LOCUS       NM_001365792            5301 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens DAB adaptor protein 1 (DAB1), transcript variant 6,
            mRNA.
ACCESSION   NM_001365792
VERSION     NM_001365792.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5301)
  AUTHORS   Kim,M.H., Jeong,Y.J., Urm,S.H. and Seog,D.H.
  TITLE     The heterotrimeric kinesin-2 family member KIF3A directly binds to
            disabled-1 (Dab1)
  JOURNAL   BMB Rep 57 (10), 447-452 (2024)
   PUBMED   38919020
  REMARK    GeneRIF: The heterotrimeric kinesin-2 family member KIF3A directly
            binds to disabled-1 (Dab1).
REFERENCE   2  (bases 1 to 5301)
  AUTHORS   Ramsden,C.E., Zamora,D., Horowitz,M.S., Jahanipour,J., Calzada,E.,
            Li,X., Keyes,G.S., Murray,H.C., Curtis,M.A., Faull,R.M., Sedlock,A.
            and Maric,D.
  TITLE     ApoER2-Dab1 disruption as the origin of pTau-associated
            neurodegeneration in sporadic Alzheimer's disease
  JOURNAL   Acta Neuropathol Commun 11 (1), 197 (2023)
   PUBMED   38093390
  REMARK    GeneRIF: ApoER2-Dab1 disruption as the origin of pTau-associated
            neurodegeneration in sporadic Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5301)
  AUTHORS   Bracher-Smith,M., Leonenko,G., Baker,E., Crawford,K., Graham,A.C.,
            Salih,D.A., Howell,B.W., Hardy,J. and Escott-Price,V.
  TITLE     Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN
            pathway in Alzheimer's disease pathogenesis
  JOURNAL   Neurobiol Aging 119, 67-76 (2022)
   PUBMED   35977442
  REMARK    GeneRIF: Whole genome analysis in APOE4 homozygotes identifies the
            DAB1-RELN pathway in Alzheimer's disease pathogenesis.
REFERENCE   4  (bases 1 to 5301)
  AUTHORS   Dlugosz,P., Teufl,M., Schwab,M., Kohl,K.E. and Nimpf,J.
  TITLE     Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal
            Growth Factor Receptor
  JOURNAL   Int J Mol Sci 22 (4), 1745 (2021)
   PUBMED   33572344
  REMARK    GeneRIF: Disabled 1 Is Part of a Signaling Pathway Activated by
            Epidermal Growth Factor Receptor.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5301)
  AUTHORS   Li,L., Hao,J., Yan,C.Q., Wang,H.F., Meng,B. and Cai,S.Y.
  TITLE     Inhibition of microRNA-300 inhibits cell adhesion, migration, and
            invasion of prostate cancer cells by promoting the expression of
            DAB1
  JOURNAL   Cell Cycle 19 (21), 2793-2810 (2020)
   PUBMED   33064976
  REMARK    GeneRIF: Inhibition of microRNA-300 inhibits cell adhesion,
            migration, and invasion of prostate cancer cells by promoting the
            expression of DAB1.
REFERENCE   6  (bases 1 to 5301)
  AUTHORS   Howell,B.W., Lanier,L.M., Frank,R., Gertler,F.B. and Cooper,J.A.
  TITLE     The disabled 1 phosphotyrosine-binding domain binds to the
            internalization signals of transmembrane glycoproteins and to
            phospholipids
  JOURNAL   Mol Cell Biol 19 (7), 5179-5188 (1999)
   PUBMED   10373567
REFERENCE   7  (bases 1 to 5301)
  AUTHORS   Trommsdorff,M., Borg,J.P., Margolis,B. and Herz,J.
  TITLE     Interaction of cytosolic adaptor proteins with neuronal
            apolipoprotein E receptors and the amyloid precursor protein
  JOURNAL   J Biol Chem 273 (50), 33556-33560 (1998)
   PUBMED   9837937
REFERENCE   8  (bases 1 to 5301)
  AUTHORS   Lambert de Rouvroit,C. and Goffinet,A.M.
  TITLE     Cloning of human DAB1 and mapping to chromosome 1p31-p32
  JOURNAL   Genomics 53 (2), 246-247 (1998)
   PUBMED   9790777
REFERENCE   9  (bases 1 to 5301)
  AUTHORS   Rice,D.S., Sheldon,M., D'Arcangelo,G., Nakajima,K., Goldowitz,D.
            and Curran,T.
