LOCUS       NM_001343               4345 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens DAB adaptor protein 2 (DAB2), transcript variant 1,
            mRNA.
ACCESSION   NM_001343
VERSION     NM_001343.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4345)
  AUTHORS   Price,Z.K., Lokman,N.A., Sugiyama,M., Koya,Y., Yoshihara,M.,
            Oehler,M.K., Kajiyama,H. and Ricciardelli,C.
  TITLE     Disabled-2: a protein up-regulated by high molecular weight
            hyaluronan has both tumor promoting and tumor suppressor roles in
            ovarian cancer
  JOURNAL   Cell Mol Life Sci 80 (11), 320 (2023)
   PUBMED   37815603
  REMARK    GeneRIF: Disabled-2: a protein up-regulated by high molecular
            weight hyaluronan has both tumor promoting and tumor suppressor
            roles in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4345)
  AUTHORS   Li,Y.P., Adi,D., Wang,Y.H., Wang,Y.T., Li,X.L., Fu,Z.Y., Liu,F.,
            Aizezi,A., Abuzhalihan,J., Gai,M., Ma,X., Li,X.M., Xie,X. and Ma,Y.
  TITLE     Genetic polymorphism of the Dab2 gene and its association with Type
            2 Diabetes Mellitus in the Chinese Uyghur population
  JOURNAL   PeerJ 11, e15536 (2023)
   PUBMED   37361044
  REMARK    GeneRIF: Genetic polymorphism of the Dab2 gene and its association
            with Type 2 Diabetes Mellitus in the Chinese Uyghur population.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4345)
  AUTHORS   Price,Z.K., Lokman,N.A., Yoshihara,M., Kajiyama,H., Oehler,M.K. and
            Ricciardelli,C.
  TITLE     Disabled-2 (DAB2): A Key Regulator of Anti- and Pro-Tumorigenic
            Pathways
  JOURNAL   Int J Mol Sci 24 (1), 696 (2022)
   PUBMED   36614139
  REMARK    GeneRIF: Disabled-2 (DAB2): A Key Regulator of Anti- and
            Pro-Tumorigenic Pathways.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4345)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 4345)
  AUTHORS   Huang,J., Xiao,R., Wang,X., Khadka,B., Fang,Z., Yu,M., Zhang,L.,
            Wu,J. and Liu,J.
  TITLE     MicroRNA-93 knockdown inhibits acute myeloid leukemia cell growth
            via inactivating the PI3K/AKT pathway by upregulating DAB2
  JOURNAL   Int J Oncol 59 (4) (2021)
   PUBMED   34476495
  REMARK    GeneRIF: MicroRNA93 knockdown inhibits acute myeloid leukemia cell
            growth via inactivating the PI3K/AKT pathway by upregulating DAB2.
REFERENCE   6  (bases 1 to 4345)
  AUTHORS   Fazili,Z., Sun,W., Mittelstaedt,S., Cohen,C. and Xu,X.X.
  TITLE     Disabled-2 inactivation is an early step in ovarian tumorigenicity
  JOURNAL   Oncogene 18 (20), 3104-3113 (1999)
   PUBMED   10340382
REFERENCE   7  (bases 1 to 4345)
  AUTHORS   Mok,S.C., Chan,W.Y., Wong,K.K., Cheung,K.K., Lau,C.C., Ng,S.W.,
            Baldini,A., Colitti,C.V., Rock,C.O. and Berkowitz,R.S.
  TITLE     DOC-2, a candidate tumor suppressor gene in human epithelial
            ovarian cancer
  JOURNAL   Oncogene 16 (18), 2381-2387 (1998)
   PUBMED   9620555
REFERENCE   8  (bases 1 to 4345)
  AUTHORS   Xu,X.X., Yi,T., Tang,B. and Lambeth,J.D.
  TITLE     Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
  JOURNAL   Oncogene 16 (12), 1561-1569 (1998)
   PUBMED   9569023
REFERENCE   9  (bases 1 to 4345)
  AUTHORS   Albertsen,H.M., Smith,S.A., Melis,R., Williams,B., Holik,P.,
            Stevens,J. and White,R.
