LOCUS       NM_001270520            5890 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens dishevelled associated activator of morphogenesis 1
            (DAAM1), transcript variant 2, mRNA.
ACCESSION   NM_001270520
VERSION     NM_001270520.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5890)
  AUTHORS   Zeni,C., Komiya,Y. and Habas,R.
  TITLE     Formin Binding Protein 1 (FNBP1) regulates non-canonical Wnt
            signaling and vertebrate gastrulation
  JOURNAL   Dev Biol 515, 18-29 (2024)
   PUBMED   38945423
  REMARK    GeneRIF: Formin Binding Protein 1 (FNBP1) regulates non-canonical
            Wnt signaling and vertebrate gastrulation.
REFERENCE   2  (bases 1 to 5890)
  AUTHORS   Phillips,A.T., Boumil,E.F., Venkatesan,A., Tilstra-Smith,C.,
            Castro,N., Knox,B.E., Henty-Ridilla,J.L. and Bernstein,A.M.
  TITLE     The formin DAAM1 regulates the deubiquitinase activity of USP10 and
            integrin homeostasis
  JOURNAL   Eur J Cell Biol 102 (4), 151347 (2023)
   PUBMED   37562219
  REMARK    GeneRIF: The formin DAAM1 regulates the deubiquitinase activity of
            USP10 and integrin homeostasis.
REFERENCE   3  (bases 1 to 5890)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   4  (bases 1 to 5890)
  AUTHORS   Chen,A., Liu,Z., Wu,Q. and Li,H.
  TITLE     Disheveled-associated activator of morphogenesis 2 promotes
            invasion of colorectal cancer by activating PAK1 and promoting MMP7
            expression
  JOURNAL   Genes Genomics 43 (8), 923-935 (2021)
   PUBMED   33974241
  REMARK    GeneRIF: Disheveled-associated activator of morphogenesis 2
            promotes invasion of colorectal cancer by activating PAK1 and
            promoting MMP7 expression.
REFERENCE   5  (bases 1 to 5890)
  AUTHORS   Venditti,M., Arcaniolo,D., De Sio,M. and Minucci,S.
  TITLE     Preliminary Investigation on the Involvement of
            Cytoskeleton-Related Proteins, DAAM1 and PREP, in Human Testicular
            Disorders
  JOURNAL   Int J Mol Sci 22 (15), 8094 (2021)
   PUBMED   34360857
  REMARK    GeneRIF: Preliminary Investigation on the Involvement of
            Cytoskeleton-Related Proteins, DAAM1 and PREP, in Human Testicular
            Disorders.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5890)
  AUTHORS   Lu,J., Meng,W., Poy,F., Maiti,S., Goode,B.L. and Eck,M.J.
  TITLE     Structure of the FH2 domain of Daam1: implications for formin
            regulation of actin assembly
  JOURNAL   J Mol Biol 369 (5), 1258-1269 (2007)
   PUBMED   17482208
  REMARK    GeneRIF: The DAAM1 FH2 domain structure, determined at 2.25 A
            resolution, and DAAM1 actin binding activity
REFERENCE   7  (bases 1 to 5890)
  AUTHORS   Sato,A., Khadka,D.K., Liu,W., Bharti,R., Runnels,L.W., Dawid,I.B.
            and Habas,R.
  TITLE     Profilin is an effector for Daam1 in non-canonical Wnt signaling
            and is required for vertebrate gastrulation
  JOURNAL   Development 133 (21), 4219-4231 (2006)
   PUBMED   17021034
  REMARK    GeneRIF: Results report that Profilin1 is an effector downstream of
            Daam1 required for cytoskeletal changes during gastrulation.
REFERENCE   8  (bases 1 to 5890)
  AUTHORS   Aspenstrom,P., Richnau,N. and Johansson,A.S.