  TITLE     Disabled-1 acts downstream of Reelin in a signaling pathway that
            controls laminar organization in the mammalian brain
  JOURNAL   Development 125 (18), 3719-3729 (1998)
   PUBMED   9716537
REFERENCE   10 (bases 1 to 5301)
  AUTHORS   Matilla-Duenas,A. and Volpini,V.
  TITLE     Spinocerebellar Ataxia Type 37
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31145571
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL442223.13, AL139219.12,
            AL354883.14, AL161740.16 and KF495961.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: The laminar organization of multiple neuronal types in the
            cerebral cortex is required for normal cognitive function. In mice,
            the disabled-1 gene plays a central role in brain development,
            directing the migration of cortical neurons past previously formed
            neurons to reach their proper layer. This gene is similar to
            disabled-1, and the protein encoded by this gene is thought to be a
            signal transducer that interacts with protein kinase pathways to
            regulate neuronal positioning in the developing brain. [provided by
            RefSeq, Jan 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.177261.1,
                                           SRR1660803.257652.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371236.7/ ENSP00000360280.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AL442223.13        2451-2581           c
            132-334             AL139219.12        29546-29748         c
            335-474             AL354883.14        120297-120436       c
            475-573             AL354883.14        111550-111648       c
            574-705             AL354883.14        47290-47421         c
            706-825             AL354883.14        46529-46648         c
            826-864             AL354883.14        46030-46068         c
            865-930             AL354883.14        44367-44432         c
            931-990             AL354883.14        37891-37950         c
            991-1053            AL161740.16        59844-59906         c
            1054-1162           AL161740.16        57394-57502         c
            1163-1711           AL161740.16        48746-49294         c
            1712-1839           AL161740.16        45008-45135         c
            1840-1950           AL161740.16        44543-44653         c
            1951-5283           AL161740.16        28659-31991         c
            5284-5301           KF495961.1         362-379             c
FEATURES             Location/Qualifiers
     source          1..5301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.2-p32.1"
     gene            1..5301
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /note="DAB adaptor protein 1"
                     /db_xref="GeneID:1600"
                     /db_xref="HGNC:HGNC:2661"
                     /db_xref="MIM:603448"
     exon            1..131
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     exon            132..334
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1935
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /note="isoform 1 is encoded by transcript variant 6;
                     disabled homolog 1; Dab reelin signal transducer 1; Dab,
                     reelin signal transducer, homolog 1; DAB1, reelin adaptor
                     protein; yotari; spinocerebellar ataxia 37"
                     /codon_start=1
                     /product="disabled homolog 1 isoform 1"
                     /protein_id="NP_001352721.1"
                     /db_xref="CCDS:CCDS607.1"
                     /db_xref="GeneID:1600"
                     /db_xref="HGNC:HGNC:2661"
                     /db_xref="MIM:603448"
                     /translation="MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKA
                     KLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTG
                     ALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQL
                     IYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEEN
