LOCUS       NM_001395010            6744 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens DAB2 interacting protein (DAB2IP), transcript variant
            3, mRNA.
ACCESSION   NM_001395010 XM_005251719
VERSION     NM_001395010.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6744)
  AUTHORS   D'Apolito,M., Santacroce,R., Vazquez,D.O., Cordisco,G.,
            Fantini,C.A., D'Andrea,G., Leccese,A., Colia,A.L., Martinez,P.,
            Zanichelli,A., Josviack,D. and Margaglione,M.
  TITLE     DAB2IP associates with hereditary angioedema: Insights into the
            role of VEGF signaling in HAE pathophysiology
  JOURNAL   J Allergy Clin Immunol 154 (3), 698-706 (2024)
   PUBMED   38823490
  REMARK    GeneRIF: DAB2IP associates with hereditary angioedema: Insights
            into the role of VEGF signaling in HAE pathophysiology.
REFERENCE   2  (bases 1 to 6744)
  AUTHORS   Ju,L., Zhou,Q., Qi,Q., She,Y., Cai,W., Cao,Y., Lu,R., Shao,J. and
            Chen,L.
  TITLE     circSLCO1B7 suppresses the malignant progression of hepatocellular
            carcinoma via the miR-556-3p/DAB2IP axis
  JOURNAL   Aging (Albany NY) 15 (22), 13329-13344 (2023)
   PUBMED   38015711
  REMARK    GeneRIF: circSLCO1B7 suppresses the malignant progression of
            hepatocellular carcinoma via the miR-556-3p/DAB2IP axis.
REFERENCE   3  (bases 1 to 6744)
  AUTHORS   Zhou,J., Deng,Z., Pei,X., Lai,J. and Qu,W.
  TITLE     DAB2IP stabilizes p27Kip1 via suppressing PI3K/AKT signaling in
            clear cell renal cell carcinoma
  JOURNAL   Funct Integr Genomics 23 (4), 326 (2023)
   PUBMED   37880458
  REMARK    GeneRIF: DAB2IP stabilizes p27[Kip1] via suppressing PI3K/AKT
            signaling in clear cell renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6744)
  AUTHORS   Miller,A.L., Perurena,N., Gardner,A., Hinoue,T., Loi,P., Laird,P.W.
            and Cichowski,K.
  TITLE     DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type
            RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer
  JOURNAL   Cancer Res 83 (11), 1800-1814 (2023)
   PUBMED   36939385
  REMARK    GeneRIF: DAB2IP Is a Bifunctional Tumor Suppressor That Regulates
            Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon
            Cancer.
REFERENCE   5  (bases 1 to 6744)
  AUTHORS   Xiong,Z., Yang,L., Li,N., Fu,J., Liu,P., Sun,P., Wei,W. and Xie,X.
  TITLE     DAB2IP attenuates chemoresistance of triple-negative breast cancer
            through sequestration of RAC1 to prevent beta-catenin nuclear
            accumulation
  JOURNAL   Clin Transl Med 12 (12), e1133 (2022)
   PUBMED   36536485
  REMARK    GeneRIF: DAB2IP attenuates chemoresistance of triple-negative
            breast cancer through sequestration of RAC1 to prevent beta-catenin
            nuclear accumulation.
REFERENCE   6  (bases 1 to 6744)
  AUTHORS   von Bergh,A.R., Wijers,P.M., Groot,A.J., van Zelderen-Bhola,S.,
            Falkenburg,J.H., Kluin,P.M. and Schuuring,E.
  TITLE     Identification of a novel RAS GTPase-activating protein (RASGAP)
            gene at 9q34 as an MLL fusion partner in a patient with de novo
            acute myeloid leukemia
  JOURNAL   Genes Chromosomes Cancer 39 (4), 324-334 (2004)
   PUBMED   14978793
REFERENCE   7  (bases 1 to 6744)
  AUTHORS   Zhang,R., He,X., Liu,W., Lu,M., Hsieh,J.T. and Min,W.
