LOCUS       NM_001201427            6185 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens dishevelled associated activator of morphogenesis 2
            (DAAM2), transcript variant 1, mRNA.
ACCESSION   NM_001201427
VERSION     NM_001201427.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6185)
  AUTHORS   Li,Z., Wei,X. and Zhu,Y.
  TITLE     The prognostic value of DAAM2 in lower grade glioma, liver cancer,
            and breast cancer
  JOURNAL   Clin Transl Oncol 25 (7), 2224-2238 (2023)
   PUBMED   36790676
  REMARK    GeneRIF: The prognostic value of DAAM2 in lower grade glioma, liver
            cancer, and breast cancer.
REFERENCE   2  (bases 1 to 6185)
  AUTHORS   de Alwis,N., Beard,S., Binder,N.K., Pritchard,N., Tong,S.,
            Kaitu'u-Lino,T.J. and Hannan,N.J.
  TITLE     Placental DAAM2 is unaltered in preeclampsia, but upregulated by
            treatment with proton pump inhibitors
  JOURNAL   Pregnancy Hypertens 30, 13-20 (2022)
   PUBMED   35933758
  REMARK    GeneRIF: Placental DAAM2 is unaltered in preeclampsia, but
            upregulated by treatment with proton pump inhibitors.
REFERENCE   3  (bases 1 to 6185)
  AUTHORS   Chen,A., Liu,Z., Wu,Q. and Li,H.
  TITLE     Disheveled-associated activator of morphogenesis 2 promotes
            invasion of colorectal cancer by activating PAK1 and promoting MMP7
            expression
  JOURNAL   Genes Genomics 43 (8), 923-935 (2021)
   PUBMED   33974241
  REMARK    GeneRIF: Disheveled-associated activator of morphogenesis 2
            promotes invasion of colorectal cancer by activating PAK1 and
            promoting MMP7 expression.
REFERENCE   4  (bases 1 to 6185)
  AUTHORS   de Alwis,N., Beard,S., Binder,N.K., Pritchard,N.,
            Kaitu'u-Lino,T.J., Walker,S.P., Stock,O., Groom,K., Petersen,S.,
            Henry,A., Said,J.M., Seeho,S., Kane,S.C., Hui,L., Tong,S. and
            Hannan,N.J.
  TITLE     DAAM2 is elevated in the circulation and placenta in pregnancies
            complicated by fetal growth restriction and is regulated by hypoxia
  JOURNAL   Sci Rep 11 (1), 5540 (2021)
   PUBMED   33692394
  REMARK    GeneRIF: DAAM2 is elevated in the circulation and placenta in
            pregnancies complicated by fetal growth restriction and is
            regulated by hypoxia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6185)
  AUTHORS   Schneider,R., Deutsch,K., Hoeprich,G.J., Marquez,J., Hermle,T.,
            Braun,D.A., Seltzsam,S., Kitzler,T.M., Mao,Y., Buerger,F.,
            Majmundar,A.J., Onuchic-Whitford,A.C., Kolvenbach,C.M.,
            Schierbaum,L., Schneider,S., Halawi,A.A., Nakayama,M., Mann,N.,
            Connaughton,D.M., Klambt,V., Wagner,M., Riedhammer,K.M.,
            Renders,L., Katsura,Y., Thumkeo,D., Soliman,N.A., Mane,S.,
            Lifton,R.P., Shril,S., Khokha,M.K., Hoefele,J., Goode,B.L. and
            Hildebrandt,F.
  TITLE     DAAM2 Variants Cause Nephrotic Syndrome via Actin Dysregulation
  JOURNAL   Am J Hum Genet 107 (6), 1113-1128 (2020)
   PUBMED   33232676
  REMARK    GeneRIF: DAAM2 Variants Cause Nephrotic Syndrome via Actin
            Dysregulation.
REFERENCE   6  (bases 1 to 6185)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   7  (bases 1 to 6185)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 6185)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human DAAM2 gene in silico
  JOURNAL   Int J Oncol 22 (4), 915-920 (2003)
   PUBMED   12632087
REFERENCE   9  (bases 1 to 6185)
  AUTHORS   Habas,R., Kato,Y. and He,X.
  TITLE     Wnt/Frizzled activation of Rho regulates vertebrate gastrulation
            and requires a novel Formin homology protein Daam1
  JOURNAL   Cell 107 (7), 843-854 (2001)
   PUBMED   11779461
REFERENCE   10 (bases 1 to 6185)
  AUTHORS   Adams,M.D., Dubnick,M., Kerlavage,A.R., Moreno,R., Kelley,J.M.,
            Utterback,T.R., Nagle,J.W., Fields,C. and Venter,J.C.
