LOCUS       XM_011511741            1587 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens D-2-hydroxyglutarate dehydrogenase
            (D2HGDH), transcript variant X8, mRNA.
ACCESSION   XM_011511741
VERSION     XM_011511741.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011511741.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1587
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..1587
                     /gene="D2HGDH"
                     /gene_synonym="D2HGD"
                     /note="D-2-hydroxyglutarate dehydrogenase; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 19 ESTs, 16 long SRA reads, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     13 samples with support for all annotated introns"
                     /db_xref="GeneID:728294"
                     /db_xref="HGNC:HGNC:28358"
                     /db_xref="MIM:609186"
     CDS             159..1484
                     /gene="D2HGDH"
                     /gene_synonym="D2HGD"
                     /codon_start=1
                     /product="D-2-hydroxyglutarate dehydrogenase,
                     mitochondrial isoform X5"
                     /protein_id="XP_011510043.1"
                     /db_xref="GeneID:728294"
                     /db_xref="HGNC:HGNC:28358"
                     /db_xref="MIM:609186"
                     /translation="MLPRRPLAWPAWLLRGAPGAAGSWGRPVGPLARRGCCSAPGTPE
                     VPLTRERYPVRRLPFSTVSKQDLAAFERIVPGGVVTDPEALQAPNVDWLRTLRGCSKV
                     LLRPRTSEEVSHILRHCHERNLAVNPQGGNTGMVGGSVPVFDEIILSTARMNRVLSFH
                     SVSGILVCQAGCVLEELSRYVEERDFIMPLDLGAKGSCHIGGNVATNAGGLRFLRYGS
                     LHGTVLGLEVVLADGTVLDCLTSLRKDNTGYDLKQLFIGSEGTLGIITTVSILCPPKP
                     RAVNVAFLGFLCSALIPLQLQSPVCRPPVVLGARGQPGCRILLFALQVSDRSHSPLRA
                     TPTSKPGGTGPVSAPSLCACETFSLENSSLISTCLCIASLSRPERWARAPSCCSVSGA
                     ARLQTSPLSSFPSLHLRVGFPRAAASLVAPTNPGALTRLLDEVLSAGKT"
     polyA_site      1587
                     /gene="D2HGDH"
                     /gene_synonym="D2HGD"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 actccggctc ggcggctctg ggcctgcggc gggcgctgcg ggttggagct cgggacgtga
       61 tcgtgggcgc gcagccagcg gctccctgcc cttcccctcc gggccctgag taccggcccc
      121 ccaccaagga ggagcccgag gtctccgtcc cggcggcgat gctgccccgt cggcctctgg
      181 cgtggcccgc gtggctgttg cggggtgctc cgggagccgc gggttcttgg ggtcggccgg
      241 ttggccccct ggcccgcaga ggctgctgct ccgccccggg gacccccgag gtgccgctga
      301 cccgggagcg ctaccccgtg cggcgcttgc cgttctccac ggtgtctaag caggacctgg
      361 ccgcctttga gcgcatcgtg cccggcgggg tcgtcacgga cccggaagcg ctgcaggctc
      421 ccaacgtgga ctggttgcgg acgctgcgag gctgtagcaa ggtgctgctg aggccacgga
      481 cgtcggagga ggtgtcccac atcctcaggc actgccacga gaggaacctg gccgtgaacc
      541 cacagggggg caacacaggc atggtgggtg gcagcgtccc cgtctttgac gagatcatcc
      601 tctccactgc ccgcatgaac cgggtcctca gcttccacag cgtgtctgga attctggttt
      661 gccaggcggg ctgcgtcctg gaggagctga gccggtatgt ggaggaacgg gacttcatca
      721 tgccgctgga cttaggagcc aagggcagct gccacatcgg gggaaacgtg gcaaccaacg
      781 ctggaggcct gcggtttctt cgatatggct cactgcatgg gactgtcctg ggcctggaag
      841 tggtgctggc cgacggcact gtcctggact gcctgacctc cctgaggaag gacaacacgg
      901 gctatgacct gaagcagctg ttcatcgggt cggagggcac tttggggatc atcaccacgg
      961 tgtccatctt gtgtccaccc aagcccaggg ctgtgaacgt ggctttcctc ggttttctgt
     1021 gttctgctct gatcccactc caactgcagt cacctgtgtg ccgcccgcct gtggtcctgg
     1081 gagcccgagg ccagcccggc tgccgcatcc tgctcttcgc actccaggtc tcagacagga
     1141 gtcactcgcc tcttcgtgcc acgcccacgt ctaagccggg tggaacaggc cctgtgtctg
     1201 cccccagcct ctgcgcctgt gagaccttct ctctggaaaa ttcttctctg atatccacat
     1261 gcctttgcat tgcctccctg tctcgccctg aaaggtgggc acgggccccc tcctgctgca
     1321 gcgtctctgg ggctgcccgc ctgcagacat ctccactcag ttcctttcca tctttgcact
     1381 tgagggtcgg cttccccagg gcagcggcct cactggtagc ccccaccaac cctggagcac
     1441 taacacgcct gttggatgag gtcctgagtg cagggaagac ctgagtgctg attgtgttaa
     1501 gagaaatgca gccattccca aaggctgcct gttgctggct ctgtgtttgc agaattccca
     1561 agatacgccc cctctgagtc ccactgc
//