  TITLE     AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating
            dissociation of ASK1 from its inhibitor 14-3-3
  JOURNAL   J Clin Invest 111 (12), 1933-1943 (2003)
   PUBMED   12813029
REFERENCE   8  (bases 1 to 6744)
  AUTHORS   Chen,H., Toyooka,S., Gazdar,A.F. and Hsieh,J.T.
  TITLE     Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in
            prostate cancer cell lines
  JOURNAL   J Biol Chem 278 (5), 3121-3130 (2003)
   PUBMED   12446720
  REMARK    GeneRIF: Epigenetic regulation of this novel tumor suppressor gene
            in prostate cancer cell lines.
REFERENCE   9  (bases 1 to 6744)
  AUTHORS   Wang,Z., Tseng,C.P., Pong,R.C., Chen,H., McConnell,J.D., Navone,N.
            and Hsieh,J.T.
  TITLE     The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate
            cancer. Characterization of a novel GTPase-activating protein
            associated with N-terminal domain of DOC-2/DAB2
  JOURNAL   J Biol Chem 277 (15), 12622-12631 (2002)
   PUBMED   11812785
REFERENCE   10 (bases 1 to 6744)
  AUTHORS   Chen,H., Pong,R.C., Wang,Z. and Hsieh,J.T.
  TITLE     Differential regulation of the human gene DAB2IP in normal and
            malignant prostatic epithelia: cloning and characterization
  JOURNAL   Genomics 79 (4), 573-581 (2002)
   PUBMED   11944990
  REMARK    GeneRIF: Normal prostatic epithelial cells have elevated DAB2IP
            mRNA compared with cancer cells, which correlates with increased
            DAB2IP promoter activity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL365274.17.
            
            On May 26, 2021 this sequence version replaced XM_005251719.4.
            
            Summary: DAB2IP is a Ras (MIM 190020) GTPase-activating protein
            (GAP) that acts as a tumor suppressor. The DAB2IP gene is
            inactivated by methylation in prostate and breast cancers (Yano et
            al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3082140.1,
                                           SRR14038191.3203988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408936.8/ ENSP00000386183.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AL365274.17        23761-24026
            267-370             AL365274.17        50805-50908
            371-504             AL365274.17        71452-71585
            505-658             AL365274.17        129140-129293
            659-757             AL365274.17        131025-131123
            758-1312            AL365274.17        132012-132566
            1313-1457           AL365274.17        135632-135776
            1458-1602           AL365274.17        135862-136006
            1603-1839           AL365274.17        138621-138857
            1840-2041           AL365274.17        140559-140760
            2042-2220           AL365274.17        142673-142851
            2221-3109           AL365274.17        144734-145622
            3110-3262           AL365274.17        146387-146539
            3263-3456           AL365274.17        148325-148518
            3457-3544           AL365274.17        153591-153678
            3545-6744           AL365274.17        154458-157657