  TITLE     Sequence identification of 2,375 human brain genes
  JOURNAL   Nature 355 (6361), 632-634 (1992)
   PUBMED   1538749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL161439.15, AB002379.2 and AW273797.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001201427.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and uses
            an alternate in-frame splice site at the 5' end of a coding exon
            compared to isoform 1. The resulting variant (1) encodes the longer
            isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB002379.2 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274867.9/ ENSP00000274867.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AL161439.15        25624-25630         c
            8-6184              AB002379.2         1-6177
            6185-6185           AW273797.1         14-14               c
FEATURES             Location/Qualifiers
     source          1..6185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..6185
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /note="dishevelled associated activator of morphogenesis
                     2"
                     /db_xref="GeneID:23500"
                     /db_xref="HGNC:HGNC:18143"
                     /db_xref="MIM:606627"
     exon            1..90
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            91..314
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..3353
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     disheveled-associated activator of morphogenesis 2"
                     /codon_start=1
                     /product="disheveled-associated activator of morphogenesis
                     2 isoform 1"
                     /protein_id="NP_001188356.1"
                     /db_xref="CCDS:CCDS56426.1"
                     /db_xref="GeneID:23500"
                     /db_xref="HGNC:HGNC:18143"
                     /db_xref="MIM:606627"
                     /translation="MAPRKRSHHGLGFLCCFGGSDIPEINLRDNHPLQFMEFSSPIPN
                     AEELNIRFAELVDELDLTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYY
                     IDRINSMAAMQSLYAFDEEETEMRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNF
                     LRSMDHATCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVA
                     VLEILGAVCLVPGGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTA
                     IMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMV
                     RNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNG
                     GYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEK
                     FRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELV
                     AQLSELSTGPVSSPPPPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPP
                     TPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQPSHPLKSFNWVKLNEERVPGTVWN
                     EIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDIYLASRKVKELSVIDGRRAQNCI
                     ILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMA
                     RADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQM
                     LEVILAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDI
                     LNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVELEYQRRQVREPSDKFVPVMS
                     DFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEAR
                     QDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSAL
                     RSGEVFDKDLCKLKRSRKRSGSQALEVTRERAINRLNY"
     exon            315..404
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            405..479
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            480..574
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            575..908
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1019
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1123
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1190
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1308
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1447
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1506
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1691
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1991
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2099
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2206