                     IYQVPTSQKKEGVYDVPKSQPVSAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSS
                     QTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMP
                     GAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPG
                     TSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKV
                     GVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDI
                     FEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDNISPQAGS"
     exon            335..474
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     exon            475..573
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     exon            574..705
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     exon            706..825
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     exon            826..864
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     exon            865..930
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     exon            931..990
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1053
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1162
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1711
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1839
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1950
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..5301
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5279..5284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /note="hexamer: AATAAA"
     polyA_site      5301
                     /gene="DAB1"
                     /gene_synonym="SCA37"
                     /note="major polyA site"
ORIGIN      
        1 ggacccagct cggcgctcgc ccgggcttcc ccgggctgca gagcgcgcct gagtgccgcc
       61 gcccgccggg catggggagc cgcttcctgg gcggctgcgg cagcggagga ggatgctctg
      121 ggctaggcga gcactcaaaa agagtgaatg aaatgtgcag ctcagagtgt catttctgaa
      181 gggaggagtc tttctcttgg agaagagtcc tcaatgagcc tggccgaggc ccgggatctg
      241 tgtgaagtgg actaaggatt aagtaggatg tcaactgaga cagaacttca agtagctgtg
      301 aaaaccagcg ccaagaaaga ctccagaaag aaaggtcagg atcgcagtga agccactttg
      361 ataaagaggt ttaaaggtga aggggtccgg tacaaagcca aattgatcgg gattgatgaa
      421 gtttccgcag ctcggggaga caagttatgt caagattcca tgatgaaact caagggcgtt
      481 gttgctggcg ctcgttccaa aggagaacac aaacagaaaa tctttttaac catctccttt
      541 ggaggaatca aaatctttga tgagaagaca ggggcccttc agcatcatca tgctgttcat
      601 gaaatatcct acattgcaaa ggacattaca gatcaccggg cctttggata tgtttgtggg
      661 aaggaaggga atcacagatt tgtggccata aaaacagccc aggcggctga acctgttatt
      721 ctggacttga gagatctctt tcaactcatt tatgaattga agcaaagaga agaattagaa
      781 aaaaaggcac aaaaggataa gcagtgtgaa caagctgtgt accagacaat attggaagag
      841 gatgttgaag atcctgtgta ccagtacatt gtgtttgagg ctggacacga gccaatccgt
      901 gatcccgaaa cggaagaaaa catttatcag gttcccacca gccaaaagaa ggaaggtgtt
      961 tatgatgtgc caaaaagtca acctgtaagt gctgtgaccc aattagaact ttttggggac
     1021 atgtccacac cccctgatat aacctctccc cccactcctg caactccagg tgatgccttt
     1081 atcccatctt catctcagac ccttccagcg agtgcagatg tgtttagttc tgtacctttc
     1141 ggcactgctg ctgtaccctc aggttacgtt gcaatgggcg ctgtcctccc gtccttctgg
     1201 ggtcagcagc ccctcgtcca acagcagatg gtcatgggtg cccagccacc agtcgctcag
     1261 gtgatgccgg gggctcagcc catcgcatgg ggccagccgg gtctctttcc tgccactcag
     1321 cagccctggc caactgtggc cgggcagttt ccgccagccg ccttcatgcc cacacaaact
     1381 gttatgcctt tgccagctgc catgttccaa ggtcccctca ccccccttgc caccgtccca
     1441 ggcacgagtg actccaccag gtcaagtcca cagaccgaca agcccaggca gaaaatgggc
     1501 aaagaaacgt ttaaggattt ccagatggcc cagcctccgc ccgtgccctc ccgcaaaccc
     1561 gaccagccct ccctcacctg tacctcagag gccttctcca gttacttcaa caaagtcggg
     1621 gtggcacagg atacagacga ctgtgatgac tttgacatct cccagttgaa tttgacccct
     1681 gtgacttcta ccacaccatc gaccaactca cctccaaccc cagcccctag acagagctct
     1741 ccatccaaat catctgcatc ccatgccagt gatcctacca cagatgacat ctttgaagag
     1801 ggctttgaaa gtcccagcaa aagcgaagag caagaagctc ctgatggatc acaggcctca
     1861 tccaacagtg atccatttgg tgagcccagt ggggagccca gtggtgataa tataagtcca
     1921 caggccggta gctagatagc gcaggtctgg gagccagagc ctctgtacgc gcagatcaac