FEATURES             Location/Qualifiers
     source          1..6744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.2"
     gene            1..6744
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /note="DAB2 interacting protein"
                     /db_xref="GeneID:153090"
                     /db_xref="HGNC:HGNC:17294"
                     /db_xref="MIM:609205"
     exon            1..266
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..3712
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     ASK1-interacting protein 1; nGAP-like protein; DOC-2/DAB2
                     interactive protein; disabled homolog 2-interacting
                     protein; DAB2 interaction protein; ASK-interacting protein
                     1"
                     /codon_start=1
                     /product="disabled homolog 2-interacting protein isoform
                     3"
                     /protein_id="NP_001381939.1"
                     /db_xref="CCDS:CCDS94477.1"
                     /db_xref="GeneID:153090"
                     /db_xref="HGNC:HGNC:17294"
                     /db_xref="MIM:609205"
                     /translation="MSAGGSARKSTGRSSYYYRLLRRPRLQRQRSRSRSRTRPARESP
                     QERPGSRRSLPGSLSEKSPSMEPSAATPFRVTGFLSRRLKGSIKRTKSQPKLDRNHSF
                     RHILPGFRSAAAAAADNERSHLMPRLKESRSHESLLSPSSAVEALDLSMEEEVVIKPV
                     HSSILGQDYCFEVTTSSGSKCFSCRSAAERDKWMENLRRAVHPNKDNSRRVEHILKLW
                     VIEAKDLPAKKKYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLPPLRTVTVHLY
                     RETDKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGPMIRIKARY
                     QTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQSTGKVKDF
                     LTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDE
                     NCEVDPSKCSAADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRG
                     RPDISERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAK
                     FGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLL
                     WEAVSQLEQSIVSKLGPLPRILRDVHTALSTPGSGQLPGTNDLASTPGSGSSSISAGL
                     QKMVIENDLSGLIDFTRLPSPTPENKDLFFVTRSSGVQPSPARSSSYSEANEPDLQMA
                     NGGKSLSMVDLQDARTLDGEAGSPAGPDVLPTDGQAAAAQLVAGWPARATPVNLAGLA
                     TVRRAGQTPTTPGTSEGAPGRPQLLAPLSFQNPVYQMAAGLPLSPRGLGDSGSEGHSS
                     LSSHSNSEELAAAAKLGSFSTAAEELARRPGELARRQMSLTEKGGQPTVPRQNSAGPQ
                     RRIDQPPPPPPPPPPAPRGRTPPNLLSTLQYPRPSSGTLASASPDWVGPSTRLRQQSS
                     SSKGDSPELKPRAVHKQGPSPVSPNALDRTAAWLLTMNAQLLEDEGLGPDPPHRDRLR
                     SKDELSQAEKDLAVLQDKLRISTKKLEEYETLFKCQEETTQKLVLEYQARLEEGEERL
                     RRQQEDKDIQMKGIISRLMSVEEELKKDHAEMQAAVDSKQKIIDAQEKRIASLDAANA
                     RLMSALTQLKERYSMQARNGISPTNPTKLQITENGEFRNSSNC"
     exon            267..370
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     exon            371..504
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     exon            505..658
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..757
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1312