  TITLE     The diaphanous-related formin DAAM1 collaborates with the Rho
            GTPases RhoA and Cdc42, CIP4 and Src in regulating cell
            morphogenesis and actin dynamics
  JOURNAL   Exp Cell Res 312 (12), 2180-2194 (2006)
   PUBMED   16630611
  REMARK    GeneRIF: DAAM1 was shown to bind to the SH3 domain of CIP4 in vivo.
REFERENCE   9  (bases 1 to 5890)
  AUTHORS   Habas,R., Kato,Y. and He,X.
  TITLE     Wnt/Frizzled activation of Rho regulates vertebrate gastrulation
            and requires a novel Formin homology protein Daam1
  JOURNAL   Cell 107 (7), 843-854 (2001)
   PUBMED   11779461
REFERENCE   10 (bases 1 to 5890)
  AUTHORS   Tanaka,K.
  TITLE     Formin family proteins in cytoskeletal control
  JOURNAL   Biochem Biophys Res Commun 267 (2), 479-481 (2000)
   PUBMED   10631086
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP199650.1, BC064999.1,
            AL133502.4 and AL159140.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001270520.1.
            
            Summary: Cell motility, adhesion, cytokinesis, and other functions
            of the cell cortex are mediated by reorganization of the actin
            cytoskeleton and several formin homology (FH) proteins have been
            associated with these processes. The protein encoded by this gene
            contains two FH domains and belongs to a novel FH protein subfamily
            implicated in cell polarity. A key regulator of cytoskeletal
            architecture, the small GTPase Rho, is activated during development
            by Wnt/Fz signaling to control cell polarity and movement. The
            protein encoded by this gene is thought to function as a
            scaffolding protein for the Wnt-induced assembly of a disheveled
            (Dvl)-Rho complex. This protein also promotes the nucleation and
            elongation of new actin filaments and regulates cell growth through
            the stabilization of microtubules. Alternative splicing results in
            multiple transcript variants encoding distinct proteins. [provided
            by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            3' coding region, compared to variant 1, and encodes a shorter
            isoform (2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064999.1, AK291790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360909.8/ ENSP00000354162.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BP199650.1         5-17
            14-4252             BC064999.1         1-4239
            4253-4633           AL133502.4         171666-172046
            4634-5890           AL159140.4         33905-35161
FEATURES             Location/Qualifiers
     source          1..5890
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.1"
     gene            1..5890
                     /gene="DAAM1"
                     /note="dishevelled associated activator of morphogenesis
                     1"
                     /db_xref="GeneID:23002"
                     /db_xref="HGNC:HGNC:18142"
                     /db_xref="MIM:606626"
     exon            1..102
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            103..322
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..3346
                     /gene="DAAM1"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="disheveled-associated activator of morphogenesis
                     1 isoform 2"
                     /protein_id="NP_001257449.1"
                     /db_xref="CCDS:CCDS58323.1"
                     /db_xref="GeneID:23002"