  TITLE     Sequence, genomic structure, and chromosomal assignment of human
            DOC-2
  JOURNAL   Genomics 33 (2), 207-213 (1996)
   PUBMED   8660969
REFERENCE   10 (bases 1 to 4345)
  AUTHORS   Mok,S.C., Wong,K.K., Chan,R.K., Lau,C.C., Tsao,S.W., Knapp,R.C. and
            Berkowitz,R.S.
  TITLE     Molecular cloning of differentially expressed genes in human
            epithelial ovarian cancer
  JOURNAL   Gynecol Oncol 52 (2), 247-252 (1994)
   PUBMED   8314147
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB989218.1, AK314381.1,
            U53446.1, AF188298.1, AK130136.1 and AI739507.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001343.3.
            
            Summary: This gene encodes a mitogen-responsive phosphoprotein. It
            is expressed in normal ovarian epithelial cells, but is
            down-regulated or absent from ovarian carcinoma cell lines,
            suggesting its role as a tumor suppressor. This protein binds to
            the SH3 domains of GRB2, an adaptor protein that couples tyrosine
            kinase receptors to SOS (a guanine nucleotide exchange factor for
            Ras), via its C-terminal proline-rich sequences, and may thus
            modulate growth factor/Ras pathways by competing with SOS for
            binding to GRB2. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.14809.1,
                                           SRR1803611.172812.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320816.11/ ENSP00000313391.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               CB989218.1         281-439
            160-1791            AK314381.1         161-1792
            1792-2870           U53446.1           1658-2736
            2871-2984           AF188298.1         2618-2731
            2985-4344           AK130136.1         1248-2607
            4345-4345           AI739507.1         20-20               c
FEATURES             Location/Qualifiers
     source          1..4345
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.1"
     gene            1..4345
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /note="DAB adaptor protein 2"
                     /db_xref="GeneID:1601"
                     /db_xref="HGNC:HGNC:2662"
                     /db_xref="MIM:601236"
     exon            1..177
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            178..369
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..2591
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     disabled homolog 2, mitogen-responsive phosphoprotein;
                     adaptor molecule disabled-2; DAB2, clathrin adaptor
                     protein; differentially expressed in ovarian carcinoma 2;
                     Dab, mitogen-responsive phosphoprotein, homolog 2;
                     differentially-expressed protein 2"
                     /codon_start=1
                     /product="disabled homolog 2 isoform 1"
                     /protein_id="NP_001334.2"
                     /db_xref="CCDS:CCDS34149.1"
                     /db_xref="GeneID:1601"
                     /db_xref="HGNC:HGNC:2662"
                     /db_xref="MIM:601236"
                     /translation="MSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFK
                     GDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGI
                     KIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVV
                     DLKDLFQVIYNVKKKEEEKKKIEEASKAVENGSEALMILDDQTNKLKSGVDQMDLFGD
                     MSTPPDLNSPTESKDILLVDLNSEIDTNQNSLRENPFLTNGITSCSLPRPTPQASFLP
                     ENAFSANLNFFPTPNPDPFRDDPFTQPDQSTPSSFDSLKSPDQKKENSSSSSTPLSNG