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1457
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1602
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1839
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..2041
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2220
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..3109
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3262
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3456
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3544
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..6744
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6719..6724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /note="hexamer: ATTAAA"
     polyA_site      6744
                     /gene="DAB2IP"
                     /gene_synonym="AF9Q34; AIP-1; AIP1; DIP1/2"
                     /note="major polyA site"
ORIGIN      
        1 gactttgtgg ggcagccagg gcctcggcgg ccgctcgggc gagcgcggga gaacgcgtgg
       61 gcgcccgccg ggctgtccgg agcggccgat ggggcccgtg tgagcgcgcc caggcccggc
      121 ccggtgcccg gcgggcggca gcatgtccgc gggcggcagc gccaggaaga gcaccgggag
      181 gtcctcctac tactaccggc tgctgaggcg gccccggctg cagcgacaga ggagccgctc
      241 ccgcagccgg acccggcctg ccagggagtc gcctcaagaa aggccgggct ctcggcgcag
      301 cctgcctggc agcctttccg agaagagccc cagcatggag ccctcggccg ccacgccgtt
      361 ccgggtcacg ggcttcctca gccgccgcct caagggctcc atcaagcgca ccaagagcca
      421 gcccaagctg gaccgcaacc acagcttccg ccacatcctg ccggggttcc ggagcgccgc
      481 cgccgccgcc gcggacaatg agaggtccca tctgatgccg aggctgaagg agtctcgctc
      541 ccacgagtcc ctgctcagcc ccagcagtgc ggtggaggcg ctggacctca gcatggagga
      601 agaggtggtc atcaagcccg tgcacagcag catccttggc caggactact gcttcgaggt
      661 gacgacgtca tcaggaagca agtgcttttc ctgccggtct gcagctgagc gggataagtg
      721 gatggagaac ctccggcgag cggtgcatcc caacaaggac aacagccggc gtgtggagca
      781 catcctgaag ctgtgggtga tcgaggccaa ggacctgcca gccaagaaga agtacctgtg
      841 cgagctgtgc ctggacgatg tgctctatgc ccgcaccacg ggcaagctca agacggacaa
      901 tgttttctgg ggcgagcact tcgagttcca caacttgccg cctctgcgca cggtcactgt
      961 ccacctgtac cgggagaccg acaagaagaa gaagaaggag cgcaacagtt acctgggcct
     1021 ggtgagccta cctgctgcct cggtggccgg gcggcagttc gtggagaagt ggtacccggt
     1081 ggtgacgccc aaccccaagg gcggcaaggg ccctggaccc atgatccgca tcaaggcgcg
     1141 ctaccaaacc atcaccatcc tgcccatgga gatgtacaaa gagttcgctg agcacatcac
     1201 caaccactac ctggggctgt gtgcagccct cgagcccatc ctcagtgcca agaccaagga
     1261 ggagatggca tctgccctgg tgcacatcct gcagagcacg ggcaaggtga aggacttcct
     1321 gacagacctg atgatgtcag aggtggaccg ctgcggggac aacgagcacc tcatcttccg
     1381 ggagaacaca ctggccacca aggccattga ggagtacctc aagctagtgg gccagaagta
     1441 cctgcaggac gccctaggtg agttcatcaa agcgctgtat gagtcagatg agaactgcga
     1501 agtggatccc agcaagtgct cggccgctga cctcccagag caccagggca acctcaagat
     1561 gtgctgcgag ctggccttct gcaagatcat caactcctac tgtgtcttcc cacgggagtt
     1621 gaaagaggtg tttgcctcgt ggaggcagga gtgcagcagt cgcggccgcc cggacatcag
     1681 tgagcggctc atcagcgcct ccctcttcct gcgcttcctc tgcccagcca tcatgtcgcc