                     /db_xref="HGNC:HGNC:18142"
                     /db_xref="MIM:606626"
                     /translation="MAPRKRGGRGISFIFCCFRNNDHPEITYRLRNDSNFALQTMEPA
                     LPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKGATSW
                     PEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSC
                     ILNFLKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIK
                     TKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVS
                     LKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDF
                     FEMLRNEDELEFAKRFELVHIDTKSATQMFELTRKRLTHSEAYPHFMSILHHCLQMPY
                     KRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTPLENFNIKNVVRMLVNENEVKQWKE
                     QAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQV
                     ADLTAQLHELSRRAVCASIPGGPSPGAPGGPFPSSVPGSLLPPPPPPPLPGGMLPPPP
                     PPLPPGGPPPPPGPPPLGAIMPPPGAPMGLALKKKSIPQPTNALKSFNWSKLPENKLE
                     GTVWTEIDDTKVFKILDLEDLERTFSAYQRQQKEADAIDDTLSSKLKVKELSVIDGRR
                     AQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHE
                     LDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSG
                     ALKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVEN
                     KYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPGDKF
                     VSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFFGIFDQFLQA
                     VSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKENSEESGEFDDLVSAL
                     RSGEVFDKDLSKLKRNRKRITNQMTDSSRERPITKLNF"
     exon            323..412
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..484
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..579
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..913
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1024
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1128
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1195
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1313
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1452
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1511
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1699
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1999
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2107
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2214
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2299
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2406
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2495
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2664
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2772
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2833
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2965
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3136
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..5890
                     /gene="DAAM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5864..5869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DAAM1"
                     /note="hexamer: AATAAA"
     polyA_site      5890
                     /gene="DAAM1"
                     /note="major polyA site"
ORIGIN      
        1 gcgagttagt aacctacgag cggctgtgaa ggaaactgtt taaccggatc ccattgtacc
       61 cagagtgcag agccgccttt ccagcatgca ggggctgctc agcgtttagt cacatcaaga
      121 aatagaacag aattcagcca tggccccaag aaagagaggt ggacgaggta tttcattcat
      181 cttttgctgt ttccgaaata atgatcaccc agaaatcacg tatcggctgc gaaatgatag