     1981 agacctaaga aatagcatcg atgcgagctc gtggtgggtg ctcaagactg gcatggacat
     2041 cagcatcacg acaggctctc ttgtattctt tcacctcttc ccacaagaaa ttcatgattg
     2101 cccaatggaa ctcgctcaga agagggaact aagcattttt ggcaaccaat ggcagatatc
     2161 tatggcagca cacaaaaaaa gtatagaaag atccacccaa cattaaatca gaaatcaagc
     2221 aaatgcttac ccaacaaata tttgagccct catagctggg tttaagatga ctcagtgtgc
     2281 aaaattatta attccctttt tatttctcta cctgttgacc actgttgaga caccaaattt
     2341 ggagtgacag gcatcagagg attacaacag ggttggaact gacttcttta agcaaaagca
     2401 aagggtcttc tgtgaccaca atatcgtcat ccatatgcct tttcacatag gatgatgtgt
     2461 tttttgtcac tccatggggc ctggtctgcc attttccccc ctttcctttt tttgtcatgt
     2521 ttgaaaatta ataggtgtac aaatttttgt attgcttttg acttttttta gatatgggtg
     2581 aagaaatcta actggggaga aaaaaagcct cagtgaaatg aattaacttg aaattacaag
     2641 acaaataagt ggttgattat tcattatgat cacgaatgtt gccaaaacag tcctttagct
     2701 attctgcatc ctggtgaaga aagacagctt tcagtacgaa ccttcattct gtgagtagga
     2761 aaagacatca gatcccattg atgagaaaga tgaaaaatgc atctgatttc ttaagaagct
     2821 ctaaactcta agtacaataa aatgatattt tttatttttc cgatatcttg ctgctgtgtt
     2881 gctatgcaga caagtgtctt ctccacgtgc cattttcaaa gaaaagtcat ttgccaaata
     2941 attctggtac aattctggta atgtggtttt ggatcttaaa aaccaacttt ctaatggaac
     3001 aatggtggca taaatattca gaataacaaa ctgattctgt ggtccaaatg gttcatctct
     3061 atctcttttt gtacatcaga aaattcaaat gggattttta ttttataact tgaaaaaaaa
     3121 accttaccat taaactcttt aaatatttaa gggaaatggc tttaaggagt tctaatgaaa
     3181 aaaaattgtc ttttttttgt aaatataaat gttaatgaaa atgattttta ataatgccat
     3241 tacactgtag agaaggtagc agattgagtg caaggtgtga caaacttgat ggatggggct
     3301 cactttccag acgttattct ggagcatatg gtaggaagct ggagtgcagg gacagctggc
     3361 aggagcagtt ggccaatcag cagctagtga acgggaaggg agcacgtgac tccatcatct
     3421 agcctttcca cgagagtccc caccctacgt gcaacacaag aaaaagacaa ttcacattct
     3481 gaagaattca gattctgaaa ctctcccacc tccccactcc cacctacccc cgatataaat
     3541 cactggactg tttgtacgtg aaacagaaga ggctaagctt ccttttttta cacttatgag
     3601 acaaaaagtg cagtgtttgg ttcgtatgtt tagcacatga ttttcataaa gaatctatat
     3661 atttttgccc tacagagaat tgttatacag gtcaagtgtg ttttcctgat gttcctatgc
     3721 agttacagta tgttgaaagt gttttaacac taagaagaaa actttaaaga ttcatgtgat
     3781 taattggatt tgaggataat tattattatt tggtttttag atttgaaaag tagaatttcc
     3841 attgagacaa ttgatttgaa taggcctgca tttgattctt catatcaata gaaactaaaa
     3901 tgatttggga gattcatttg aaaaatgatt gtatacttgt tcacaaagcg aaaagtgata
     3961 catgaaggta atggttatca tttaaagccc acattttaca ctatcaggtc acaggagtct
     4021 aatttttttt tcagttagat aaactgacca aacgtctatt caagaatata tgtcaatatc
     4081 atcctaatgt ggaaggtccg aagaaccaga aaagtgagaa gggccgttta cctccctctg
     4141 tagctatcac ctgttggtcc acagagtttc ttgagaaatg agcaaacatt ttatgattag
     4201 gtaacccttt cacatgaacg ggaagatggg aaaggtggaa tgaccataag agttggcctg
     4261 agaccagttt gttttctggg gatttggtaa gataggcagt tcccatggga aattgcttaa
     4321 attgctttgt tgcctatgat ttgattctaa acaagtggtg ctatcttctc cctcaatatg
     4381 gctgtcttga gtttgtcttg cagtatcaca ccattatacc aattctttgg gttgcttctg
     4441 acacattcaa agtgaactct ggctgatgtt gctgtttcag gtataccatc tggagttaat
     4501 ttcctagcag aaggtgaaag tccaggagaa ttgtcctctt tcattgaaca tgattgaaaa
     4561 tgtaactggc tctgaacttc aagaagatag atgcccaagt gatgcattaa agtaagggaa
     4621 ataaagtcaa gtttttcaac tgccatccat attctcattg gcagaattct gatttttttc
     4681 caagcactgt ttggtgagcc tggaagcacc gtatcctgtc ccaggagtac agtgaaattt
     4741 ccaagcaaga gctgaggtgc caataccaaa agaccatggg gagtctgcac ggttctggtt
     4801 agatcaatag aaaatccatg tgtacaactg ttaattcctc atcctccact agcactaaat
     4861 ttgtcacttt aaattttgaa accagggaaa caccacctgt cattctgtcc ccattctcca
     4921 tagctcttca atctttacat gccgcaagac ttttttgata gctcgtactc atcccagtgt
     4981 ctcctgaaac cccatcatgt aatgtactgg gcaccttctt ttaaacaaat gtttactctg
     5041 tgggtttggt tcatttcaat ttctgcgttc tgacacatat ttttttaata aagatgagaa
     5101 agagaaaatg actgttgcag tacctttcta gacctacttt aactttacct cagatgacag
     5161 tttgttaaca tatatggaca cattattttt aactttatgt acaatgcatt caacagaaca
     5221 gcaaaatttt tagaaatttt ccattaattt ctgtaacaca ccatgtaaaa ctgttacaaa
     5281 taaacatgtt tgagaacaac a
//