     1741 ctcactcttc aacctgctgc aggagtaccc tgatgaccgc actgcccgca ccctcaccct
     1801 catcgccaag gtcacccaga acctggccaa ctttgccaaa tttggcagca aggaggaata
     1861 catgtccttc atgaaccagt tcctagagca tgagtggacc aacatgcagc gcttcctgct
     1921 ggagatctcc aaccccgaga ccctctccaa tacagccggc ttcgagggct acatcgacct
     1981 gggccgcgag ctctccagcc tgcactcact gctctgggag gccgtcagcc agctggagca
     2041 gagcatagta tccaaactgg gacccctgcc tcggatcctg agggacgtcc acacagcact
     2101 gagcacccca ggtagcgggc agctcccagg gaccaatgac ctggcctcca caccgggctc
     2161 tggcagcagc agcatctcag ctgggctgca gaagatggtg attgagaacg atctttccgg
     2221 tctgatagat ttcacccggt taccgtctcc aacccccgaa aacaaggact tgttttttgt
     2281 cacaaggtcc tccggggtcc agccctcacc tgcccgcagc tcgagttact cggaagccaa
     2341 cgagcctgat cttcagatgg ccaacggtgg caagagcctc tccatggtgg acctccagga
     2401 cgcccgcacg ctggatgggg aggcaggctc cccggcgggc cccgacgtcc tccccacaga
     2461 tgggcaggcc gctgcagctc agctggtggc cgggtggccg gcccgggcaa ccccagtgaa
     2521 cctggcaggg ctggccacgg tgcggcgggc aggccagaca ccaaccacac caggcacctc
     2581 cgagggcgcg ccaggccggc cccagctgtt ggcaccgctc tccttccaga accctgtgta
     2641 ccagatggcg gctggcctgc cgctgtcacc ccgtggcctt ggcgactcag gctctgaggg
     2701 ccacagctcc ctgagctcac acagcaacag cgaggagttg gcggctgctg ccaagctggg
     2761 aagtttcagc actgccgcgg aggagctggc tcggcggccc ggtgagctgg cacggcgaca
     2821 gatgtcactg actgaaaaag gcgggcagcc cacggtgcca cggcagaaca gtgctggccc
     2881 ccagaggagg atcgaccagc ctccgccccc acccccgccg ccacctcctg ccccccgcgg
     2941 ccggacgccc cccaacctgc tgagcaccct gcagtaccca agaccctcaa gcggaaccct
     3001 ggcgtcggcc tcacctgatt gggtgggccc cagtacccgc ctgaggcagc agtcctcttc
     3061 ctccaagggg gacagcccag aactgaagcc acgggcagtg cacaagcagg gcccttcacc
     3121 tgtgagcccc aatgccctgg accgcacagc cgcttggctc ttgaccatga acgcgcagtt
     3181 gttagaagac gagggcctgg gcccagaccc cccccacagg gataggctaa ggagtaagga
     3241 cgagctcagc caagcagaaa aggacctggc ggtgctgcag gacaagctgc gaatctccac
     3301 caagaagctg gaggagtatg agaccctgtt caagtgccag gaggagacga cgcagaagct
     3361 ggtgctggag taccaggcac ggctggagga gggcgaggag cggctgcggc ggcagcagga
     3421 ggacaaggac atccagatga agggcatcat cagcaggttg atgtccgtgg aggaagaact
     3481 gaagaaggac cacgcagaga tgcaagcggc tgtggactcc aaacagaaga tcattgatgc
     3541 ccaggagaag cgcattgcct cgttggatgc cgccaatgcc cgcctcatga gtgccctgac
     3601 ccagctgaaa gagaggtaca gcatgcaagc ccgtaacggc atctccccca ccaaccccac
     3661 caaattgcag attactgaga acggcgagtt cagaaacagc agcaattgtt aacctgcctg
     3721 aggagggagg aagctaccca aggagagggg gactatggtg gccaagggca gggtctcggc
     3781 ctggggaggc acccacggtt gcagccccag cgcgggtgtc aggaggccga gcctcccctc
     3841 cctgccgctg tccaggaggc ggccgcagag ggagccacca gagactgaag cagcgtgagg
     3901 cgaggtcacc agccgctccc tgtggggtgc gggcagaaga gactgcacgc tggggagtgg
     3961 ggacagcctg atggggcagg gggcctgcca aaaatatgtc tgttggttcc tgaatgtggt
     4021 gtgtccttgt cctcctggat ctggccgagt gcatgtgtcc ccccacacct gtgccaggga
     4081 gggggcttcc tggagggggg attcaagggc taggggccta cacctgtggc ttcccctcgc
     4141 ctccttgggg ggcccgggac tccctggcag ccaggccctg tcatgtggga cctggcactt
     4201 ggcagatcag ttggcaggca ggaagatagg aggacacaga gcaggaggtc agtgtcccct