      241 caactttgcg cttcagacca tggaaccagc attgcccatg ccccctgtgg aggagctgga
      301 tgtcatgttc agtgaactgg tggatgaact ggacctcaca gacaaacaca gagaagccat
      361 gtttgcactt ccagctgaga aaaaatggca aatatactgt agcaagaaaa aggaccagga
      421 agaaaacaag ggagctacaa gttggcctga attctacatt gatcagctca attccatggc
      481 tgctagaaaa tctctgctgg ctttagagaa ggaagaagaa gaagaaagaa gtaaaactat
      541 agagagttta aagacagcac tgaggacaaa accaatgagg tttgtaacca gattcatcga
      601 cttggatggc ctatcatgta tcctcaactt tctaaagacc atggactacg agacctcaga
      661 gtctcgaata catacttctc tcattggctg tataaaggcg ttaatgaaca actctcaagg
      721 ccgggctcac gtcctggctc attctgagag tattaatgta attgctcaga gtctgagcac
      781 agagaacatt aaaacgaagg tggccgtgct ggaaatcttg ggcgccgtgt gcctggttcc
      841 cgggggccac aagaaggttc tgcaggccat gctgcactac cagaagtatg ccagcgaaag
      901 gacccgcttt cagacattaa ttaacgactt ggataaaagc actgggcggt atcgagatga
      961 agtgagtctc aagactgcca tcatgtcctt cattaatgca gtgctcagcc aaggtgcagg
     1021 agtggagagt ttggacttta gacttcatct tcgctatgaa tttctgatgt taggaattca
     1081 acctgtaata gataaattaa gggaacacga aaattcaaca ttagataggc atttagactt
     1141 ttttgaaatg ctccgaaatg aagatgaact agaatttgcc aaaagatttg aactggttca
     1201 catagacaca aaaagtgcaa ctcagatgtt tgagctgacc aggaagaggc tgacacatag
     1261 tgaagcttac ccgcatttca tgtccatcct gcaccactgc ctccaaatgc cttacaagag
     1321 gagtggcaac actgttcagt actggctact actagataga attatacagc agatagttat
     1381 ccagaatgac aaaggacagg accctgactc cacacctttg gaaaacttta atattaagaa
     1441 tgtcgtacga atgttggtta atgaaaatga agttaagcag tggaaagaac aagcggaaaa
     1501 aatgagaaaa gagcacaatg agctacaaca gaaactggaa aagaaagaac gagaatgtga
     1561 tgctaagact caagagaagg aagagatgat gcagacctta aataaaatga aagagaaact
     1621 tgaaaaggag actactgagc ataagcaagt caagcagcag gtggcggacc tcacagcaca
     1681 gctccatgag ctcagcagga gggccgtctg tgcttcaatc ccaggtggac cctcgcctgg
     1741 agcaccagga gggccctttc cttcctctgt gcctggatct ctccttcctc ccccaccacc
     1801 cccacctcta ccaggtggga tgcttccccc tccaccgcct cccctccctc caggtggccc
     1861 tcctcctccc ccagggcctc ctcccttagg ggcaatcatg ccacctcctg gtgctccaat
     1921 gggcctagca ctgaagaaga aaagcattcc tcagcccaca aatgccctga aatccttcaa
     1981 ctggtctaaa ctgcccgaga acaaactgga aggaacagta tggaccgaaa ttgatgatac
     2041 aaaagtcttc aaaattctag atcttgaaga cctggaaaga accttctctg cctatcaaag
     2101 acagcagaaa gaagcagatg ccattgatga cactctgagt tccaaactta aagttaaaga
     2161 gctttcggtg attgatggtc ggagagctca gaattgcaac atccttctat cgaggttgaa
     2221 attatccaat gacgaaatca aacgggcaat tctaacaatg gacgaacagg aagatctgcc
     2281 caaggacatg ttggaacagc tcttgaaatt tgttcctgaa aaaagtgaca ttgacctatt
     2341 ggaggaacat aaacacgaac tggatcggat ggccaaggct gataggttcc tttttgagat
     2401 gagccgaatt aatcactatc agcaaaggtt gcaatcgctg tacttcaaaa agaagtttgc
     2461 agagcgtgtg gcagaagtga aacctaaagt ggaagcaatt cgttctggct cagaagaggt
     2521 gtttaggagt ggtgccctca agcagttgct ggaggtggtt ttggcatttg gaaattatat
     2581 gaataaaggt caaagaggga atgcatatgg attcaagata tctagcctaa acaaaattgc
     2641 tgacacaaaa tccagcatcg acaaaaacat tacccttttg cactatctca tcactattgt
     2701 ggaaaataag taccccagtg ttctcaatct aaatgaagaa ttgcgagata ttcctcaagc
     2761 tgcgaaagta aacatgactg agctggacaa agaaataagt accttgagaa gtggcttgaa
     2821 agcagtagag acagagctgg aatatcagaa gtctcagccc ccacagcccg gagataagtt
     2881 tgtgtctgtt gtcagccagt tcatcacagt agccagcttc agcttctctg atgttgaaga
     2941 ccttctagca gaagctaaag acctgtttac taaagcagtg aagcactttg gggaagaggc
     3001 tggcaaaata caaccagatg agttctttgg catttttgat caatttcttc aagctgtgtc