                     PLNGDVDYFGQQFDQISNRTGKQEAQAGPWPFSSSQTQPAVRTQNGVSEREQNGFSVK
                     SSPNPFVGSPPKGLSIQNGVKQDLESSVQSSPHDSIAIIPPPQSTKPGRGRRTAKSSA
                     NDLLASDIFAPPVSEPSGQASPTGQPTALQPNPLDLFKTSAPAPVGPLVGLGGVTVTL
                     PQAGPWNTASLVFNQSPSMAPGAMMGGQPSGFSQPVIFGTSPAVSGWNQPSPFAASTP
                     PPVPVVWGPSASVAPNAWSTTSPLGNPFQSNIFPAPAVSTQPPSMHSSLLVTPPQPPP
                     RAGPPKDISSDAFTALDPLGDKEIKDVKEMFKDFQLRQPPAVPARKGEQTSSGTLSAF
                     ASYFNSKVGIPQENADHDDFDANQLLNKINEPPKPAPRQVSLPVTKSTDNAFENPFFK
                     DSFGSSQASVASSQPVSSEMYRDPFGNPFA"
     exon            370..509
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..608
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..740
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            741..821
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..848
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            849..902
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..965
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1619
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1782
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..2415
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2525
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2596
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..4345
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2965..2970
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /note="hexamer: AATAAA"
     polyA_site      2984
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /note="major polyA site"
     regulatory      4324..4329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /note="hexamer: AATAAA"
     polyA_site      4345
                     /gene="DAB2"
                     /gene_synonym="DOC-2; DOC2"
                     /note="major polyA site"
ORIGIN      
        1 agtcctcagc tgccagcatc tgattagaac catatctctc gccgggagtg gccgcgcggc
       61 tccgaagctc ccggccggcg gctatttaag cgaggcccgc cgcatccgct gcgctgtagc
      121 ctggaggctc cgggcgcggg gaagtcatgc tcgcttcacg gaggcaatag ctagccggtg
      181 tctgtgggag gttatgttta tttgagactt ctccatcggg atcgcctggt gtcaccaagt
      241 gtccactggt actgaggttt gctgcctgcc ttcttgccat gtctaacgaa gtagaaacaa
      301 gtgcaaccaa tggtcagccc gaccaacagg ccgcaccaaa agcaccctca aagaaggaaa
      361 aaaagaaagg ccctgaaaag acagatgaat atctcttagc aaggttcaaa ggcgatggtg
      421 taaaatataa ggccaagctg attggcattg atgatgtgcc agatgcaaga ggggataaaa
      481 tgagccaaga ctctatgatg aaactaaagg gaatggcggc agctggtcgg tctcagggac
      541 aacacaaaca aaggatctgg gtcaacattt ccctttctgg gataaaaata attgatgaga
      601 aaactggggt aatagagcat gaacatccag taaataagat ttctttcatt gcccgtgatg
      661 tgacagacaa ccgggcattt ggttacgtgt gtggaggaga aggccagcat cagttttttg
      721 ccataaaaac cgggcaacag gctgaaccat tagttgttga tcttaaagac ctttttcaag
      781 ttatctataa tgtaaagaaa aaggaagaag aaaagaaaaa gatagaggaa gccagcaaag
      841 cagttgagaa tgggagtgag gccctaatga ttctagatga ccaaactaac aaactgaaat
      901 cgggtgttga ccagatggat ttgtttgggg acatgtctac acctcctgac ctaaatagtc
      961 caacagaaag caaagatatc ctgttagtgg atctaaactc tgaaatcgac accaatcaga
     1021 attctttaag agaaaatcca ttcttaacaa acggcatcac ctcctgttct cttcctcgac
     1081 caacgcctca ggcatccttc ttgcctgaaa atgccttttc tgccaatctc aacttctttc
     1141 ccacccctaa tcctgatcct ttccgtgacg atcctttcac acagccagac caatcgacac
     1201 cttcttcgtt tgattctctc aaatctccag atcagaagaa agagaattcg agtagctcgt
     1261 ctactccgct gagtaatggg cccctgaatg gtgatgttga ctactttggt cagcaatttg
     1321 accagatctc taaccggact ggcaaacagg aagctcaggc aggcccatgg cccttttcaa
     1381 gttcgcaaac ccagccagca gtgagaactc aaaatggggt atctgaaaga gaacagaacg
