3961 acctttaaag actgatatga atcagtacgg tcactataca ttttatgatt tttctgtcat
     4021 cttaaaattg tatgatcgta acattattta ttaccacaaa acagcaaaat cttcaatgtc
     4081 taagaaaact agcttaaaat gtttaaatat agttctgatt gggtattaat tacttgatta
     4141 agaaaaaatt aacattatag atactctggc attacgcttc tatacctttt aggtcttcct
     4201 tgcaatactg gaacataatt cttttgtgta gctcactatt agccagctaa gttcatcttt
     4261 ttaataccat aaaaaggtta tatgtacagt tcctatttta gcttgcttac aaagggagca
     4321 ttatttttat ttaaagtatt gctagtaaat gatttgtaga aacttggttt tctaagcata
     4381 gttcttccat aaccaccttt tgttgtttga gcacaaggga ttcttttcct agttctatgt
     4441 gtttgtttcc ctatatgcag tctttaaagg attacaacac ttaaaattga atggacttgt
     4501 gtcaagcttt ttgcatcata cattttttga aagattttta aaaaagccta caacttacat
     4561 atgtagtaga atcagccatt gctctgctcc tggcatagag tcacctgttt gttatgtgga
     4621 ttaaatagtt ttaaaataca tatttgaaga cctttgagaa tgctttagtg tttgatttga
     4681 aataaaagga aattttagca aggattaaag aaaaaagcta tcagctgtat gttaagagag
     4741 actcttacta acatgttgta aatattacaa ttcatgaaat gttattgtaa gtctgtaact
     4801 taattttttc cctgttttag ttatacaggt tggtttggaa atttgtgttt tggcataaac
     4861 aagtaaaatg tgcccatttt atggtttcca tgcttttgta atcctaaaaa tattaatgtc
     4921 tagttgttct atattataac cacatttgcg ctctatgcaa gcccttggaa cagaacatac
     4981 tcatcttcat gtaggaccta tgaaaattgt ctatttttat ctatatattt aaagttttct
     5041 aaaaatgata aaaggttatt acgaattttg ttgtacaaaa tctgtacaaa aatctgtttt
     5101 tacatcataa tgcaagaatt ggaaattttt ctatggtagc ctagttattt gagcctggtt
     5161 tcaatgtgag aaccacgttt actgttattg tatttaattt tcttttcctt ttcaacaatc
     5221 tcctaataaa actgtctgaa atctc
//