     4261 gcctgtctcc atccgaagca cctgccactg catgcagcct gttgggacct tcctggctgt
     4321 gaggaactga ggattcctac ccacccaccc cctctgaacc tgtccccaga gcaccacctg
     4381 ctaccttctt ccctgcctta gttgtattgc cagatagacc cagtgagggc catggctttt
     4441 tcttgtgagc tcttgtccct gtggggagga cccacagctt cccacacctc ccacacaggc
     4501 ccaggctgat gctctagggc tcccagaagc cagagatctg ggcggatctg gccagatggc
     4561 tctgagcact gtatctgcct tctcctgggg cccagcacac ccagggcaca gtggtcctgt
     4621 agggagtgcc acctggtgct caccctgaaa gaaaaggtga tccttcctct gagtgatggt
     4681 ttaaaaaaag attctaacgc ctgcaggccc tgagaaggtg gataactgtg attttttttc
     4741 ctttcacagt atgcattaga aacaaaagcc cgcttgctcg cttgctggaa cacaggggcc
     4801 ttttaagttg agcgtgcgca ctgcatggga aatagcggcc ctggaggatg ttagacttgc
     4861 tccctctcca agacagcagc agcctgcacc tgccccgtgt gtgtggccgg cctcctcctc
     4921 acccttcccg gcccccggcc aaggacccag gcgctgcata caggggaggg gcgcacccca
     4981 cagctggggc cggttttcct cagctctagg ctgttctgta gcttatctgc ccctccccca
     5041 ctttcaagac agatgagcag gagcttgggt ctctctcggc ccctgtctgt tcccagcccc
     5101 tgcagattct gagcaaaggc cctgggtaag aagggtggga gtggggcctt tgccagcaga
     5161 gccagggcag ggcgagctgc aggaatcacc cctctgcccc tgcagctgga atgtgccaca
     5221 gaggccccac ctgaagggtg gatgtgctgg aggggtggcc cagagccata ctgcgtccac
     5281 cctgagctcg gggacaggtg acagtggctg ctctgggaag gggcttttag atgtaaccta
     5341 caattcagtt aggctagaga cagatgctgg tggaggaagg gctgggccac cagggatcac
     5401 agaccacagg aagatgggag gtggaagcag aggccctgcc cccacccctt cctgtctcac
     5461 tcttctgtct tgtccccacc catgcgcctt cgtgcctgag accagggtgg ccacacaggc
     5521 agggcctggc tccagtctca tcctcccatt gcccagtgag ccctgctctt ctctccccag
     5581 ccccctccca ccgctgcctc gtagagtgac ctcggacaga gcccccctag caatacaggg
     5641 aggctcccgg ggcctggaca ggcgggctcg gaggctaccc gctgtggccg gtgccagctg
     5701 cccttgcagg gtgggtgagc tctcaggccg agagccttat ttacctagtg caaaaactgt
     5761 aaaagtgtac agactcttca cagattttta tcttaattgc aagtctgccg attttgtaaa
     5821 tgttcttggt gtttgactgt aatgtaacta tctcacctaa tggttgtaca tatcctttgg
     5881 tcctggtgct gccgagggct ggccgggact gctgctctcc caagggtttt attttatttc
     5941 tgaatctaga gaacagtatt gggcaggagg aaaaggcttg gtgtctgcgg ggggtgtctt
     6001 ccctgcctgt ggcatttgtg tgttggcttt gcagctgctg tctgagtagt ggccactggg
     6061 gtgccttcac tgggccagtc aacggggggc tcctgcccag gccacagaga acctgagttc
     6121 ccgggagctg ggccctgcct gcagccaggg ctggggttgc cagaggccct ggagggaagg
     6181 acagtccctg ctggggaaga acagccccgg ggccccctgg tcaccgagac tcagcctctg
     6241 ctggagaaag ccacgccctc cctgctagca cagaggcctg actgactttt ttgcttaact
     6301 tccatgttct gggtgatgga aactgccaaa cctcctgtca gtgaggactc tttccgactg
     6361 cccagaaagt gggggtggag gaccgaggct acagctccac acgccccggt cccccagagc
     6421 atctgcccca ggtacacctc cccctgcgcc ccgcacgact gcgggagcca gactgtccag
     6481 ggaaacagcc tctctctttt ctacacactc agccacaaag ccccccagct cccacaccgc
     6541 gtcccagctc ccctcttttg taagtatgtg aaaaggaaaa aatgcaaacg ttggagtttg
     6601 ggctggagct cctccctcca gctgcgactt ttaactatgt aataatgtac agaggaagct
     6661 gttggtgttc taagactctg tgtggctgtg caatttctgt acatttgcaa ttagaaatat
     6721 taaagattta tttagctatt ttaa
//