     3061 agaagccaaa caagaaaacg aaaatatgag aaagaaaaag gaggaagaag aacgtcgagc
     3121 tcgcatggaa gctcagctca aagaacaacg tgaaagggaa cgtaaaatga gaaaagctaa
     3181 agagaatagt gaagaaagcg gagagtttga tgaccttgtt tcagctttac gctcaggaga
     3241 agtgtttgac aaagaccttt ctaaattgaa acggaatcgc aaacgtatta ccaaccagat
     3301 gactgacagc agcagagaga gaccaatcac aaaacttaat ttctaatttt ccatgaatac
     3361 ttttttttag aaagctcatt agcagccctc taaagtgact agaacgtttc attacactgc
     3421 cttgcaatcc aaacagtggc aattttttcc ttcatctgtg agtgaatgtg tgaacgtgtg
     3481 tatgtaaatg tatgtgtgta tatattaaaa aatgtatata gatgtctgag tgttgtctgg
     3541 agacctatac gtatggttaa aaagatttat gttaatgtat gtgctccaaa acctttcgtg
     3601 tatgcattca cattgagtgt ggctcatttt ctttccccga acgccatgac tgttcagaag
     3661 cacaatacta tctcctgaaa gagataagag acattcccta gattcaaagg caaaacagaa
     3721 gaaacaaaca aacaaacaaa aaaagcttgc aaaatatttt atggtttcca agcttgatat
     3781 cctttaaaat tattttcatt gatggaactg gagttgttgg aaaaacatag atttaaaatg
     3841 atttttgata gctgacattg tgatgttgat gtatcacatc agtaatagga ccagctttga
     3901 atttctgaca ttggtgtggg gatacagtct gtaaatgttt attgagaaca tcttgcacac
     3961 aatttgaatt atgtagaatg tcaatcaagt ttttgtatat ttaaaagttg gacatcaatt
     4021 ttttcccctg atttcatcaa gttatctctg ccaagtgctc ttgataattt cttcagattt
     4081 ttggaaaaaa acactatata aatgcaatcc atgctttttt taaagaacaa cattgccaga
     4141 gtatgcttgt tctaacaata tagatatata aaccttaaaa ataataaaat atctcaccca
     4201 agacttaaag gaagaattct ctgaagggat aaagattact aaaaaaaaaa aaaaaaaaaa
     4261 aaaattaatg gggtgccttt ttgttatagt ttctattttc tgttttgtag gacaagctgc
     4321 attttctgta aatataggtc tggactaaag gatacataaa gaatgcacaa aatgtcaaca
     4381 tcagcagaga tgcccagatc tatttatctc taagtatatt tgaagtgatt gctgtttata
     4441 tgttgtcatt ttaaaattgt gtgtcagtaa agctacctgt aaaatttcag tccaaaaaaa
     4501 taaagctctc agggagacat gaataaaatc aatgaacatt agaaaataaa atatagatgc
     4561 ttaccattaa cctaccaact cttaatatcc ttaaattatg tgatatataa agaggactgt
     4621 tactttttta cttttttttt tttttttttt tttttttggc tttgctttat ttatttgtag
     4681 ttgggggcta acgttttctc ttttctttct attgatcctg ttgtggttgg gtttcctgtg
     4741 gagagagtag tttgtcctgt tgcactagaa cattatttac tcactaaatt gagtttttca
     4801 gtcaattaac aaatatttat taagttccta ctatgtacca ggcatagtag ggctacaatg
     4861 gtaagcaaga cagagtccct gcccccaaag agcttatatt ctaatgggga tattaaggga
     4921 tgaatagaat accaatgtgt gcactgtaca ggaatcatac tatttaaaaa taatttgtat
     4981 aaactataat gcttagcaca gatggcgagt tatctgtgct atgtgaaagc tgtgaaatag
     5041 tgctctaaga gttgtcaaga gctgtggttt tacatctttt cctcattgca aatttagtga
     5101 ctttctacac actatatgga aataaatgac tagcaaataa aacagtcata aatacaaagc
     5161 agaggttgca ctcccccaat cccgagttaa cccaggtctg caataacacc atgttaaagg
     5221 tgcagataga gacttggctc aaaaaggctt ggagatgagg aagattggaa tataatgatg
     5281 gttttgtctg ttccttaact aaagtgcctc tatgtatatt cttttctatt tgtagcagga
     5341 taaatttggt ctggctcagt tttggaactg tattttgaaa atggctttgt cttacagttt
     5401 aaggaataga caggtggagg gaaagtcaca taaaggagca agtttgtgta gctgtccctc
     5461 ttgccccttt taatcatcct cctttgatat ggccatcctg gtgggcctcc tttgccattt
     5521 ccatttttgg tttctttccc tgaaaactgt gtgcaggtaa ttccatgtgc cattgttgaa
     5581 aagaaaaaaa aaaaacaaaa aaaaaaccta ctttttagat tggtgctggt gtaagtagcc
     5641 acttttctct cttgggtgtg tattttaaac tttttttgtt tttttaaatt aatgccaaaa
     5701 agaaaatgca taatttgtaa acttaattat atgtcttata tcttattagc ttagtagttg
     5761 gaaccactta gtctttaggt gcaagactgt tgttagatag tactgagaaa aaaaaagtat
     5821 gtgttatgag actgtacatg tttttttaaa aatagcaata tgcaataaag agatgaattc
     5881 attgggtgta
//