     1441 gcttctctgt caaatcctcc ccgaaccctt ttgtgggaag ccctcccaaa ggactgtcca
     1501 tacagaatgg cgtaaagcag gacttggaaa gctctgtcca gtcctcacca catgactcca
     1561 tagccattat cccacctcca caaagtacca aaccaggaag aggcagaagg actgctaagt
     1621 cttcagccaa tgacttgctt gcatcagaca tctttgctcc tcccgtctca gaaccttcag
     1681 gccaggcgtc acccacagga caacctacag ccctgcagcc caaccctctg gatctcttca
     1741 aaacaagtgc tcctgcccca gtggggcccc tggtgggtct aggtggtgta actgtcacac
     1801 tccctcaggc aggaccatgg aacacagcat ctttggtctt caatcagtcc ccttcaatgg
     1861 ctccgggagc catgatgggt ggtcaacctt caggttttag tcagcccgtc atttttggta
     1921 caagtccagc tgtttcaggt tggaaccagc cttcaccctt tgcagcctca actccccctc
     1981 cagtgcctgt tgtctggggc ccttctgcat ctgtggcacc caatgcttgg tcaacaacaa
     2041 gccctttggg gaatcctttt cagagcaata tttttccagc tcctgctgtg tccactcagc
     2101 ccccatccat gcactcctct ctcctggtca ctcctcctca gccacctccc agagctggcc
     2161 ctcccaagga catctccagt gatgccttca ctgccttaga cccacttggg gataaagaga
     2221 tcaaggatgt gaaagaaatg tttaaggatt tccaactgcg gcagccacct gctgtgcccg
     2281 cgcggaaggg agagcagact tcttctggga ctttgagtgc ctttgccagt tatttcaaca
     2341 gcaaggttgg cattcctcag gagaatgcag accatgatga ctttgatgct aatcaactat
     2401 tgaacaagat caatgaacca ccaaagccag ctcccagaca agtttccctg ccagttacca
     2461 aatctactga caatgcattt gagaaccctt tctttaaaga ttcttttggt tcatcacaag
     2521 cctctgtggc ttcttctcaa cctgtatctt ctgagatgta tagggatcca tttggaaatc
     2581 cttttgccta aattctgaac ttggtctgca gaccatccag aggaataaaa aggttggcct
     2641 tagtagtcaa aaacaaagct gatagccaga cacgttctga tttctgccct tgttccagct
     2701 ttgacgtatt atctgttgcc ttatttctca ttgcctcttc tacttgtaaa atgcttttca
     2761 ctttctgtct aggttaaagc taaactgaat ctatggcttt aaataaatta agatcctaaa
     2821 ctctctagct taagtgtaaa tgaagtacag tagtttccct actgaaccct gcctcttgtg
     2881 tccctggaac cttctagaac acctgccttc taccctctgg ttgggagatg cagccaccac
     2941 atcccttcat atcatactgt tttgaataaa ttttcaaatc cttattgttc agagttgttt
     3001 gggggttctg tttcagagca taaaacctaa aggttatagt agaacaaggc accttcttaa
     3061 aagaaatctt gcttcagacc atcagttaca gagaatttct aaagtaaaat tgaagcaact
     3121 acaacttctc cttagacact ttggaatcta accacttaag gaccttttta aagagatagc
     3181 ttctcttctt tctgaagatc aatttctccc aaggccaaga ttgtcctttt ctcccatttc
     3241 ttgctagcta ttgcaaatga gggaagaaca ttattcatct ctcctcccct tttttttctg
     3301 attctttttt cagtcagttt tgctcctggg ttcaagtagt attaccaccc tttcacaagc
     3361 aacagactct cacagggcaa aaaaaaaaaa aaatctaatg attcacagac agatctggag
     3421 cctctcttca ttctcagtaa ttgctagtcc caagaactag aattgcaaat gggcacaacc
     3481 tatatccttc ctgtggaaga ggaggccact ctcttgagct gaagttccag aagagcagtt
     3541 aatgttcaag agaaattgaa ctcaactcag caacaaagga ctctattttg aagagcaaca
     3601 tatcacaaag ctaaatgtga ttgtgccaaa cacattaggt gcttatttgg ggtcatgcta
     3661 ggcctttatc aagtaactgg aaaacttttc ttgcagccac aatctcaatg tcgttagtag
     3721 gaagataaga ggggagaaaa agctgtagaa caaatgtttg gggttaccat tgaaaatcta
     3781 atgtctgcaa tatttttctc ctcacaactt ggaaacgttc ccagttcatt ttcagtcctg
     3841 ttgtgagcac agttctgaag ggtttattat tgtcaaaata agttttgttt tgttttgttt
     3901 atgttgggtt tttaatgttg tctcttgacc cttaatgctc aggttcttgt gggagttaat
     3961 cagccacatc caatgttacc ttgaggggga agaagagggt gatgctcaga agctaaacaa
     4021 gacaggggcc acatgaccct ctattgatta gccccaagta gaaagtcctg tggttttatg
     4081 tttaatggta atagttgatc atatatggca taattttcta tcagcttcct actcagtcac
     4141 tataaacaca gacttgaaat agtactttaa atgtccaaat acctaaatgt gctaaactgg
     4201 aggtaactat ttctaggtag ttgaattttt gaaagtcatg atcagccaca caactgtttt
     4261 gtacatactt attttctcat gcacttttct gtatgcaaat aaagctataa atttactcat
     4321 ttcaataaac tggagtggca gaata
//