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2291
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2398
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2487
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2656
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2764
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            2765..2825
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2957
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3128
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..6185
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6161..6166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /note="hexamer: ATTAAA"
     polyA_site      6185
                     /gene="DAAM2"
                     /gene_synonym="dJ90A20A.1; NPHS24"
                     /note="major polyA site"
ORIGIN      
        1 gatagcgcgg agcacgcagc agcgagcgga gcgcgggcgg cggcgccgta cctcgggctg
       61 cgggagcgcg ggcgccctgg ggtcctcgga atcacaatga ggacctaggg catctgtctg
      121 ctgacgcccc ctggcctgca gtgaccatgg ccccccgcaa gaggagccac catggcctgg
      181 gcttcctgtg ctgcttcggg ggcagtgaca tccccgaaat caacctccgg gacaaccacc
      241 ctctgcagtt catggagttc tccagcccca tcccgaacgc agaggagctc aacatccgct
      301 ttgcagagct ggtggatgaa ttggatctca ctgacaaaaa ccgagaggct atgtttgcac
      361 tgccccctga gaagaaatgg cagatctact gcagcaagaa gaaggagcag gaggacccca
      421 acaagctggc aaccagctgg cctgactatt acatcgaccg catcaattcc atggctgcga
      481 tgcagagtct gtacgcgttt gatgaggagg agacggagat gaggaaccaa gtcgtggaag
      541 acctgaagac agccctccgg acacagccta tgaggtttgt gacccgcttc attgagctgg
      601 agggcttgac ctgtctgcta aatttcctcc ggagcatgga ccacgccacc tgtgagagcc
      661 gcatccacac ctcactcatt ggctgcatca aagcattgat gaacaactcc caggggcggg
      721 cacatgtgct ggcacagcct gaggccatta gtaccatagc ccagagccta cgcacagaga
      781 acagcaagac caaggtggct gtgctggaga tcctgggtgc tgtgtgcctc gtgcctggtg
      841 gccacaagaa ggtgctgcag gccatgctgc actaccaggt gtatgcagca gagcgaaccc
      901 gcttccagac cctgctgaac gagctagacc gaagtctggg ccggtaccgg gatgaagtga
      961 atctgaaaac agccatcatg tccttcatca atgctgtcct caatgctgga gctggagagg
     1021 ataatctgga gttccgccta catctacggt atgaattcct gatgctgggt atacagcctg
     1081 tgattgacaa gctccggcaa catgaaaatg ccatcctgga caaacattta gacttcttcg
     1141 agatggtgcg gaatgaggat gacctggagc tagccaggag gtttgacatg gtccacatcg
     1201 acaccaagag tgcttcccag atgtttgagt tgatccacaa gaagctgaag tacacggagg
     1261 cctacccctg cctgctctct gtgctgcacc actgcctgca gatgccctac aaacggaacg
     1321 gtggctactt ccagcagtgg cagctcctgg accgcatcct ccagcagatt gtcctccagg
     1381 atgagcgggg tgtggaccct gacctggctc ccttggagaa cttcaatgtc aagaacatcg
     1441 tcaacatgct catcaacgag aatgaagtga aacagtggcg agaccaggca gagaagttcc
     1501 ggaaagaaca catggagctt gtgagccgtc tggagaggaa ggagcgggaa tgcgagacaa
     1561 agacattgga gaaggaagag atgatgcgga cgctgaacaa aatgaaggac aagctggccc
     1621 gggagtccca ggagctgcgc caggctcggg gacaagtggc agagctggta gcccagctca
     1681 gtgaactctc aacaggccct gtatcttccc caccaccccc tgggggccca ctcaccttgt
     1741 cttcctcaat gacaaccaat gacctgcctc caccccctcc tcctctgccc tttgcctgtt
     1801 gtccccctcc cccaccacca ccccttcctc ccgggggacc cccgactccc ccaggtgccc
     1861 caccttgcct cggcatgggc ctgcccctcc ctcaggaccc ctaccccagc agtgacgtcc
     1921 cactcaggaa aaagcgtgtc ccccagcctt ctcacccact gaagtccttc aactgggtga
     1981 agctgaatga ggagcgtgtc cctggcaccg tatggaatga gattgatgac atgcaggtat
     2041 ttcggatcct ggacctagag gattttgaaa agatgttttc agcctaccag aggcaccaga
     2101 aagagctggg ctccactgaa gacatctacc tggcttcccg caaggtcaaa gagctgtcgg
     2161 tcattgatgg ccggagggcc caaaactgca tcatccttct ttccaagttg aagctttcta
     2221 acgaggagat ccggcaggcc atcttgaaga tggatgagca ggaggacctt gctaaggaca
     2281 tgctggagca gctcctcaag ttcatcccag agaagagtga cattgacctc ctggaggagc
     2341 acaagcatga aattgagcgg atggcccgtg ctgaccgctt cctctatgaa atgagcagga
     2401 ttgaccacta ccagcagcga ctgcaagccc tcttcttcaa gaagaaattc caggagcggc
     2461 tggctgaggc aaagcccaaa gtggaagcca tcctgttggc ctcccgggag ctggtccgca
     2521 gcaagcgtct tagacagatg ctagaggtca tcctagccat aggcaacttc atgaacaaag
     2581 ggcagcgtgg gggcgcctac gggttccggg tggccagcct caacaagatc gctgacacca
     2641 agtccagcat cgacagaaac atctctctgc tccattacct gatcatgatc ctggagaagc
     2701 attttcctga tattctaaac atgccttcag agctgcaaca tcttccagaa gctgccaaag
