LOCUS       NM_017887               1102 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens CXXC motif containing zinc binding protein (CZIB),
            transcript variant 1, mRNA.
ACCESSION   NM_017887
VERSION     NM_017887.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1102)
  AUTHORS   A Rahaman,S.N., Mat Yusop,J., Mohamed-Hussein,Z.A., Aizat,W.M.,
            Ho,K.L., Teh,A.H., Waterman,J., Tan,B.K., Tan,H.L., Li,A.Y.,
            Chen,E.S. and Ng,C.L.
  TITLE     Crystal structure and functional analysis of human C1ORF123
  JOURNAL   PeerJ 6, e5377 (2018)
   PUBMED   30280012
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1102)
  AUTHORS   Furukawa,Y., Lim,C., Tosha,T., Yoshida,K., Hagai,T., Akiyama,S.,
            Watanabe,S., Nakagome,K. and Shiro,Y.
  TITLE     Identification of a novel zinc-binding protein, C1orf123, as an
            interactor with a heavy metal-associated domain
  JOURNAL   PLoS One 13 (9), e0204355 (2018)
   PUBMED   30260988
  REMARK    GeneRIF: Study performed yeast two-hybrid screening of the human
            proteome and found an uncharacterized protein encoded as open
            reading frame 123 in chromosome 1 (C1orf123) that can interact
            specifically with the heavy metal-associated domain of a copper
            chaperone for superoxide dismutase.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1102)
  AUTHORS   Rahaman,S.N., Mat Yusop,J., Mohamed-Hussein,Z.A., Ho,K.L.,
            Teh,A.H., Waterman,J. and Ng,C.L.
  TITLE     Cloning, expression, purification, crystallization and X-ray
            crystallographic analysis of recombinant human C1ORF123 protein
  JOURNAL   Acta Crystallogr F Struct Biol Commun 72 (Pt 3), 207-213 (2016)
   PUBMED   26919524
REFERENCE   4  (bases 1 to 1102)
  AUTHORS   Mate,S.E., Brown,K.J. and Hoffman,E.P.
  TITLE     Integrated genomics and proteomics of the Torpedo californica
            electric organ: concordance with the mammalian neuromuscular
            junction
  JOURNAL   Skelet Muscle 1 (1), 20 (2011)
   PUBMED   21798097
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA305789.1, BC010908.1 and AK000587.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017887.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.85583.1,
                                           SRR5189661.184283.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294360.5/ ENSP00000294360.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DA305789.1         6-22
            18-884              BC010908.1         5-871
            885-1102            AK000587.1         868-1085
FEATURES             Location/Qualifiers
     source          1..1102
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..1102
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /note="CXXC motif containing zinc binding protein"
                     /db_xref="GeneID:54987"
                     /db_xref="HGNC:HGNC:26059"
     exon            1..65
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..542
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0587 protein C1orf123"
                     /codon_start=1
                     /product="CXXC motif containing zinc binding protein
                     isoform 1"
                     /protein_id="NP_060357.1"
                     /db_xref="CCDS:CCDS576.1"
                     /db_xref="GeneID:54987"
                     /db_xref="HGNC:HGNC:26059"
                     /translation="MGKIALQLKATLENITNLRPVGEDFRWYLKMKCGNCGEISDKWQ
                     YIRLMDSVALKGGRGSASMVQKCKLCARENSIEILSSTIKPYNAEDNENFKTIVEFEC
                     RGLEPVDFQPQAGFAAEGVESGTAFSDINLQEKDWTDYDEKAQESVGIYEVTHQFVKC
                     "
     exon            66..149
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /inference="alignment:Splign:2.1.0"
     exon            150..206
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /inference="alignment:Splign:2.1.0"
     exon            207..288
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /inference="alignment:Splign:2.1.0"
     exon            289..320
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /inference="alignment:Splign:2.1.0"
     exon            321..398
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /inference="alignment:Splign:2.1.0"
     exon            399..464
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /inference="alignment:Splign:2.1.0"
     exon            465..1102
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /inference="alignment:Splign:2.1.0"
     regulatory      705..710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /note="hexamer: AATAAA"
     polyA_site      728
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /note="major polyA site"
     regulatory      1015..1020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /note="hexamer: ATTAAA"
     regulatory      1043..1048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /note="hexamer: AATACA"
     polyA_site      1044
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /note="major polyA site"
     polyA_site      1067
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /note="major polyA site"
     regulatory      1080..1085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /note="hexamer: ATTAAA"
     polyA_site      1102
                     /gene="CZIB"
                     /gene_synonym="C1orf123"
                     /note="major polyA site"
ORIGIN      
        1 acgacgcgcc ggaaagcaac ggcaagggcc gcagccagca ccgggcggag agggctacca
       61 tggggaaaat cgcgctgcaa ctcaaagcca cgctggagaa catcaccaac ctccggcccg
      121 tgggcgagga cttccggtgg tacctgaaga tgaaatgtgg caactgtggt gagatttcgg
      181 acaagtggca gtacatccgg ctgatggaca gtgtggcact gaaggggggc cgtggcagtg
      241 cttccatggt ccagaagtgc aagctgtgtg caagagaaaa ttccatcgag attttaagca
      301 gcaccatcaa gccttacaat gctgaagaca atgagaactt caagacaata gtggagtttg
      361 agtgccgggg ccttgaacca gttgatttcc agccgcaggc tgggtttgct gctgaaggtg
      421 tggagtcagg gacagccttc agtgacatta atctgcagga gaaggactgg actgactatg
      481 atgaaaaggc ccaggagtct gtgggaatct atgaggtcac ccaccagttt gtgaagtgct
      541 gatccctctt ccttcccagt tgcccttaag aactgagaaa ggacaaagta ctctaagcag
      601 cagagcccac agaggctcgt tcctttgacc cttgtctcct ggtggctata cgaaaccttc
      661 acaatctgca tgctggactt tattacagct tcccaagccc catcaataaa gcccctgttc
      721 acgctgcact ggtgcatgaa ggtgaagtaa ggaggcagct actccctcca caaataagaa
      781 ttcgtgcagc agcagttcac tccttaggaa aatgaagagt atttttaagg agatggtatc
      841 tccccagtca agggcaagtt tacagagatg aaaccgcgat cccaccatca ctcaatgagc
      901 cagaagccaa tggtgacgta ctgttacctg aacttactga acttgctgtt ggaaagatct
      961 ttgtgaggat taggaattag gttaaaagaa attaagaacc atcttcaagc aaaaattaaa
     1021 ctttatttct gcttaaacaa taaatacacc tgagttagtt ttccaaacct ttcctcctga
     1081 ttaaatgccc ttaaaactta aa
//