     2761 tcaacctagc agaactggag aaggaggtgg gcaacctcag gaggggcctg agagcggtgg
     2821 aggtggagct ggagtatcag aggcgccagg tacgggagcc cagtgacaag tttgtccctg
     2881 tcatgagcga cttcatcacg gtgtccagct tcagcttctc cgagctggag gaccagctaa
     2941 atgaggccag ggacaagttc gccaaggcct tgatgcactt cggggagcat gacagcaaga
     3001 tgcagccaga cgaattcttt ggcatctttg ataccttctt gcaggccttc tcagaggccc
     3061 ggcaggatct agaggccatg aggaggagga aggaggagga ggagcggcgg gcgcgcatgg
     3121 aagccatgct gaaggagcag agggaacgtg agcggtggca gcggcagcgg aaggtcctgg
     3181 ctgcaggcag ctcgctggag gagggaggag agttcgatga cctggtgtcg gccctgcgct
     3241 ctggggaggt cttcgacaag gacttatgca agctcaagcg cagccgcaag cgatcaggga
     3301 gccaggccct ggaagttacc cgggagcggg caataaaccg gctaaattat tgacctgggg
     3361 aactagccac acaggaggcc gggagacagg gactggtgag aatggggctg agtggaggag
     3421 gtggtgatat ttaaaccatt tggtgcttgg tttagagcct tgggctgggt cctgggatgg
     3481 ggggctgtgt gtggctggac caggtgtctc cccacgctta ccttaagggg ctcctcttat
     3541 ctccccttca catgattcct tctgtgccct ggccccaggt attattctga ggctgccttg
     3601 gatggcctca ggccaggtaa ccccaggctg aaggggccct gctccccatc ccctaccatg
     3661 ggcacccatg tgctggcaca gaacagttcc agatctagac tggagaggtc cacagccttg
     3721 tccagagttc ctgtgtagca cggggagcaa tgatggaggg agcccctgag agggaatctg
     3781 gtgagggaat ccagactccc ttctctcaag gggaggctca acagaacatt gacctggggg
     3841 caaactttcc tcttgaatgg gaacagagga ggcattatat attctagtta gatcagctct
     3901 ggtaggttcc agagaacagt caatgttgga aggatgatgc agggaccaaa gccatcagga
     3961 cagagtagca gtgtctgttt cccatgtcac aagtcctctg gcctctccct gcatgtctta
     4021 agtatctttc ccttccttct ctaccctcac ctccatcctg tctactaatc cacagtccta
     4081 gaagactcac cttgggtttc cacagctatg gctcactacc aggtgcttga tgaatctggc
     4141 gaggggctca agacagacct catgcatcac cacacctcat gccttttggg catctcccat
     4201 gtccccatct cctggacacc tggccattgt tgtgaagcca gacagtgacc tcaaatgttg
     4261 ccttggagtc ccctacagcc cctcagcaga gggcagcact tgaatgctta gctccatccc
     4321 atagttctct acttcatata aattgctcag gccctcccac cccttctcta acactagctt
     4381 caaggcagaa gccacagcag cctctgtcca gcctgcaggt ggccacttgg aaccatgtgt
     4441 ccactggcgt tggggagttg gttcctgaga ggtctgaggg ccagagctgc cctctacatt
     4501 aacatgctgt ctctaagggt ggcccctcct ctcaggcgtt cagatggtgc gaacagcaga
     4561 gcaggcaagg gaaactgggg agatggggat ggaggaggaa ggctgatatc ctctggggag
     4621 cacatcacct gaaggtgcca aggaggaagg ctgagagggg ggccacccca tttctggtac
     4681 ccaatttggt tcttcagccc aacttgcaag gggttccttc tggtcctccc atccactgcc
     4741 accttccatt ttgtccatct catgctggcc ttggtggatg ggatggctgt atctagacaa
     4801 aatttttcta aaactccatc aaggctctta ttcaatacca cgttccgagt tggcctttca
     4861 tcttctttga gactggccct gcctaacctc taccatcaat gagctcttgg cccttctgcc
     4921 cttccctgtg tttctcactt tccaacctaa tccctggctc agggttattg ccagtggaga
     4981 ctggtgagct gggcctactc tcagctgcct atcttctgcc tttcacttgc atccaactcc
     5041 tggggctggg accgtagtag ctgcgggggg gaagaaacac agggtcggtg agcccagcat
     5101 gtgcgttggt ttgagggggc gggcggtgtg tgtgtgttct ggtgggaggg atctgagcaa
     5161 gtgcaagcct ggctgacaca ggtgtgaaga ggccatcctg gaacccaggt gagggcaaga
     5221 tgaaggcttc caggcagaac agctgcagag agtttggcta tatgcatctg cagccccaag
     5281 agctcccact gcaagacaag tgttggggaa gatgggaggt tgtgggtgag gcctctaaag
     5341 gtcctctccc aaactgacca ggctgatgtc aacctaaccc cctcaggggc agggaacagg
     5401 ggagggctcc acaagcgtgt ctggcattcc cacccaccat ggaagactgg atacgcacct
     5461 ggaaacaaaa ggactatgga agctgttcaa gatacatttg atcttcagaa aagcagaatt
     5521 tggttcaact gttgacagag gacacaaata cgttgttcca gagctcagcc ttctcactct
     5581 aaaagaaaga tatttttcta tttattttct acatctggcc agtggctctg gtgctagatg
     5641 ccactgtagc cagatctcca acagtgcctt ggaccatgga ctcatactca actgagtaag
     5701 aaggggctgg tgcccagtcg gggtggctga gctggtcctt aataggttgt ttcttggtct
     5761 tgctttcttc atgccctccc cactgctcct gccaccttta gataagtttc tctagctaat
     5821 tttgtggcca atgtaaaatt cgtcatcaac ctaacaaaca caaccttctc agcagcattt
     5881 ctcccctgtg atggaaataa agtgtttagg gcagtgggag gagaaaattc tccaggtgaa
     5941 tggggaaggg tctgttccag cctctcccta ctcccatccc atttccacca actggggaac
     6001 tgtgactatc tatctccccc gacttctacc agggatgcct tcacgccaag gctgttctca
     6061 ccagctgcct cagatgacaa atgaggctaa tggacataat ctacagtgtc ctttttcact
     6121 tgcacctttt ttataagaat atattgtaat actaaaaaat attaaattca taccatccct
     6181 accca
//
